AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Blood ProteinsBlood Protein ElectrophoresisSerum AlbuminOrosomucoidProtein BindingIsoelectric FocusingElectrophoresis, Polyacrylamide GelGlycoproteinsPlasmaMolecular WeightChromatography, High Pressure LiquidSeminal Plasma ProteinsPlasma CellsChromatography, LiquidFibrinogenTandem Mass SpectrometryPregnancy-Associated Plasma Protein-AHaptoglobinsRadioimmunoassayalpha-MacroglobulinsMass SpectrometryDrug StabilityPlasma VolumeCell MembraneReproducibility of ResultsAlpha-GlobulinsLipoproteinsCalibrationLipoproteins, HDLKallikreinsLiverApolipoproteinsChromatography, GelImmunoelectrophoresisTime FactorsProtein SChromatography, AffinityBlood CoagulationAmino Acid SequenceBiological MarkersPrealbuminalpha 1-AntitrypsinDialysisLipoproteins, LDLSpectrometry, Mass, Electrospray IonizationBlood Chemical AnalysisKininogensMolecular Sequence DataPlasma GasesReference StandardsProtein CKineticsMetabolic Clearance RateCapillary PermeabilityAcute-Phase ProteinsImmunoelectrophoresis, Two-DimensionalApolipoprotein A-ICeruloplasminSensitivity and SpecificityAlbuminsCholesterolSerum GlobulinsHeparinReference ValuesHemopexinRabbitsPeptide FragmentsLimit of DetectionApolipoproteins ACarrier ProteinsFibrinPlasminogenChemical FractionationProteomicsSemenTransferrinCattleRetinol-Binding Proteins, PlasmaFibrinolysinDose-Response Relationship, DrugLysine CarboxypeptidaseArea Under CurveFibronectinsHalf-LifeLipidsSeminal Vesicle Secretory ProteinsBlood Coagulation FactorsEnzyme-Linked Immunosorbent AssayLipoproteins, VLDLGas Chromatography-Mass SpectrometryHematocritTissue DistributionAmino AcidsMethodsDogsPlasma KallikreinImmunodiffusionProteinsMacroglobulinsInjections, Intravenous
SerumPeptidesAntibodiesAssaySeminal plasmaCoagulation factorsImmunoglobulinsBiologicalBindsQuantitationQuantitativeInhibitorAntibodyImmunodeficiency virusDeficiencyExtracellularNanoparticleLipoproteinRecombinantGenesDeteriorationLipidsReceptor1992DegradationGeneBloodProteomicCardiacMembraneSynthesisEnzymesMoleculesTissueBoundPathwaysSevereDonorsCentersGeneticsLevelsStableInteractionsRatsDynamicsFractionTypeProteomeLiverClustersConcentratesHeparinAbundanceTotal protein
Serum10
  • Here, we explore this aspect of the protein binding capacity of bleomycin to the two most abundant plasma proteins , human serum albumin (HSA) and α1- acid glycoprotein (AGP), which are known to bind and to be carriers of many drug molecules using spectroscopic techniques , such as circular dichroism , UV-vis absorbance, and fluorescence . (bvsalud.org)
  • We describe a robust nano liquid chromatography-mass spectrometry (nanoLC-MS) platform for measuring the total amount of OT in human plasma/serum. (nature.com)
  • The method (R/A + robust nanoLC-MS) was used to determine total OT plasma/serum levels to startlingly high concentrations (high pg/mL-ng/mL). (nature.com)
  • Proteomic analysis of the nanoparticle protein corona revealed molecular profile differences between cancer and noncancer serum samples. (acs.org)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
  • Conse- demonstrated that this protein signature provided an added value quently, using minute amounts of nonfractionated serum (14) and compared with conventional clinical parameters. (lu.se)
  • Naturally occurring anti-A and anti-B are the only RBC antibodies in normal human serum or plasma. (medscape.com)
  • 2] Experiments demonstrated that mixing plasma or serum from Stuart and Prower did not mutually correct the abnormality, thus showing that the two lacked an identical factor. (medscape.com)
  • A full 96-well plate can be processed and analyzed in 8 h which is five times faster than our previous 96-well plate method and only requires 50 µL of serum, plasma, or whole blood. (cdc.gov)
Peptides5
  • The MS instrument allows unambiguous identification/quantification of e.g. peptides, by first recording the molecular mass of a compound (single MS) and then creating a "molecular fingerprint" by fragmenting the compound to smaller parts (MS/MS). Separating compounds in a mixture (e.g. plasma) prior to MS detection further strengthens identification and sensitivity. (nature.com)
  • Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
  • The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
  • Time scales of water dynamics at biological interfaces: peptides, proteins and cells. (lu.se)
  • Sulfur mustard is an alkylating agent which quickly reacts with nucleophiles such as DNA, RNA, water, lipids, peptides, and proteins via an episulfonium ion intermediate. (cdc.gov)
Antibodies7
  • Human myeloma IgG1, λ was also used as control in size-exclusion chromatography to analyse purity of recombinant antibodies. (sigmaaldrich.com)
  • The process, which was developed through a multi-site study that produced more than 1,000 antibodies targeting 20 different SH2 domain proteins, is meant as a template for future, larger efforts and could help improve antibody validation procedures, said one of the researchers. (genomeweb.com)
  • Working together under the " The Fight Is In Us " campaign, the coalition is seeking to mobilize tens of thousands of people in the United States who have recovered from COVID-19 to donate their blood plasma, which contains vital antibodies that have fought off the disease and could now help others do the same. (biospace.com)
  • The campaign is working against two urgent timelines: to recruit COVID-19 survivors within two months of their recovery to ensure that their blood plasma contains a robust enough concentration of antibodies to have a positive effect, and to address the substantial seasonal increase in COVID-19 cases anticipated this fall in the Northern Hemisphere by the Centers for Disease Control and Prevention (CDC) and other public health experts. (biospace.com)
  • Through the manufacturing process, the plasma is pooled, concentrated and purified, resulting in a vial of medicine with consistent levels of antibodies that is easy to store, distribute and administer to patients. (biospace.com)
  • The average window period of the most sensitive contemporary recombinant protein-based EIA for HIV-1 and HIV-2 antibodies is now 20 days less (4), yielding an average infectious window period of 25 days (95% CI=9-41 days) (5). (cdc.gov)
  • 135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)
Assay5
  • Frozen, immuno-depleted plasmas are certified to have less than 1% for the deficient factor considered, both for the antigenic and functional assay in haemostasis. (cryopep.com)
  • Called the Human Disease Blood Atlas, the project aims to profile roughly 10,000 individuals a year, amounting to annual Olink assay costs of more than $5 million. (genomeweb.com)
  • Using a two-step gold nanoparticle-enabled dynamic light scattering assay, we discovered that the amount of human immunoglobulin G (IgG) in the gold nanoparticle protein corona is increased in prostate cancer patients compared to noncancer controls. (acs.org)
  • The hybridization LC-MS/MS platform provided unique advantages, including minimal matrix effects and high specificity, compared with traditional ligand binding assays or liquid scintillation approaches, which enabled efficient and reliable in vitro protein binding assay. (aspetjournals.org)
  • Here, we describe a method to detect microcystins in human plasma by using immunocapture followed by a protein phosphatase inhibition assay. (cdc.gov)
Seminal plasma3
  • Human seminal plasma (SP) is a complex fluid where sperm cells are bathed. (unisi.it)
  • Biological significance: Seminal plasma vesicles are emerging as rich reservoirs of biomarkers for male infertility and urogenital disorders. (unisi.it)
  • Protein C inhibitor (PCI) is serine protease inhibitor of serpin type that is found in most tissues and fluids, including blood plasma, seminal plasma and urine of human. (wikipedia.org)
Coagulation factors2
Immunoglobulins1
Biological4
  • This network is an important forum for the confidential exchange of quality and technical information on human biological medicinal products and related methods and is a key link in the regulatory chain. (edqm.eu)
  • The history of protein dynamics traces back to 1935, when Schoenheimer and Rittenberg synthesized the first isotopologs of biological molecules to demonstrate the continuous renewal of proteins throughout life 14 , 15 . (nature.com)
  • Even if we had a treatment to make, for example, the human brain younger today, in order to deliver this treatment to the proper patients, we need to be able to measure the biological age of their brain noninvasively, so we know who needs treatment and who benefits from it," says Rosenthal. (jax.org)
  • Biotest is a provider of plasma proteins and biological drugs. (pharmiweb.com)
Binds4
  • The results showed that bleomycin binds to plasma proteins with an order-of- magnitude higher affinity for AGP than HSA. (bvsalud.org)
  • OT binds strongly to plasma proteins, but a reduction/alkylation (R/A) procedure breaks this bond, enabling ample detection of total OT. (nature.com)
  • AHG is an animal antibody that binds to the F c portion of human immunoglobulin. (medscape.com)
  • Sulfur mustard binds to reactive cysteine residues, forming a stable sulfur-hydroxyethylthioethyl [S-HETE] adduct that can be used as a long-term biomarker of sulfur mustard exposure in humans. (cdc.gov)
Quantitation2
  • As a result, a simple and high-throughput method has been developed and validated for the quantitation of sulfur mustard blood protein adducts in low volume blood specimens which should be readily adaptable for quantifying human exposures to other alkylating agents. (cdc.gov)
  • The quantitation range for the detection of microcystin in human plasma using this method is 0.030-0.50 ng/mL microcystin-LR equivalents. (cdc.gov)
Quantitative2
  • Human myeloma IgG1, λ was used as non-specific control in quantitative ELISA and solid-phase ELISA. (sigmaaldrich.com)
  • Here, we assayed the abundance levels of proteins in plasma from 96 elderly Europeans using a new aptamer-based proteomic technology and performed genome-wide local (cis-) regulatory association analysis to identify protein quantitative trait loci (pQTL). (ox.ac.uk)
Inhibitor27
Antibody6
  • IgG is the main antibody type found in plasma and extracellular fluid and is expressed on B cell membrane. (sigmaaldrich.com)
  • Inside COVID-19 survivors is the antibody-rich blood plasma that may help stem the tide of this pandemic. (biospace.com)
  • Blood donations in the United States have been screened for antibody to human immunodeficiency virus type 1 (HIV-1) since March 1985 and type 2 (HIV-2) since June 1992. (cdc.gov)
  • Routine testing for p24 antigen in settings other than blood and plasma centers as a method for diagnosing HIV infection is discouraged because the estimated average time from detection of p24 antigen to detection of HIV antibody is 6 days, and not all recently infected persons have detectable levels of p24 antigen. (cdc.gov)
  • In the United States, the implementation of antibody testing in 1985 of all donated blood for human immunodeficiency virus type 1 (HIV-1) resulted in a substantial decrease in the transmission of HIV through blood transfusions (1,2). (cdc.gov)
  • We targeted this Adda side chain using a commercial antibody and extracted microcystins from human samples for screening and analysis. (cdc.gov)
Immunodeficiency virus2
  • HA371 trade name] is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children. (who.int)
  • Includes patients co-infected with human immunodeficiency virus (HIV). (medicines.org.uk)
Deficiency2
  • Special plasmas are derived from patients with acquired deficiency, severe or moderate, or presenting a particular profile. (cryopep.com)
  • Factor X deficiency may arise because of reduced synthesis of the protein, which is known as type I deficiency state, or because of production of a dysfunctional molecule, which is known as type II deficiency state. (medscape.com)
Extracellular3
  • Our proteomic approach to human SP diverges from the general trend in SP characterization, investigating not sperm extracellular vesicles but rather the vesicle-depleted SP fraction. (unisi.it)
  • We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation. (lu.se)
  • We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protein relevant in body-composition homeostasis. (lu.se)
Nanoparticle3
  • When citrate ligands-capped gold nanoparticles are mixed with blood sera, a protein corona is formed on the nanoparticle surface due to the adsorption of various proteins in the blood to the nanoparticles. (acs.org)
  • A sensitive magnetic nanoparticle -based immunoassay of phosphorylated acetylcholinesterase using protein cage templated lead phosphate for signal amplification with graphite furnace atomic absorption spectrometry detection. (cdc.gov)
  • We developed a new magnetic nanoparticle sandwich-like immunoassay using protein cage nanoparticle s (PCN) for signal amplification together with graphite furnace atomic absorption spectrometry (GFAAS) for the quantification of an organophosphorylated acetylcholinesterase adduct (OP-AChE), the biomarker of exposure to organophosphate pesticides (OPs) and nerve agents. (cdc.gov)
Lipoprotein5
  • [ 13 ] For these patients, concerns are the persistent insulin resistance and dyslipidemia, together with the elevated plasma insulin and lipoprotein(a) levels observed with GH replacement. (medscape.com)
  • To study whether nontransferable lipoprotein lipase has physiological actions, we placed an α-myosin heavy-chain promoter upstream of a human lipoprotein lipase minigene construct with a glycosylphosphatidylinositol anchoring sequence on the carboxyl terminal region. (jci.org)
  • Hearts of transgenic mice expressed the altered lipoprotein lipase, and the protein localized to the surface of cardiomyocytes. (jci.org)
  • Hearts, but not postheparin plasma, of these mice contained human lipoprotein lipase activity. (jci.org)
  • The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). (nih.gov)
Recombinant1
  • The commercial introduction of recombinant human growth hormone (rhGH) in 1985 dramatically changed the field of therapy for growth hormone (GH). (medscape.com)
Genes3
  • Importantly, we identified evidence of cis-regulatory variation for 20 previously disease-associated genes encoding protein, including variants with strong evidence of disease association show significant association with protein abundance levels. (ox.ac.uk)
  • Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. (medscape.com)
  • We performed additional in silico analyses to identify more evidence for the associated variants and genes in relation to the plasma MPO-DNA complex levels. (frontiersin.org)
Deterioration1
  • We also need measurements that apply to genetically diverse human populations and, ideally, measure rates of aging and deterioration rather than a single timepoint. (jax.org)
Lipids1
Receptor1
  • This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. (nih.gov)
19921
Degradation1
  • Ferritin in lysosomes is converted into hemosiderin upon partial degradation of its protein shell by lysosomal enzymes. (medscape.com)
Gene4
  • A number of studies in human have recently shown that genetic factors significantly contribute gene expression variation. (ox.ac.uk)
  • A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. (medscape.com)
  • Human ortholog(s) of this gene implicated in malaria. (mcw.edu)
  • The human gene encoding factor X is primarily expressed in the liver and is located on the long arm of chromosome 13, just downstream from the gene for factor VII. (medscape.com)
Blood20
  • The content and distribution of plasma proteins in Octaplas are comparable to reference ranges for healthy blood donors, except for Protein S and alpha2-antiplasmin. (rxlist.com)
  • Each lot of Octaplas is manufactured from pooled plasma of a single AB0 blood group (A, B, AB, or 0). (rxlist.com)
  • Plasma is the fluid compartment of blood that contains the soluble clotting factors. (medscape.com)
  • GSHPx) activity, and also Se and GSHPx in whole blood, erythrocytes and plasma. (cambridge.org)
  • Selenomethionine was more effective in raising blood Se concentrations than selenate, but both were equally effective in raising GSHPx activities in whole blood, erythrocytes and plasma, indicating a similar bioavailability for the two forms. (cambridge.org)
  • slow acetylators generally have higher plasma levels of hydrALAZINE and require lower doses to maintain control of blood pressure. (nih.gov)
  • There are about 3,000 different proteins in your blood plasma, the fluid that conducts cells through the circulatory system. (jax.org)
  • Plasma is a liquid part of the human blood mostly made of water and protein. (selfgrowth.com)
  • To collect plasma, the surgeon takes samples of blood from your body and to separate the platelet-rich plasma from the blood he uses the machine. (selfgrowth.com)
  • The time is now for superhero volunteers to donate their blood plasma and help stop COVID-19 in its tracks. (biospace.com)
  • Individuals who have recovered from COVID-19, or know someone who has, can visit TheFightIsInUs.org to understand if they may be eligible to donate and find a nearby blood or plasma donor center using a simple self-screening tool. (biospace.com)
  • Donating blood plasma is a generally safe and proven process. (biospace.com)
  • Donations can be made at both blood and plasma donor centers. (biospace.com)
  • One approach is the direct transfusion of blood plasma though the Expanded Access Program for convalescent plasma, which is currently being administered with authorization from the Food & Drug Administration by Mayo Clinic . (biospace.com)
  • Blood donor centers throughout the country are currently collecting convalescent plasma from COVID-19 survivors for this purpose. (biospace.com)
  • Because maintaining a safe blood supply is a public health priority, the Food and Drug Administration (FDA) recommended in August 1995 that all donated blood and plasma also be screened for HIV-1 p24 antigen, effective within 3 months of licensure of a test labeled for such use. (cdc.gov)
  • Sex hormone-binding globulin (SHBG) is the blood transport protein for testosterone and estradiol. (cdc.gov)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • Red blood cells (RBCs) carry numerous protein and carbohydrate antigens on their surface. (medscape.com)
  • The digestion of sulfur mustard-exposed blood samples with proteinase K following total protein precipitation with acetone produces the tripeptide biomarker [S-HETE]-Cys-Pro-Phe. (cdc.gov)
Proteomic2
  • Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. (lu.se)
  • Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supervised, 20-week endurance exercise training intervention. (lu.se)
Cardiac2
  • Using an integrated platform of metabolic labeling, high-resolution mass spectrometry and computational analysis, we report here a comprehensive dataset of the in vivo half-life of 3,228 and the expression of 8,064 cardiac proteins, quantified under healthy and hypertrophic conditions across six mouse genetic strains commonly employed in biomedical research. (nature.com)
  • The dataset contains over 1.92 million data points in protein isotope labeling kinetics, culminating as the in vivo turnover rates of 3,228 cardiac proteins and the expression levels of 8,064 proteins. (nature.com)
Membrane1
Synthesis1
  • 1991) are consistent with the incorporation of Se from selenomethionine into a general tissue protein pool while selenate is directly available for GSHPx synthesis, and explain the poorer correlation between Se and GSHPx in individuals with higher Se status. (cambridge.org)
Enzymes1
Molecules3
  • In contrast to steady-state protein abundance, which may be quantified directly in mass spectrometry (MS) by spectral intensity 16 , 17 or sampling frequency 18 , 19 , protein turnover rates cannot be predicted from steady-state data 20 , requiring instead methods that can distinguish old and new protein molecules in mass spectra 11 , 21 . (nature.com)
  • A major class of molecules involved in heart disease are the plasma lipoproteins. (otago.ac.nz)
  • Nanosecond to microsecond protein dynamics probed by magnetic relaxation dispersion of buried water molecules. (lu.se)
Tissue3
  • Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (hmdb.ca)
  • The Stanford group will analyze the samples and develop noninvasive, tissue-specific plasma protein-based clocks. (jax.org)
  • This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
Bound1
Pathways2
  • Proteins with quantified dynamics belong to over 10 major cellular compartments and over 200 known pathways. (nature.com)
  • Key proteins in mitochondria and metabolic pathways are encompassed, in addition to contractile machineries and sarcolemmal signaling proteins. (nature.com)
Severe1
  • Severe hypersensitivity to milk proteins or any ingredients of ARMONAIR RESPICLICK. (drugs.com)
Donors2
  • We investigated HAV incidence rates among source plasma donors in the United States since 2016. (cdc.gov)
  • The manufacturing plasma pool is limited to 390 kg comprising 630-1,520 individual donors. (rxlist.com)
Centers1
Genetics2
  • Because you can't fix what you can't measure, the goal of intervening in these processes has been hampered by the difficulty of precisely measuring aging in humans, with their mixed-up genetics and haphazard diet and exercise regimes. (jax.org)
  • Human Genetics & Genomic Advances , 4 , 100204. (otago.ac.nz)
Levels11
  • Protein S and alpha2-antiplasmin, which are labile to S/D treatment, are controlled to ensure levels in the final product of ≥ 0.4 International Units (IU) per mL. (rxlist.com)
  • Identification of cis-regulatory variation influencing protein abundance levels in human plasma. (ox.ac.uk)
  • These results demonstrate that common genetic variants contribute to the differences in protein abundance levels in human plasma. (ox.ac.uk)
  • HydrALAZINE is rapidly absorbed after oral administration, and peak plasma levels are reached at 1 to 2 hours. (nih.gov)
  • Plasma levels of apparent hydrALAZINE decline with a half-life of 3 to 7 hours. (nih.gov)
  • Plasma levels of hydrALAZINE vary widely among individuals. (nih.gov)
  • The team determined that levels of 373 of these proteins, taken together, predict the participants' ages with a high degree of accuracy. (jax.org)
  • These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
  • Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
  • We performed a genome-wide association study (GWAS) and exome-sequencing analysis to identify common and rare genetic variants associated with plasma myeloperoxidase (MPO)-DNA complex levels, a biomarker for NETs, in the population-based Rotterdam Study cohort. (frontiersin.org)
  • however, plasma ferritin levels are markedly increased in persons with excess iron. (medscape.com)
Stable1
  • All plasmas are stable when stored at -40° C to -80° C. (cryopep.com)
Interactions1
  • To date, a limited number of protein interactions with bleomycin have been studied, but the plasma binding has not yet been determined. (bvsalud.org)
Rats3
  • All of the chemicals discussed of this chemical was raised to carci- lung and the nasal cavity were iden- here are IARC Group 1 agents and nogenic to humans (Group 1) based tified as target organs in humans as such can be characterized as on strong mechanistic evidence and rats, respectively. (who.int)
  • Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
  • or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)
Dynamics11
  • Information on global protein dynamics therefore has the potential to expand the depth and scope of disease phenotyping and therapeutic strategies. (nature.com)
  • Because proteostatic events often trigger zero net change in protein abundance but instead alter protein temporal dynamics 11 - 13 , they typically elude conventional experiments that measure only the steady-state abundance of proteins. (nature.com)
  • Protein dynamics data are therefore sought to better describe homeostatic processes and enhance the utility of phenotyping-by-omics approaches. (nature.com)
  • However, large-scale protein dynamics datasets have remained scarce, due to the specialized technologies necessary to measure turnover of individual proteins on a global scale. (nature.com)
  • We report here a large dataset of protein turnover dynamics in the heart of six common genetic strains of mice, acquired under both normal and hypertrophic conditions. (nature.com)
  • How proteins modify water dynamics. (lu.se)
  • Analysis of protein dynamics simulations by a stochastic point process approach. (lu.se)
  • Hydration dynamics of a halophilic protein in folded and unfolded states. (lu.se)
  • Slow internal protein dynamics from water 1 H magnetic relaxation dispersion. (lu.se)
  • Does the dynamic Stokes shift report on slow protein hydration dynamics? (lu.se)
  • Dynamics at the protein-water interface from 17 O spin relaxation in deeply supercooled solutions. (lu.se)
Fraction1
  • Here we discussed how also SP soluble fraction may be considered actively involved in spermatozoa maturation, and we suggested that vf-SP protein profile may offer a precious overview on spermatogenesis, epididymal maturation, ancillary gland functionality, and sperm quality, thus highlighting its potentiality as a biomarker source in man health and reproduction. (unisi.it)
Type1
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. (sigmaaldrich.com)
Proteome2
  • Regulation of proteome integrity requires chaperone-assisted folding of unfolded proteins, dissolution of misfolded aggregates, proteolytic removal of proteins, and other concerted proteostatic processes 1 , 2 . (nature.com)
  • The present dataset was collected using a technology platform we recently developed, which overcame several technical challenges in quantifying individual protein turnover rates on a proteome scale. (nature.com)
Liver1
  • When exposed to microcystins, humans are at risk of hepatic injury, including liver failure. (cdc.gov)
Clusters1
  • Generated nets and clusters revealed tight functional correlations among identified proteins as well as their involvement in key functions for spermatozoa support and fertilization. (unisi.it)
Concentrates1
  • Agents used include fresh frozen plasma (FFP), prothrombin complex concentrates (PCCs), and vitamin K. (medscape.com)
Heparin1
  • Heparin enhances the rate of inhibition leading to the conformational change in the structure of Protein C and other proteases. (wikipedia.org)
Abundance1
  • In contrast, very little is known about the genetic basis of variation in protein abundance in man. (ox.ac.uk)
Total protein1
  • Within a mean total protein content of 57 mg/mL, albumin comprises ~50% and immunoglobulin classes G, A, and M comprise ~12%, ~3%, and ~1%, respectively. (rxlist.com)