ORNsProteinsGeneMicroRNAChromosomeGenomeRNAsSequencesHomoBindNaturalInteractionUbiquitousAntibodiesExpressionMouseLongVirusDiseaseOrderActivityAntisenseAffinityImmunodeficiency virus type1995ProteinGenome locationGenesCharacterizationMiRNAsMiceProteomicStructuralGeneticTargetsDepartmentStructureAnalysisIdentificationCell
ORNs6
- Nevertheless, oligoribonucleotides (ORNs) synthesized by chemical reactions activate human TLR8 and mouse TLR7. (visualassembler.com)
- How do microRNA or ORNs ( oligoribonucleotides) effect your immune system? (bioimmersion.com)
- Small pieces of RNA, called MicroRNA (miRNA) or oligoribonucleotides (ORNs), are released by pathogenic bacteria as well as a beneficial bacterium such as Lactobacillus casei , which we find in fermented foods like yogurts. (bioimmersion.com)
- Oligoribonucleotides (ORNs) are fragments of genetic material, the RNA pieces (micro RNA) that reside within the cytoplasm of all bacteria. (bioimmersion.com)
- 30 AUs of ORNs is sufficient to upregulate the human immune system through the oral cavity. (bioimmersion.com)
- Another proposed countermeasure are peculiar antisense oligoribonucleotides (ORNs) we have targeted to a cis-acting destabilizing element of bcl-2 mRNA and then patented for their ability to prevent apoptosis by preventing bcl-2 gene down-regulation in response to apoptotic stimuli. (unifi.it)
Proteins1
- The central dogma of molecular biology states that the transfer of genetic information within cells transpires sequentially from DNA to RNA to proteins, whose coding sequences comprise a paltry 1.5-2% of the human genome [ 2 , 3 ]. (biomedcentral.com)
Gene7
- In humans it is encoded by the RPS5 gene. (wikipedia.org)
- Cordon-bleu protein-like 1 is a protein that in humans is encoded by the COBLL1 gene. (wikipedia.org)
- Human COBLL1 genome location and COBLL1 gene details page in the UCSC Genome Browser. (wikipedia.org)
- Selectin P ligand , also known as SELPLG or CD162 ( cluster of differentiation 162), is a human gene . (wikidoc.org)
- The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. (wikidoc.org)
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
- Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene . (wikidoc.org)
MicroRNA1
- MicroRNA have emerged as major players in the interaction between host (human body) and bacterial pathogens, with an integral part in the host immune response to bacterial infection (Aguilar et al. (bioimmersion.com)
Chromosome1
- DNA sequence and analysis of human chromosome 9. (nih.gov)
Genome1
- Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
RNAs3
- Inasmuch as artificial box C/D RNAs decreased viability of transfected human cells, we propose that natural snoRNAs as well as their artificial analogues can influence the maturation of complementary pre-mRNA and can be effective regulators of vital cellular processes. (hindawi.com)
- As soon as the endogenous TLR3 exercise was eliminated, they discovered that the entire above vitro-transcribed RNAs brought about stimulation of human TLR7. (visualassembler.com)
- MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that have been detected in human aqueous humor (AH). (arvojournals.org)
Sequences1
- Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
Homo1
- human-ABHD12 Homo sapiens (Human) abhydrolase domain-containing protein 12. (inrae.fr)
Bind1
- One, RNA is proven to bind human TLR7. (visualassembler.com)
Natural1
- LactORN contains the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides. (bioimmersion.com)
Interaction1
- 1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. (wikipedia.org)
Ubiquitous1
- Human respiratory syncytial virus (RSV) is a ubiquitous virus of worldwide distribution and is the leading cause of infant morbidity from respiratory infections. (intechopen.com)
Antibodies1
- The methods and compositions of the invention use binding agents, e.g., antibodies, specific for the extracellular domain of human prostate specific membrane antigen (PSMA). (patsnap.com)
Expression1
- We found that transfection of artificial box C/D snoRNA analogues directed to HSPA8 pre-mRNAs into human cells induced suppression of the target mRNA expression in a time- and dose-dependent manner. (hindawi.com)
Mouse1
- Earlier research present that in vitro transcription produces RNA acknowledged by human TLR3 and mouse TLR7. (visualassembler.com)
Long1
- a function of the long life span of humans. (what-when-how.com)
Virus1
- similar to human immunodeficiency virus such as Epstein-Barr and others) and protects human cells from PFV-1 (Lecellier et al. (bioimmersion.com)
Disease1
- disease in humans. (what-when-how.com)
Order1
- In order to be human-readable, please install an RSS reader. (mdpi.com)
Activity1
- Here we highlight prominent miRNAs that may represent potential therapeutic targets in human malignancies, as well as review current technologies available for inactivating or restoring miRNA activity in clinical settings. (biomedcentral.com)
Antisense4
- 24. Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs. (nih.gov)
- 36. Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells. (nih.gov)
- 37. Repression of human thymidylate synthase mRNA translation by antisense 2'-O-methyl oligoribonucleotides. (nih.gov)
- Branched poly-labelled oligonucleotides: enhanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection. (ox.ac.uk)
Affinity1
- A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol. (wikipedia.org)
Immunodeficiency virus type2
- The nucleocapsid (NC) protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is important for encapsidation of the virus genome, RNA dimerization, and primer tRNA annealing in vitro. (nih.gov)
- Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers. (nih.gov)
19951
- 1995). «Corticosteroid-binding globulin mRNA levels in human uterine endometrium. (wikipedia.org)
Protein5
- Cordon-bleu protein-like 1 is a protein that in humans is encoded by the COBLL1 gene. (wikipedia.org)
- Fractalkine also known as chemokine (C-X3-C motif) ligand 1 is a protein that in humans is encoded by the CX3CL1 gene . (wikidoc.org)
- CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin -like stalk and a chemokine domain on top. (wikidoc.org)
- Detailed information about target genes, target processes, and open-source software for target prediction (miRanda) is available at http://www.microrna.org Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes. (gene-quantification.org)
- Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
Genome location1
- Human COBLL1 genome location and COBLL1 gene details page in the UCSC Genome Browser. (wikipedia.org)
Genes2
- Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
- We report about 2,000 human genes with miRNA target sites conserved in mammals and about 250 human genes conserved as targets between mammals and fish. (gene-quantification.org)
Characterization1
- 1990). «Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid. (wikipedia.org)
MiRNAs2
- We have predicted target sites on the 3' untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments. (gene-quantification.org)
- Here we highlight prominent miRNAs that may represent potential therapeutic targets in human malignancies, as well as review current technologies available for inactivating or restoring miRNA activity in clinical settings. (biomedcentral.com)
Mice1
- It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). (wikidoc.org)
Proteomic1
- Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. (nih.gov)
Structural1
- 1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. (wikipedia.org)
Genetic1
- Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. (nih.gov)
Targets1
- Human microRNA targets. (gene-quantification.org)
Department1
- 2224. U.S. Department of Health and Human Services, Seventh Annual Report on Carcinogens, DHHS Pub. (nanomedicine.com)
Structure2
- 29. A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line. (nih.gov)
- The crystallographic structure of the synthetic oligoribonucleotide, U(UA)6A, has been solved at 2.25 A resolution. (nih.gov)
Analysis2
- Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region. (wikipedia.org)
- Ng CJ, Liu A, Venkataraman S, Ashworth KJ, Baker CD, O'Rourke R, Vibhakar R, Jones KL, Di Paola J. Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels. (ucdenver.edu)
Identification2
- Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay. (wikipedia.org)
- Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva. (wikipedia.org)
Cell2
- 23. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. (nih.gov)
- Human ß-defensin 2 (hBD-2) is an endogenous epithelial cell-derived host-defense peptide. (bvsalud.org)