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  • HEK293
  • For [ 3 H]5-HT binding, scintillation proximity binding assays were initially carried out using wheat germ agglutinin-coated beads saturated with membranes from HEK293-A cell line expressing human 5-HT 2C receptors. (aspetjournals.org)
  • yeast
  • To combine the high yield/productivity and scalable protein features of bacteria and yeast, and advanced epigenetic features of plants, insects and mammalians systems, other protein production systems are developed using unicellular eukaryotes (i.e. non-pathogenic ' Leishmania ' cells). (wikipedia.org)
  • primates
  • Passive immunotherapy using anti-HIV broadly neutralizing monoclonal antibodies (mAbs) has shown promise as an HIV treatment, reducing mother-to-child-transmission (MTCT) of simian/human immunodeficiency virus (SHIV) in non-human primates and decreasing viral rebound in patients who ceased receiving anti-viral drugs. (jove.com)
  • organism
  • Since the study and testing on human beings may not be acceptable due to exposure to risks and practical and ethical concerns, in vitro strategies are of paramount importance to rely on human organism and avoid non-fully predictive animal models. (unipd.it)
  • Expression
  • There are also significant applications for expression systems in industrial fermentation , notably the production of biopharmaceuticals such as human insulin to treat diabetes , and to manufacture enzymes . (wikipedia.org)
  • protein
  • Here, we show that hamartin and tuberin function together to inhibit mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). (pnas.org)
  • mouse
  • These data are consistent with the observation that S6K1 activity is aberrantly increased within lesions of lymphangioleiomyomatosis patients as a result of TSC2 mutations ( 9 ) and within TSC1 -null mouse embryonic fibroblast cell lines ( 10 ), whereas the basal activity of PI3K and Akt remain unchanged. (pnas.org)
  • mammal
  • 10. The method of claim 1 , wherein greater than 50 pM of human C-peptide is detectable in the serum of the mammal post glucose-stimulation. (google.es)
  • function
  • RNAi screen indicates widespread biological function for human natural antisense transcripts. (nih.gov)
  • To gain insight into the function of Spy1 during the DNA damage response, we have undertaken a biochemical and cellular analysis of human Spy1 with agents that induce DNA damage. (aacrjournals.org)
  • methods
  • So far, human iPSC (hiPSC) have not been applied to clinics due to some unexplored aspects on their derivation, non clinical-grade methods and the significative cost of hiPSC derivation per patient. (unipd.it)
  • Variant
  • Guo X, Delio M, Haque N, Castellanos R, Hestand MS, Vermeesch JR, Morrow BE, Zheng D. Variant discovery and breakpoint region prediction for studying the human 22q11.2 deletion using BAC clone and whole genome sequencing analysis. (yu.edu)
  • family
  • 4. The method of claim 3, wherein the inhibitory nucleic acid that hybridizes to the member of the SIR family comprises an siRNA that is directed against a human SIR, optionally a human SIR that is encoded by a nucleic acid as set forth in any of SEQ ID NOs: 1, 3, and 5. (freepatentsonline.com)
  • better
  • Probing the binding site of gH/gL and gp42 with gp42 peptides is critical for a better understanding of the interaction of gH/gL with gp42 as well as for the design of novel entry inhibitors of EBV and related human herpesviruses. (asm.org)
  • cause
  • New genome wide technologies such as microarrays and next-generation sequencing have made it possible to uncover the cause of human disease. (yu.edu)
  • animal
  • Veterinarians are the only medical professionals comprehensively trained in comparative medicine and human-animal interactions, she writes, and they have a deep background in infectious disease. (animalhealthfoundation.net)
  • Clearly, human and animal health are more connected than most people realize, and doctors can learn much from the breakthrough work of veterinarians. (animalhealthfoundation.net)
  • possible
  • For the first time, it is possible to obtain human iPSC clones in microfluidics with a remarked reduction of minimum requirements (materials, reagents, overall expenses). (unipd.it)