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  • allele
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • The null allele DRB4*0103102N has been found on HLA-DRB1*04:01, *04:02 and *04:04 haplotypes 13;14 . (dorak.info)
  • Of these, HLA*B44 was present in almost half of the patients and was thus the most common susceptibility allele. (beds.ac.uk)
  • In renal dialysis patients, HLA-A*02 was the most frequent allele in both carriers (25.5%) and non-carriers (21.2%) of S. aureus . (biomedcentral.com)
  • Regarding HLA-B and HLA-DRB1, no allele was shown to be involved in protection against or susceptibility to carriage of S. aureus . (biomedcentral.com)
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • The first childhood leukaemia studies examined HLA class-II antigen frequencies found an increased allele frequency of DR7 in Switzerland where DR7 is the most common DR53 group antigen 8;9 . (dorak.info)
  • The increased HLA-DR53 allele frequency in adult ALL (66.7% vs 52.3%) could have been significant if homozygosity had been considered 11 . (dorak.info)
  • In December 2007, the United States Food and Drug Administration announced that, because of the associated risk of Stevens-Johnson syndrome and toxic epidermal necrolysis, people of Asian descent should be genetically tested for the HLA-B*1502 allele before starting therapy with carbamazepine. (mja.com.au)
  • In addition, we utilized HLA genotype data from more than four million individuals from publicly accessible repositories such as the Allele Frequency Net Database, Major Histocompatibility Complex Database and Immune Epitope Database to study the HLA alleles associated with DILI. (biomedcentral.com)
  • In addition, with the advance of the next generation sequencing (NGS) technologies, HLA typing by NGS seems to be a promising approach for HLA sequencing and allele assignment owing to its efficiency and cost effectiveness. (biomedcentral.com)
  • We have studied the HLA-class I and class II antigen distribution in a sample of 75 Spanish Gypsies and 74 Spanish non-Gypsies by serology, restriction fragment length polymorphism, and protein chain reaction and hybridization with allele-specific oligonucleotide probes. (semanticscholar.org)
  • Finally, case control analyses using imputed HLA types indicated that the DR10 allele of HLA-DRB1 was more frequent in individuals with SLI than population controls ( P = 0.004, relative risk = 2.575), as has been reported for individuals with attention deficit hyperactivity disorder (ADHD). (biomedcentral.com)
  • gene
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • A total of more than 1500 alleles of HLA-B gene have been identified [ 2 ]. (hindawi.com)
  • Alaturi de genele clasice, in regiunea MHC I mai sunt incluse gene cu un polimorfism redus desemnate ca HLA-E, HLA-F si HLA-G 2;8 . (synevo.ro)
  • The gene family contains the most polymorphic genes in humans and the difference between two alleles is only a single base pair substitution in many cases. (biomedcentral.com)
  • genotypes
  • 11 Genetic mapping involved a comparison of HLA genotypes for 44 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis with those of 101 controls who had taken carbamazepine for at least 3 months without development of any skin reaction, and 93 healthy individuals. (mja.com.au)
  • Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and inflammatory bowel diseases, and there are emerging evidences of correlations between HLA genotypes and renal diseases such as diabetic nephropathy, IgA nephropathy, and glomerulonephritis. (biomedcentral.com)
  • In this work, we tried to understand whether combined genotypes of CCR5-▵32, CCR2-64I, SDF1-3′A and HLA alleles can predict the LT-NP status. (bloodjournal.org)
  • In this report, we studied chemokine receptors (CCR2, CCR5), chemokine (SDF1), and HLA class I and II genotypes in LT-NP and attempted to find out whether any particular pattern of host genetics could be implicated in the LT-NP phenotype. (bloodjournal.org)
  • genetic
  • The test checks for the presence of specific genetic material, called HLA-B*5701, which has been associated with the abacavir hypersensitivity reaction. (catie.ca)
  • When abacavir hypersensitivity testing was initially done, researchers in Australia who pioneered this screening used HIV-positive people whose ancestors were mainly from northwest Europe and found that HLA-B*5701 (genetic material) was relatively common. (catie.ca)
  • The completion of the Human Genome Project in 2003 and the development of cost-effective means for scanning large regions of DNA have paved the way for large-scale pharmacogenetic investigations involving many genetic loci. (mja.com.au)
  • Both of these mechanisms highlight that the unique interaction between drug, T-cell receptor and MHC molecule is a key factor in the development of immune-mediated adverse reactions to drugs and, as such, the study of HLA alleles represents a logical route to study the genetic basis of such immune-mediated reactions. (biomedcentral.com)
  • Since the description of the first human leukocyte antigen group termed MAC in 1958, there has been rapid growth in the interest and knowledge about the genetic structure and biologic function of the MHC which in man is known as the Human Leukocyte Antigen (HLA) system. (ihiws.org)
  • antibodies
  • It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
  • In most TRALI cases, human leukocyte antigen (HLA) class II antibodies are detected in implicated donors. (bloodjournal.org)
  • Monocytes become activated when incubated with matched HLA class II antibodies and are capable of activating neutrophils, which, in turn, can induce disturbance of an endothelial barrier. (bloodjournal.org)
  • Our data suggest that in most TRALI cases, monocytes are cellular key players, because HLA class II antibodies induce TRALI by a reaction cascade initiated by monocyte activation. (bloodjournal.org)
  • The capability of antibodies recognizing either HNA 9 ⇓ - 11 or HLA class I 12 , 13 to precipitate TRALI has been proved in different animal models. (bloodjournal.org)
  • Of note, it remains unclear how HLA class II antibodies can induce TRALI. (bloodjournal.org)
  • An unexpected positive crossmatch may be obtained in recipients with an autoimmune disease or preexisting antibodies not detected by single-antigen bead array due to complement interference or who have been previously treated by desensitization protocols such as rituximab, antithymocyte globulin, or intravenous immunoglobulins. (hindawi.com)
  • Prior to transplantation, recipients are therefore routinely screened for preformed anti-HLA antibodies and prospective crossmatches are performed by conventional complement-dependent cytotoxicity crossmatch (CDC-XM) techniques, but also by flow-cytometry-based methods [ 1 , 2 ]. (hindawi.com)
  • The presence of anti-HLA antibodies in serum, targeting donor HLA antigens, induces donor cells complement-dependent cytotoxicity. (hindawi.com)
  • DR53
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • serologic
  • In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A, −B and -DR were analyzed using a low resolution serologic equivalent. (biomedcentral.com)
  • DRB1
  • Our findings suggest that HLA-DRB1*03 may be involved in susceptibility to nasal carriage of S. aureus in transplant patients. (biomedcentral.com)
  • Specific alleles (please see a note regarding the terminology in the Methods section) of HLA-DRB1 , including DR4 and DR12, have been associated with autism, ADHD, and schizophrenia, although these findings have not always replicated within or between disorders. (biomedcentral.com)
  • found
  • The latest list of officially recognized HLA-DRB alleles can be found at the ANRC site . (dorak.info)
  • Eosinophilic pneumonia, chronic Eosinophilic pneumonia, simple Follicular broncholitis/ bronchitis Hypersensitivity pneumonitis Langerhans cell histiocytosis (histiocytosis [surgpathcriteria.stanford.edu] None of the supposedly high-risk human leukocyte antigen types were found in the children. (symptoma.com)
  • HLA *B44 was also found to be over-represented among patients who presented to our clinic with adult-onset recurrent sinopulmonary infections (RESPI) and normal serum immunoglobulin levels, a cohort that included first and second degree relatives of patients with CVID. (beds.ac.uk)
  • The very first paper which studied HLA-A, and -B frequencies in childhood leukaemia found a significant increase in HLA-A2B12 (Ref.3). (dorak.info)
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • Although Stevens-Johnson syndrome with carbamazepine also occurs among Caucasians, HLA-B*1502 has not been found in this group. (mja.com.au)
  • polymorphisms
  • We report association analyses of single-nucleotide polymorphisms (SNPs) and HLA types in a cohort of individuals affected by language impairment. (biomedcentral.com)
  • The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. (biomedcentral.com)
  • In this study, HLA class I and II polymorphisms of ESRD patients were compared to a healthy control group in an effort to provide a better understanding of the etiology of this disease. (biomedcentral.com)
  • Chang Gung Memorial Hospital
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)
  • Conclusions
  • [everything2.com] CONCLUSIONS: Zinc oxide welding fume was associated with a marked dose-dependent increase in the number of polymorphonuclear leukocytes recovered in bronchoalveolar lavage [ncbi.nlm.nih.gov] When respiratory symptoms are prominent, metal fume fever may be confused with acute bronchitis or pneumonia. (symptoma.com)
  • silico
  • The next generation sequencing (NGS) technologies could be used for high throughput HLA typing but in silico methods are still needed to correctly assign the alleles of a sample. (biomedcentral.com)
  • group
  • Jean Dausset described the first human MHC antigen MAC (HLA-A2) as part of the Hu-1 system 5 followed by the discovery of the FOUR series 4a and 4b (HLA-Bw4 and -Bw6) by the Leiden group led by Jon van Rood in 1963 6;7 . (dorak.info)
  • exon
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • The PacBio system has the longest read length among available NGS platforms, and therefore is the only platform capable of having exon 2 and exon 3 of HLA genes on the same read to unequivocally solve the ambiguity problem caused by the "phasing" issue. (biomedcentral.com)
  • type 1 diabet
  • HLA genes, islet autoantibodies and residual C-peptide were studied to determine the independent association of each exposure with diabetic retinopathy (DR), 15 years after the clinical onset of type 1 diabetes in 15-34 year old individuals. (pubmedcentralcanada.ca)
  • donors
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • association
  • In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs. (hindawi.com)
  • P = 0.000003), this association remains one of the strongest HLA - cancer associations ever reported. (dorak.info)
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • As a test of our original hypothesis that the HLA-associated susceptibility to childhood leukaemia is a recessive trait and not a simple allelic association 5;6 , we examined the homozygosity rates. (dorak.info)
  • We perform quantitative association analyses of three linguistic measures and case-control association analyses using both SNP data and imputed HLA types. (biomedcentral.com)
  • known
  • Analysis is restricted to children from families having both affected and unaffected siblings and is conducted with and without adjustment for known HLA class I and II effects. (genes2cognition.org)
  • assay
  • The workshop was convened for the purpose of comparing the different in vitro assay systems used at the time to define antigens which were described as Hu-1 (Dausset and Ivanyi), LA (Payne and Bodmer), and Four (van Rood). (ihiws.org)
  • system
  • The dramatic advance in knowledge has been due largely to the early appreciation of the scope of work necessary to elucidate the HLA system requiring broad collaboration beyond what is possible within individual laboratories. (ihiws.org)