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  • Lysates
  • Important data were provided by co-immunoprecipitation and in vitro kinase analyses using lysates from HCMV-infected cells, nuclear fractions, or infectious virions. (mdpi.com)
  • pore complex
  • Specifically, the monoclonal nuclear pore complex antibody 414 shows that NCSs are present in about half of all human endometrial epithelial cells but not in any other cell type, tissue or species. (biologists.org)
  • The nucleocytoplasmic trafficking of proteins occurs through the nuclear pore complex (NPC) and is mediated by an active and selective mechanism that is controlled by saturable transport receptors and the corresponding cis- acting transport signals that are termed nuclear localization signals (NLSs) and nuclear export signals (NESs) (reviewed in reference 15 ). (asm.org)
  • spliceosome
  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. (uniprot.org)
  • Examples include the NLSs of the influenza virus NP protein ( 55 ), the Borna disease virus p10 protein ( 62 ), the cellular transcription factor Stat1 ( 47 , 34 , 35 ), the histone deacetylase 4 ( 18 , 54 ), and the U1A spliceosome protein ( 22 ). (asm.org)
  • molecular
  • Proteins in the entire region from pH 7.0 to 9.0 with molecular weights (Mr) ranging from 35,000 to 41,000 and a protein focusing from pH 5.2 to 5.3 with Mr of 55,000 were strikingly reduced in MSS. (ahajournals.org)
  • GSH is a small molecular weight non protein thiol found ubiquitously in all mammalian cells. (pubmedcentralcanada.ca)
  • NLSs
  • These basic, generally lysine-rich signals are typified by the simian virus 40 (SV40) large T-antigen (TAg) NLS (PKKKRKV) or the cellular nucleoplasmin protein NLS (KRPAATKKAGQAKKKK) and are frequently referred to as classical NLSs. (asm.org)
  • motif
  • We have characterized a new type of histidine triad (HIT) motif protein (Nhm1) that co-purifies with the cap-binding complex eIF4F of Schizosaccharomyces pombe. (openrepository.com)
  • kinase
  • Recent studies have demonstrated that targeting of Ku and DNA dependent protein kinase (DNAPK), major DNA DSB repair proteins, by small interfering RNA in human cancer cells enhanced their sensitivity to DNA damaging agents ( 15 , 16 ). (pubmedcentralcanada.ca)
  • cytomegalovirus
  • To date, the mechanism of the association of human cytomegalovirus (HCMV) capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. (mdpi.com)
  • interaction
  • Interaction with RAN BP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). (rcsb.org)
  • Combined, the findings support a refined concept of HCMV nuclear trafficking and NEC-capsid interaction. (mdpi.com)
  • importin
  • Strong interactions were found between pUL84 and four members of the importin α protein family. (asm.org)
  • Deletion mutagenesis of pUL84 revealed a domain of 282 amino acids which is required for binding to the importin α proteins. (asm.org)
  • The human immunodeficiency virus type 1 Rev and Tat proteins exemplify a subgroup of factors that utilize exclusively importin β for nuclear import with no apparent requirement for the importin α subunit. (asm.org)
  • exclusively
  • Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in CD3+ T cells in peripheral lymphoid tissues. (bloodjournal.org)
  • Moreover, fluorescence and immunofluorescence microscopy show that Nhm1 is predominantly, although not exclusively, nuclear. (openrepository.com)
  • similarity
  • Sequence searches have revealed that proteins with strong sequence similarity over all regions of the new protein exist in a wide range of eukaryotes, yet none has been characterized up to now. (openrepository.com)
  • replication
  • Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. (uniprot.org)
  • Although the exact role of pUL84 in DNA replication is unknown, the nuclear localization of this protein is a prerequisite for this function. (asm.org)
  • version
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