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Integrin beta3IntegrinsIntegrin beta4Integrin beta ChainsIntegrin alpha2Integrin alpha6Integrin alpha1beta1Antigens, CD29Receptors, CollagenReceptors, Very Late AntigenCell AdhesionPoint MutationMolecular Sequence DataIntegrin alphaVbeta3Amino Acid SequenceMutation, MissenseIntegrin alpha5beta1Antigens, CDMutationIntegrin alpha6beta4Integrin alpha5Integrin alpha ChainsIntegrin alphaVIntegrin alpha3beta1Integrin alpha2beta1Antibodies, MonoclonalIntegrin alpha4TalinIntegrin alpha6beta1Integrin alpha3Integrin alpha1Frameshift MutationReceptors, VitronectinFibronectinsBase SequenceGerm-Line MutationSignal TransductionCell MovementCell LineHemidesmosomesAntigens, CD18Interleukin-1betaCells, CulturedProtein BindingLamininPedigreeProtein Structure, TertiaryPlatelet Glycoprotein GPIIb-IIIa ComplexAmino Acid SubstitutionBinding SitesTransfectionPolymerase Chain ReactionExtracellular MatrixMutagenesis, Site-DirectedCytoplasmbeta 2-MicroglobulinPhosphorylationMutation RateCHO CellsCricetinaeVitronectinReceptors, FibronectinExonsOligopeptidesRNA, MessengerFocal Adhesion Protein-Tyrosine KinasesPlatelet Membrane GlycoproteinsCell Adhesion MoleculesCell Line, TumorHeterozygoteRecombinant ProteinsSequence Homology, Amino AcidDNA PrimersDNA Mutational AnalysisModels, MolecularFocal Adhesion Kinase 1FilaminsPhenotypeMutagenesisAllelesLigandsCloning, MolecularPlectinMembrane ProteinsTransforming Growth Factor betaFocal AdhesionsBlotting, WesternProtein ConformationTumor Cells, CulturedRecombinant Fusion ProteinsReceptors, Adrenergic, betaSequence DeletionPolymorphism, Single-Stranded ConformationalHomozygoteCollagenReverse Transcriptase Polymerase Chain ReactionMice, KnockoutFibrinogenGenotypeGene Expression Regulation
SubunitAlphaIIb beta3Regulating integrin-mediatedReceptorsReceptorSignal transductionPlateletsNormal integrinTransmembraneAlternatively splicedKinaseExtracellularProteinsGlanzmannClot formationCytoplasmic domainFibrinogenLamininAngiogenesisMissenseAutosomal recessiveIntracellularBRCA1GenesDisease100,000ProteinTherapeuticsCarriersMelanomaInteractionsTumorITGA2BDefectCellBetaDiseasesITGB3Breast cancerSignalsImmuneBoneAlphaInflammation
Subunit11
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (cusabio.com)
  • Subjects with leukocyte adhesion deficiency-1 (LAD-I) do not express beta2 integrins because of mutations in the gene specifying the beta2 subunit, and they suffer recurrent bacterial infections. (ox.ac.uk)
  • The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
  • The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. (medlineplus.gov)
  • The mutations that cause this disorder occur in both copies of the gene in each cell and impair the production or activity of the beta3 subunit, which disrupts the formation of functional integrin αIIbβ3. (medlineplus.gov)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Integrin α subunit domains: Top: Linear domain arrangement. (mechanobio.info)
  • Bottom: simplified version of the integrin α subunit. (mechanobio.info)
  • Each integrin heterodimer consists of an alpha (α) and a beta (β) subunit associated by noncovalent interactions forming an extracellular ligand-binding head, two multi-domain `legs', two single-pas s transmembrane helices and two short cytoplasmic tails. (mechanobio.info)
  • The β subunit comprises of 4 cysteine-rich epidermal growth factor (EGF) repeats, a hybrid domain (split in sequence), an I-like domain (βI) and a plexin-sempahorin-integrin (PSI) domain. (mechanobio.info)
AlphaIIb beta32
  • Trikha M, Timar J, Lundy SK, Szekeres K, Cai Y, Porter AT, Honn KV: The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. (exbio.cz)
  • These genes provide instructions for making the two parts (subunits) of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3). (medlineplus.gov)
Regulating integrin-mediated1
Receptors8
  • Integrin-linked kinase has been shown to interact with: ACP6, AKT1, ILKAP, and LIMS1, ILKs function by interacting with the many transmembrane receptors to regulate different signaling cascades. (wikipedia.org)
  • Integrins are the major adhesion receptors of leukocytes and platelets. (ox.ac.uk)
  • Integrins on circulating cells bind poorly to their ligands but become active after 'inside-out' signaling through other membrane receptors. (ox.ac.uk)
  • The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
  • Integrins function as adhesion receptors for extracellular ligands and transduce biochemical signals into the cell, through downstream effector proteins. (mechanobio.info)
  • Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Receptor4
  • The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. (exbio.cz)
  • Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)
  • Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. (musc.edu)
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Signal transduction1
Platelets5
  • Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. (medlineplus.gov)
  • Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
  • The overactive integrin αIIbβ3 binds inappropriately to clotting proteins within the cell during the formation of platelets, causing the platelets to become misshapen and large. (medlineplus.gov)
  • Because the mutation that causes this disorder affects only one copy of the ITGB3 gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (medlineplus.gov)
  • integrin αIIbβ3 helps platelets bind together. (medlineplus.gov)
Normal integrin1
  • People with type I (the most common type) have less than 5 percent of normal integrin αIIbβ3 levels, people with type II have between 5 and 20 percent of normal integrin αIIbβ3 levels, and people with the variant type have adequate integrin αIIbβ3 levels but produce only nonfunctional integrin. (medlineplus.gov)
Transmembrane4
  • MemProtMD simulation of Micelle-embedded integrin beta3 transmembrane segment in a lipid bilayer at both coarse-grained and atomistic respresentation, including both file download and analysis. (ox.ac.uk)
  • CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. (exbio.cz)
  • The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. (mechanobio.info)
  • Comparison of Integrin αIIbβ3 Transmembrane Association in Vesicles and Bicelles. (sc-ctsi.org)
Alternatively spliced1
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
Kinase3
  • Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. (wikipedia.org)
  • Similarly, marked modifications occur in the larger phosphoprotein clusters involving cytoskeleton and neuronal structures, membrane stabilization, and kinase regulation in the late elderly.Present findings may increase understanding of human brain proteostasis modifications in the elderly in the subpopulation of individuals not having AD neuropathological change and any other neurodegenerative change in any telencephalon region. (ibecbarcelona.eu)
  • The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)
Extracellular4
  • Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. (wikipedia.org)
  • Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. (mechanobio.info)
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
Proteins2
Glanzmann4
  • At least 130 mutations in the ITGB3 gene have been found to cause Glanzmann thrombasthenia, which is a rare bleeding disorder. (medlineplus.gov)
  • Unlike Glanzmann thrombasthenia, this disorder results from a mutation in only one copy of the ITGB3 gene in each cell, and the mutations result in the formation of some integrin αIIbβ3 that is abnormally turned on (active), even when no clot is being formed. (medlineplus.gov)
  • Mutations in the ITGA2B or ITGB3 gene cause Glanzmann thrombasthenia. (medlineplus.gov)
  • Three types of Glanzmann thrombasthenia have been classified according to the amount of integrin αIIbβ3 that is available. (medlineplus.gov)
Clot formation1
Cytoplasmic domain1
  • Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)
Fibrinogen1
  • Beta1 and beta2 integrin function on leukocytes is crucial for a successful immune response and the platelet integrin alpha(IIb)beta3 initiates the process of blood clotting through binding fibrinogen. (ox.ac.uk)
Laminin1
  • Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
Angiogenesis3
  • Using knockin mice expressing functionally stunted β 3 integrin, we show that bone marrow transplantation rescues impaired angiogenesis in these mice by normalizing BMDC recruitment. (rupress.org)
  • Thus, β 3 integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis. (rupress.org)
  • Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
Missense2
  • SwissProt sequences and OMIM curated human diseases associated with missense mutations within the PSI domain. (embl.de)
  • Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. (musc.edu)
Autosomal recessive1
  • In conclusion, we successfully identified the causative mutation for a very rare autosomal recessive mutation with only one case by exploiting the most recent DNA sequencing technologies. (biomedcentral.com)
Intracellular3
  • The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
  • Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
  • Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
BRCA11
  • 6 months vs ≥ 6 months showed significant enrichment of Notch signaling pathway genes, along with a trend for enrichment for luminal progenitor gene signature similar to what is observed in BRCA1 mutation carriers and basal-like breast tumors. (biomedcentral.com)
Genes3
  • This study aimed to identify genes that show signatures of selection for mutations in Iranian native cattle breeds. (ac.ir)
  • Subsequent screening for structural variants in candidate genes located in the same regions identified a homozygous deletion that includes exons 17 to 23 of the integrin beta 4 ( ITGB4 ), a gene that was previously associated with the same defect in humans. (biomedcentral.com)
  • Together, our results point to both antibiotics and phages as inverse correlates of disease severity, while also selecting for resistance genes or mutations within cholera patients. (bvsalud.org)
Disease5
  • Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. (nih.gov)
  • Novel Insight into the Potential Pathogenicity of Mitochondrial Dysfunction Resulting from PLP1 Duplication Mutations in Patients with Pelizaeus-Merzbacher Disease. (nih.gov)
  • As such, integrins are central to the etiology and pathology of many disease states. (thno.org)
  • Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
  • Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated. (thno.org)
100,0001
  • It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet. (medlineplus.gov)
Protein5
  • It is a 59kDa protein originally identified in a yeast-two hybrid screen with integrin β1 as the bait protein. (wikipedia.org)
  • This Human ILK ELISA Kit was designed for the quantitative measurement of Human ILK protein in serum, plasma, tissue homogenates, cell lysates. (cusabio.com)
  • Instead, we identify mutations in the KINDLIN3 (official symbol FERMT3) gene specifying the KINDLIN-3 protein as the cause of LAD-III in Maltese and Turkish subjects. (ox.ac.uk)
  • Two independent mutations result in decreased KINDLIN3 messenger RNA levels and loss of protein expression. (ox.ac.uk)
  • Rap-1 is an essential protein involved in signaling mediated by integrins. (medscape.com)
Therapeutics1
  • Millard M, Odde S, Neamati N. Integrin Targeted Therapeutics. (thno.org)
Carriers1
  • Mining of Illumina BovineSNP50 Beadchip genotyping data from 6870 Charolais cattle detected only 44 heterozygous animals for a 5.6-Mb haplotype around ITGB4 that was shared with the carriers of the mutation. (biomedcentral.com)
Melanoma2
  • In these studies the migration of human and mouse melanoma on fibronectin was inhibited by purified T4 and HAP1 bacteriophage preparations. (biomedcentral.com)
  • The migration of human melanoma was also inhibited by the HAP1 phage preparation on matrigel. (biomedcentral.com)
Interactions1
  • Mutations that disrupt these interactions abrogate kindlin-2 and ILK colocalization in HeLa cells. (cusabio.com)
Tumor1
  • β4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex. (fmu.ac.jp)
ITGA2B1
  • ITGA2B or ITGB3 gene mutations result in a shortage (deficiency) of functional integrin αIIbβ3. (medlineplus.gov)
Defect1
  • Notably, transfection of the subjects' lymphocytes with KINDLIN3 complementary DNA but not CALDAGGEF1 cDNA reverses the LAD-III defect, restoring integrin-mediated adhesion and migration. (ox.ac.uk)
Cell5
  • Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. (cusabio.com)
  • which means both copies of the gene in each cell have mutations. (medlineplus.gov)
  • Evidence that human haematopoietic stem cells (HSC) do not reside within the CD34+KIT- cell population. (musc.edu)
  • Quantitative analysis of β1,6GlcNAc-branched N-glycans on β4 integrin in cutaneous squamous cell carcinoma. (fmu.ac.jp)
  • Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
Beta1
  • ILK is linked to beta-1 and beta-3 integrin cytoplasmic domains and is one of the best described integrins. (wikipedia.org)
Diseases1
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
ITGB31
  • Mutations in the ITGB3 gene can also cause another rare bleeding disorder called platelet-type bleeding disorder 16. (medlineplus.gov)
Breast cancer1
  • Similar analysis was done using gene expression data generated from human breast samples obtained from parous women enrolled on a tissue collection study, OSU-2011C0094, and were undergoing reduction mammoplasty without history of breast cancer. (biomedcentral.com)
Signals1
  • In addition to biochemical signals and genetic considerations, mechanical forces are rapidly emerging as a master regulator of human physiology. (ibecbarcelona.eu)
Immune1
  • Their hematopoietically-derived cells express beta1, beta2 and beta3 integrins, but defective inside-out signaling causes immune deficiency and bleeding problems. (ox.ac.uk)
Bone1
  • We demonstrate that α v β 3 integrin enhances BMDC recruitment and retention at angiogenic sites by mediating cellular adhesion and transmigration of BMDCs through the endothelial monolayer but not their release from the bone niche. (rupress.org)
Alpha1
  • Mutations affecting alpha(IIb)beta3 integrin cause the bleeding disorder termed Glanzmann's thrombasthenia. (ox.ac.uk)
Inflammation1
  • In' such Normal Terms, this international large Inflammation pulled anyway submitted, whereas crescent different human loss selection was Similar. (oldandelegant.com)