AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
Induced Pluripotent Stem CellsSkinNuclear ReprogrammingKeratinocytesPluripotent Stem CellsFibroblastsUltraviolet RaysOctamer Transcription Factor-3Cell DifferentiationEmbryonic Stem CellsSOXB1 Transcription FactorsMelanocytesCells, CulturedEpidermisCell Culture TechniquesSkin NeoplasmsSkin AgingDose-Response Relationship, RadiationCell LineSkin Physiological PhenomenaSkin, ArtificialDermisGenetic VectorsSkin DiseasesSkin PigmentationKruppel-Like Transcription FactorsCell DedifferentiationSkin AbsorptionTeratomaSunlightEmbryoid BodiesMice, HairlessLentivirusCysteamineMelaninsWound HealingCell EngineeringSkin TestsAdministration, TopicalRegenerative MedicineGene Expression RegulationProto-Oncogene Proteins c-mycTetraploidyPyrimidine DimersOxidative StressDNA DamageErythemaPhotosensitizing AgentsCell ProliferationChromosomes, Artificial, HumanRNA, MessengerMelanomaKeratinsGene ExpressionFeeder CellsMice, Inbred C57BLCell Line, TransformedMice, SCIDEpigenesis, GeneticImmunohistochemistryTransduction, GeneticCulture Media, ConditionedOctamer Transcription FactorsMicroscopy, FluorescenceChimeraTransgenesStage-Specific Embryonic AntigensCell SurvivalModels, BiologicalSkin TransplantationStem Cell TransplantationGenes, Transgenic, SuicideApoptosisCell LineageTelomere HomeostasisBase SequenceGene Expression ProfilingSignal TransductionReverse Transcriptase Polymerase Chain ReactionPhthalic AnhydridesTranscription Factors
Somatic cellsPluripotent stemFibroblastsDifferentiationEmbryosProgenitor cellsCreate iPS cellsFetalDiseasesTissuePatient'sGeneticResearchersCalled inducedParkinson'sTissuesNeuronsTherapiesGenerateBehaveGenesProteinsOrgansTherapeuticTypesEmbryonic stem celCorticalDifferentiate into any cellBone marrowGrownShinya YamanakaSickle cell aStem-cell researcherRegenerative MedicineClinical trialHematopoietic Stem Cell TransScientistsMutationsBiologyEpithelial cellsLaboratoryGenomeEthicalDonorTumorRegulates cell growthMakeCardiacGlial cellsBloodTransplantationOrganoidsPotentialIPSC-derivedPatientsTakahashiNeurodegenerativeInvolvesSuccessfully
Somatic cells6
  • The findings, reported yesterday in Nature, suggest a process that doesn't require the reprogrammed adult somatic cells called induced pluripotent stem (iPS) cells. (stanforddaily.com)
  • Recent development of induced pluripotent stem (iPS) cells that are generated from the somatic cells of individual patients could provide an ideal source of therapy. (ca.gov)
  • These include 'adult' differentiated cells of the body (known as somatic cells, e.g. skin cells) and stem cells from a range of sources - embryonic, foetal, cord blood, and mature tissues. (eurostemcell.org)
  • European cell therapy firms are split almost equally between therapies based on stem cells and therapies based on somatic cells. (eurostemcell.org)
  • Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
  • In 2006, the Yamanaka lab reported a new method to produce pluripotent stem cells from somatic cells with the help of exogenous expression of transcription factors. (yu.edu)
Pluripotent stem25
Fibroblasts13
  • Lately, his group employed lineage-specific transcription factors for reprogramming cellular identity and generating therapeutic relevant neuronal subtypes from conversion of skin fibroblasts. (michaeljfox.org)
  • Then, his group identified a minimal combination of three transcription factors (Mash1, Nurr1 and Lmx1a) able to directly convert model and human fibroblasts into functional dopaminergic neurons. (michaeljfox.org)
  • He decided he would focus his efforts on manipulating a naturally occurring process in cells, in particular in a type of adult cell called fibroblasts, which give rise to connective tissue. (x-journals.com)
  • This naturally occurring process - called MET (mesenchymal to ephithelial cell transition) - pushes fibroblasts closer to a stem-cell-like state. (x-journals.com)
  • The researchers found two chemicals - ALK5 inhibitor SB43142 and MEK inhibitor PD0325901 - used in combination were highly effective in promoting the transformation of fibroblasts into stem cells. (x-journals.com)
  • Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with human skin cells called dermal fibroblasts. (scienceblog.com)
  • Instead, stem cells are being induced to make fibroblasts by implanting fibroblast DNA into a ghost cell. (gcimagazine.com)
  • The gold standard is still to use fibroblasts harvested from circumcised infant skin. (gcimagazine.com)
  • Even the use of stem cells in plastic surgery is primarily with the hope that they will become growth factor production cells, such as fibroblasts or macrophages. (gcimagazine.com)
  • It is this special shape that makes growth factors from stem cells and fibroblasts much more stable and active in the skin. (gcimagazine.com)
  • CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. (rndsystems.com)
  • iPS cells produced from three somatic cell types: adult skin fibroblasts as well as embryonic and fetal mesenchymal stem cells, show that regardless of the age of the donor cells, the iPSC produced are fully reprogrammed into a pluripotent state that is undistinguishable from that of hES cells based and low and high-throughput expression analysis and detailed analysis of globin expression patterns by HPLC. (yu.edu)
  • For cell reprogramming simply provide us with users patient/donor skin fibroblasts, blood cells or iPS cells and we will take care of the rest. (technologynetworks.com)
Differentiation9
  • He, then, has translated some of this knowledge in the stem cell research field contributing to develop protocols and methods for generating sub-type specific telencephalic neurons through in vitro differentiation of embryonic and neural stem cells. (michaeljfox.org)
  • Han S, Guo J, Liu Y. Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation. (novoprolabs.com)
  • Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells. (novoprolabs.com)
  • This suggests that reprogramming with the four original Yamanaka pluripotency factors leads to complete erasure of all functionally important epigenetic marks associated with hematopoietic differentiation regardless of the age or the tissue type of the donor cells. (yu.edu)
  • Dr. Kaneko is a member of the Department of Cell Growth and Differentiation, which is researching using iPS cells to regenerate immune cells for use in treatment of cancer and infections such as HIV. (wujapan.news)
  • However, the use of bFGF for human ES cell culture, particularly at the high levels used by some for 'feeder-free' culture, must be considered carefully, as bFGF may drive ES cells towards differentiation. (ddw-online.com)
  • The need to control differentiation of embryonic stem cells in vitro presents another set of challenges. (ddw-online.com)
  • AMSBIO also offer a complete suite of cell reprogramming and neural differentiation services to meet users neural research needs. (technologynetworks.com)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
Embryos11
  • Like embryonic stem cells, iPS cells can give rise to different types of tissue, but they offer a way to avoid both the ethical and practical hurdles of dealing with human embryos. (technologyreview.com)
  • One aspect to this project will be to source oocytes, or immature egg cells to generate SCNT embryos from which embryonic stem cells are harvested. (medicalxpress.com)
  • The experiments will involve inserting human stem cells into rat and mouse embryos. (bigthink.com)
  • Stem cell biologist Hiromitsu Nakauchi plans to grow a small amount of human cells inside rat and mouse embryos - both of which will be altered so the animals can't produce a pancreas - for about 15 days. (bigthink.com)
  • In March, Japan overturned a ban on growing human cells inside animal embryos for more than 14 days. (bigthink.com)
  • But some bioethicists are concerned that introducing human cells into other species' embryos could cause problems. (bigthink.com)
  • The current experiments are designed to test the limits of growing human cells inside animal embryos. (bigthink.com)
  • In November, Yamanaka's team reported the creation of cell that were indistinguishable from those taken from human embryos. (cellmedicine.com)
  • Since viable embryos had to be destroyed to extract embryonic stem cells (cells which are thought to have the greatest potential among all stem cells), stem cell research was highly controversial: until now. (cellmedicine.com)
  • These cells have been specially derived from human embryos (embryonic stem cells) or from reprogrammed adult cells (iPS cells). (bioethicsobservatory.org)
  • Human embryonic stem cell research is ethically and politically controversial because since it involves the destruction of human embryos that have the potential to become human beings, it is the topic of several debates addressing morals and beliefs. (ysjournal.com)
Progenitor cells11
  • They used immature cells called glial progenitor cells taken from aborted fetuses, infused them into the brains of newborn mice, and watched what happened. (nbcnews.com)
  • Progenitor cells are partly along the path to from undefined to "adult" cells, and seem to have a better ability to flourish when transplanted. (nbcnews.com)
  • The human glia cells essentially took over to the point where virtually all of the glial progenitor cells and a large proportion of the astrocytes in the mice were of human origin, and essentially developed and behaved as they would have in a person's brain," said Goldman. (nbcnews.com)
  • They are seeking to develop a method to transplant muscle progenitor cells differentiated using iPS cells to the impaired muscles, and using cells from muscular dystrophy patients to reproduce the diseased state for use in drug development. (wujapan.news)
  • Progenitor cells are similar to embryonic stem cells in their capacity to differentiate into various cell types. (ddw-online.com)
  • However, progenitor cells can only differentiate into a limited number of cell types. (ddw-online.com)
  • Progenitor cells can be far easier to handle in culture than ES cells. (ddw-online.com)
  • For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)
  • AMSBIO offers an extensive range of iPSC derived neural cells including normal and Alzheimer's disease neural progenitor cells, and cerebral cortical neurons. (technologynetworks.com)
  • After users receive the neural progenitor cells and/or functional neurons from us, AMSBIO will also provide ongoing support to facilitate adaptation of the neural cells in their experimental systems. (technologynetworks.com)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
Create iPS cells3
  • His lab was the first in Australia to create iPS cells in mouse models. (medicalxpress.com)
  • Hanna, a fellow at the Whitehead Institute, took skin cells from a diseased mouse and reprogrammed them create iPS cells, which behave like embryonic stem cells, readily turning into any cell type in the body. (technologyreview.com)
  • earlier this week Wu, who co-directs the Stanford Cardiovascular Institute , received$1.44 million from the California Institute for Regenerative Medicine to collect tissue samples to create iPS cells from several hundred patients with idiopathic familial dilated cardiomyopathy - that is, members of families with a predisposition to develop enlarged and weakened hearts without an obvious cause. (stanford.edu)
Fetal8
  • The utility of these models has been hindered by the widespread belief that the cells that make up these organoids remain stuck in a developmental state analogous to the cells seen in fetal development. (neurosciencenews.com)
  • Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
  • To the researchers' amazement, spheroids of both types fused together, with nerve cells from subpallial spheroids migrating and poking extensions into the cortical spheroids and establishing working connections with nerve cells of a different type in the latter spheroids, just as occurs in fetal development. (stanford.edu)
  • We have previously shown that human embryonic stem cells can be differentiated into embryonic and fetal type of red blood cells that sequentially express three types of hemoglobins recapitulating early human erythropoiesis. (yu.edu)
  • The ability to produce large numbers of erythroid cells with embryonic and fetal-like characteristics is likely to have many translational applications. (yu.edu)
  • Inclusion of fetal bovine serum in stem cell media further contributes to an illdefined culture system. (ddw-online.com)
  • 56°C for 30 min) fetal bovine serum (FBS) to prepare an cacodylate buffer, stained en bloc in 1% uranyl acetate in approximate 10% (wt/vol) tissue homogenate. (cdc.gov)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
Diseases23
  • The use of various types of stem cells for research purposes to make disease "models" in the lab for regenerative medicine and for "therapies" to cure sick patients for diseases is constantly in the news. (lifeissues.net)
  • Initially, he established genetic cell reprogramming for generating iPS cells with the aim to model human diseases like Alzheimer's and Parkinson's disease and atypical Rett syndrome. (michaeljfox.org)
  • Australia is already a global leader in overall stem cell research and this new and clear regulatory framework gives us an opportunity to extend our leadership into SCNT which could transform how we treat diabetes, heart diseases and Parkinson's," Mr Jennings said. (medicalxpress.com)
  • Genetic skin diseases constitute a diverse group of several hundred diseases that affect up to 2% of the population and include common disease such as psoriasis, atopic dermatitis, and wound healing. (ca.gov)
  • Because of recent advances by our team and others in stem cell technology, our hypothesis is that we can create genetically corrected iPS cells for dominant skin diseases such as DDEB as well as recessive diseases such as RDEB. (ca.gov)
  • The ability to therapeutically reprogram and replace diseased skin would allow this procedure to develop therapeutic reprogramming approaches for a variety of both common and life-threatening skin diseases. (ca.gov)
  • The hope of most researchers in the field is that one day it will be possible to use stem cells - which possess the ability to develop into many other distinct cell types, such as nerve, heart, or lung cells - to repair damaged tissue from any number of diseases, from Type 1 diabetes to Parkinson's disease, as well as from injuries. (x-journals.com)
  • So you can easily imagine that without this technology, it's impossible to take cardiac cells from patients who have some kinds of cardiac diseases. (achievement.org)
  • The study shows that it may be possible to grow the cells to a maturity that will allow scientists to better study adult-onset diseases, such as schizophrenia or dementia. (neurosciencenews.com)
  • However, the use of stem cells to treat diseases is still extremely limited in the present day. (zmescience.com)
  • One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," says Cheng. (hopkinsmedicine.org)
  • Reprogramming cells to cure diseases. (technologyreview.com)
  • Before iPS cells can be used to treat diseases such as sickle-cell anemia in humans, a lot of work has to be done to make sure they won't cause adverse side effects and to improve the efficiency of deriving them from skin cells. (technologyreview.com)
  • The experiments are aimed at making models to study human brain diseases such as Huntington's and schizophrenia, as well as nerve diseases such as multiple sclerosis. (nbcnews.com)
  • Down the road, Goldman hopes the findings might lead to procedures to transplant brain cells to treat diseases as diverse as multiple sclerosis, bipolar disease and even the brain shrinkage that causes memory loss in aging. (nbcnews.com)
  • There are a number of diseases that are specific to humans -- neuropsychiatric diseases, schizophrenia, bipolar disease. (nbcnews.com)
  • The hope is that, in the future, these cells can be used to treat diseases where cell damage has occurred by transplantation of the patient's own iPS-derived cells. (sciencewatch.com)
  • On Wednesday, a Japanese scientist who recently broke new ground in the field of stem cells said that the technology could be used to cure diseases and heal injuries within 10 years. (cellmedicine.com)
  • iPS cell technology holds vast promises to cure genetic diseases. (yu.edu)
  • Speaking on disease treatments, these cells could be used to treat several types of diseases, such as diabetes and Parkinson's disease [4], since with them any type of tissue needed could be formed and used to replace a damaged one. (ysjournal.com)
  • Despite strong interest in these diseases, high quality human in vitro cell models for cortical neurophysiology were unavailable until now. (technologynetworks.com)
  • Our laboratory for the first time combines transplantation of stem cells, stimulation of endogenous neurogenesis and modulation of inflammatory responses in order to develop clinically effective cell replacement therapies for human neurodegenerative diseases. (lu.se)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
Tissue23
  • Scientists have made human iPS cells from skin and hair follicles, as well as from tissue harvested from people with various ailments. (technologyreview.com)
  • Another focus at Gladstone is building on the development of induced pluripotent stem cell technology by one of its investigators, 2012 Nobel Laureate Shinya Yamanaka, to improve drug discovery, personalized medicine and tissue regeneration. (wikipedia.org)
  • Their research has included: Determining the genetic factors of congenital birth defects in early heart development Studying various methods to repair damaged hearts, including creating heart cells from skin samples and converting scar tissue into muscle. (wikipedia.org)
  • We are currently doing extensive testing of the iPS-derived skin cells using human skin tissue models to ensure the safety and efficacy of these cells. (ca.gov)
  • A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. (x-journals.com)
  • The creation of iPS cells from adult cells sidesteps ethical concerns associated with the use of embryonic stem cells, and allows the generation of stem cells matched to a patient's own immune system, avoiding the problem of tissue rejection. (x-journals.com)
  • Undifferentiated cells, found in a differentiated tissue, that can renew themselves and - with certain limitations - differentiate to yield all the specialized cell types of the tissue from which they originated. (michaeljfox.org)
  • Although they have potential in fat injections and face-lifts to offer more stable tissue replacement, they are otherwise not part of skin care as you know it. (gcimagazine.com)
  • In vitro models of human hair follicle-like tissue could be fundamental tools to better understand hair follicle morphogenesis and hair drug screening. (researchgate.net)
  • These are at all stages of development from early preclinical research, as with a neural stem cell therapy being developed for Parkinson's Disease by Axontherapix S.L of Spain, through to products that are available to treat patients now such as Chondroselect ® , a cell therapy for repairing damaged tissue in knee joints produced by Belgian cell therapy firm TiGenix. (eurostemcell.org)
  • These healthy cells were transplanted back into the mouse, whose immune system accepted them as the animal's own tissue. (technologyreview.com)
  • We explore the possibility of creating a tight, durable skin-implant interface for OI implants using mesenchymal stem cells MSCs derived from naturally occurring porcine integumentary tissues or human induced pluripotent stem iPS cells, which have the intrinsic potential to form an impervious seal at hard and soft tissue junctions. (dtic.mil)
  • We have expertise in the derivation and culture of 3D organoid lines from human tissue samples. (wabri.net)
  • Pasca's particular interest was in the brain, and in the experiments detailed in the study, his lab had caused human iPS cells to multiply and differentiate into small spherical clusters of brain tissue suspended in laboratory glassware. (stanford.edu)
  • These clusters recapitulated the architecture and physiology of the human cerebral cortex -- the outermost layer of brain tissue, critical to perception, cognition and action. (stanford.edu)
  • Positive IHC detected in human lung cancer tissue, human colon cancer tissue, human skin tissue. (novoprolabs.com)
  • Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:109124(CD44 Antibody) at dilution of 1:200 (under 10x lens). (novoprolabs.com)
  • Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:109124(CD44 Antibody) at dilution of 1:200 (under 40x lens). (novoprolabs.com)
  • When stem cells were first discovered in 1961 by the biophysicist James Till and the cellular biologist Ernest McCulloch, the scientific community became quickly enthusiastic about its coming possibilities: with the ability to self-renew and replace damaged tissue in the body, these new-known cells came to be the core of the upcoming field of medical treatment, the regenerative medicine. (ysjournal.com)
  • E.g in cardiac therapies, the induced pluripotent stem cell line promotes cardiac tissue regeneration and when this one is applied to the organ, it leads to improvements in cardiac function [2]. (ysjournal.com)
  • Emborg explains that although the results are encouraging overall, the authors report differences in dopamine production and innervation of the host tissue by the grafts, so it will be necessary to identify the best cell lines in order to improve replicability. (the-scientist.com)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • The integrity of the skin and mucous membranes, the vascular supply to tissue, and the nutritional status of the patient also influence the risk of infections. (msdmanuals.com)
Patient's6
  • In this process, the patient's own cells can be induced to make normal collagen VII. (ca.gov)
  • The goal of the EB Disease team is to develop iPS cells of patients with DEB and genetically correct the patient's own collagen VII defect. (ca.gov)
  • We then plan to convert the iPS cell back into skin cells that can be grafted onto the patient's wounds. (ca.gov)
  • We plan to develop the processes necessary for iPS cell generation, genetic correction and development of a product that can be grafted back onto the patient's own skin. (ca.gov)
  • Because they're generated from a patient's cells, the iPS cells harbor the same TSC1 or TSC2 mutations causing that patient's disease. (novartis.com)
  • They then used induced pluripotent stem, or iPS, cell technology to convert the skin cells in the laboratory into functioning heart cells that reflected each patient's specific heart aliment. (stanford.edu)
Genetic11
  • the most recent development, as of this writing, is the transformation of human skin cells into iPS cells using proteins rather than the currently most common approach of genetic engineering. (technologyreview.com)
  • But in order to become a part of medical history, parahuman reproduction and human genetic engineering must circumvent the recalcitrance of an antiquated culture. (lifeissues.net)
  • We have generated iPS cell lines from subjects with documented DEB, identified the genetic mutations, and commenced work on the correction of several mutations in the iPS Cells. (ca.gov)
  • Moreover, genetically-corrected pluripotent iPS cells could form the basis of future systemic therapies to other organs besides the skin to treat common genetic disorders. (ca.gov)
  • Ding and colleagues essentially solved the first problem, the reliance on genetic manipulation, earlier this year in a paper published in Cell Stem Cell (Volume 4, Issue 5, May 8, 2009). (x-journals.com)
  • Importantly, the use of human-derived culture systems means such findings are being examined in the context of relevant human genetic backgrounds. (sfari.org)
  • What's more, the process Xu used to create iPSCs involves genetic modification of human cells with genes encoding oncogenic proteins and so needs more refinement. (scienceblog.com)
  • A chemical compound or substance that inhibits oxidation - damage to cells' membranes, proteins or genetic material by free radicals (the same chemical reaction that causes iron to rust). (michaeljfox.org)
  • This caused genetic changes that turned the adult cells into stem cells. (zmescience.com)
  • He then corrected the sickle-cell genetic defect and prodded the iPS cells to develop into the type of marrow stem cell that manufactures a mouse's blood cells. (technologyreview.com)
  • Even if the cells carried genetic risk factors for the disease, "environmental insults" are likely also required to make the cells show signs of pathology, he says. (the-scientist.com)
Researchers34
  • The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
  • The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
  • These researchers found that total flux of hydrocarbons across the skin was a relatively slow 20.3 :g/cm2/hour. (cdc.gov)
  • Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (ibtimes.com)
  • The Japanese researchers set out to create an immortalized cell line with a large number of high-quality megakaryocytes -- precursor cells that develop into platelets -- from stem cells that can be grown indefinitely and differentiate into a variety of cell types in the body. (ibtimes.com)
  • Researchers have long hoped to use stem cells to restore normal production of the neurotransmitter chemical. (deccanchronicle.com)
  • Parkinson's is caused by a lack of dopamine made by brain cells and researchers have long hoped to use stem cells to restore normal production of the neurotransmitter chemical. (deccanchronicle.com)
  • Still, the researchers plan to terminate any experiment if they ever detect that more than 30 percent of the rodent brains are human, per the government's guidelines. (bigthink.com)
  • Experimental models mimic the processes thought to be at play in human patients and allow researchers to assess possible treatments before moving into clinical trials. (neurodegenerationresearch.eu)
  • In the paper, the researchers demonstrated that they could use purified proteins to transform adult cells all the way back to the most primitive embryonic-like cells, avoiding the problems associated with inserting genes. (x-journals.com)
  • The researchers identified the most active compounds, then looked at their effects on stem cell creation when used singly and in combination. (x-journals.com)
  • Critical to this study was the researchers' use of cortical organoids, a human-based cellular model system. (sfari.org)
  • Still, he notes that stem-cell researchers are developing more workarounds, including strategies using only chemical agents. (scienceblog.com)
  • The researchers say that cells from women could be used to produce sperm, but that sperm would only be able to produce female babies because they lack a Y chromosome. (naturalnews.com)
  • A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived 'mini brain' organoids can mature in a manner that is strikingly similar to human brain development. (neurosciencenews.com)
  • Human stem cell-derived organoids have the potential to revolutionize the practice of medicine by giving researchers unprecedented insights into how complex organs - including the brain - develop and respond to disease. (neurosciencenews.com)
  • For several years, researchers have been growing human brain organoids to study human neurological and neurodevelopmental disorders, such as epilepsy, autism and schizophrenia. (neurosciencenews.com)
  • UK researchers have rejuvenated the skin cells of a 53-year-old woman so they are the equivalent of a 23-year-olds. (zmescience.com)
  • The technique used by Reik and his team comes from the 1990s when researchers from the Roslin Institute found a way to turn an adult mammary gland cell taken from a sheep into an embryo. (zmescience.com)
  • Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)
  • Using stem cells to treat Parkinson's Disease Japanese researchers announced that they have begun a clinical trial using stem cells to treat Parkinson's disease (PD). (ndpl.net)
  • Human brain cells in a mouse glow green because researchers have tagged them with a gene that looks green under fluorescent light. (nbcnews.com)
  • Mice with the human cell transplants were smarter than normal mice, the researchers report. (nbcnews.com)
  • Researchers who transplanted human brain cells into newborn mice said the rodents grew up to be smarter than their normal littermates, learning how to associate a tone with an electric shock more quickly and finding escape hatches faster. (nbcnews.com)
  • To make sure it wasn't just the transplant of fresh cells that was improving learning, the researchers transplanted mouse progenitor glial cells into newborn mice. (nbcnews.com)
  • Today, researchers around the world are using similar methodology to create models, broadly known as "organoids," to study other parts of the human body. (stanford.edu)
  • Researchers at Sapporo Medical University drew fluid from his bone marrow, isolated a type of stem cell found there, multiplied the cells in the lab, and infused them back into his bloodstream intravenously. (sci-info-pages.com)
  • Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
  • Nearly two years ago, researchers discovered a method to transform skin cells into pluripotent stem (iPS) cells , the stem cells that can become other cell types (e.g., neural, cardiac, cartilage, and others). (answersingenesis.org)
  • A separate team of U.S. researchers at the University of Wisconsin at Madison, led by James Thompson, also reprogrammed skin cells at the same time as the Japanese team. (cellmedicine.com)
  • In short, the researchers collected painless skin samples from patients with one of three inherited cardiac conditions, as well as from healthy family members. (stanford.edu)
  • The researchers found that the heart cells in the dish responded in much the same way to the medications as did human patients. (stanford.edu)
  • Then, the researchers grafted the reprogrammed cells into the brains of 2- to 3-year-old, male cynomolgus monkeys ( Macaca fascicularis ) that had been treated with the neurotoxin MPTP, which kills dopamine-releasing neurons and results in PD-like movement defects. (the-scientist.com)
  • With the deepening of the research on the mechanism of cell death, more and more researchers have devoted their attention to the underlying pathologic research and the drug therapy research of DKD. (bvsalud.org)
Called induced1
  • The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
Parkinson's6
  • This discovery allows for the straightforward production of a homogenous source of human functional dopaminegic neurons amenable for a cellular replacement therapy in Parkinson's disease and its in vitro modeling. (michaeljfox.org)
  • Japanese scientists said on Monday they will start clinical trials next month on a treatment for Parkinson's disease , transplanting "reprogrammed" stem cells into brains, seeking a breakthrough in treating the neurodegenerative disorder. (deccanchronicle.com)
  • This will be the world's first clinical trial using iPS cells on Parkinson's disease," Jun Takahashi, professor at Kyoto University's Centre for iPS Cell Research and Application, told a news conference. (deccanchronicle.com)
  • CENTER FOR IPS CELL RESEARCH AND APPLICATION, KYOTO UNIVERSITY C ell therapy for Parkinson's disease (PD) is closer than ever. (the-scientist.com)
  • This is an important step in the translation of iPSC-derived technology to clinical cell transplants in Parkinson's," Patrik Brundin , a neuroscientist at the Van Andel Institute in Michigan who did not participate in the work, tells The Scientist . (the-scientist.com)
  • By linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson's disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms. (lu.se)
Tissues4
  • Cell therapies are treatments that use human cells, including stem cells, with the aim of restoring, maintaining, or improving the functioning of human tissues or organs. (eurostemcell.org)
  • IHC-P: Human testis, Human skin, Mouse testis and Rat testis tissues. (abcam.com)
  • With the hope that stem cells can replace diseased or damaged cells, tissues, and organs, the therapeutic potential of stem cells is enormous. (cellmedicine.com)
  • Based on the results of recent research, efforts have begun on research with the goal of regenerating human organs and tissues, and using iPS cells to develop new medicine. (wujapan.news)
Neurons11
  • With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
  • This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
  • it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
  • The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
  • While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
  • Human glia are far more complex than mouse glia, and they help form many, many more connections, called synapses, between neurons. (nbcnews.com)
  • AMSBIO neural cells are capable of generating a spectrum of cortical neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. (technologynetworks.com)
  • We are transplanting different types of neuroblasts generated either from human skin cell-derived induced pluripotent stem (iPS) cells or via direct conversion of skin cells to neurons (iN cells) (Fig.1). (lu.se)
  • We are currently generating neurons by iPS and iN cell technology aiming to produce cortical neurons and after intracerebral transplantation or direct in vivo reprogramming of non-neuonal cells restore damaged neuronal network. (lu.se)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
Therapies13
  • He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
  • Work on regenerative medicine is not only happening in academic laboratories, novel cell-based therapies are also being developed by commercial companies in Europe and across the world. (eurostemcell.org)
  • Biotech products include protein drugs made by genetically-engineered cell cultures, monoclonal antibodies (laboratory-made copies of a single human antibody, often for use in cancer treatment ) and, most recently, human cell-based therapies. (eurostemcell.org)
  • There are currently around 50 firms developing cell therapies within Europe. (eurostemcell.org)
  • Companies face a choice between a range of human cell types to work with when developing new therapies. (eurostemcell.org)
  • The REMEDiE project identified some 65 cell therapies under development in the European commercial sector. (eurostemcell.org)
  • There are more cell therapies than firms because several firms have more than one product in development. (eurostemcell.org)
  • Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies. (hopkinsmedicine.org)
  • However, his method was not suitable for actual human therapies, as it used viruses to deliver the reprogramming factors needed to make iPS cells. (sciencewatch.com)
  • These insights will be crucial for developing efficient and safe cell-based therapies in the future. (sciencewatch.com)
  • Their exploration has allowed the study of cells with similar states of pluripotency as found in embryonic stem cells (ESCs), breaking the ethical barrier that interfered with the study of ESCs, as well as their use in therapies, disease modeling and drug development. (ysjournal.com)
  • A website for Stem Cell Center of NJ features Spiel and exosome therapies. (ipscell.com)
  • The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
Generate9
  • They were able to produce a cell line that turned off certain genes to generate functional platelets. (ibtimes.com)
  • Soon we will work together with the FDA and our collaborators to generate patient-specific skin grafts. (ca.gov)
  • But it hasn't been possible to generate sufficient number of hair-follicle-generating stem cells - until now. (scienceblog.com)
  • Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells. (scienceblog.com)
  • Xu and his team mixed iPSC-derived EpSCs and mouse dermal cells to generate hair follicles to achieve the growth of the follicles. (scienceblog.com)
  • We generate human iPS cells from blood and skin samples and differentiate those pluripotent cells into a range of different cell types. (wabri.net)
  • Dr. Woltjen is a member of the Department of Life Science Frontiers, which has succeeded in determining the mechanism for initializing cells with iPS cells, and in using genome engineering to generate iPS cells to knockout genes. (wujapan.news)
  • It has now been shown that if iPS cells obtained from the skin or bone marrow of a person are injected back into the same person, they can generate tumours and trigger inflammation. (bioethicsobservatory.org)
  • The remarkable potential of stem cells to generate several hundred differentiated cell types is driving their use for regenerative medicine and for supporting the traditional drug discovery and development process (Figure 1). (ddw-online.com)
Behave4
  • So-called iPS cells are made by removing mature cells from an individual - often from the skin or blood - and reprogramming them to behave like embryonic stem cells. (deccanchronicle.com)
  • Unlike SCNT, iPS cells are derived from adult cells, such as skin, which are reprogrammed to behave like embryonic stem cells. (medicalxpress.com)
  • cells that behave very like embryonic stem cells and can differentiate into all the different types of cells in the body. (eurostemcell.org)
  • Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," says Cheng, who explains that rigorous follow-up tests are required to determine if the reprogrammed cells really behave like pluripotent embryonic stem cells. (hopkinsmedicine.org)
Genes6
  • I remember it clearly, but I didn't feel the earthquake at the time: a youngish, earnest Japanese researcher named Shinya Yamanaka gave a talk at the annual meeting of the International Society for Stem Cell Research, reporting that he could make mouse skin cells look and act like embryonic stem cells just by adding a few genes. (technologyreview.com)
  • These four genes then produced transcription factors turning on and off other genes, and pushing the cell to "dedifferentiate" into stem cells. (x-journals.com)
  • This work represents an important milestone by showing which aspects of human brain development are modeled with the highest fidelity and which specific genes are behaving well in vitro and when best to model them. (neurosciencenews.com)
  • When mutated, though, the genes can't do their job, and affected cells grow when they're not supposed to. (novartis.com)
  • The discovery of a multi-purpose cell that can be made by introducing genes into human body cells such as skin or blood, with the potential to transform into other cell types such as heart, liver, or nerves. (wujapan.news)
  • It was found out that, with the expression of only four genes, Oct3/4, Sox2, c-Myc and Klf4, somatic stem cells could be reprogrammed into the pluripotent-like state. (ysjournal.com)
Proteins5
  • Those cells were then purified using the proteins they expressed on their surfaces. (scienceblog.com)
  • A clumping of proteins inside cell bodies in the brain, which may be toxic. (michaeljfox.org)
  • Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation through its conversion into palmitoyl coenzyme A. Although palmitoylation affects many proteins, its pathophysiological functions are only partially understood. (researchgate.net)
  • Using a cocktail of proteins and small molecules - and with the help of a room-sized cell culture robot he affectionately calls "the neuron factory" - Salick then guides the iPS cells to become nerve cells. (novartis.com)
  • Use of feeder layers requires two cell types to be maintained in parallel and introduces mouse proteins into the culture system. (ddw-online.com)
Organs4
  • The ultimate goal is to grow organs inside animals that could be transplanted into humans. (bigthink.com)
  • The Japanese government plans to let a stem cell researcher conduct human-animal embryo experiments, with the ultimate goal of someday creating organs to be transplanted into humans. (bigthink.com)
  • We don't expect to create human organs immediately, but this allows us to advance our research based upon the know-how we have gained up to this point. (bigthink.com)
  • From these "magic" iPS cells grew a complex conglomerate of cells capable of modeling specific organs. (stanford.edu)
Therapeutic3
  • In particular, scientific developments in areas such as iPS cells open new possibilities of research and, at mid term, of therapeutic applications, but they also bring new ethical challenges and problems requiring further reflection and debate. (lifeissues.net)
  • SCNT, or therapeutic cloning, is one method used to produce a source of individually-tailored stem cells. (medicalxpress.com)
  • The use of mouse feeder layers and animal serum are particularly problematic in the culturing of stem cells for possible therapeutic applications. (ddw-online.com)
Types13
  • The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people. (scienceblog.com)
  • When a person loses hair, they lose both types of cells. (scienceblog.com)
  • Shinya Yamanaka: Because of this technology, iPS technology, now we can prepare many types of human cells. (achievement.org)
  • their ability do differentiate into other types of human cells. (ndpl.net)
  • Hanna is now developing simulations to understand what happens when cells are reprogrammed, and he's searching for new types of human stem cells that could be easier to turn into adult cells. (technologyreview.com)
  • We use highly efficient methods that take advantage of CRISPR-Cas9 technology to genetically engineer a range of cell types. (wabri.net)
  • Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. (rndsystems.com)
  • There are 220 different types of cells in the human body, and stem cells which are primitive cells, have the potential to differentiate into any of these. (cellmedicine.com)
  • With organoids we can study the interactions of multiple cell types in something close to a living model," says Kaykas, who leads the team. (novartis.com)
  • In the last 3 years, several protocols have been developed to derive various types of lung cells from iPS and embryonic cells. (bioethicsobservatory.org)
  • In mammal's development there are three types of stem cells: totipotent, pluripotent and somatic stem cells. (ysjournal.com)
  • Somatic ones are adult cells, bi or unipotent since they only have one or two viable outcomes and are more specialized than the other types of cells. (ysjournal.com)
  • We also provide an overview of the types and specific mechanisms involved in each type of cell death in DKD, as well as related targeted therapy methods and drugs are reviewed. (bvsalud.org)
Embryonic stem cel1
  • Critics of embryonic stem cell research, which include the Roman Catholic Church, praised the discovery. (cellmedicine.com)
Cortical4
  • Iakoucheva, Muotri and colleagues created cortical organoids using skin cells from people with both 16p11.2 deletions and 16p11.2 duplications who participate in SFARI's Simons Searchlight - first converting these skin cells into induced pluripotent stem (iPS) cells and then reprogramming them to become brain cells. (sfari.org)
  • In contrast, cells from people with 16p11.2 duplications resulted in smaller cortical organoids. (sfari.org)
  • Pasca named these clusters, which grew to several millimeters in diameter and contained millions of cells, "cortical spheroids. (stanford.edu)
  • We can efficiently differentiate the iPS cells (provided by users or generated by us) to cerebral cortical neural lineage using defined neural induction medium and substrates. (technologynetworks.com)
Differentiate into any cell1
  • IPS cells can then, in turn, be directed to differentiate into any cell type found in the human body. (sciencewatch.com)
Bone marrow2
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Grown7
  • The number of human cells grown in the bodies of sheep is extremely small, like one in thousands or one in tens of thousands," he told The Asahi Shimbun . (bigthink.com)
  • In a feat of bioengineering, scientists take adult skin cells and then essentially reprogram them to turn them into embryonic stem cells that can be grown into all manner of cells. (naturalnews.com)
  • All cells are grown in an environment that is typically called "growth media. (gcimagazine.com)
  • Because each spheroid begins with skin cells, they can be grown on a personalized basis -- and can therefore be extracted from patients with neurological disorders known or suspected to spring from early developmental aberrations (such as autism or schizophrenia). (stanford.edu)
  • Novartis neuroscientists are bringing them into the light, using human brain cells grown in the lab. (novartis.com)
  • Every cell type has its own unique needs when grown in vitro and stem cells are no exception. (ddw-online.com)
  • Alternatively, stem cell cultures can be grown on extracellular matrix extracts and supplemented with conditioned medium from mouse fibroblast cultures. (ddw-online.com)
Shinya Yamanaka3
  • The center is headed by Shinya Yamanaka, who in 2012 shared a Nobel Prize for medicine with a British scientist, John Gurdon, for the discovery that adult cells can be transformed back into embryo-like cells. (deccanchronicle.com)
  • Kyoto University is pioneering the frontier of life science, and this press tour will visit the Graduate School of Science and the Center for iPS Cell Research and Application (CiRA), which Professor Shinya Yamanaka is the director of. (wujapan.news)
  • These iPS cells were discovered by Professor Shinya Yamanaka, winner of the 2012 Nobel Prize in Physiology or Medicine. (wujapan.news)
Sickle cell a1
  • Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)
Stem-cell researcher2
  • One stem cell researcher points out the possibility of a man producing the sperm as well as the eggs, essentially cloning himself, while others have said that people could try to create a baby with someone else's skin cells - which are easily obtainable as humans shed a lot of skin each day - without their permission or knowledge . (naturalnews.com)
  • This is essentially an unproven therapy," said Arnold Kriegstein, a stem cell researcher at the University of California, San Francisco. (sci-info-pages.com)
Regenerative Medicine3
  • Other countries such as Spain and Switzerland have made significant investments in regenerative medicine and can be considered 'emerging' or secondary sites of strength in the European cell therapy field. (eurostemcell.org)
  • It's arguably the world's most ambitious approved stem cell treatment and should have been a cause for celebration: a long-awaited breakthrough for the field of regenerative medicine - using modern biological tools to repair the body - and a harbinger of more impressive medicines. (sci-info-pages.com)
  • The increasing importance of iPS cells as regards their potential usefulness within regenerative medicine is widely known. (bioethicsobservatory.org)
Clinical trial5
  • The fact that the clinical trial uses iPS cells rather than human embryonic cells means the treatment would be acceptable in countries such as Ireland and much of Latin America, where embryonic cells are banned. (deccanchronicle.com)
  • Most recently, a reported human stem cell clinical trial may lead to a new treatment for non-neovascular age-related macular degeneration (NNAMD). (ndpl.net)
  • But our 'clinical trial in a dish' with patient-specific iPS cells allows us to model this personalized response and identify high-risk groups who should not receive the drug. (stanford.edu)
  • We need to confirm efficacy and safety of the cells which will be used in the clinical trial. (the-scientist.com)
  • In the planned clinical trial, the research team will use iPSCs derived from healthy donors , not from the subjects' own cells, which could raise issues with graft rejection. (the-scientist.com)
Hematopoietic Stem Cell Trans1
  • Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
Scientists9
  • The relatively few embryonic-stem-cell lines in existence have been well characterized by many scientists. (technologyreview.com)
  • IPS cells and embryonic stem cells must be compared, directly, by a lot of scientists in a lot of ways before we can think seriously about what cells to use for medical applications. (technologyreview.com)
  • Gladstone cardiovascular scientists research the spectrum of cardiovascular disease, utilizing developmental, chemical, and stem cell biology approaches, as well as genomics techniques, across a variety of research programs and institutes. (wikipedia.org)
  • Reuters) - Scientists have for the first time created blood platelet cells by reprogramming stem cells derived from adult cells, offering the potential for a renewable supply of the fragile blood component. (ibtimes.com)
  • Scientists are expected to have the ability to create babies from human skin cells within the next two decades in a process known as in vitro gametogenesis, or IVG. (naturalnews.com)
  • A group of scientists outlined serious reservations about the consequences of such technology, writing in the Science Translational Medicine journal: "I.V.G. may raise the specter of 'embryo farming' on a scale currently unimagined, which might exacerbate concerns about the devaluation of human life. (naturalnews.com)
  • The cells can then be used to create models to probe these disorders' molecular, cellular and circuit-based deviations from the pathways of normal brain development, allowing scientists to study the brain in way they could never do with a living patient. (stanford.edu)
  • He also uses the patient-derived cells to grow what scientists call a cerebral organoid. (novartis.com)
  • We empower scientists to focus on their research interests and not consume valuable lab time and resources in the generation of cells prior to the onset of experiments. (technologynetworks.com)
Mutations1
  • Patients with these mutations get growths all over their bodies - their skin, their kidneys, the heart, their lungs," says Salick, who is a postdoctoral researcher. (novartis.com)
Biology9
  • Ewen Callaway investigates a new field in cell biology. (nature.com)
  • It is quite possible that the advances in human biology in the remainder of the twentieth century will be remembered as the most significant scientific achievement of the animal species known as Homo sapiens . (lifeissues.net)
  • In 2011, the S.D. Bechtel, Jr. Foundation helped launch the Center for Comprehensive Alzheimer's Disease Research, while the Roddenberry Foundation helped launch the Roddenberry Stem Cell Center for Biology and Medicine. (wikipedia.org)
  • Dr Paul Verma, Program Leader of MIMR's Stem Cell Biology Program and the Chief Investigator of the Victorian project team, will create the iPS cells for this project. (medicalxpress.com)
  • In addition to its significant practical advantages, the development of the technique deepens the understanding of the biology behind the transformation of adult human cells into stem cells. (x-journals.com)
  • If he could manipulate such a fundamental process to encourage MET and the formation of stem cells, Ding reasoned, such a method would be both safer and more direct than hijacking other aspects of biology, for example those directly involved in cancer. (x-journals.com)
  • The Cellular Operations team provides cell biology expertise and support to enable the delivery of projects across the various scientific programmes at the Sanger Institute. (wabri.net)
  • My laboratory has a long history in the field of developmental biology, genetics, and stem cell research. (sciencewatch.com)
  • All you need is a basic technology, cell biology" and "you don't need special technology or equipments. (cellmedicine.com)
Epithelial cells2
  • First, a hair follicle contains epithelial cells - a cell type that lines the body's vessels and cavities - as well as a specific kind of adult stem cell called dermal papillae. (scienceblog.com)
  • Li Q, Tanaka Y, Saitoh Y , Miwa N. Effects of Platinum Nanocolloid in Combination with Gamma Irradiation on Normal Human Esophageal Epithelial Cells. (pu-hiroshima.ac.jp)
Laboratory6
  • As reported in a Penn news release , Xiaowei "George" Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice. (scienceblog.com)
  • The technique to produce iPS cells was first discovered in Shinya Yamanaka's laboratory in Japan. (sciencewatch.com)
  • Our paper builds on the findings made in Dr. Yamanaka's laboratory that skin cells can be turned into stem cells (induced Pluripotent Stem or iPS cells). (sciencewatch.com)
  • We were the first and, until now, the only laboratory to establish new lines of human embryonic stem cells in Canada. (sciencewatch.com)
  • non-embryonic stem cells have had proven laboratory and clinical successes and don't require any loss of human life. (answersingenesis.org)
  • The pathologic features of MPXV in ground squirrels are were cared for in accordance with the guidelines of the similar to that described with MPXV in macaques and Committee on Care and Use of Laboratory Animals severe variola (smallpox) virus infection in humans. (cdc.gov)
Genome1
  • Exploring human evolution and metabolism to understand the human genome, and illnesses at the cellular level. (wikipedia.org)
Ethical3
  • When they were first discovered in 2006, iPS cells looked like a perfect solution to the ethical debate over the use of embryonic stem cells, but the process of producing non-mutated cells has proved challenging. (ibtimes.com)
  • Objectives ethical difficulties therapy solved by iPS cells? (bioethicsobservatory.org)
  • Reprogramming of somatic (e.g., skin or blood) cells is an emerging technology which gives the possibility to develop any cell type avoiding the ethical concerns with the use of human embryonic stem (ES) cells. (lu.se)
Donor1
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Tumor3
  • There are many animals that carry human cells -- from the millions of lab mice injected with human tumor cells to study cancer, to sheep engineered to produce human liver cells. (nbcnews.com)
  • Adhesion with HA plays an important role in cell migration, tumor growth and progression. (novoprolabs.com)
  • [ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
Regulates cell growth1
Make10
  • On paper, iPS cells appear to be a preferable alternative to working with human embryonic stem cells, but it's too early to make this assumption. (medicalxpress.com)
  • Comparison of the gene expression patterns of the human iPSC-derived epithelial stem cells with epithelial stem cells obtained from human hair follicles showed that the team had succeeded in producing the cells they set out to make in the first place. (scienceblog.com)
  • We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet. (scienceblog.com)
  • And then we can make cardiac cells from those iPS cells. (achievement.org)
  • Let's be clear: If you are simply using stem cells, the growth factors that might be made-and there's no guarantee a cell will make growth factors-are less likely to be skin-specific. (gcimagazine.com)
  • To make life even easier for subjects, the company is developing a version of the device that gathers data and beams it to a subject's cell phone, which can then send it wirelessly to NeuroVigil for analysis. (technologyreview.com)
  • But the team at the University of Rochester say their findings also suggest that these brain cells, called glial cells, may very well be one of the important factors that make humans different from other animals. (nbcnews.com)
  • The benefits of using fat cells to make iPS cells is that one liter of fat produces hundreds of millions of stem cells, they take less time to be cultured (twice as quickly as skin cells), and they are easier to "program" for use throughout the body. (answersingenesis.org)
  • Some stem cell clinics and related firms are looking for new ways to make profits and toward that goal a few have latched onto the legitimate buzz around exosome research . (ipscell.com)
  • Just based on the state of the science, I believe that exosome research is not to the point where anyone should be directly marketing it to consumers (or indirectly to physicians) to try to make money, but people are doing this anyway lately and it seems centered on the supposed benefits of exosomes made specifically from stem cells. (ipscell.com)
Cardiac4
  • For example, heart cells - cardiac cells - or neural cells from patients. (achievement.org)
  • If the patient dies, we may be able to get a small amount of cardiac cells from that patient, but those cells do not proliferate, so we cannot increase the number. (achievement.org)
  • So I think for the first time in the history of medicine, we now have an opportunity to prepare many, many cardiac or neural cells directly from patients, and those cells should be very, very useful, to understand why those patients become sick. (achievement.org)
  • Even companies relying on genetically normal human embryonic-stem-cell-derived cardiac cells won't be able to see all these effects. (stanford.edu)
Glial cells3
  • The human glial cells not only survived in the brains of the mice - they thrived, Goldman says. (nbcnews.com)
  • Again, the mice with human glial cells learned faster. (nbcnews.com)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
Blood7
  • A thin layer of tightly packed cells separating the central nervous system from the body's blood stream. (michaeljfox.org)
  • The treated mouse began producing healthy red blood cells on its own. (technologyreview.com)
  • For example, stem cells have been extracted from hippocampal and periventricular regions of the brain, umbilical cord blood, pancreatic ducts, hair follicles, skin biopsies, and liposuctioned fat. (answersingenesis.org)
  • Kyoto University neurosurgeon Jun Takahashi and colleagues generated eight iPSC lines from skin or blood cells collected from seven human subjects-three with PD and four without-and derived dopaminergic progenitors from these cell lines. (the-scientist.com)
  • This antibody attached to red blood cells (RBCs) in the cold and induced hemolysis when the RBCs are warmed due to complement activity. (medscape.com)
  • Diagnosis is by white blood cell count with a differential count, and evaluation requires identification of the cause. (msdmanuals.com)
  • 0.2 × 10 9 /L), the inflammatory response may be muted, and the usual inflammatory findings of leukocytosis or white blood cells in the urine or at the site of infection may not occur. (msdmanuals.com)
Transplantation2
  • Hanna's work was a turning point for iPS research, says George Daley, director of the Stem Cell Transplantation Program at Boston's Children's Hospital and a professor at Harvard Medical School: "It was a beautiful demonstration of a mouse model of a human disease, and really demonstrated the potential of iPS cells. (technologyreview.com)
  • In addition, using iPS and iN cell technology patient-specific cells can be generated for transplantation, avoiding the need for immunosuppression and risk for rejection. (lu.se)
Organoids4
  • Brain organoids, or mini-brains, created from human stem cells appear to develop in much the same way as a human brain. (neurosciencenews.com)
  • The organoids follow an internal clock that guides their maturation in sync with the timeline for human brain development. (neurosciencenews.com)
  • They found that these 3D organoids follow an internal clock that guides their maturation in sync with the timeline of human development. (neurosciencenews.com)
  • We've shown that these organoids can mature and replicate many aspects of normal human development - making them a good model for studying human disease in a dish," he said. (neurosciencenews.com)
Potential10
  • Currently, iPS cell lines show variability in their potential to produce mature cells. (medicalxpress.com)
  • While the work was a major breakthrough, it left two major challenges for the field to solve before iPS cell therapy could be considered of any potential practical use. (x-journals.com)
  • One potential approach to reversing hair loss uses stem cells to regenerate the missing or dying hair follicles. (scienceblog.com)
  • There are a lot of potential uses for IVG, ranging from helping infertile women create eggs using their own skin cells to allowing for two men to create a baby related to both of them biologically. (naturalnews.com)
  • Stem cells have much greater potential to treat chronic health conditions affecting large numbers of people including diabetes, heart disease, neurodegenerative and autoimmune illnesses. (eurostemcell.org)
  • Having these new cell lines available might enable some bigger projects, like screening for potential drugs. (hopkinsmedicine.org)
  • In the last part we discuss the complexity and potential crosstalk between various modes of cell death, which will help improve the understanding of podocyte death and lay a foundation for new and ideal targeted therapy strategies for DKD treatment in the future. (bvsalud.org)
  • Displacement of the dome by as little as 5 ,um can result in a supra-threshold generator potential within the Merkel cell-axon ter- minal complex. (cdc.gov)
  • The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
IPSC-derived1
  • That said, iPSC-derived epithelial stem cells are not yet ready for use in human subjects, Xu adds. (scienceblog.com)
Patients7
  • We intend to carry on conducting our research carefully, yet expeditiously, in coordination with Kyoto University Hospital, so that new treatment using iPS cells will be brought to patients as soon as possible," Yamanaka said in a statement. (deccanchronicle.com)
  • The patients can then receive their own corrected cells back onto their skin. (ca.gov)
  • In addition, see what patients on our Patient Council have to share on the topic of stem cells . (michaeljfox.org)
  • Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to hair regeneration have yet to be fully elucidated, particularly in terms of alterations in androgenetic alopecia patients. (researchgate.net)
  • And most patients have a few fat cells they'd be willing to donate. (answersingenesis.org)
  • In the lab, the team biologically re-programs skin cells from TSC patients into induced pluripotent stem (iPS) cells. (novartis.com)
  • The authors confirmed that cells derived from both PD patients and healthy donors made dopamine in vivo, at levels about half that of cells in normal monkeys. (the-scientist.com)
Takahashi1
  • The idea of inducing a pluripotent stem cell similar to the ESCs was executed by Shinya Yakama and his student Kazutoshi Takahashi at Kyoto University, Japan, in 2006. (ysjournal.com)
Neurodegenerative1
  • These centers focus on stem and iPS cell research, as well as neurodegenerative disease research and therapeutics. (wikipedia.org)
Involves1
  • New technique: It involves iPS cells from hiv resistant people for the treatment of people infected with this virus. (bioethicsobservatory.org)
Successfully3
  • We are developing the process necessary for future skin grafting of the corrected cells back onto the patient, and have already successfully generated the initial GMP manufacturing protocols leading to clinical grade, corrected patient skin cells. (ca.gov)
  • Now, for the first time, skeletal muscle cells have been derived from iPS successfully. (bioethicsobservatory.org)
  • Identifying the right cocktail of media conditions, supplements and growth factors that successfully drive stem cells toward a desired lineage on a reproducible basis is a time-consuming, iterative exercise. (ddw-online.com)