• Dr. Benninger's research focuses on understanding the mechanisms underlying pancreatic islet function and decline in type1 and type2 diabetes. (cuanschutz.edu)
  • Qian's current research involves the development of chemical proteomic approaches for site-specific quantification of cysteine-based redox modifications and more sensitive selected reaction monitoring-based targeted quantification techniques with applications in pancreatic islets, diabetes, and oxidative stress-related disease areas. (pnnl.gov)
  • One promising approach to treating type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. (medicalxpress.com)
  • Islet transplantation improves metabolic control in patients with unstable type 1 diabetes. (bvsalud.org)
  • These networks appear to govern the secretory activity of the whole islet and be affected in some forms of diabetes mellitus. (birmingham.ac.uk)
  • 2016. The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets . (wisc.edu)
  • 2021. Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet . (wisc.edu)
  • A major focus has been understanding the role of intra-islet communication and functional sub-populations of cells in islet function, and how disruption to intra-islet communication mechanisms and changes in sub-populations occur in diabetes and may contribute to islet decline. (cuanschutz.edu)
  • Complimentary to these studies, Dr Benninger's lab is also developing ultrasound-based imaging diagnostics for non-invasively detecting islet decline in pre-symptomatic diabetes and as a platform for image-guided drug delivery. (cuanschutz.edu)
  • Islet cell malfunction underlies diabetes development and progression. (rna-seqblog.com)
  • 2005 (October 1- December 15) Visiting Scientist Harvard Medical School, Joslin Diabetes Centre, Section of Islet Transplantation and Cell Biology, Boston/USA. (livhospital.com)
  • It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia and Alzheimer's in a large dose, as well as type 2 diabetes or type 1 diabetes with multiple low doses. (streptozotocininhibitor.com)
  • A proteome analysis of mammalian glomeruli was performed in mouse using two-dimensional-gel electrophoresis with separate Coomassie and silver staining and subsequent mass spectrometric identifications. (researchgate.net)
  • To examine gender-dimorphic regulation of skeletal muscle proteins between healthy control and STZ-induced diabetic rats of both genders, we performed differential proteome analysis using two-dimensional electrophoresis combined with mass spectrometry. (karger.com)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
  • Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
  • Metabolic and secretory heterogeneity are fundamental properties of pancreatic islet β cells. (birmingham.ac.uk)
  • However, predictive pre-transplantation criteria of islet quality for clinical outcomes are lacking. (bvsalud.org)
  • Aliquots of 8 human donor islets from the STABILOT study, sampled from islet preparations before transplantation, were characterized for purity and split for glucose-induced insulin secretion and electrical activity using multi-electrode-arrays. (bvsalud.org)
  • 2021. "Facile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells. (pnnl.gov)
  • The normal human diet consists not only of cholesterol, but also xenosterols, such as plant sterols, but the mammalian body uses a number of different mechanisms to protect itself against the entry and effect of dietary xenosterols. (uc.edu)
  • Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia. (uchicago.edu)
  • The effects of an imidazoline compound (BL11282) on protein expression in rat pancreatic islets were investigated with a proteomic approach. (researchgate.net)
  • The Zhang research group focuses on the development of new capabilities for more accurate, more sensitive and higher throughput measurement of biomolecules, and the application of the most reproducible methods to characterize clinical specimen at proteomic, lipidomic and metabolomic levels for comprehensive identification of disease biomarkers, and systems biological understanding of the pathogenic mechanism underlying the complex human diseases. (uncg.edu)
  • We are funded by the NIH for a comprehensive identification of biomarkers correlated to the progression of this disease, through proteomic, lipidomic, and metabolomic characterization of human pancreatic tissues and longitudinally collected serum samples, as well as for a comprehensive validation of the candidate markers in diseases that share the similar clinical and immunological outcomes with T1D. (uncg.edu)
  • Extended analysis of in vitro isolated endocrine islets identified an additional set of 42 genes with elevated expression in these specialized cells. (scilifelab.se)
  • Blood glucose levels are tightly controlled by the coordinated actions of hormone-producing endocrine cells that reside in pancreatic islets. (rna-seqblog.com)
  • 2021. "A comprehensive urine proteome database generated from patients with various renal conditions and prostate cancer. (pnnl.gov)
  • Recent findings have shown the relevance of cellular hierarchy in islets from multiple species including human, mouse and fish, and shown that it is preserved in vivo in the context of the fully vascularized and innervated islet. (birmingham.ac.uk)
  • The focus of Dr. Baker's research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. (cuanschutz.edu)
  • To induce experimental T1DM in animals, streptozotocin (STZ) has been widely used due to its cytotoxic activity against pancreatic β-cells [ 7,8 ], and chronic STZ-induced diabetic rodents mimic diabetic complications observed in diabetic humans [ 9 ]. (karger.com)
  • Human cervix cells under magnification. (acs.org)
  • These islets also have alpha cells, which make glucagon, as well. (mirmankursun.com)
  • Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
  • Interestingly, animal studies and a human study have demonstrated that a gluten-free (GF) diet during pregnancy reduces the risk of T1D. (mdpi.com)
  • To demonstrate the utility of CompNet, we have compared a (time-series) human gene-expression dataset, post-infection by two strains of Mycobacterium tuberculosis , overlaid on the human protein-protein interaction network. (biomedcentral.com)
  • In this study, we tested the effect of local administration of human MSC-Exo on established EAU in the same species. (nature.com)
  • In this proof-of-concept study, we examined whether characterization of the electrical activity of donor islets could provide a criterion. (bvsalud.org)
  • Development of chemical and antibody based enrichment strategies for quantitative characterization of novel protein post-translational modifications (PTMs) and proteoforms that are important to human diseases. (uncg.edu)
  • Short-term fasting lowers glucagon levels under euglycemic and hypoglycemic conditions in healthy humans. (uc.edu)
  • Cardiac aging: from molecular mechanisms to significance in human health and disease. (springer.com)
  • One of these mechanisms was identified by us when we elucidated the gene defect causing the human disorder of sitosterolemia. (uc.edu)
  • Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. (uchicago.edu)
  • Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections. (cdc.gov)
  • To define the molecular constituents with elevated expression in the human pancreas, we employed a genome-wide RNA sequencing analysis of the human transcriptome to identify genes with elevated expression in the human pancreas. (scilifelab.se)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the US Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene. (wikipedia.org)
  • ADH is a dimeric zinc metalloprotein and occurs as five different classes in humans, resulting from gene duplications during vertebrate evolution, the first one traced to ~500. (researchgate.net)
  • Morimoto RI, Cuervo AM. Proteostasis and the aging proteome in health and disease. (springer.com)
  • Framing the discussion of microorganisms as a facet of social equity in human health. (cdc.gov)
  • In this study, we wanted to examine the efficacy of periocular injection of human umbilical cord-derived MSC-Exo in a rat EAU model. (nature.com)
  • The human monoclonal antibodies used in this study are almost identical with these approved antibodies. (frontiersin.org)
  • Very recently, human monoclonal antibodies were approved for use on patients with COVID-19. (frontiersin.org)
  • The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action. (medicalxpress.com)