• This Human OCLN ELISA Kit was designed for the quantitative measurement of Human OCLN protein in serum, plasma, tissue homogenates, cell lysates. (cusabio.com)
  • Occludin protein may contribute to the development of cervical cancer. (cusabio.com)
  • Occludin is an important protein in tight junction function. (wikipedia.org)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Occludin, the putative tight junction integral membrane protein, is an attractive candidate for a protein that forms the actual sealing element of the tight junction. (rupress.org)
  • The effect on occludin was specific because other tight junction components, ZO-1, ZO-2, cingulin, and the adherens junction protein E-cadherin, were unaltered by OCC2 treatment. (rupress.org)
  • P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-β. (open.ac.uk)
  • Proximity ligation assay, immunoblotting, and phosphatase assay were performed to study the effect of DUSP3 on the TJ protein occludin (OCLN). (biomedcentral.com)
  • In this study, we investigated the pathogenic potential of these marine V. parahaemolyticus strains by studying their adherence ability, their cytotoxicity, their effect on zonula occludin protein 1 (ZO-1) of the tight junctions, and their effect on transepithelial resistance (TER) in infected Caco-2 cells. (umd.edu)
  • Researchers at the University of Missouri have discovered a protein known as the occludin protein that plays a pivotal role in the transmission of the coronavirus from cell to cell. (breathinglabs.com)
  • Led by Wenjun Ma, the team discovered that when the occludin protein in a cell is compromised by the virus, it can rapidly reproduce and spread to neighboring cells, potentially exacerbating the infection and symptoms. (breathinglabs.com)
  • University of Missouri scientists have discovered that the occludin protein in human cells plays a crucial role in COVID-19 transmission. (breathinglabs.com)
  • While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection - a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future. (breathinglabs.com)
  • The finding provides new insight into how the protein, known as the occludin protein, serves as a mediator for cell-to-cell transmission of the virus. (breathinglabs.com)
  • Researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the coronavirus spreads from cell to cell after infection. (breathinglabs.com)
  • In the study, Ma found that when the occludin protein in a single cell is damaged by the coronavirus, the virus is able to quickly replicate and spread to neighboring cells throughout the body, making the infection worse and symptoms potentially more severe. (breathinglabs.com)
  • Ma said this newly discovered knowledge could assist developers of antiviral drugs by examining the potential impact the antiviral drugs have in strengthening the occludin protein against infection. (breathinglabs.com)
  • We learned that the virus may only start off by infecting a singular cell, but cells are incredibly complex, and when the occludin protein gets damaged, the virus quickly replicates and spreads to neighboring cells. (breathinglabs.com)
  • Going forward, Ma plans to study if other viral infections also impact the occludin protein in an effort to better understand how viruses interact at the cellular level with the hosts they infect. (breathinglabs.com)
  • Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission" was recently published in PNAS . (breathinglabs.com)
  • Reference: "Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission" by Jialin Zhang, Wenyu Yang, Sawrab Roy, Heidi Liu, R. Michael Roberts, Liping Wang, Lei Shi and Wenjun Ma, 17 April 2023, Proceedings of the National Academy of Sciences . (breathinglabs.com)
  • Lower panel: The expression of hippocampal occludin protein. (ilsalotto.be)
  • as well as the tight junction protein claudin-1 and occludin. (biotech2012.org)
  • Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex. (cornell.edu)
  • Repeated exposure to ODE or H2S or ODE+H2S induced oxidative stress and cytokine production, decreased tight junction protein occludin and cytoskeletal protein ezrin expression, disrupted epithelial integrity and resulted in increased Klebsiella pneumoniae invasion. (cdc.gov)
  • A study revealed that truncation of occludin decreases transendothelial electrical resistance, suggesting a key role of occludin in the barrier function of the tight junction [ 8 ]. (researchsquare.com)
  • To study the role of occludin in the formation of the tight junction seal, synthetic peptides (OCC1 and OCC2) corresponding to the two putative extracellular domains of occludin were assayed for their ability to alter tight junctions in Xenopus kidney epithelial cell line A6. (rupress.org)
  • The correlation between a decrease in occludin levels and the perturbation of the tight junction permeability barrier provides evidence for a role of occludin in the formation of the tight junction seal. (rupress.org)
  • We now report that TJ function, as well as claudin-1 and occludin expression, change in parallel during late epidermal development. (nih.gov)
  • Specifically, TJ block the paracellular movement of Lanthanum (La(3+)) early in rat in vivo prenatal epidermal development, at gestational days 18-19, with concurrent upregulation of claudin-1 and occludin. (nih.gov)
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human OCLN. (signetlabs.com)
  • Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human OCLN. (signetlabs.com)
  • After TMB substrate solution is added, only those wells that contain Human OCLN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (signetlabs.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Occludin (OCLN) in tissue homogenates, cell lysates and other biological fluids. (signetlabs.com)
  • This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glycoprotein 130 (gp130) in serum, plasma and other biological fluids. (gentaur.co.uk)
  • This monoclonal antibody is an excellent marker for human cells in xenographic model research. (neobiotechnologies.com)
  • Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • In standard cells, loss or disruption of occludin and other tight junction proteins leads to initiation of apoptosis through extrinsic pathways. (wikipedia.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • Purpose: The levels of tight junction proteins (TJs), especially occludin correlate with blood-brain barrier (BBB) disruption caused by central nervous system (CNS) inflammation during perioperative period. (researchsquare.com)
  • Cerebral microvascular endothelial cells are linked together through the interactions among multiple tight junction proteins including claudins, occludin and ZO-1 [ 5 ]. (researchsquare.com)
  • The decreased expression of tight junction proteins, especially occludin, correlates with BBB disruption in several situations such as cerebral ischemic injury [ 7 ]. (researchsquare.com)
  • Because of course, all of these same target proteins that are bound by caffeine, things like adenosine receptors and phosphodiesterases, all of those are present in pretty much every human cell type. (thenakedscientists.com)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • To determine the mechanism by which PrP c downregulation leads to increased permeability of an endothelial monolayer, we examined changes in expression and localization of tight junction proteins, occludin and claudin-5, and found that decreased PrP c leads to decreased total and membrane-associated occludin and claudin-5. (elsevierpure.com)
  • In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
  • The expression and phosphorylation of Hif-1α, VEGF, VEGFR-2, ERK and occludin were measured by Western blot analysis. (researchsquare.com)
  • Together with Claudins, and zonula occludens-1 (ZO-1), occludin has been considered a staple of tight junctions, and although it was shown to regulate the formation, maintenance, and function of tight junctions, its precise mechanism of action remained elusive and most of its actions were initially attributed to conformational changes following selective phosphorylation, and its redox-sensitive dimerization. (wikipedia.org)
  • We then immunostained the cell membranes for occludins and claudins to observe for changes in the structure of the tight junctions after tryptase application. (arizona.edu)
  • Description: A sandwich ELISA kit for detection of Occludin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (signetlabs.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Occludin (OCLN) in samples from serum, plasma, tissue homogenates, cell lysates. (signetlabs.com)
  • Our results indicate that, similarly to clinical strains, marine V. parahaemolyticus strains carrying vopT and vopB2 and that other genes included in the VP-PAI are capable of adhering to human cells and of causing cytoskeletal disruption and loss of membrane integrity in infected cells. (umd.edu)
  • Summary Collectively, our findings suggest that in brain endothelial cells blocking PTPN-2 mediated tyrosine phosphorylation of Occludin is a novel mechanism to maintain BBB function, and may offer a key therapeutic strategy for neuro-inflammatory disorders associated with BBB disruption. (johnshopkins.edu)
  • Mast cell-mediated inflammation in the human airway can cause a disruption of this barrier. (arizona.edu)
  • Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. (open.ac.uk)
  • Results: Our data show that tryptase does not alter paracellular permeability in human airway cells over minutes or hours, and that tryptase does not alter the structure of the cell junction. (arizona.edu)
  • Conclusion: Tryptase alone does not alter paracellular permeability in human airway cells. (arizona.edu)
  • Chang, EH , Lee, JH & Zabner, J 2010, ' Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells ', American Journal of Rhinology and Allergy , vol. 24, no. 2, pp. 126-128. (arizona.edu)
  • Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. (cusabio.com)
  • Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
  • The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)
  • These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
  • Right here, we established whether physiological concentrations of ouabain induces EMT in human being renal epithelial cells from individuals with ADPKD. (biotech2012.org)
  • We've previously shown how the NKA of epithelial cells produced from the CRT0044876 cysts of individuals with ADPKD CRT0044876 show an affinity for ouabain, which is greater than that of normal human kidney epithelial cells considerably. (biotech2012.org)
  • Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)
  • Our current research study has shown significant differences in the marker expressions of human cord blood-derived mast cells (hCBMCs) based on donor dependency and the type of medium used for culturing and differentiation. (bvsalud.org)
  • We also found that Ang-1 inhibits thrombin induced tyrosine phosphorylation of Occludin and promote Occludin interaction with Zona Occludens-1 (ZO-1) to stabilize TJs. (johnshopkins.edu)
  • They belong to the genus Norovirus in the family Caliciviridae and consist of 3 genogroups (I, II, and IV) that infect humans ( 8 - 11 ). (cdc.gov)
  • For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
  • Damage was characterized by degradation of OCLN (occludin), a known substrate of MMP9 and a key component of the paracellular barrier. (edu.au)
  • Recent work, using molecular modeling, supported by biochemical and live-cell experiments in human cells demonstrated that occludin is a NADH oxidase that influences critical aspects of cell metabolism like glucose uptake, ATP production and gene expression. (wikipedia.org)
  • In this study, we investigated the effects of TNF-α and propofol on occludin expression in human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), and explored the underlying mechanisms. (researchsquare.com)
  • Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. (open.ac.uk)
  • Amyloid Beta Transport and Effects on Permeability in a Human Brain Endothelial Cell Line. (open.ac.uk)
  • The extracellular loops are thought to be involved in the regulation of paracellualr permeability and the second extracellular has been shown to be involved in the localization of occludin at the tight junction. (wikipedia.org)
  • Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
  • In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)
  • To assess the linearity of the assay, samples were spiked with high concentrations of human OCLN in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. (cusabio.com)
  • The recovery of human OCLN spiked to levels throughout the range of the assay in various matrices was evaluated. (cusabio.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Occludin (OCLN) in samples from tissue homogenates, cell lysates or other biological fluids. (signetlabs.com)
  • Adaptation of the validated SkinEthic Reconstructed Human Epidermis (RHE) skin corrosion test method to 0.5 cm2 tissue sample. (episkin.com)
  • A catch-up validation study on reconstructed human epidermis (SkinEthic RHE) for full replacement of the Draize skin irritation test. (episkin.com)
  • Assessment of the optimized SkinEthic Reconstructed Human Epidermis (RHE) 42 bis skin irritation protocol over 39 test substances. (episkin.com)
  • Reconstructed Human Pigmented Epidermis (RHPE): an in vitro model for the evaluation of melanogenesis. (episkin.com)
  • Studies have shown that rather than being important in tight junction assembly, occludin is important in tight junction stability and barrier function. (wikipedia.org)
  • Indeed, MDCK cells lacking occludin and its homolog tricellulin exhibit less complex tight junction strand network and impaired barrier function. (wikipedia.org)
  • Immunohistochemical staining of human breast cancer shows membranous immunoreactivity in tumor cells. (atlasantibodies.com)
  • The OCC2 peptide decreased the amount of occludin present at the tight junction, as assessed by indirect immunofluorescence, as well as decreased total cellular content of occludin, as assessed by Western blot analysis. (rupress.org)
  • Furthermore, studies in which mice were deprived of occludin expression showed morphological stability in several epithelial tissues but also found chronic inflammation and hyperplasia in the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in straited duct cells of salivary gland, and thinning of the compact bone. (wikipedia.org)
  • Loss of occludin or abnormal expression of occludin has been shown to cause increased invasion, reduced adhesion and significantly reduced tight junction function in breast cancer tissues. (wikipedia.org)
  • The kit CSB-EL016263HU is used for cell lysates sample and for the quantitative determination of human occludin (OCLN). (cusabio.com)
  • There exsit the quantitiy difference between different cell type Occludin(OCLN). (cusabio.com)
  • The C-terminus of occludin is important in receiving and transmitting cell survival signals. (wikipedia.org)
  • So, the really fascinating thing for me is that this biological rhythm in humans is something that's present in every single cell of the body. (thenakedscientists.com)
  • Our results demonstrate that the highly differentiated 3-D cell culture model can support the natural growth of human noroviruses, whereas previous attempts that used differentiated monolayer cultures failed. (cdc.gov)
  • CXCR1 is expressed in the human IEC line Caco-2 BBE [ 3 ], which is in agreement with our own microarray data using Caco-2 BBE cell mRNA (see below). (biomedcentral.com)
  • Human MCs can be isolated and differentiated from various tissue sources, including cord blood, when supplemented with cytokines such as stem cell factor, interleukin 3, and interleukin 6. (bvsalud.org)
  • Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. (cusabio.com)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Maternal viral load, human immunodeficiency virus coinfection, prolonged rupture of membranes, fetal exposure to maternal infected blood consequent to vaginal or perineal lacerations and invasive monitoring of fetus increase the risk of viral transmission. (wjgnet.com)
  • Conclusion: TNF-α could decrease the expression of occludin via Hif-1α/VEGF/VEGFR-2/ERK signaling pathway, which was attenuated by propofol. (researchsquare.com)
  • It has been reported that TNF-α could decrease the expression of occludin in endothelial cells [ 13 ]. (researchsquare.com)
  • Pulse-labeling and metabolic chase analysis suggested that this decrease in occludin level could be attributed to an increase in turnover of cellular occludin rather than a decrease in occludin synthesis. (rupress.org)
  • To examine the effect of inflammation on PrP c expression in BMVEC, we used these mediators and found that TNF-α and VEGF decrease surface PrP c on primary human BMVEC. (elsevierpure.com)
  • Understanding of the pathogenesis of human noroviruses has been limited by our inability to propagate these viruses in vitro ( 12 ). (cdc.gov)
  • Method and Result To study the barrier protective mechanism of Ang-1, we challenged human brain microvascular endothelial cells in-vitro, with a potent inflammatory mediator thrombin. (johnshopkins.edu)
  • In vitro assessment of eye irritancy using the Reconstructed Human Corneal Epithelial SkinEthic HCE model: application to 435 substances from consumer products industry. (episkin.com)
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. (sigmaaldrich.com)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • Furthermore, manipulation of occludin content in human cells is capable of influencing the expression of glucose transporters, and the activation of transcription factors like NFkB, and histone deacetylases like sirtuins, which proved capable of diminishing HIV replication rates in infected human macrophages under laboratory conditions. (wikipedia.org)
  • Studies involving high levels of expression of occludin in cancer cells have shown that occludin mitigates several important cancer proliferation properties. (wikipedia.org)
  • Results: TNF-α (10 ng/ml, 4 h) significantly decreased the expression of occludin, which was attenuated by propofol (25 μM). (researchsquare.com)
  • In addition, the inhibitors of Hif-1α, VEGF, VEGFR-2, and ERK could reduce the effect of TNF-α on occludin expression. (researchsquare.com)
  • In this study, we sought to explore whether propofol could attenuate the effect of TNF-α on occludin expression and identify the underlying mechanisms. (researchsquare.com)
  • It was also demonstrated that propofol inhibited sevoflurane-induced inflammation through NF-κB pathway in human neuroglioma cells [ 15 ]. (researchsquare.com)
  • Representative models of differentiated human intestinal epithelium can be established by growing cells in 3 dimensions (3-D) on collagen-I-coated porous microcarrier beads in rotating-wall vessel (RWV) bioreactors that model the physiologic fluid-shear environment in their respective organs ( 21 - 24 ). (cdc.gov)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • To obtain insight into the renewal activity of the human fallopian tube mucosa, we carried out immunofluorescence analysis of healthy samples from gynaecological tissue specimens. (nature.com)
  • Cesarean delivery and breastfeeding increases the transmission risk in HCV/human immunodeficiency virus coinfected women. (wjgnet.com)
  • Furthermore, patients with metastatic disease displayed significantly lower levels of occludin suggesting that the loss of occludin and thereby loss of tight junction integrity is important in metastatic development of breast cancer. (wikipedia.org)
  • Genomic markers close to the human S1PR2 gene were significantly associated with auditory thresholds in the 1958 British Birth Cohort (n? (omicsdi.org)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • Primary normal human bronchial epithelial (NHBE) cells or mouse precision cut-lung slices (PCLS) were treated with media, swine confinement facility organic dust extract (ODE) or H2S or ODE+H2S for one or five days. (cdc.gov)
  • Methods: We tested this hypothesis by applying tryptase on the apical and basolateral surface to primary human airway epithelia grown in an air-liquid interface and measured changes in the transepithelial conductance and paracellular permeability of the membrane during short (every minute) and longer (over hours) time courses. (arizona.edu)
  • The search for genetic determinants of human neural tube defects. (cornell.edu)
  • The presence of occludin decreased cellular invasiveness and motility, enhanced cellular sensitivity to apoptogenic factors and lowered tumorigenesis and metastasis of the cancer cells. (wikipedia.org)
  • Therefore, this new organoid model closely mimics the normal physiology and anatomy of the human fallopian tube epithelium and provides a starting point for future investigations into the regulatory mechanisms involved in its cellular renewal and pathology. (nature.com)
  • Thus, mutation or absence of occludin increases epithelial leakiness which is an important barrier in preventing metastasis of cancer. (wikipedia.org)
  • Recently, we engineered an R91W;Nrl −/− mouse model 1 to analyze the impact of a human-blinding mutation found in RPE65 (the R91W) specifically on cone photoreceptors. (nature.com)
  • We show that noroviruses can infect and replicate in a 3-dimensional (3-D), organoid model of human small intestinal epithelium. (cdc.gov)
  • We present the results of our first attempts to infect a physiologically relevant 3-D small intestinal epithelium model (INT-407) with genogroup I and II human noroviruses. (cdc.gov)
  • It is a part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. (neobiotechnologies.com)
  • However, mounting evidence demonstrated that occludin is not only present in epithelial/endothelial cells, but is also expressed in large quantities in cells that do not have tight junctions but have very active metabolism: pericytes, neurons and astrocytes, oligodendrocytes, dendritic cells, monocytes/macrophages lymphocytes, and myocardium. (wikipedia.org)
  • Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)
  • However, these models do not answer the fundamental questions of human norovirus attachment and entry into cells of the human gastrointestinal tract. (cdc.gov)
  • However, it is not known if CXCR1 is expressed on the apical or basolateral poles in polarized Caco-2 BBE cells or human intestinal tissue or whether the direction of TLR signalling influences the direction of IL-8 secretion. (biomedcentral.com)
  • It reacts specifically with human cells. (neobiotechnologies.com)
  • MAb235-1R recognizes an antigen associated with the nuclei in human cells. (neobiotechnologies.com)
  • These ramifications of ouabain weren't observed in regular human being kidney (NHK) cells. (biotech2012.org)
  • This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. (cusabio.com)
  • Very recently, human monoclonal antibodies were approved for use on patients with COVID-19. (frontiersin.org)
  • The human monoclonal antibodies used in this study are almost identical with these approved antibodies. (frontiersin.org)