Human lung cancer microrna expression. Medical search. Frequent questions

In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (nih.gov)
MicroRNAs (miRNAs) are a category of small nonencoding RNAs of 22 nucleotides in length. (hindawi.com)
Here, microRNA-127 (miR-127) is one of the miRNAs that focuses on lung diseases [ 31 - 33 ]. (hindawi.com)
MicroRNAs (miRNAs) play vital roles in regulating various biological processes. (biomedcentral.com)
The dysregulations of miRNAs may result in severe human diseases, including cancer. (biomedcentral.com)
The expression profiling of miRNAs has already been used in cancer clinics as diagnostic and prognostic biomarkers to assess tumor development [ 4 ]. (biomedcentral.com)
For detecting and quantifying the expression of specific miRNAs, RNA was reverse transcribed using a Bulge-Loop™ miRNA qRT-PCR Primer Set and quantified by SYBR Green-based real-time PCR analysis in the FTC-3000P PCR instrument. (biomedcentral.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)
As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
Therefore, miRNAs could consider as cancer targets. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
The understanding of miRNA has increased over the past 10 years, and particularly the involvement of miRNAs in cancer. (ukessays.com)
MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. (jcancer.org)
The mechanism of how miRNAs modulate lung cancer metastasis remains unclear. (jcancer.org)
MicroRNAs (miRNAs) são pequenos RNAs não-codantes, conservados ao longo da evolução, capazes de regular a expressão gênica através da degradação ou repressão da tradução de moléculas-alvo de RNA mensageiro. (bvsalud.org)
Thus, is not completely clear whether the altered expression of miRNAs is cause or consequence of malignant transformation. (bvsalud.org)
In this work, we develop a novel method using multiple types of data to calculate miRNA and disease similarity based on mutual information, and add miRNA family and cluster information to predict human disease-related miRNAs (FCMDAP). (biomedcentral.com)
Results confirm the 100, 98 and 96% of the top 50 predicted miRNAs reported in case studies on colorectal, lung, and pancreatic neoplasms. (biomedcentral.com)
MicroRNAs (miRNAs) are small endogenous non-coding RNAs with length of about 22 nt and can regulate gene expression mainly through post-transcription [ 1 ]. (biomedcentral.com)
The latest version of miRBase consists of 1881 human miRNAs, and most of them regulate more than 60% of human protein-coding genes. (biomedcentral.com)
METHODS: Discovery utilised Taqman Low Density Arrays (754 miRNAs) in 20 non-small cell lung cancer (NSCLC) tumour/normal pairs. (edgehill.ac.uk)
Here we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management.METHODS: Discovery utilised Taqman Low Density Arrays (754 miRNAs) in 20 non-small cell lung cancer (NSCLC) tumour/normal pairs. (edgehill.ac.uk)
He worked as Scientist of the Molecular Medicine Program with prof Di Fiore (2011-2012) and, jointly with clinicians at the European Institute of Oncology (IEO- Milan), he developed one of the first signatures of circulating miRNAs, effective in identifying asymptomatic early-stage lung cancers and developing into a clinical grade test to be used in large-scale cancer screenings. (iit.it)
After collecting exhaled breath samples from the study's 351 participants, Dr. Spivack's team used a highly sensitive PCR assay to look for potential microRNA lung-cancer biomarkers from among a panel of 24 miRNAs found in human lung tissue. (einsteinmed.edu)
MicroRNAs (miRNAs), a family of endogenous, small non-coding RNAs (20-25 nucleotides in length), are important regulators in a variety of biological processes, including cell development, infection, immunity, and carcinogenesis, through post-transcriptional regulation of mRNA expression. (revoluciondelosgladiolos.org)
Currently, miRNAs have been used in clinic for predicting cancer classification, prognosis, and response to therapy [27C29]. (revoluciondelosgladiolos.org)
Regulation of COX-2 expression by miRNAs has been extensively studied in a variety of human tumors, but this kind of regulation in ESCC remains unclear [30C40]. (revoluciondelosgladiolos.org)
We searched the databases TargetScan, PicTar, miRwalk, DIANAmT, microRNA, Microcosm Targets and MicroRanda for miRNAs that might bind to the 3 -UTR of COX-2. (revoluciondelosgladiolos.org)
This study will pave the way for the utilizing the potential of exosomes/miRNAs as a novel theranostic agents in understanding the lung injury caused by tobacco smoking and vaping. (researchsquare.com)
They established which miRNAs were differentially expressed regardless of cancer subtype, as well as signatures for both adenocarcinoma and squamous cell carcinoma specifically, after finding that the miRNAs strongly differed between those two groups. (genomeweb.com)
According to the researchers, several miRNAs in their predictive signatures are associated with important cancer-related pathways, including miR-31, and miR-34. (genomeweb.com)
MicroRNAs (miRNAs) are single-stranded, endogenously expressed, short, noncoding RNAs with a length of 18-25 nucleotides. (nature.com)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. (cdc.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
MicroRNAs (miRNAs), which are rapidly released from damaged tissues into the host fluids, constitute a promising biomarker for the prognosis of SM. (cdc.gov)
We applied next-generation sequencing to evaluate the differential expression of miRNAs in SM and in uncomplicated malaria (UM). (cdc.gov)
These findings suggest that different physiopathological processes in SM and UM lead to differential expression of miRNAs and pave the way for future studies to assess their prognostic value in malaria. (cdc.gov)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)

Specifically, one type of miRNA is also involved in different cancers. (biomedcentral.com)
A greater understanding of miRNA could possibly lead to better diagnostic and treatment of cancer. (ukessays.com)
Restored protein expression in miRNA-overexpressed/ miRNA-suppressed cells attenuated the inhibitory/ inducing effect of the miRNA on lung cancer cells. (jcancer.org)
microRNA (miRNA) is a small molecule RNA that can be stably expressed in body fluids such as serum, plasma, saliva and can be sensitively detected. (researchsquare.com)
MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)
The expression of miRNA is deregulated in several pathological processes, including cancer. (bvsalud.org)
However, changes in expression of miRNA may be secondary to the tumor phenotype. (bvsalud.org)
Here we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management. (edgehill.ac.uk)
miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal Cancer. (biomedcentral.com)
After pioneering the exploitation of circulating microRNAs for diagnostic purposes in cancer, he has recently brought to attention the mechanisms of miRNA degradation, highlighting the involvement of a novel mechanism, termed Target-Dependent miRNA degradation (TDMD), to whose discovery his lab decisively contributed. (iit.it)
Over the past few years, emerging numerous bioinformatic tools have been developed to identify candidate disease-causing genes [ 4 ], including microRNA (miRNA) genes. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
Cigarette smoke exposure causes various diseases involving changes in miRNA expressions in the pathogenesis of atherosclerosis, chronic obstructive pulmonary disease (COPD) and lung cancer (12-15). (researchsquare.com)
With several recent studies correlating miRNA expression with outcome in lung cancer, the investigators set out to try to identify miRNA signatures that could accurately predict prognosis in what they claim is the largest study of its kind to date. (genomeweb.com)
Using an Illumina human miRNA expression profiling V2 panel, the group measured miRNA expression levels from all 357 samples, comparing the group of patients with recurrence in two years against those who didn't recur for more than seven years. (genomeweb.com)
The group found that Cox model risk scores estimated by miRNA expression gave better prediction that tumor stage information, with areas under the curve of 86 percent to 91 percent for the miRNA signature and only 64 percent to 69 percent for staging. (genomeweb.com)
This clearly demonstrates that miRNA expression signatures combined with stage information has higher classification power than the staging method to predict survival," the authors wrote. (genomeweb.com)
These data show, for the first time, that miRNA-related genetic variations may underlie the etiology of breast cancer in both populations of African and European ancestries. (cdc.gov)

MicroRNAs are ~22-25 nucleotide non-coding RNAs. (ukessays.com)
MicroRNAs are small noncoding RNAs that function to control gene expression. (biomedcentral.com)
These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. (biomedcentral.com)
MicroRNAs are a group of small noncoding functional RNAs that are approximately 22 nucleotides in length [ 1 ]. (biomedcentral.com)
Scientific interests are centered on the exploitation of genomic approaches to the study of mechanisms in control of gene expression dynamics provided by non-coding RNAs (microRNAs and long noncoding RNAs) and their impact on cell behaviour and human disease, with emphasis on Cancer. (iit.it)
Since 2012, he joined the Center of Genomic Science at Istituto Italiano di Tecnologia (IIT), as Researcher and leading his own scientific group, focusing on microRNAs and regulatory non-coding RNAs. (iit.it)
He is recognized for the key contribution in the field of non-coding RNAs, in particular for characterizing the function and regulation of microRNAs in the gene expression regulatory network. (iit.it)
Project 1: To study the role of non-coding RNAs in brain tumor and brain metastasis malignancy and uncover new therapeutic targets: Non-coding RNAs are regulatory RNAs that play important roles in regulating normal and cancer biology. (virginia.edu)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)

In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. (biomedcentral.com)
Our goals are to 1) uncover novel mechanisms of tumorigenesis and metastasis, 2) identify biomarkers that prognosticate disease progression or predict treatment response and 3) collaborate with industry to develop new therapies for the prevention and treatment of cancer progression. (utah.edu)
Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
Diagnostic value of seven biomarkers for breast cancer: an overview with evidence mapping and indirect comparisons of diagnostic test accuracy. (cdc.gov)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Numerous studies have screened and dysregulated the microRNA in various cancers via microarray assay. (ijpsonline.com)
Tissue factor pathway inhibitor 2 (TFPI-2) is identified as an important tumor suppressor in various cancers. (bvsalud.org)

Induction of miR-370 over-expression significantly reduced the levels of EGFR expression and the EGFR 3'untranslated region (UTR)-regulated luciferase activity in XWLC-05 and H157 cells, suggesting that miR-370 may bind to the 3'UTR of EGFR mRNA. (oncotarget.com)
One of the microRNA strands of the duplex is loaded onto the RNA-induced silencing complex (RISC) where it is then able to either cleave RNA targets or repress protein translation dependent upon its complementarity to the target mRNA. (biomedcentral.com)
Through their binding to target mRNA sequences, microRNAs have a large number of biologically diverse functions. (biomedcentral.com)
Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured. (nature.com)
Identification of a 13‑mRNA signature for predicting disease progression and prognosis in patients with bladder cancer. (cdc.gov)
Prognostic Role of KRAS mRNA Expression in Breast Cancer. (cdc.gov)

MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
Genetic knockdown of the particular genes in cancer cells were achieved by lentiviral-mediated interference. (biomedcentral.com)
New sequencing technologies have shown that a large number of aberrantly expressed lncRNAs are associated with multiple cancer types and indicated they have emerged as an important class of pervasive genes during the development and progression of cancer. (biomedcentral.com)
By comparing their expression patterns, we determined novel hESC-specific genes and transcriptomes that could serve as reliable hESC markers associated with the "stemness" phenotype. (molcells.org)
They have the capacity to control the expression of many downstream genes which can affect several cell regulatory pathways, such as cell growth, differentiation, mobility and apoptosis. (biomedcentral.com)
He moved to IFOM in Milan for post-doc in Pier Paolo Di Fiore's lab (2005-2010), identifying novel genes and transcriptional signatures deregulated in human cancers and useful for the prognostic stratification of breast and lung cancer patients. (iit.it)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
identified 189 frequently mutated genes associated with these cancers, most of which were not previously known. (frontiersin.org)
Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. (cancerindex.org)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)

The expression patterns, function and regulation of microRNAs in normal and neoplastic human cells are largely unknown but emerging data and their frequent location at fragile sites, common break-points or regions of amplification or loss of heterozygosity reveal that they may play significant roles in human carcinogenesis. (biomedcentral.com)

Despite advances in our understanding of primary lung oncogenesis, the biological basis driving the progression from primary to metastatic lung cancer remains poorly characterized. (biomedcentral.com)
Although the function of NAP1 is associated with the invasive potentials of cancers and therefore their aggressive nature, there is lack of preclinical evidence and mechanisms reporting the importance of NAP1 during the metastasis and progression of NSCLC. (biomedcentral.com)
However, its biological role and molecular mechanisms in the progression of breast cancer remain unclear. (bvsalud.org)
Much like the expression of your transmembrane mucins MUC1 and MUC4, MUC5AC expression has also been relevant to Computer progression and it is related using a shorter survival period of Pc patients. (micrornainhibitors.com)
Given the functional and pathological significance of MUC1, MUC4 and MUC5AC in Computer progression and their regulation by inflammatory setting inside the human disorder, we analyzed the irritation in the pancreas of KrasG12DPdx1 Cre mice. (micrornainhibitors.com)
Conclusions Our studies are the to start with to set up that KrasG12DPdx1 Cre mouse model recapitulates the alterations in mucin expression observed throughout the progression of human Computer. (micrornainhibitors.com)
The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
In addition, microRNAs have been associated with cancer progression. (biomedcentral.com)
MicroRNA-145 downregulation associates with advanced tumor progression and poor prognosis in patients suffering osteosarcoma. (biomedcentral.com)
2013;6:833-8 https://www.dovepress.com/microrna-145-downregulation-associates-with-advanced-tumor-progression-peer-reviewed-article-OTT . (biomedcentral.com)
Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. (stanford.edu)
Our laboratory focuses on understanding mechanisms of cancer progression and developing clinical interventions. (utah.edu)
Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. (nature.com)
According to the present data, miR-183 may play a vital role in the progression of breast cancer by reducing PTEN expression. (nature.com)
Carbon nanotube s promote lung tumor progression through the induction of cancer-associated fibroblasts and cancer stem-like cells. (cdc.gov)

However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified. (oncotarget.com)
They regulate gene expression through different mechanisms [ 10 ] and play a diverse role in many cellular processes [ 11 - 14 ]. (hindawi.com)
In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. (biomedcentral.com)
The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer. (utah.edu)
We are studying the expressions, targets, mechanisms of action and functions of microRNAs, TUCRs and lncRNAs in gliomas and brain metastasis. (virginia.edu)
However, the literature elucidating their functional roles and their mechanisms of action in cancer is very sparse, with the literature on their role in glioblastoma being inexistent. (virginia.edu)
The mechanisms through which cancer spreads to the lungs are direct extension and true metastatic spread through the bloodstream, airway, or lymphatic system. (medscape.com)

The seven microRNAs that were common and differentially expressed of when all the smoking and vaping groups were compared with non-smokers (NS) are hsa-let-7a-5p, hsa-miR-21-5p, hsa-miR-29b-3p, hsa-let-7f-5p, hsa-miR-143-3p, hsa-miR-30a-5p and hsa-let-7i-5p. (researchsquare.com)
The e-cig vs. NS group has differentially expressed 5 microRNAs (hsa-miR-224-5p, hsa-miR-193b-3p, hsa-miR-30e-5p, hsa-miR-423-3p, hsa-miR-365a-3p, and hsa-miR-365b-3p) that is specific for this group and are not expressed in other three groups. (researchsquare.com)
BC-related differentially expressed microRNAs (DE-miRs) were recognized and assessed in the present study. (nature.com)

Moreover, miR-370 over-expression significantly reduced the levels of EGFR and CD31 expression and inhibited the growth and lung metastasis of xenograft NSCLC tumors in mice. (oncotarget.com)
These β-catenin-activated HCC represent 20-40% of human HCC, and our current research focuses primarily on these tumors. (utah.edu)
We are investigating the roles of microRNAs in priming the brain microenvironment for metastasis from primary lung, breast and melanoma tumors using paired human tumors and metastasis animal models. (virginia.edu)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
Most of the tumors are found in the abdomen (65%), often in the adrenal medulla, or elsewhere in the human body where sympathetic nervous system components are present [ 2 ]. (biomedcentral.com)
We mainly concentrated on the PI3K/AKT pathway, which is one of the most vital signaling paths included in the growth and control of tumors in breast cancer. (nature.com)
Secondary lung tumors are neoplasms that spread from a primary lesion. (medscape.com)
Metastatic malignant neoplasms are the most common form of secondary lung tumors. (medscape.com)
In this article, the approach to secondary lung tumors is discussed, with an emphasis on clinical decision-making to determine whether tissue diagnosis would alter clinical management. (medscape.com)
Almost any cancer has the ability to spread to the lungs, but the tumors that most commonly do so include bladder cancer , colon cancer , breast cancer , prostate cancer , sarcoma, Wilms tumor , and neuroblastoma . (medscape.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
People with DICER1 syndrome who develop tumors most commonly develop pleuropulmonary blastoma, which is characterized by tumors that grow in lung tissue or in the outer covering of the lungs (the pleura). (medlineplus.gov)

Our study showed that the expression of microRNA-340-5p in lung cancer tissues and was significantly lower than normal tissues. (ijpsonline.com)
We also confirmed that microRNA-340-5p and beta-catenin are negatively correlated in lung cancer tissues and the role of microRNA-340-5p in lung cancer can be reversed by overexpression of beta-catenin. (ijpsonline.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In this study, we sought to determine the expressions of miR-127 in the lung tissues of sodium taurocholate-induced AP models in rats and that in plasma of AP patients and to preliminarily explore the association of miR-217 levels and LI. (hindawi.com)
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients. (biomedcentral.com)
Prior studies with human tissues have implicated Kras activation in rigorous inflammatory responses in Computer, mostly by activating the NF B pathway. (micrornainhibitors.com)
We found RCC tissues displayed significantly higher miR-34a expression level than their corresponding noncancerous tissues, particularly in chromophobic subtype. (hindawi.com)
MIR-34A has its own transcript and is expressed at higher levels than MIR-34B/C in most tissues, and this expression could be dysregulated in multiple diseases, especially in cancers [ 11 ]. (hindawi.com)
It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)

Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis. (biomedcentral.com)
Non-small-cell lung cancer (NSCLC) accounts for 85%-90% of all lung cancer cases, and is the most common cause of cancer-related deaths worldwide [ 1 ]. (biomedcentral.com)
BACKGROUND: This study aimed to evaluate the efficacy and safety of KN046, a novel recombinant humanised antibody targeting PD-L1 and CTLA-4 in advanced non-small cell lung cancer (NSCLC) patients after failure or intolerance to platinum-based chemotherapy. (bvsalud.org)
The concentration of survivin in diseased tissue and miR-29a and IGRAs in serum in 25 patients with non-small-cell lung carcinoma (NSCLC) complicated by active pulmonary tuberculosis (APT) and 32 patients with NSCLC and 30 patients with APT were measured. (researchsquare.com)
According to the study authors, gene expression analysis has failed to identify expression-based prognostic signatures in stage I NSCLC robust enough for clinical applications. (genomeweb.com)

Collectively, our findings highlight that miR-378 and miR-1827 could serve as novel therapeutic targets in lung cancer. (jcancer.org)
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma. (biomedcentral.com)
a CRISPR-based platform, to perform genetic screens aimed at identifying molecular targets effective in cancer phenotypes, including growth, migration, drug tolerance and tumour initiation in vivo. (iit.it)
Four candidates including miR-101, miR143, miR-26a and miR-144 were found via computational prediction of microRNA targets. (revoluciondelosgladiolos.org)
Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)

Our study indicates that miR-370 may bind to the 3'UTR of EGFR to inhibit EGFR expression and the growth, angiogenesis and metastasis of non-small cell lung cancer by down-regulating the ERK1/2 and AKT signaling. (oncotarget.com)
WASF3 is a tumor metastasis driver in breast cancer, and its knockdown leads to a significant reduction in metastatic breast cancer cell invasion and metastasis in mice [ 5 ]. (biomedcentral.com)
Our previous studies further demonstrated that NAP1 is required for the protein stability of WASF3 in breast cancer cells, implicating that NAP1 is a critical regulator in favor of breast cancer metastasis [ 5 ]. (biomedcentral.com)

The data will provide new insights for the treatment of lung cancer and new guidance for clinical treatment of lung cancer. (ijpsonline.com)
Moreover, the potential application of microRNAs in clinical settings will also be highlighted. (biomedcentral.com)
Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed. (biomedcentral.com)
Kai Y, Qiang C, Xinxin P, Miaomiao Z, Kuailu L. Decreased miR-154 expression and its clinical significance in human colorectal cancer. (biomedcentral.com)
Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients. (biomedcentral.com)
Recently, he has implemented technological platform for RNA research in IIT and developed ad hoc tools for their application to human disease and clinical research. (iit.it)
First, this article summarizes the history of massively parallel next-generation sequencing (NGS) in the context of cancer genomics and reviews recent research and clinical applications. (frontiersin.org)
Therefore, specific inhibitors targeting proteins of the PI3K/AKT pathway are now being evaluated in clinical trials as a new approach against breast cancer 14 . (nature.com)

In this context, we conducted microarray-based differential gene expression analyses using two Korean embryo-derived hESC lines (CHA3 and CHA4) to identify undifferentiated and spontaneously dif-ferentiated (human embryoid body, or hEB) status. (molcells.org)

In molecular biology mir-500 microRNA is a short RNA molecule. (wikipedia.org)
Our aim was to explore the role of microRNA-340-5p in lung cancer and its underlying molecular mechanism. (ijpsonline.com)
Our findings indicate that tumor associated macrophages including Kupffer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects. (stanford.edu)
We believe it is highly likely that molecular issues will play a more prominent role in lung cancer cases moving forward. (asbestoscasetracker.com)
As we have discussed previously [see here , here , and here ], the ongoing revolution in molecular science has led to dramatic increases in our understanding of the human genome, including how environmental agents may impact the genome (e.g. (asbestoscasetracker.com)
In other words, these molecular techniques are potentially useful tools for investigating potential attribution to genetic causes and other potential environmental agents in cases of lung cancer, and may allow for the attribution of disease causation at the individual level, depending on what judges and juries decide about evidence and legal issues. (asbestoscasetracker.com)
Given the significant increase in asbestos-related lung cancer case filings over the past five years, it is highly likely that molecular issues will play a more prominent role in lung cancer cases moving forward. (asbestoscasetracker.com)
In recent years, scientists have raised new issues for asbestos litigation by seeking to identify molecular signatures or genetic patterns that could provide a biological explanation for lung cancers to counter the view that low levels of asbestos exposure were causally associated with the development of the tumor. (asbestoscasetracker.com)
Gene set enrichment analysis of microRNAs showed significant changes in the top six enriched functions that consisted of biological pathway, biological process, molecular function, cellular component, site of expression and transcription factor in all the groups. (researchsquare.com)
Thus, the present work aimed to investigate the molecular mechanism of miR-183 in breast cancer. (nature.com)

piloted the use of NGS to study the exomes of 140 samples of human acute myeloid leukemia (AML) cells in 2003, identifying 6 previously described and 7 undescribed mutations relevant for AMP pathogenesis. (frontiersin.org)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma. (nih.gov)
The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)

Our results demonstrate that up-regulation of microRNA-340-5p attenuates lung cancer cell invasion and proliferation via inhibiting wingless-related integration site/beta-catenin pathway. (ijpsonline.com)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)

Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
MiR-133a-5p inhibits androgen receptor (AR)-induced proliferation in prostate cancer cells via targeting FUsed in Sarcoma (FUS) and AR. (nih.gov)
The lung cancer cell lines of human lung squamous cell carcinoma cell line SKMES1, human lung adenocarcinoma cell line A549, lung adenocarcinoma cells H23, human lung cancer cell line SPC-A1 and human squamous cell carcinoma H520 were used in present study. (ijpsonline.com)
Transwell assay was conducted to determine the invasion of human squamous cell carcinoma H520 cells under different treatment conditions. (ijpsonline.com)
Moreover, overexpression of microRNA-340-5p could suppress the invasion and proliferation of lung cancer cells. (ijpsonline.com)
Here, we show higher levels of epidermal growth factor receptor (EGFR), but lower levels of miR-370 expression in most human lung cancer cells and non-tumor cells. (oncotarget.com)
Compared with the control cells, induction of miR370 overexpression significantly inhibited the proliferation, clone formation capacity, migration and invasion of XWLC-05 and H157 cells while miR-370 inhibitor over-expression enhanced their tumor behaviors in vitro . (oncotarget.com)
Furthermore, miR-370 over-expression down-regulated the EGFR and hypoxia-inducible factor (HIF)-1α expression, and attenuated the extracellular single-regulated kinase (ERK)1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
In contrast, miR370 inhibitor over-expression increased the EGFR and HIF-1α expression as well as the ERK1/2 and AKT phosphorylation in XWLC-05 and H157 cells. (oncotarget.com)
During the cascade events of activation of proinflammatory cytokines and mediators in AP, the injured cells of the lungs recruit immune cells and release cytokines, chemokines, growth factors, and prostaglandins, contributing to acute inflammatory response [ 4 - 7 ]. (hindawi.com)
RNAi-Mediated Targeting of Noncoding and Coding Sequences in DNA Repair Gene Messages Efficiently Radiosensitizes Human Tumor Cells. (nih.gov)
Cigarette smoke exerts inflammatory and suppressive effects on immune cells, alters mucosal immunity and promotes autoimmunity, resulting in oral cancers [ 10 ]. (biomedcentral.com)
Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
The complex interplay between cancer cells and the TIME influences the outcome of immunotherapy and other anticancer therapy (Fig. 1 ). (biomedcentral.com)
During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
The establishment of the first human embryonic stem cells (hESCs) in 1998 provided a unique tool for studying human development. (molcells.org)
some mice were given intraperitoneal injections of antibodies against PD1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), or CD8 before the cancer cells were injected. (stanford.edu)
MicroRNAs are involved in regulating gene expression and often become deranged in cancer cells. (einsteinmed.edu)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
RESULTS MiR-26a and miR-144 are frequently downregulated in human being ESCC cells and cell lines The expressions of miR-26a and miR-144 in medical specimens of ESCC and related adjacent normal cells from 30 individuals with ESCC. (revoluciondelosgladiolos.org)
Open in a separate window Number 1 Downregulation of miR-26a and miR-144 in human being ESCC cells and cell linesThe manifestation levels of miR-26a A. and miR-144 B. in 30 pairs of ESCC tumor cells and corresponding normal cells were determined by quantitative real time RT-PCR as explained in Materials and Methods. (revoluciondelosgladiolos.org)
PTEN insufficiency promotes the PI3K/AKT path, which is a vital signal for the survival of cancer cells. (nature.com)
The miR-96 and -26a derived from platelets inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)

We should be on guard against patients with APT complicated by lung cancer, when miR-29a was low expression in serum and survivin was high expression in diseased tissue of the patient who was pathologically diagnosed with APT. (researchsquare.com)
This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. (biomedcentral.com)
Although various microRNAs have been detected from tissue sources, these methods require invasive techniques to collect the starting material. (biomedcentral.com)

Table 1 provides a summary of cancers and gene mutations. (frontiersin.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Our previous study demonstrated that miR-378 is up-regulated while miR-1827 is down-regulated in high invasive lung cancer sub-cell lines, and their biological functions have been described. (jcancer.org)
The disparities in breast cancer incidence and survival between AA and EA populations have been attributed to several factors, including disease management, access to proper care, and biological influences. (cdc.gov)

Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. (nih.gov)
For instance, overexpression of cyclins or the elimination of CDK inhibitors or pRB due to genetic mutation are common cause in human cancer. (ukessays.com)

Within this review, we conducted a in depth pathway examination of the prostate cancer GWAS dataset utilizing four representative strategies from the two hypothesis testing schemes. (micrornainhibitors.com)
DESCRIPTION (provided by applicant): Prostate cancer is the second most common cancer in men, and the second leading cause of cancer death. (sbir.gov)
However, when prostate cancer is diagnosed in its early stages, it can be effectively treated and cured. (sbir.gov)
Combined with the digital rectal examination, the prostate specific antigen (PSA) test has been widely used to detect prostate cancer in its early stages. (sbir.gov)

Cigarette smoke exposure causes various diseases including COPD, atherosclerosis, and lung cancer. (researchsquare.com)

In their study, the researchers were able to validate one signature that was predictive independent of cancer subtype and another specific to adenocarcinoma. (genomeweb.com)

Despite advances in diagnosis and treatment, the morbidity and mortality of lung cancer remains to mount up. (intechopen.com)
When lung cancer is combined with tuberculosis at the same time, it increases the difficulty of diagnosis and treatment, and is easy to be misdiagnosed and missed. (researchsquare.com)
When lung imaging indicates space occupying or exudative changes, the probability of diagnosis of lung cancer complicated with tuberculosis is not high. (researchsquare.com)
CONCLUSION: The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. (edgehill.ac.uk)
This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. (cancer-genetics.org)

MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)

The expression of TUCRs is commonly deregulated in cancer, where they might exert crucial regulatory roles. (virginia.edu)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

OCT4 as a Target of miR-34a Stimulates p63 but Inhibits p53 to Promote Human Cell Transformation. (nih.gov)

This forms a hairpin precursor of approximately 60-70 nucleotides, termed pre-microRNA, which is exported to the cytoplasm and modified by another enzyme, the RNAseII endonuclease, Dicer, to form a duplex of mature microRNA. (biomedcentral.com)

MicroRNA is a type of RNA, a chemical cousin of DNA, that attaches to a protein's blueprint (a molecule called messenger RNA) and blocks the production of proteins from it. (medlineplus.gov)

The microRNA-217 functions as a tumor suppressor and is frequently downregulated in human osteosarcoma. (biomedcentral.com)

Abnormal microRNA-370 (miR-370) expression has been frequently reported in several types of cancers, including lung cancer. (oncotarget.com)

Non-invasive techniques for detecting lung cancer could encourage larger-scale testing of people at risk for the disease, leading to lives saved through early detection and treatment. (einsteinmed.edu)

Here, we report that miR-378 and miR-1827 modulate lung cancer cell invasion and migration via epithelial-mesenchymal transition (EMT). (jcancer.org)
Cancer spread through direct extension is not frequently encountered and most commonly includes direct invasion by a primary neoplasm, involving a contiguous organ or structure (eg, thyroid, esophagus, thymus, or chest wall), or spread from a neoplasm metastatic to another intrathoracic structure (eg, rib or mediastinal lymph node, commonly causing an obstructive lesion of the trachea or bronchus). (medscape.com)
Lymphangitic spread can occur in association with hematogenous dissemination, which is subsequently followed by invasion of the adjacent interstitium and lymphatics, with subsequent tumor spread toward the hila or toward the periphery of the lung. (medscape.com)

Of note, recent study identified that miR-127 expression was aberrant in the inflammation-related pulmonary disorders [ 36 ] and further revealed that enhanced expression of miR-127 could promote the development of inflammatory macrophages and contribute to the exaggerated lung inflammation and injury [ 37 ]. (hindawi.com)
These benefits correlate with a rise within the expression of Muc1, Muc4 and Muc5AC within the pancreas of KrasG12D Pdx1 Cre spontaneous PDAC mouse model, suggesting a achievable link in between inflammation and mucin expres sion, which more recapitulates the research performed while in the human disease. (micrornainhibitors.com)

Individuals with pleuropulmonary blastoma may also develop an abnormal accumulation of air in the chest cavity that can lead to the collapse of a lung (pneumothorax). (medlineplus.gov)

As the integration of NGS in the study and treatment of cancer continues to mature, we believe that the field of cancer genomics will need to move toward more complete 100% genome sequencing. (frontiersin.org)
Non-coding regions represent an important frontier in cancer genomics. (frontiersin.org)

I studied the tumor microenvironment of liver cancer during my graduate training in Hong Kong. (stanford.edu)

More importantly, we summarize the potential of various RNA-based therapeutics clinically available for cancer treatment. (biomedcentral.com)
RNA-dependent targeting of the TIME, as monotherapy or combined with other evolving therapeutics, might be beneficial for cancer patients' treatment in the near future. (biomedcentral.com)

Researchers from the Medical College of Wisconsin, the Mayo Clinic, and Washington University in St. Louis have identified two microRNA expression signatures predictive of prognosis in patients with stage I non-small cell lung cancer. (genomeweb.com)

and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)

The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
The primary tumor can arise within the lung or outside the lung, with the metastases traveling through the bloodstream or lymphatic system or by direct extension to reach their destination. (medscape.com)
Lung metastases are identified in 30-55% of all cancer patients, though prevalence varies according to the type of primary cancer. (medscape.com)

Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury? (hindawi.com)
The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI). (hindawi.com)
Lung injury (LI) is commonly involved in 15%~60% of severe AP, and severe LI is likely to trigger acute respiratory distress syndrome (ARDS) and respiratory failure (RF). (hindawi.com)
Although mycotoxins may be graded according to acute lethality tests, the major concerns in human health relate to epidemiological evidence. (cabi.org)
However, the researchers believe that refinements currently in process can improve the test, which might also have potential for monitoring acute inflammatory processes and infections as well as other lung conditions. (einsteinmed.edu)
This extensive sequestration of parasitized erythrocytes in the microvasculature, together with the production of inflammatory mediators, leads to the dysfunction of one or more peripheral organs, such as the lungs (acute respiratory distress syndrome), kidneys (acute kidney injury) or brain (coma) ( 6 , 7 ). (cdc.gov)

DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ. (nih.gov)

Real time polymerase chain reaction was performed to detect microRNA-340-5p and beta-catenin messenger RNA expression. (ijpsonline.com)

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. (sigmaaldrich.com)

SUMMARY: Findings of research misconduct have been made against Ya Wang, M.D., Ph.D. (Respondent), retired Professor and Director, Division of Experimental Radiation Oncology, Department of Radiation Oncology, Winship Cancer Institute, Emory University (EU). (nih.gov)

2019) Isolation and quantitation of exosomes isolated from human plasma via hydrophobic interaction chromatography using a polyester, capillary-channeled polymer fiber phase . (exosome-rna.com)

How is the expression of the ANXA4 protein regulated? (creativebiomart.net)
Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Western blot was utilized to assess the effect of miR-183 on PTEN protein expression. (nature.com)

In a study involving 165 patients with non-small cell lung cancer and 185 controls, Simon Spivack, M.D., M.P.H. , and colleagues showed in principle that a test for detecting microRNA molecules in exhaled breath can distinguish patients with lung cancer from controls. (einsteinmed.edu)
At a very high level, this could distinguish a lung cancer which is related to asbestos exposure relative to one that is not. (asbestoscasetracker.com)
Plasma exosomes of cigarette smokers, waterpipe smokers, e-cig users and dual smokers have common differential expression of microRNAs which may serve to distinguish smoking and vaping subjects from NS. (researchsquare.com)

This group has been cited as a possible contributory risk factor in primary hepatocellular cancer in China. (cabi.org)

Anatomy15

Organisms6

Diseases39

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Psychiatry and Psychology1

Phenomena and Processes63

Disciplines and Occupations3

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MiRNAs47

MiRNA19

RNAs9

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Various cancers2

MRNA6

Genes11

Function and regulation of microRNAs1

Progression15

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Differentially3

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Diagnosis5

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Performed to detect1

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20191

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