AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Antigens, Human PlateletThrombocytopenia, Neonatal AlloimmuneBlood PlateletsTerminology as TopicPlatelet AggregationPlatelet Membrane GlycoproteinsPurpura, ThrombocytopenicThrombocytopeniaPlatelet CountPlatelet TransfusionPlatelet Glycoprotein GPIb-IX Complex
AntibodiesCarcinoembryonic antigenLeukocyteAggregationAntibodyFIBRINVasculitisPathogenesisEndothelial cellsImmuneVesiclesPatientsFluidsBroad spectrumHemorrhagicCellsDescribeLeukocytesPLASMAMolecularCountRecombinantSignificantlyFeverPhosphorylationProteinProductionSystemCellFormationGeneMajorDeathsSurfaceSevereMouseDifferencesSkinShowsAnimalSampleNormalDisease
Antibodies4
  • These can stimulate production of alloantibodies (that is, antibodies against other people's antigens) in recipients of transfused platelets from donors with different HPAs. (wikipedia.org)
  • These antibodies cause neonatal alloimmune thrombocytopenia, post-transfusion purpura, and some cases of platelet transfusion refractoriness to infusion of donor platelets. (wikipedia.org)
  • Regardless of the need for Th2 cells and their connected cytokines in the pathogenesis of sensitive respiratory disease, research of antigens regarded as causes of T-cell reactions have up to now been mostly limited by those recognized to bind IgE antibodies (7, 8) and induce IgE-mediated instant hypersensitivity reactions (9). (enmd-2076.com)
  • Blood group antigens and antibodies. (entri.app)
Carcinoembryonic antigen2
  • Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)
  • INTRODUCTION: It is worth noting the limitations in sensitivity of the existing biomarkers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in detection of colorectal cancer (CRC). (bvsalud.org)
Leukocyte3
  • Laboratory studies showed extremely low leukocyte and low platelet counts and slightly elevated aspartate aminotransferase, alanine aminotransferase (ALT), and total bilirubin levels ( Table ). (cdc.gov)
  • On day 3, slightly decreased leukocyte count along with continued low platelet count and high liver aspartate aminotransferase levels were detected. (cdc.gov)
  • Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Aggregation2
  • It is known that ATX-LPA signaling increases during wound healing, and both are produced and detected in blister fluids, where they mediate platelet aggregation and skin reepithelization [ 8 ]. (hindawi.com)
  • This process result in neutrophils infiltration, hemorrhage , fibrin deposition and platelet aggregation. (wikidoc.org)
Antibody6
  • Cell Adhesion Mediated by JAM‑B/VE‑JAM and Neutral-ization by Human JAM‑B/ VE‑JAM Antibody. (rndsystems.com)
  • Adhesion elicited by Recombinant Human JAM-B/VE-JAM Fc Chimera (0.2 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human JAM-B/ VE-JAM Monoclonal Antibody (Catalog # MAB10741). (rndsystems.com)
  • The problem of whether T-cell reputation can be always necessarily associated with antibody recognition offers broader significance with regards to the classic idea of linked reputation of the antigen by both T helper cells and antigen-specific B cells. (enmd-2076.com)
  • 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
  • So the basic principle of blood donation is that there should be no antibody to match the RBCs' surface antigen. (labpedia.net)
  • Belimumab (Benlysta) is a monoclonal antibody developed by Human Genome Sciences and GlaxoSmithKline , with significant discovery input by Cambridge Antibody Technology , which specifically recognizes and inhibits the biological activity of B-Lymphocyte stimulator (BLyS) and is in clinical trials for treatment of Systemic lupus erythematosus and other autoimmune diseases. (wikidoc.org)
FIBRIN1
  • The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). (lookformedical.com)
Vasculitis2
  • [ 1 , 2 ] It is defined as "granulomatous inflammation of the aorta and its major branches" by the Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitis. (medscape.com)
  • Nomenclature of Cutaneous Vasculitis: Dermatologic Addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. (medscape.com)
Pathogenesis7
  • The pathogenesis of SFTSV has been studied in human ( 1 , 6 ) and animal models using immunocompromised mice that show a lethal SFTS-like illness ( 7 , 8 ). (cdc.gov)
  • Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. (biomedcentral.com)
  • This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease. (biomedcentral.com)
  • Animal models of MVD are necessary to develop and test potential vaccines and treatments, and the ability of these models to reflect human pathogenesis is essential to moving forward into clinical trials. (biomedcentral.com)
  • This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research. (ersjournals.com)
  • Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. (bmrat.org)
  • These results demonstrate a mixed unbiased transcriptomic, proteomic, and immunomic strategy identifies a significantly broadened repertoire of proteins antigens targeted by T cells involved with allergy pathogenesis. (enmd-2076.com)
Endothelial cells2
  • They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)
  • EVs were instrumental in transferring selected miRNAs from HLSCs to human endothelial cells absent in the latter cells. (spandidos-publications.com)
Immune1
  • citation needed] To date, 24 platelet-specific alloantigens have been defined by immune sera, of which 12 are grouped in six biallelic systems (HPA-1, -2, -3, -4, -5, -15). (wikipedia.org)
Vesicles1
  • Vesicles derived from adult human liver stem-like cells (HLSCs) have also been shown to contain ribonucleoproteins and different RNA species involved in hepatic regeneration ( 20 ). (spandidos-publications.com)
Patients3
  • genus Phlebovirus , family Phenuiviridae [previously known as family Bunyaviridae ]) ( 1 , 2 ), causes severe and often fatal febrile illness in humans, especially in elderly patients. (cdc.gov)
  • Among hepatitis B e antigen (HBeAg)-positive patients (n=172, 51.5%), 37 (21.5%) experienced HBeAg loss. (e-cmh.org)
  • CAP values were negatively correlated with the probability of hepatitis B e antigen (HBeAg) loss among HBeAg-positive patients. (e-cmh.org)
Fluids1
  • The presence of the A, B, and H antigens in the saliva and body fluids are called secretors. (labpedia.net)
Broad spectrum1
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Hemorrhagic1
  • The family , known as filoviruses, contains several viruses that are known to cause hemorrhagic, often lethal disease in humans and nonhuman primates (NHPs) all of which are within the Marburgvirus or Ebolavirus genera. (biomedcentral.com)
Cells8
  • Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
  • Relating to this idea, particular B cells internalize and procedure the antigen, resulting in the demonstration of antigen fragments destined by surface area MHC course II molecules that may be recognized EI1 by particular T cells guaranteeing how the T cells deliver help B cells particular for the same antigen (connected help). (enmd-2076.com)
  • Therefore, it could be feasible that, so long as the antigen identified by T cells can be in a few physical association with the prospective of B-cell reputation (as regarding a small disease or a pollen particle), the integrity from the antigenic bridge can be preserved. (enmd-2076.com)
  • PspA and PspC appeared crucial for the hemolytic effects of S. pneumoniae on human red blood cells. (bvsalud.org)
  • At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
  • In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)
  • Chitinase-3-like 1 protein (YKL-40) is a secreted glycoprotein originally isolated from human osteosarcoma cells [ 9 ]. (biomedcentral.com)
  • The aim of the present study was to evaluate whether Alix is involved in the packaging of miRNAs within EVs released by human liver stem‑like cells (HLSCs). (spandidos-publications.com)
Describe1
  • The authors used various nomenclatures to describe conditions related to the presence of IgG4 until 2010 in Kanazawa, where it was unified as an "IgG4-related disease" with the consensus that it can affect various organs, including the thyroid and the eye with its adnexa and extraocular muscles [ 4 ]. (hindawi.com)
Leukocytes2
PLASMA1
  • Human immunoglobulin G (IgG) subclasses were numbered in an order reflecting the time of their discovery, which also corresponds to their prevalence in plasma [ 1 ]. (hindawi.com)
Molecular2
  • Since inception of this list, a greater number of antigens have been described and the molecular basis of many has been resolved. (wikipedia.org)
  • The molecular basis of 22 of the 24 serologically defined antigens has been resolved. (wikipedia.org)
Count2
  • Dragging of hind limbs was observed on day 2, and hematologic tests revealed a moderately low platelet count and elevated ALT ( Table ). (cdc.gov)
  • This phase can be mainifested by fever, generalized lymphadenopathy, low platelet and wbc count, and mild anemia. (treatfip.org)
Recombinant2
  • 1618. The Neutralization Dose (ND 50 ) is typically 0.6-3.0 µg/mL in the presence of 0.2 µg/mL Recombinant Human JAM‑B/VE‑JAM Fc Chimera. (rndsystems.com)
  • Recombinant Human JAM-B/VE-JAM Fc Chimera (Catalog # 1074-VJ ), immobilized onto a microplate previously coated with Goat Anti-Human IgG Fc (Catalog # G-102-C ), supports the adhesion of the J45.01 human acute lymphoblastic leukemia T lymphocyte cell line in a dose-dependent manner (orange line), as measured by endogenous cellular lysosomal acid phosphatase activity. (rndsystems.com)
Significantly1
  • The main difference observed was a significantly higher proliferative effect on hASCs cultured in pooled allogeneic human serum. (biomedcentral.com)
Fever1
  • In humans, SFTS begins with a high fever, marked thrombocytopenia and leukocytopenia, and a high serum viral load, followed by multiorgan dysfunction, which may be a consequence of systemic inflammatory responses and disseminated intravascular coagulation ( 9 , 10 ). (cdc.gov)
Phosphorylation1
  • Human JAM-B cDNA predicts a 298 amino acid (aa) precursor protein with a putative 28 aa signal peptide, a 209 aa extracellular region containing two Ig domains, a 23 aa transmembrane domain and a 38 aa cytoplasmic domain containing a PDZ-binding motif and a PKC phosphorylation site. (rndsystems.com)
Protein3
  • however, C-MYC protein expression was enhanced in pooled allogeneic human serum cultures compared to fetal bovine serum cultures. (biomedcentral.com)
  • This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
  • B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
Production2
  • In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
  • ABO genes do not actually code for the production of ABO antigens but rather produce specific glycosyl-transferases that add sugars to the basic precursor substance. (labpedia.net)
System1
  • Nomenclature for factors of the HLA system, 2004. (ox.ac.uk)
Cell4
  • Measured by its ability to neutralize JAM‑B/VE‑JAM-mediated adhesion of the J45.01 human acute lymphoblastic leukemia T lymphocyte cell line. (rndsystems.com)
  • Furthermore, data from human being studies have proven too little relationship between antigen-specific IgE amounts and T-cell reactions (12C16). (enmd-2076.com)
  • Tests for the ABH secretion may help establish the true ABO group of an individual whose red blood cell antigens are poorly developed. (labpedia.net)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Formation2
  • We explored the role of the three CBPs on adhesion and pathogenicity in a human host by performing relevant imaging and functional analyses, such as electron microscopy, confocal laser scanning microscopy, and functional quantitative assays, targeting biofilm formation and the hemolytic capacity of S. pneumoniae. (bvsalud.org)
  • There is the formation of A and B antigens. (labpedia.net)
Gene1
  • A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele). (beds.ac.uk)
Major1
Deaths1
  • Snakes are of great human interest due to the existence of many dangerously venomous species which are responsible for tens of thousands of human deaths per year 3 . (nature.com)
Surface1
  • Blood grouping is done based on the presence of antigens on the surface of RBCs. (labpedia.net)
Severe1
  • Loxoscelism is a severe human envenomation caused by Loxosceles spider venom. (biomedcentral.com)
Mouse2
  • Human JAM-B shares approximately 79% aa sequence homology with its mouse homologue. (rndsystems.com)
  • Knockin of human VWF exon 28 and crossbreeding with hGPIbα Tg generated a humanized mouse model of platelet GPIbα-VWFA1 interaction. (ashpublications.org)
Differences1
  • The hASCs expanded in medium with pooled allogeneic human serum did not show remarkable differences in morphology, viability, differentiation capacity or immunophenotype. (biomedcentral.com)
Skin1
Shows2
  • The peripheral smear below shows leukoerythroblastosis and giant platelets in a patient with myelofibrosis. (medscape.com)
  • This photomicrograph also shows giant platelets. (medscape.com)
Animal1
Sample1
  • A fecal sample was negative for Helicobacter pylori antigen, enteric bacteria, and ova-parasite. (cdc.gov)
Normal1
  • Moreover, the hASCs presented normal karyotype undergoing senescence, and did not form in vivo tumors, eliminating the possibility that spontaneous immortalization of hASCs had occurred with pooled allogeneic human serum. (biomedcentral.com)
Disease3
  • Marburg virus (MARV) is the causative agent of Marburg virus disease (MVD) in humans, with a case fatality rate ranging from 23 to 90%, depending on the outbreak [ 1 ]. (biomedcentral.com)
  • Leishmaniasis is a parasitic disease transmitted to humans through sand fly bites. (123dok.net)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. (cdc.gov)