• Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
  • Simultaneous comparison of peripheral blood and cerebrospinal fluid from one patient revealed 2.5-fold more Tax11-19-specific T cells in the cerebrospinal fluid (23.7% vs. 9.4% in peripheral blood lymphocyte). (pnas.org)
  • Tac homogeneous strongly expressing) peripheral blood mononuclear cell (PBMC)in the peripheral blood will be deemed to have measurable disease. (knowcancer.com)
  • Murine AIDS is characterized by activation and proliferation of T and B cells, impaired T and B cell function, an aberrant regulation of cytokine production, hypergammaglobulinemia, decreased NK cell function, the development of B cell lymphoma, and susceptibility to opportunistic infections ( 11 ). (jimmunol.org)
  • due to natural susceptibility of genome to translocations in periods of genomic instability, especially in initial Ig/Tcell receptor rearrangement -this occurs during B/T cell maturation and class recombination and somatic hypermutation in B cell activation. (brainscape.com)
  • ATL usually occurs in adulthood and comprises only 1 to 2% of T-cell lymphomas in the United States and Europe, though accounts for a much higher proportion in endemic areas such as Japan. (renalandurologynews.com)
  • Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies of different biology and prognosis. (medscape.com)
  • Non-Hodgkin lymphoma (NHL) is a collective term for a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. (medscape.com)
  • myeloid malignancies: arising from mature/immature members of granulocytic, monocytic, erythroid, megakaryociytic, mast cells -lymphoid malignancies: arising from mature/immature members of B, T, NK cells -acute leukemia: majority are classified as AML or ALL. (brainscape.com)
  • This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • Tax11-19-specific T cells were seen consistently over a 9-yr time course in one patient as far as 19 yrs after the onset of clinical symptoms. (pnas.org)
  • The signs and symptoms of non-Hodgkin's lymphoma vary depending upon its location within the body. (wikipedia.org)
  • The DNA copy can then be integrated into the genome of the cell. (cdc.gov)
  • Non-Hodgkin lymphoma ( NHL ) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas . (wikipedia.org)
  • The Center for Disease Control and Prevention (CDC) included certain types of non-Hodgkin's lymphoma as AIDS-defining cancers in 1987. (wikipedia.org)
  • for all ages/races, Non-hodgkin lymphoma is 7th most frequent cancer (but 4-5x's lower than breast/prostate -leukemia doesn't appear in the 15 deadliest cancers. (brainscape.com)
  • This enzyme is expressed in epithelial, macrophage, and dendritic cells (DCs) induced by proinflammatory cytokines, including type I and type II IFN ( 3 ). (jimmunol.org)
  • How it is handled depends primarily on the type of leukemia. (wikipedia.org)
  • Knockdown of CA9 with shRNAs suppressed the ability of ST1-CA9(high) cells to initiate tumors, and the tumorigenicity of ST1 cells was significantly enhanced by introducing wild-type CA9 or a CA9 mutant with deletion of an intracytoplasmic domain. (physiciansweekly.com)
  • These findings suggest that CA9, and particularly its carbonic anhydrase activity, promotes the tumorigenicity of ATL-derived cells and may be involved in malignant development of lymphoma-type ATL. (physiciansweekly.com)
  • Bone marrow is the soft tissue inside bones that helps form blood cells. (adam.com)
  • Molecular studies have identified key alterations in T cell signaling and DNA methylation that may further guide drug development. (springer.com)
  • Integrated molecular analysis of adult T-cell leukemia/lymphoma. (springer.com)
  • This is an integrated molecular study of 426 ATL cases which identifies alterations in T cell receptor-NFκB signaling, T cell trafficking, and other T cell related pathways which will guide the development of new diagnostics and therapeutics in ATL. (springer.com)
  • The inflammatory response is a fundamental immune mechanism which involves several molecular and cellular components consisting of cytokines and chemokines that are released by various proinflammatory cells. (hindawi.com)
  • HLA class II-positive and HLA class II-negative groups also showed a significant difference in complete remission rate (p = 0.0421), HLA class I/β2 microglobulin expression (p=0.0165), and the number of PD-1 positive tumor infiltrating cells (p=0.0020). (haematologica.org)
  • Additionally, the number of plasmacytoid dendritic cells in IDO −/− mice was higher in the former than in the WT mice. (jimmunol.org)
  • Attenuated human leukocyte antigen (HLA) class I expression is implicated as a major immune escape mechanism in several tumor types. (haematologica.org)
  • Recent findings by a number of investigators in both mouse models of cancer and humans with cancer now offer compelling evidence that particular immune cell types, effector molecules, and pathways can sometimes collectively function as extrinsic tumor suppressor mechanisms. (pubmedcentralcanada.ca)
  • Third, the immune system can specifically identify and eliminate tumor cells on the basis of their expression of tumor-specific antigens or molecules induced by cellular stress. (pubmedcentralcanada.ca)
  • The third process is referred to as tumor immune surveillance, whereby the immune system identifies cancerous and/or precancerous cells and eliminates them before they can cause harm. (pubmedcentralcanada.ca)
  • The idea that the immune system, which so effectively protects the host from microbial pathogens, might also recognize and destroy tumor cells was first discussed over a century ago and has recently been reviewed in detail ( 1 ). (pubmedcentralcanada.ca)
  • The elimination phase of cancer immunoediting is exactly the same process described in the initial theory of tumor immune surveillance, whereby the immune system detects and eliminates tumor cells that have developed as a result of failed intrinsic tumor suppressor mechanisms. (pubmedcentralcanada.ca)
  • The pressure exerted by the immune system during this phase is sufficient to control tumor progression, but eventually, if the immune response still fails to completely eliminate the tumor, the process results in the selection of tumor cell variants that are able to resist, avoid, or suppress the antitumor immune response, leading to the escape phase. (pubmedcentralcanada.ca)
  • The development of tools and strategies using viruses to hijack the immune response is mostly linked to the presence of regulatory T-cells (Treg) that can inhibit inflammation and antiviral responses of other effector cells. (hindawi.com)
  • In general, tumors occur when cells divide and grow excessively in the body. (adam.com)