Human lungs. Medical search. Frequent questions

In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
Maryna Perepelyuk et al, Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer, Molecular Pharmaceutics (2018). (phys.org)

Therefore, in this study, the anticancer effects of terpinen-4-ol were evaluated on two NSCLC cell lines, namely, A549 and CL1-0 human lung adenocarcinoma cells. (hindawi.com)
The A549 human lung adenocarcinoma and CL1-0 lung adenocarcinoma cell lines were cultured in Dulbecco′s modified eagle medium supplemented with 10% fetal bovine serum (FBS) and 1% antibiotic antimycotic. (hindawi.com)
Here, we investigate the effects of the photovoltaic activity of p-i-n nanowire arrays on A549 human lung adenocarcinoma cells. (lu.se)
This study aimed to investigate the anti-proliferative effects of Khz on A549 lung cancer cells. (springer.com)
In the present study, the venoms from five sea anemones (Heteractis crispa, Heteractis magnifica, Heteractis malu, Cryptodendrum adhaesivum and Entacmaea quadricolor) were obtained by the milking technique, and the potential of these venoms to kill cancer cells was tested on three cell lines (A549 lung cancer, T47D breast cancer and A431 skin cancer). (scielo.br)

A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania. (worldhealth.net)
AT2 cells are known to become abnormal in COPD and other lung diseases, and the researchers found evidence that defects in RASCs might be an upstream cause of those abnormalities. (worldhealth.net)
While the core of the Human Lung Cell Atlas is data from healthy lungs, the team also took datasets from more than 10 different lung diseases and used machine learning to project these onto the healthy data, in order to understand disease states. (myscience.de)
Finding these shared disease-associated cells is really exciting, and reveals a totally different way of looking at lung diseases, opening possibilities for novel treatment targets and developing treatment response biomarkers. (myscience.de)
For example, first author Lisa Sikkema from the Institute of Computational Biology and the scientific team saw that monocyte-derived macrophages (a specific type of immune cell) showed activity of similar genes in cancer, COVID-19, and lung fibrosis, likely playing a role in scar formation in the lung in all three diseases. (myscience.de)
In this review, we aim to analyze how the lung and gut microbiota influence each other and may impact on respiratory diseases. (frontiersin.org)
Viruses are also known to be key players in numerous respiratory diseases and to interact with the human immune system, but technical issues still limit the amount of data regarding virobiota ( Mitchell and Glanville, 2018 ). (frontiersin.org)
While GLA mycobiota also influences chronic gut diseases such as IBD, we will not address this key role in the present review: we aimed at analyzing how lung and gut bacteriobiota and mycobiota influence each other, how they interact with the human immune system, and their role in respiratory diseases. (frontiersin.org)
Recent hypotheses suggesting a role for environmental toxicants in the pathogenesis of lung diseases, such as lung cancer and chronic obstructive pulmonary disease have stimulated interest in research on the xenobiotic metabolizing capability of the lung. (eurekaselect.com)
Interindividual differences in in situ activation and inactivation of xenobiotics may contribute to the risk of developing of lung diseases associated with these compounds. (eurekaselect.com)
Some lung diseases can lead to respiratory failure . (medlineplus.gov)
Over the last few decades, lung transplantation has become an accepted modality of treatment for many end-stage lung diseases. (medscape.com)
Many occupational lung diseases are associated with exposure to aerosolized fibers in the workplace. (cdc.gov)

The researchers, who report their findings today in Nature , analyzed human lung tissue to identify the new cells, which they call respiratory airway secretory cells (RASCs). (worldhealth.net)
The cells line tiny airway branches, deep in the lungs, near the alveoli structures where oxygen is exchanged for carbon dioxide. (worldhealth.net)
They soon recognized that RASCs, which don't exist in mouse lungs, are "secretory" cells that reside near alveoli and produce proteins needed for the fluid lining of the airway. (worldhealth.net)
Respiratory specimens (i.e., lung, trachea, and large-airway specimens) collected at autopsy were submitted to CDC by medical examiners, hospitals, and local and state health departments for additional evaluation. (cdc.gov)
For patient education resources, see the Lung and Airway Center , as well as Heart and Lung Transplant and Bronchoscopy . (medscape.com)
Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
The cross- sectional averaged convective-diffusion equation was solved analytically to find closed-form solutions for particle concentration and losses per lung airway. (cdc.gov)
Airway losses were combined to find lobar, regional, and total lung deposition. (cdc.gov)
Deposition of man-made fibers in a human nasal airway. (cdc.gov)
The nasal airway is a critical route for fiber aerosol to enter the human respiratory tract. (cdc.gov)
In this research, experiments of fiber deposition in the human nasal airway were conducted. (cdc.gov)
The deposition studies were carried out by delivering aerosolized fibers into a human nasal airway replica at constant human inspiratory flow rates ranging from 15 l/min to 43.5 l/min. (cdc.gov)

Among lung cancers, nonsmall cell lung carcinomas (NSCLC) account for approximately 80% of lung cancer cases [ 1 ]. (hindawi.com)
T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. (harvard.edu)
P.10569 right column 2nd paragraph: 'Mutations in p53 are found in more than 50% of lung cancers (primary source). (harvard.edu)
Although rhabdoid variants of LCLC are sometimes referred to as "rhabdoid carcinomas", this particular term should be reserved for examples of "pure" rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) Lung cancers are now considered a large and extremely heterogeneous family of neoplasms that feature widely varying genetic, biological, and clinical characteristics. (wikipedia.org)
More than 99% of primary lung cancers are carcinoma, which are tumors composed of cells that originate from embryonic ectoderm or endoderm, or that feature epithelial characteristics or differentiation. (wikipedia.org)
The histogenesis of most lung cancers is not well understood. (wikipedia.org)
Conversely, mortality rates per 100,000 are lower in Native Americans than in the general population for cancers of the lung (43.0 vs 66.7) and breast (9.8 vs 17.7) (3). (cdc.gov)
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)

From 1986 through June 2016, 2330 lung and 730 heart-lung transplants in children were reported to the Registry for the International Society for Heart and Lung Transplantation (ISHLT). (medscape.com)
According to the International Society of Heart and Lung Transplantation (ISHLT) Registry, 2,330 pediatric lung and 730 pediatric heart-lung transplants have been performed through June 30, 2016. (medscape.com)
The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)

Coal Miner Andy Martin, who has black lung, speaks during a public hearing hosted by the federal Mine Safety and Health Administration about its draft rule to limit worker exposure to silica dust at the agency's office in Beaver, W.Va. on Thursday, Aug. 10, 2023. (cbs42.com)

Mice implanted with human lung tissue model pathogen infection and immune responses. (nature.com)
Lung tissue harbors various cell types that are involved in the infection and immunity of many human pathogens, and it could be an ideal source for humanizing mouse models. (nature.com)
Pursuing this line, Wahl, J. Victor Garcia and colleagues created lung-only mice (LoM) by implanting human lung tissue subcutaneously into the backs of immunodeficient mice. (nature.com)
To further model human immunity against pathogens in vivo, the team created a second model, BLT-L mice, by implanting autologous bone marrow-liver-thymus tissue and lung tissue into the immunodeficient mice. (nature.com)
In lung tissue from people with COPD, as well as from people without COPD who have a history of smoking, they observed many AT2 cells that were altered in a way that hinted at a faulty RASC-to-AT2 transformation. (worldhealth.net)
In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 virus in lung tissue. (cdc.gov)
Comparative replication competence of zoonotic-like influenza A(H3N8) viruses isolated from chicken and other human and avian viruses in ex vivo cultures of human bronchus and lung tissue. (cdc.gov)
Characterizing engineered human lung tissue is an important step in developing a functional tissue replacement for lung tissue repair and in vitro analysis. (fiu.edu)
Small tissue constructs were grown by seeding IMR-90 fetal lung fibroblasts and adult microvascular endothelial cells onto a Polyglycolic acid (PGA) polymer template. (fiu.edu)
These findings suggest that the necessary ECM can be established in engineered tissue constructs and that optimization of this procedure has the capacity to generate the load bearing elements required for construction of a functional lung tissue equivalent. (fiu.edu)
When viewed under a light microscope, the transformed cancer cells in LCLC are undifferentiated, lacking specific cytological and tissue architectural characteristics of other types, subtypes, and variants of lung cancer. (wikipedia.org)
Smith's lungs are riddled with fibrotic tissue. (wqln.org)
Coughing violently, he spit out what looked like moist and crusty bits of dark gray paper with black streaks - dead lung tissue, his respiratory therapist told us. (wqln.org)
CDT1 was upregulated in the vast majority of cancer tissues , based on pan- cancer analysis in TCGA and GEO datasets, as to lung cancer , the level of CDT1 expression was much higher in LUAD tissue than in healthy lung tissue . (bvsalud.org)

Human-mouse chimeric models (humanized mice), generated by engrafting human tissues and/or stem cells into immunodeficient mice, are powerful tools for in vivo studies of human pathogens. (nature.com)
Given the scarcity of donated human lungs, the ability to use those that have been previously frozen would expand the availability of these tissues for research purposes and help replace the use of animals in tests to assess the effects of chemicals on the human lung. (peta.org)
The viral RNA level of H5N1 virus was the highest among all the tested strains in human lung tissues, followed by H9N2 ( Figure 1 , panels B, D). Viral RNA levels of novel H3N8 and pH1N1 viruses were higher than those of avH3N8 virus. (cdc.gov)
Many of the lung and colon cancerous tissues we provide here have mutations detected for both genes, with the exception of one lung sample - lot. (biochain.com)
Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. (spandidos-publications.com)
The major xenobiotic metabolizing enzymes, including both phase I and phase II enzymes, have been detected in animal and human lung tissues. (eurekaselect.com)
Although the lung cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes share many common features with those present in other tissues such as liver, kidney and gut, there are some distinctive differences. (eurekaselect.com)

Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. (nih.gov)
Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta2m(null), and NOD-scid IL2Rgamma(null) as xenograft tumor recipients. (nih.gov)
Here, we show that BD is not toxic and its oral application significantly suppresses time-dependent increase in tumor sizes and inhibits breast-to-lung cancer metastasis. (spandidos-publications.com)
Eight major groups of lung carcinomas are recognized in WHO-2004: Squamous cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma Carcinoid tumor Salivary gland-like carcinoma of the lung LCLC-RP are considered variants of large cell carcinoma. (wikipedia.org)
While undifferentiated large-cell lung carcinoma is the most common parent lung tumor from which a rhabdoid phenotype evolves, malignant cells with a rhabdoid phenotype are known to occur in many different histological variants of lung cancer, including adenocarcinoma, sarcomatoid carcinoma, squamous cell carcinoma, combined large cell neuroencrine carcinoma, and mucinous bronchioloalveolar carcinoma and combined small cell lung carcinoma. (wikipedia.org)
A pill has been shown to halve the risk of death from a certain type of lung cancer when taken daily after surgery to remove the tumor, according to clinical trial results presented on Sunday. (zawya.com)
The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. (nature.com)

In the present study, we developed a novel computational pipeline to utilize the LungMAP CellCards as a dictionary to consolidate single-cell transcriptomic datasets of 104 human lungs and 17 mouse lung samples to construct "LungMAP CellRef" and "LungMAP CellRef Seed" for both normal human and mouse lungs. (pnnl.gov)
An international team of researchers now created a single-cell atlas of the human lung by combining 49 different published and newly generated datasets. (myscience.de)
Dr Malte L cken, Group leader at the Institute of Computational Biology and the Institute of Lung Health & Immunity at Helmholtz Munich adds: "A comprehensive organ atlas requires many datasets to capture the diversity between both cells and individuals, but combining different datasets is a huge challenge. (myscience.de)
We developed a benchmarking pipeline to find the optimal method to integrate all datasets into the atlas, using artificial intelligence, and combined knowledge and data from almost 40 previous lung studies. (myscience.de)

Carcinomas of the lung are thought to arise from the uncontrolled growth of mutated, transformed, multipotent "cancer stem cells" with epithelial characteristics or lineage. (wikipedia.org)

With studies like this we're starting to get a sense, at the cell-biology level, of what is really happening in this very prevalent disease," said senior author Edward Morrisey, Ph.D., the Robinette Foundation Professor of Medicine, a professor of Cell and Developmental Biology, and director of the Penn-CHOP Lung Biology Institute at Penn Medicine. (worldhealth.net)
The novel H3N8 virus was isolated from chickens and is genetically closely related to the virus causing zoonotic human disease in China (A/Henan/4-10CNIC/2022/H3N8) ( 8 ). (cdc.gov)
They found other responses in e-cigarette users that were not present in cigarette smokers, suggesting that e-cigarettes have a different risk profile from cigarettes, but that is at least as dangerous in terms of lung disease. (ucsf.edu)
Dr. Shoyele and colleagues showed that these components formed a spherical nanoparticle capable of properly finding the lung tumors and shrinking the tumors in mouse models of the disease. (phys.org)
This atlas elucidates the diversity of single lung cell types and allows learning about lung biology in health and disease. (myscience.de)
Whether you are a patient living with lung disease or a caregiver, join the Patient & Caregiver Network for timely education, support and connection. (lung.org)
The American Lung Association strongly supports research to prevent, and reduce exacerbation, discover cures and improve the diagnosis of lung disease. (lung.org)
In addition, research should investigate measures to eliminate disparities in lung disease morbidity and mortality for people of color and low income and other underserved populations. (lung.org)
The American Lung Association supports increased federal funding levels for biomedical, behavioral, epidemiological, environmental and intervention research and research training programs, including but not limited to those conducted by the National Institutes of Health, the Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, the Department of Veterans Affairs, Department of Defense and the Environmental Protection Agency. (lung.org)
The American Lung Association recognizes that research with human stem cells offer significant potential to further our understanding of fundamental lung biology and to develop cell-based therapies to treat lung disease. (lung.org)
Lung cancer is the form of the disease that causes the most deaths, with approximately 1.8 million fatalities every year worldwide. (zawya.com)
Lung transplantation has matured into an accepted therapeutic alternative for children with end-stage lung disease. (medscape.com)
That is, patients trade their end-stage lung disease for transplant lung disease, with the hope that it can be better managed. (medscape.com)
Smith, 51, suffers from an advanced and incurable stage of black lung disease. (wqln.org)
Smith suffers from progressive massive fibrosis, or complicated black lung, an advanced, incurable and fatal stage of black lung disease. (wqln.org)
Danny Smith spent just 12 years mining coal before he was diagnosed with complicated black lung disease at 39. (wqln.org)
But if the rule is adopted, the agency predicts it would save only 63 coal miner lives and avoid 244 cases of black lung disease over 60 years. (wqln.org)
Silica dust is 20 times more toxic than coal dust and causes severe forms of black lung disease even after a few years of exposure. (cbs42.com)
People with lung disease have difficulty breathing. (medlineplus.gov)
Millions of people in the U.S. have lung disease. (medlineplus.gov)
If all types of lung disease are lumped together, it is the number three killer in the United States. (medlineplus.gov)
The term lung disease refers to many disorders affecting the lungs, such as asthma , COPD , infections like influenza , pneumonia and tuberculosis , lung cancer , and many other breathing problems . (medlineplus.gov)
The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
See also Lung Cancer Staging -- Radiologic Options , a Critical Images slideshow, to help identify stages of the disease process. (medscape.com)

NK cells were detected in all strains except NOD-scid IL2Rgamma(null), and in vitro activated scid, NOD-scid, and NOD-scid beta2m(null) NK cells kill human melanoma lines and primary melanoma cells. (nih.gov)
Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model. (ajtmh.org)
Using an in vitro model of human lung endothelial cells, we studied different characteristics of Plasmodium falciparum isolates as potential factors for malaria severity in 2 Thai patient groups: 27 with complicated malaria and 42 with uncomplicated malaria. (ajtmh.org)
We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically active nutritional compounds (diindolylmethane and quercetin), inhibits proliferation and metastatic behavior of MDA-MB-231 invasive human breast cancer cells in vitro. (spandidos-publications.com)
BreastDefend™ (BD) is a polybotanical dietary supplement which inhibits growth and invasive behavior of highly metastatic human breast cancer cells in vitro ( 6 ). (spandidos-publications.com)

Although ex vivo lung perfusion (EVLP) is able to recover marginal quality donor lungs, extension of normothermic support beyond 6 h has been challenging. (nature.com)
Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering. (nature.com)
Extended criteria donor lungs and clinical outcome: results of an alternative allocation algorithm. (nature.com)
Improved understanding of the mechanism of lung injury during brain death and during transition from donor to recipient may one day lead to techniques and preservation solutions that prevent ischemia-reperfusion injury. (medscape.com)
Lastly, Bowdish et al and other groups demonstrated that living-donor lobar lung transplantation can be successfully performed. (medscape.com)
Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)

Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. (nature.com)
Normothermic ex vivo lung perfusion in clinical lung transplantation. (nature.com)
However, the phrase "children are not just small adults" is nowhere more true than in the field of lung transplantation. (medscape.com)
This article is meant not only to serve as an overview of the field of lung transplantation but also to highlight the unique challenges faced by pediatric lung transplant recipients, their families, and their healthcare teams. (medscape.com)
Pediatric lung transplantation actuarial survival by era. (medscape.com)
In 1963, James Hardy, MD, at the University of Mississippi, performed the first human lung transplantation in a 58-year-old convict serving a life sentence. (medscape.com)
Joel Cooper, MD, at the University of Toronto achieved success in 1983 with the transplantation of a single lung. (medscape.com)
This procedure was soon followed by successful double lung transplantation. (medscape.com)
Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)

In a new research paper, an algorithm developed in a partnership between Google and medical professionals has demonstrated its incredible accuracy at detecting lung cancer. (bgr.com)

Additional tests are needed before the technology is ready for testing in human clinical trials. (phys.org)
While safeguarding patient and research participant privacy, the American Lung Association supports full transparency in the conduct of all research, including clinical trials. (lung.org)
CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical stakeholders are investigating a nationwide outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) ( 1 ). (cdc.gov)

To date there is no specific therapeutic treatment or vaccine for COVID-19 caused by the SARS-CoV-2 virus and relevant animal models that mimic human COVID-19 pathologies are lacking. (pasteur.fr)
Collectively, our findings highlight that miR-378 and miR-1827 could serve as novel therapeutic targets in lung cancer. (jcancer.org)
It thereby offers a uniquely rich picture of how diseased lungs differ from healthy ones and provides pointers for potential therapeutic targets. (myscience.de)

Avian influenza viruses (AIVs) with reassortments between AIVs from domestic poultry and wild birds sporadically cross species barriers, leading to human infections. (cdc.gov)
In 2022, two human infections with novel influenza A(H3N8) viruses were reported in Henan and Hunan Province, China ( 4 , 5 ). (cdc.gov)
These findings confirm that bacterial lung infections are occurring among patients with fatal cases of 2009 pandemic influenza A (H1N1) and underscore both the importance of pneumococcal vaccination for persons at increased risk for pneumococcal pneumonia and the need for early recognition of bacterial pneumonia in persons with influenza. (cdc.gov)
The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
No human bird flu infections have been reported from proper handling of Bird Flu in Poultry poultry meat or from eating properly cooked poultry or poultry products. (cdc.gov)
however, because other bird flu viruses have infected people, it is possible that human infections with these viruses could occur. (cdc.gov)

The most common type of lung cancer, non-small cell lung cancer (NSCLC), continues to be difficult to treat, with five year survival rates of about 36 percent for stage 3A tumors. (phys.org)
Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC). (bvsalud.org)

We realized that there was a large need for preclinical in vivo models that could be used to study these human pathogens, novel treatment and prevention approaches, as well as vaccine vectors and the human immune response that they elicit," says Angela Wahl of the University of North Carolina School of Medicine. (nature.com)
Infection of HuLung and HIS-HuLung mice with SARS-CoV-2 will provide an in vivo model for viral replication and will enable the study of pathological mechanisms provoked by the anti-viral human immune responses to SARS-CoV-2. (pasteur.fr)

With greater experience and analysis of significant numbers of cases, lung transplant recipients are living longer, and follow-up regimens are becoming streamlined. (medscape.com)

The results indicate that the sea anemone venom is cytotoxic to human cancer cells. (scielo.br)
In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. (spandidos-publications.com)
In the present study, we evaluated toxicity and anti-cancer activities of BD in an animal model of breast-to-lung cancer metastasis with triple-negative highly invasive humane breast cancer cells MDA-MB-231 implanted in the mammary pad of nude mice. (spandidos-publications.com)
Restored protein expression in miRNA-overexpressed/ miRNA-suppressed cells attenuated the inhibitory/ inducing effect of the miRNA on lung cancer cells. (jcancer.org)

Expression of human NKG2D ligands MHC class I chain-related A and B molecules renders melanoma susceptible to murine NK cell-mediated cytotoxicity and killing is inhibited by antibody blockade of murine NKG2D. (nih.gov)
The absolute NK deficiency in NOD-scid IL2Rgamma(null) animals makes this strain an excellent recipient of melanoma and potentially other human malignancies. (nih.gov)
Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)

Development of alveolar and bronchial human microphysiological systems for use in respiratory infection research and therapeutics evaluation. (ddw-online.com)
In Kjelstrup's team's cell, they've designed channels modelled on the bronchial structure of the lungs in order to supply hydrogen and oxygen gas to their respective electrodes. (inhabitat.com)

Progress in understanding COPD has been gradual in part because mice -- the standard lab animal -- have lungs that lack key features of human lungs. (worldhealth.net)
More research is needed, Morrisey said, but the findings point to the possibility of future COPD treatments that work by restoring the normal RASC-to-AT2 differentiation process -- or even by replenishing the normal RASC population in damaged lungs. (worldhealth.net)
This extensive degranulation of neutrophils is a feature of lung disorders involving inflammation, such as severe asthma and COPD. (ucsf.edu)

Human innate and adaptive immune cells are systematically reconstituted in BLT-L mice, thus facilitating examining various immune responses upon infection. (nature.com)
We were surprised at just how many different human pathogens replicated in the models and at how well the human immune cells in BLT-L mice could control infection, just like they would in people," says Wahl. (nature.com)
We envisioned that LoM and BLT-L mice could be used to study important emerging human pathogens like severe acute respiratory syndrome coronavirus (SARS), Middle East respiratory syndrome coronavirus (MERS), and tuberculosis. (nature.com)

However, by combining the experience of a human doctor with the brains of a deep learning algorithm, it's likely that fewer errors in diagnosis will be made, resulting in better overall quality of life for all of us. (bgr.com)
And that great strides have been made in the diagnosis and treatment of lung cancer . (mainlinehealth.org)
Exposure to silica dust likely explains Smith's complicated black lung diagnosis at the relatively young age of 39 and after just 12 years of cutting rock and coal underground. (wqln.org)
We evaluated associations of race, primary payer at diagnosis, and survival among patients diagnosed in Florida with lung cancer (n = 148,140) and breast cancer (n = 111,795), from 1996 through 2007. (cdc.gov)

The mechanism of how miRNAs modulate lung cancer metastasis remains unclear. (jcancer.org)
However, its prognostic value in lung adenocarcinoma (LUAD) remains unclear. (bvsalud.org)

In fact, a new paper about human lung slices coauthored by PETA Science Consortium International e.V. and other experts is poised to revolutionize the field of inhalation research and toxicity testing and reduce the number of animals used in these tests. (peta.org)
Silicosis, commonly referred to as black lung, is an occupational pneumoconiosis caused by the inhalation of crystalline silica dust present in minerals like sandstone. (cbs42.com)

Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. (cdc.gov)
The efficacy of prophylactic endotracheal administration of superoxide dismutase (SOD) was assessed in an animal model of acute lung injury induced by intratracheal endotoxin in neonatal piglets. (karger.com)
The animals received recombinant human SOD (5 or 20 mg/kg intratracheally) 10 min before induction of acute lung injury with intratracheal endotoxin (20 mg/kg). (karger.com)
Thus, the present findings suggest that prophylactic treatment with SOD may be, at least in part, effective for alleviating acute lung injury caused by endotoxins. (karger.com)
With a current surge of Covid-related lung dysfunction, as well as an increase in acute lung injuries due to increasing level of air pollution a new strategy to regenerate lungs is needed. (ddw-online.com)

In the current study, we collected high-throughput gene expression data related to human lung epithelial cells infected with SARS-CoV-2 or other respiratory viruses (SARS, H1N1, rhinovirus, avian influenza, and Dhori) and compared the effect of these viruses on the human transcriptome. (biorxiv.org)
To help determine the role of bacterial coinfection in the current influenza pandemic, CDC examined postmortem lung specimens from patients with fatal cases of 2009 pandemic influenza A (H1N1) for bacterial causes of pneumonia. (cdc.gov)

Having a way to follow up on abnormal findings on a CT scan is very important, especially since they may not be considered high risk for lung cancer. (mainlinehealth.org)
Our key findings add to the evidence that a changing climate is making it harder to protect human health. (lung.org)

Here, we report that miR-378 and miR-1827 modulate lung cancer cell invasion and migration via epithelial-mesenchymal transition (EMT). (jcancer.org)

However, for human-specific pathogens that only infect non-hematopoietic cells, the lack of target human cell types in mouse models can limit their utility in basic and translational research. (nature.com)
Cell replacement in human lung bioengineering. (nature.com)
These atlases incorporate 48 human and 40 mouse well-defined lung cell types catalogued from diverse anatomic locations and developmental time points. (pnnl.gov)
Using a total of 20 testing data from five independent studies, we demonstrated the utility of our CellRefs for automated cell type annotation analysis of both normal and diseased lungs. (pnnl.gov)
Preformed immunoreactive TNF-α has been observed within the granules of mast cells from human skin (5) and lung (6), suggesting its rapid availability following mast cell activation. (soton.ac.uk)
Our previous study demonstrated that miR-378 is up-regulated while miR-1827 is down-regulated in high invasive lung cancer sub-cell lines, and their biological functions have been described. (jcancer.org)
Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). (wikipedia.org)
Recent studies have shown beyond doubt that the old classification paradigm of "small cell carcinoma vs. non-small cell carcinoma" is now obsolete, and that the correct "subclassification" of lung cancer cases is necessary to assure that patients receive optimum management. (wikipedia.org)
Can a human organ be mapped on a single-cell level, to learn about the functionality of each individual cell? (myscience.de)
International researchers have taken up this challenge and developed the Human Lung Cell Atlas, using artificial intelligence (AI)-based techniques. (myscience.de)
This provided insight into the wide variety of cells and cell types existing in our lungs. (myscience.de)
Our study not only supports the presence of lung fibrosis in COVID-19, it allows us to identify and define a shared cell state between lung fibrosis, COVID-19 and lung cancer patients. (myscience.de)
By pooling and integrating all the bits of knowledge and data that had been generated previously, the researchers created the first integrated Human Lung Cell Atlas: For each of the 2.4 million cells in this atlas, they know which genes were active in which cell, thereby learning about the functionality of those cells. (myscience.de)
Sikkema remarks: "One of the big problems in creating the integrated lung cell atlas was with cell type annotation. (myscience.de)
It targets a particular type of lung cancer in patients suffering from so-called non-small cell cancer, the most common type, and showing a particular type of mutation. (zawya.com)
We started entering the personalized therapy era for early stage patients,' said Pennell, who did not take part in the trials, and noted that 'we should firmly close the door on one-size-fits-all treatment for people with non- small cell lung cancer. (zawya.com)
The phrase lives of a cell refers to the independent yet interrelated parts of a human cell including mitochondria, centrioles, and basal bodies that once led independent lives. (cdc.gov)
Non-small cell lung cancer. (medscape.com)
Go to Small Cell Lung Cancer for complete information on this topic. (medscape.com)

these included CSF2 (colony-stimulating factor 2) and S100A8 and S100A9 (calcium-binding proteins), all of which are involved in lung/respiratory disorders. (biorxiv.org)

Following a steady increase in pediatric lung transplants in the first decade of this millennium, with 125 reported to the ISHLT registry in 2009, numbers have remained stable with a range of 90 to 137 observed during the past 12 years. (medscape.com)

Second, the research team added the MUC1 antigen, which acts like a navigation system guiding the nanoparticles to the MUC1-covered lung tumors. (phys.org)
2004), manufactured fusion and secondarily by thermophoretic effects in the first few nanoparticles may be biopersistant and remain intact and cause airways of the lung during exhalation. (cdc.gov)
Because of potential toxic effects, it is critical to have a re- alistic assessment of the regional deposition of nanoparticles in the lung. (cdc.gov)

Thanks to an increase in lung cancer screening, suspicious lung nodules are being found on CT scans in patients who don't have any symptoms. (mainlinehealth.org)
Early lung cancer detection and cure offers huge survival benefits to patients," she adds. (mainlinehealth.org)
These mutations, on what is called the epidermal growth factor receptor, or EGFR, affect 10 percent to 25 percent of lung cancer patients in the United States and Europe, and 30 to 40 percent in Asia. (zawya.com)
No survival association was found for Native American compared with white lung cancer patients or those using the Indian Health Service versus private insurance in fully adjusted models. (cdc.gov)
however, 176 lung cancer patients and 177 breast cancer patients reported using IHS providers ( Table 1 ). (cdc.gov)
Nomograms and Kaplan-Meier plots were generated to assess the survival rates of patients with lung adenocarcinoma (LUAD). (bvsalud.org)
Approximately 80% of all patients with lung cancer are considered for systemic therapy at some point during the course of their illness. (medscape.com)

The atlas is a first step towards a consensus annotation of the human lung, which will help bring together the field of lung research. (myscience.de)

Prof. Fabian Theis, Head of the Computational Health Center, Director of the Institute of Computational Biology at Helmholtz Munich and Professor at the Technical University of Munich (TUM), explains the project: "We have created a first integrated reference atlas of the human lung, which includes data from more than a hundred healthy people and reveals how the cells from individuals vary with age, sex, and smoking history. (myscience.de)

Lung nodules can also be found on a cardiac CT scan. (mainlinehealth.org)
The majority of these nodules fall in the outer third of the lung, which is very hard to reach with traditional bronchoscopy," says Jacqueline Sutter, DO , Main Line Health interventional pulmonologist . (mainlinehealth.org)

A quick intraoperative gross examination of the lung allograft may reveal previously unrecognized lesions, the nature of which could be addressed with frozen section analysis. (medscape.com)

Although one-year survival rates have improved, long-term outcomes for children receiving lung transplants have not (see the image below). (medscape.com)
In this study, we used the Florida Cancer Data System (FCDS), a Florida population-based cancer registry, to examine breast and lung cancer survival by Native American race and IHS use for the Seminole and the Miccosukee tribes, the 2 federally recognized tribes in Florida. (cdc.gov)

A few sea anemone species can cause a mild to severe sting that leads to pain, erythema, ulcer and sometimes necrosis, for example, Anemonia sulcata and Phyllodiscus semoni which are dangerous to humans (4, 5). (scielo.br)
BEAVER, W.Va. (AP) - Laboring to breathe, West Virginia coal miner Terry Lilly told federal regulators Thursday he is appreciative the U.S. government is finally considering a proposal to limit the poisonous rock dust causing a severe resurgence of black lung. (cbs42.com)

The study found that both fresh and frozen human lung slices could be used to assess the toxicity of inhaled chemicals. (peta.org)
Like several other deep learning algorithms tested for use in medical fields, the computer brain in this study was trained using scans from past lung cancer screenings. (bgr.com)
In the new study, Morrisey and his team uncovered evidence of RASCs while examining gene-activity signatures of lung cells sampled from healthy human donors. (worldhealth.net)
Using a mAb specific for the activated form of NF-κB, immunocytochemistry, confocal microscopy, and gel shift assays have been used in conjunction to localize this transcription factor to human lung mast cells and to study its activation. (soton.ac.uk)
Prof. Martijn Nawijn, a senior author on the paper and Professor at the University Medical Center Groningen, the Netherlands, said: "This is the first effort to compare healthy and diseased lungs in one study in an integrated way. (myscience.de)
The American Lung Association opposes the exclusion of the results of a study from use in policymaking simply because the study utilized private research participant data. (lung.org)
dict deposition of inhaled particles in the lungs of humans and This study was supported in part by the EPA STAR grant RD animals. (cdc.gov)
This study aimed to evaluate the smoking behaviour of Jordanian secondary-school students (aged 16-18 years), their awareness of the dangers of smoking and their perceived susceptibility to lung cancer. (who.int)

Murine NKG2D recognition of MICA/B is an important receptor-ligand interaction used by NK cells in immunodeficient strains to limit engraftment of human tumors. (nih.gov)
Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. (springer.com)
Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)
NF-κB and TNF-α: A positive autocrine loop in human lung mast cells? (soton.ac.uk)
In human lung mast cells, we demonstrate the presence and activation of NF-κB and the generation of TNF-α. (soton.ac.uk)
The human body is arguably one of the finest machines ever created by nature, and now a team from Norway's Academy of Science and Letters in Oslo are looking to it for inspiration as they design the next generation of hydrogen fuel cells. (inhabitat.com)
More specifically, they are looking at the lungs - according to Signe Kjelstrup, who is heading the team, making fuel cells in the shape of lungs could cut down on the amount of expensive catalysts needed, such as platinum, while increasing efficiency. (inhabitat.com)
But what makes the shape of the lung benefical to the efficiency of fuel cells? (inhabitat.com)
The American Lung Association supports the responsible pursuit of research involving the use of human stem cells. (lung.org)
The majority of genes (99%) amplified in human stools are from bacteria, which are as numerous as human cells and comprise 150 distinct bacterial species, belonging mainly to Firmicutes and Bacteroidetes phyla. (frontiersin.org)
Our human lives do not depend just on the lives in our individual cells. (cdc.gov)

Boris Reidel and his colleagues at the University of North Carolina just published E-Cigarette Use Causes a Unique Innate Immune Response in the Lung Involving Increased Neutrophilic Activation and Altered Mucin Secretion which adds to the growing case that e-cigarettes have a different risk profile that conventional cigarettes and, at least for some effects, may be more dangerous than conventional cigarettes. (ucsf.edu)
a unique e-cigarette-induced innate lung response that includes markers of aberrant neutrophilic response and altered mucin secretion and indicate that the effects of e-cigarettes are overlapping with yet distinct from those observed in otherwise healthy cigarette smokers. (ucsf.edu)
E-Cigarette Use Causes a Unique Innate Immune Response in the Lung Involving Increased Neutrophilic Activation and Altered Mucin Secretion. (ucsf.edu)

As such, this design enables the spread of gases much more uniformly and efficiently - just like oxygen in the lungs. (inhabitat.com)
When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. (medlineplus.gov)

Among the relevant inter-organ connections, the gut-lung axis (GLA) remains less studied than the gut-brain axis. (frontiersin.org)
Human lung is a major target organ for all inhaled drugs, environmental toxicants and carcinogens. (eurekaselect.com)
Examples include organ transplants and iron lungs. (cdc.gov)

To test this assumption, they collected sputum from nonsmokers, smokers, and e-cigarette users and looked to see what proteins connected with immune response in the lungs that protect the linings of airways in the lungs were altered. (ucsf.edu)

Concern over silica's role in black lung has been growing for decades, and mine safety advocates have urged regulators to act since 1974. (wqln.org)
It found more than 4,000 cases of complicated black lung since 2010 and more than 1,500 diagnoses in just the last five years alone. (wqln.org)
The scale of human tragedy is profound," said Kirsten Almberg, an epidemiologist at the Black Lung Data and Resource Center at the University of Illinois Chicago . (wqln.org)
President of the National Black Lung Association Gary Hairston, who lives in neighboring Fayette County, said that too often, miners have to choose between their safety and their livelihood. (cbs42.com)
We can fix this when we start making the coal mining companies responsible for what they're doing," said Hairston, becoming emotional speaking into the microphone wearing a "black lung kills shirt. (cbs42.com)
one in 20 has the most disabling form of black lung. (cbs42.com)

This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. (nature.com)
About 50 different lung cancer variants are recognized under the 2004 revision of the World Health Organization ("WHO-2004") histological typing system, the most widely recognized and used lung cancer classification scheme. (wikipedia.org)

If your doctor sees a shadow on your lungs, you should know that many lung tumors are not cancerous. (mainlinehealth.org)

Anatomy24

Organisms8

Diseases45

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology1

Phenomena and Processes59

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care8

Nonsmall cell lung cancer3

A5495

Diseases13

Airway12

Cancers9

Heart and Lung Transplantation3

20231

Tissue14

Tissues7

Tumor7

Awaiting lung transplantation1

Datasets4

Carcinomas1

Disease24

Vitro5

Donor6

Transplantation11

Detecting lung cancer1

Clinical3

Therapeutic3

Infections6

NSCLC2

Vivo2

Transplant recipients1

Cancer cells4

Melanoma3

Bronchial2

COPD3

Mice3

Diagnosis4

Remains unclear2

Inhalation2

Acute5

Influenza2

Findings2

Epithelial1

Cell19

Disorders1

ISHLT1

Nanoparticles3

Patients7

Field of lung1

Biology1

Nodules2

Allograft1

Survival2

Severe2

Study8

Cells11

Innate3

Oxygen2

Organ3

Airways1

Black lung6

Histological2

Cancerous1