• Although some mucins are membrane -bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane , most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva . (wikipedia.org)
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers. (wikipedia.org)
  • MUC5B, the predominate mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans , a bacteria with the potential to form cavities. (wikipedia.org)
  • In the mouth, mucins can also recruit anti-microbial proteins such as statherins and histatine 1 , which further reduces risk of infection. (wikipedia.org)
  • Mucins have been found to have important functions in defense against bacterial and fungal infections. (wikipedia.org)
  • Fusion of the vesicles to the plasma membrane causes release of the mucin, which as it exchanges Ca 2+ for Na + expands up to 600 fold. (wikipedia.org)
  • Mucins are also overexpressed in lung diseases such as asthma , bronchitis , chronic obstructive pulmonary disease (COPD) or cystic fibrosis . (wikipedia.org)
  • N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)