Human immune globulin. Medical search. Frequent questions

Rho(D) immune globulin is made up of antibodies to the antigen Rho(D) present on some red blood cells. (wikipedia.org)
citation needed] If a fetus is RhD positive and the mother is RhD negative, the mother is at risk of RhD alloimmunization, where the mother mounts an immune response (develops antibodies) to fetal red blood cells. (wikipedia.org)
Rh immune globulin is composed of IgG antibodies and therefore is able to cross the placenta. (wikipedia.org)
This medication is made from healthy human blood that has a high level of certain defensive substances ( antibodies ), which help fight infections. (webmd.com)
Human Rho(D) immune globulin is a solution of antibodies used to prevent isoimmunization of Rho(D) negative patients exposed to Rho(D) positive blood in pregnancy or transfusion. (drugbank.com)
Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the Rh0 (D) antigen (D antigen) under the name Rhophylac (IM/IV). (drugbank.com)
Immune globulin contains natural substances called antibodies (a type called IgG) that come from healthy human blood ( plasma ). (webmd.com)
Antibodies from different classes also differ in where they are released in the body and at what stage of an immune response. (wikipedia.org)
Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)
SYN: group i.. humoral i. i. associated with circulating antibodies, in contradistinction to cellular i.. infection i. the paradoxical immune status in which resistance to reinfection coincides with the persistence of the original infection. (theodora.com)
Intravenous Immune Globulin contains antibodies to tetanus and can be considered for treatment if TIG is not available. (slideserve.com)

We aimed to establish whether 10% caprylate-chromatography purified immune globulin intravenous (IGIV-C) has short-term and long-term benefit in patients with CIDP. (nih.gov)

Imogam Rabies-HT (rabies immune globulin, human). (drugs.com)

Human Rho(D) immune globulin therapy prevents immunization to Rho (D)-positive red blood cells (RBC) by inducing antibody-mediated immunosuppression (AMIS) effectively clearing Rho-positive RBCs by rapidly binding to them. (drugbank.com)
In the United States, passive immunization consists of administration of HRIG pooled from the sera of immunized human donors. (medscape.com)
Z28.03 Immunization not carried out because of immune compromised state of patient. (fortherecordmag.com)
The only treatment for human exposure to rabies is rabies specific immune globulin and rabies immunization. (abcactionnews.com)

Lexington, Mass. - November 16, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces the launch of CUVITRU [Immune Globulin Subcutaneous (Human), 20% Solution], the first and only Subcutaneous 20% treatment option without proline available in the U.S. to treat adult and pediatric patients (two years of age and older) with primary immunodeficiency (PI). (takeda.com)
The U.S. Food and Drug Administration (FDA) approved CUVITRU in September 2016 as a subcutaneous immune globulin (IG) replacement therapy for PI, a group of more than 300 genetic disorders in which part of the body's immune system is missing or functions improperly, in some cases making it more difficult to fight off infections. (takeda.com)
March 16, 2018 -- (Healthcare Sales & Marketing Network) -- Global biotherapeutics leader CSL Behring today announced that the U.S. Food and Drug Administration (FDA) approved Hizentra ( immune globulin Subcutaneous [Human] 20% Liquid) as the first and only subcutaneous immunoglobulin (SCIg) for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) as maintenance therapy to prevent relapse of neuromuscular disability and impairment. (salesandmarketingnetwork.com)
Hizentra ( immune globulin Subcutaneous [Human] 20% Liquid), the first 20 percent SCIg developed for subcutaneous use, is registered in over 51 countries and approved to treat certain immune deficiencies. (salesandmarketingnetwork.com)

Heat-treated and cold alcohol-fractionated immunoglobulin is derived from pooled human plasma from individuals immunized with human diploid cell rabies vaccine. (medscape.com)
One new product approved is Vaccinia Immune Globulin Intravenous (Human) (VIGIV), which contains vaccinia-specific immunoglobulin G (IgG) representative of immunized donors. (medscape.com)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
Octapharma USA today announced the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) has awarded seven years of marketing exclusivity for Octagam ® 10% [Immune Globulin Intravenous (Human)], the first and only intravenous immunoglobulin (IVIg) to be indicated for the treatment of adult dermatomyositis (DM). (octapharma.com)

Octagam, Immune Globulin Intravenous (Human) 5% Liquid Preparation Initial U.S. Approval: 2004 - These highlights do not include all the information needed to use Octagam, Immune Globulin Intravenous (Human), safely and effectively. (nih.gov)
Octagam is an immune globulin intravenous (human), 5% liquid, indicated for treatment of primary humoral immunodeficiency (PI) (1). (nih.gov)

Nevertheless, because immune globulins manufactured before 1985 were derived from plasma of human donors who were not screened for antibody to human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), CDC and the U.S. Food and Drug Administration (FDA) have received inquiries concerning the safety of immune globulin (IG), hepatitis B immune globulin (HBIG), and intravenous immune globulin (IVIG). (cdc.gov)
Studies performed before zidovudine became standard therapy found that intravenous immune globulin decreases the number of serious bacterial infections in these children. (soton.ac.uk)
We designed a multicenter study to evaluate the efficacy of intravenous immune globulin in children with advanced HIV infection who were receiving zidovudine. (soton.ac.uk)
METHODS: In a double-blind trial 255 children between 3 months and 12 years of age who had the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were randomly assigned to receive either intravenous immune globulin (400 mg per kilogram of body weight) (n = 129) or placebo (0.1 percent albumin) (n = 126) every 28 days. (soton.ac.uk)
CONCLUSIONS: In children with advanced HIV disease who are receiving zidovudine, intravenous immune globulin decreases the risk of serious bacterial infections. (soton.ac.uk)

Several epidemiologic and laboratory studies have shown that recipients of hepatitis B immune globulin (HBIG) and immune globulin (IG), including recipients of lots manufactured before April 1985, have not developed either antibody responses indicative of HIV infection or clinical illness associated with HIV infection (4). (cdc.gov)
Safety of therapeutic immune globulin preparations with respect to transmission of human T-lymphotropic (sic) virus type III/lymphadenopathy-associated virus infection. (cdc.gov)
This medication is used to strengthen the body's natural defense system ( immune system ) to lower the risk of infection in persons with a weakened immune system. (webmd.com)
KEDRAB is a human rabies immune globulin (HRIG) indicated for passive, transient post-exposure prophylaxis (PEP) of rabies infection to persons of all ages when given immediately after contact with a rabid or possibly rabid animal. (kedrab.com)
This medication is used to boost the body's natural defense system against infection in persons with a weakened immune system (primary immune deficiency). (webmd.com)
Rabies virus is by far the most common Lyssavirus infection in humans. (cdc.gov)
Infection from non-bite exposures (e.g., organ transplantation from infected humans) has occurred, but human-to-human transmission generally does not occur otherwise. (cdc.gov)
Globulins play an important role in liver function, blood clotting, and fighting infection. (medlineplus.gov)
Virus Infection in Human Immunodeficiency Virus/AIDS. (bvsalud.org)
Fatal Human Rabies Infection with Suspected Host-mediated Failure of Post-Exposure Prophylaxis Following a Recognized Zoonotic Exposure-Minnesota, 2021. (cdc.gov)
5 ]. Hepatitis C virus and human immuno- bodies we used a third generation enzyme deficiency virus (HIV) co-infection in hae- immunoassay (HCV EIA, United Biomedi- mophilia patients is common and causes a cal Inc., Hauppauge, New York). (who.int)

Immune globulins produced by plasma fractionation methods approved for use in the United States have not been implicated in the transmission of infectious agents. (cdc.gov)
ADMA manufactures its immune globulin products at its FDA-licensed plasma fractionation and purification facility located in Boca Raton, Florida. (biospace.com)

In predisposed patients, kidney malfunction and acute kidney failure, potentially fatal, can occur with the administration of human immune globulin intravenous (IGIV) products. (privigen.com)
Renal dysfunction, acute renal failure, osmotic nephropathy, and death may occur with the administration of immune globulin intravenous (Human) (IGIV) products in predisposed patients. (octapharma.com)

Raise platelet counts in patients over 15 with chronic immune thrombocytopenic purpura (ITP). (privigen.com)
Also indicated in Rh0(D)-positive, non-splenectomized adult patients with chronic immune thrombocytopenic purpura (ITP) to raise platelet counts. (drugbank.com)
Rho immune globulin increase platelet counts and reduce bleeding in Rho-positive patients with ITP by inhibiting autoantibody-mediated platelet clearance. (drugbank.com)

Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). (drugbank.com)

The two main types of blood proteins are globulins and albumin . (medlineplus.gov)

BACKGROUND: No rabies post-exposure prophylaxis (PEP) failure has been documented in humans in the United States using modern cell-culture vaccines. (cdc.gov)

Rho(D) immune globulin (RhIG) is a medication used to prevent RhD isoimmunization in mothers who are RhD negative and to treat idiopathic thrombocytopenic purpura (ITP) in people who are Rh positive. (wikipedia.org)
It was approved by FDA as treatment for suppression of rhesus (Rh) isoimmunization or chronic immune thrombocytopenic purpura (ITP) in adults. (drugbank.com)
Therapeutic efficacy of Rho (D) immune globulin in chronic immune thrombocytopenic purpura (ITP) may be explained by FcR blockade as well as the increase in the platelet count by substituting antibody-coated RBCs for antibodycoated platelets 2 . (drugbank.com)

The IG, HBIG, IVIG, and other special immune globulins used in the United States are produced by several manufacturers using the Cohn-Oncley fractionation process (1,2). (cdc.gov)
HBIG and other specific immune globulins (e.g., varicella-zoster IG) may be prepared from plasma pools from fewer donors. (cdc.gov)

Some side effects of rabies immune globulin, human may occur that usually do not need medical attention . (drugs.com)
Thrombosis (blood clotting) can occur with immune globulin products, including Privigen. (privigen.com)
Globally, about 59,000 human rabies deaths occur each year, and 98% of these deaths are caused by the canine (dog) rabies virus variant. (immunize.org)
Tens of millions of potential human exposures and tens of thousands of deaths from rabies occur each year. (cdc.gov)
4.7 million dog bites, 400 000 cat bites, and 250 000 human bites occur annually in the United States. (slideserve.com)

In controlled clinical trials, plasma exchange prevented or ameliorated neurological deficits, but the efficacy of immune globulin infusion remains unproved. (nih.gov)

and NABI-HB® (hepatitis B immune globulin, human) to provide enhanced immunity against the hepatitis B virus. (biospace.com)
Other vaccinations for adults include rubella, HPV (human papillomavirus), hepatitis A or B, and pneumococcus. (fortherecordmag.com)

Who should not take Immune Globulin,Gamma(Igg)Klhw Human 10 Gram/50 Ml(20%)Subcut Solution? (webmd.com)
There are different types of globulins called alpha, beta, and gamma globulins. (medlineplus.gov)

rabies immune globulin, human (RIG) decreases effects of BCG vaccine live by Other (see comment). (medscape.com)

On September 18, 1987, the Armed Forces Medical Logistical Office issued instructions to temporarily suspend from distribution and use in military hospitals one lot (RHG 636) of RhoGAM* Rho(D) Immune Globulin (human) (Rh-IG), manufactured by Ortho Diagnostic Systems, Inc. This action was taken because a woman on active duty who had received an injection from the lot was subsequently found to be infected with human immunodeficiency virus (HIV). (cdc.gov)
BACKGROUND: Serious bacterial infections are common in children infected with the human immunodeficiency virus (HIV). (soton.ac.uk)

It is suggested that Rho immune globulin predominantly prevents the antibody response during incompatible pregnancy by accelerating the phagocytosis of RBC's and clearance from the circulation before the recognition by the immune system. (drugbank.com)

A serum protein electrophoresis test measures the levels of the different types of globulins and other proteins in your blood. (medlineplus.gov)

Because KEDRAB is made from human plasma donors hyper-immunized with rabies vaccine, it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. (kedrab.com)
ADMA's mission is to manufacture, market and develop specialty plasma-derived, human immune globulins targeted to niche patient populations for the treatment and prevention of certain infectious diseases and management of immune compromised patient populations who suffer from an underlying immune deficiency, or who may be immune compromised for other medical reasons. (biospace.com)
specific i. the immune status in which there is an altered reactivity directed solely against the antigenic determinants (infectious agent or other) that stimulated it. (theodora.com)
Rabies is a zoonotic disease, an infectious agent that can be transmitted between animals and humans. (cdc.gov)

Rh-IG and other immune globulins used in the United States are produced by several manufacturers using one of the modifications of the Cohn-Oncley fractionation process (1,2), which has been shown to be effective in removing HIV by partitioning and inactivation (3). (cdc.gov)
Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma. (cdc.gov)

It is believed to work by blocking a person's immune system from recognizing this antigen. (wikipedia.org)
In response to the IgG-antigen complex formation, the immune globulin enhances the presentation of specific peptides and proliferation of epitope-specific T cells 4 . (drugbank.com)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
for exchange transfusions, for patients who require cytomegalovirus-negative blood that is unavailable, and possibly for the prevention of human leukocyte antigen (HLA) alloimmunization to help prevent refractoriness to platelet transfusion (failure to achieve the target level of blood platelets after platelet transfusion). (msdmanuals.com)

HDCV vaccine (Imovax, Sanofi) is produced in human diploid cell culture. (immunize.org)

However, these reports have focused on the entire non-specific immune diversity, and not directly on the cellular immunity specific to virus. (nature.com)

Patients who are getting immune globulin for the first time, those who are switched from another brand of immune globulin, or those who have not received immune globulin in the past 2 months may be at risk of developing fever, chills, nausea , vomiting , and rarely shock. (webmd.com)
Canadian Blood Services has shared an ambitious plan with governments outlining how we will ensure a safe and secure supply of plasma needed to manufacture immune globulin (Ig) for Canadian patients. (blood.ca)
The monkeypox virus is an orthopoxvirus which can spread from infected animals to humans and also from person to person through skin-to-skin contact with skin lesions or body fluids from patients with monkeypox. (cdc.gov)

KEDRAB administration may interfere with the development of an immune response to live attenuated virus vaccines. (kedrab.com)
KEDRAB can interfere with the immune response to the rabies vaccine. (kedrab.com)

They requested assistance with the epidemiologic investigation and patient treatment options, such as adjunctive therapy with anthrax immune globulin. (cdc.gov)

The two-year survival was similar in the two groups: 79.2 percent among immune globulin recipients and 75.4 percent among placebo recipients (P = 0.41). (soton.ac.uk)

This blood test measures the level of each type of protein in your blood, including the different types of globulins. (medlineplus.gov)
Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and human cell lines. (octapharma.com)

The rabies immune globulin (RIG) injection is administered with the first vaccine injection if it is a person's first time exposed to the virus. (cdc.gov)

The constant region at the trunk of the antibody includes sites involved in interactions with other components of the immune system. (wikipedia.org)

Also unknown is whether immune globulin infusion is as effective, or more effective, than plasma exchange and what dosages and frequencies are best. (nih.gov)
Plasma exchange (twice a week for 3 weeks then once a week for 3 weeks) and immune globulin infusion (0.4 gm/kg once a week for 3 weeks, then 0.2 gm/kg once a week for the next 3 weeks) were used. (nih.gov)

Globulins are a group of proteins in your blood. (medlineplus.gov)

Hizentra is currently approved in 51 countries for the treatment of certain immune deficiencies. (salesandmarketingnetwork.com)
February 12, 2021 - Pfizer announced the FDA approval of Panzyga (immune globulin intravenous, human - ifas), for the treatment of adults with chronic inflammatory demyelinating polyneuropathy (CIDP) to improve neuromuscular disability and impairment. (optumrx.com)
Ig therapy is a type of treatment that is infused into the body to help block the immune system from attacking the nerve myelin, though exactly how it works is not completely understood. (hizentra.com)
The use of Vaccinia Immune Globulin in the Treatment of Severe Mpox. (bvsalud.org)

Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. (privigen.com)
Previous severe reaction to human immune globulin. (empr.com)

Platelets are needed to stop bleeding and form blood clots .Some immune globulin products may also be used to treat certain types of muscle weakness problem ( multifocal motor neuropathy , dermatomyositis ) or a certain nerve disorder ( chronic inflammatory demyelinating polyneuropathy - CIDP ). (webmd.com)
Some immune globulin products may also be used to treat a certain nerve disorder ( chronic inflammatory demyelinating polyneuropathy - CIDP ). (webmd.com)

They weaken your immune system and decrease your body's. (healthplan.org)

Human RIG should be used concomitantly with the first dose of vaccine. (slideserve.com)

Rabies is a disease of the nervous system and is fatal to warm-blooded animals and humans. (abcactionnews.com)
The rabies virus is present in the saliva of infected animals and humans. (cdc.gov)

These agents promote immunity by inducing an active immune response. (medscape.com)
Immune, immunity. (theodora.com)

The question of safety arises out of concern that some immune globulins currently available were prepared from plasma pools that included units from donors who may have had HTLV-III/LAV viremia. (cdc.gov)
Immune globullin was purified via ion-exchange chromatography method and prepared from pools of human plasma, where the donors are Rho (D)-negative donors who have been immunized with Rho(D)-positive RBCs. (drugbank.com)

It is made from human blood plasma. (wikipedia.org)
In vitro studies of cytokine expression in human monocytes and granulocytes exposed to anti-D coated red blood cells have demonstrated enhanced secretion of interleukin 1 receptor antagonist resulting in down-regulation of FcγR mediated phagocytosis. (drugbank.com)
Globulin tests are blood tests. (medlineplus.gov)
There is no special preparation necessary for a globulin blood test. (medlineplus.gov)

Low globulin levels may be a sign of liver or kidney disease, or malnutrition . (medlineplus.gov)

In an RhD negative mother, RhIG can prevent temporary sensitization of the maternal immune system to RhD antigens, which can cause rhesus disease in the current or in subsequent pregnancies. (wikipedia.org)
Though your immune system generally keeps you healthy by fighting off germs, with CIDP, your immune system does not recognize parts of your nerves and attacks them. (hizentra.com)
Specifically, the immune system mistakenly attacks your nerves' protective myelin. (hizentra.com)
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
Many parents decide not to have their children vaccinated despite a child's immune system being more vulnerable without vaccinations. (fortherecordmag.com)
They are made in your liver by your immune system. (medlineplus.gov)
The levels of specific globulins provide information about how well your immune system is working. (medlineplus.gov)
So, this test can be used to diagnose disorders of the immune system , a type of cancer called multiple myeloma , and a variety of other conditions. (medlineplus.gov)
In addition, the health profile of the population has changed, because there are more citizens with immune system problems. (netce.com)
This is because the immune system will try to destroy the new organ. (healthplan.org)

Numerous, diverse lyssavirus variants are found in various animal species throughout the world, all of which can cause fatal human rabies. (cdc.gov)
After viral invasion of the PNS and then CNS, clinical illness in humans culminates in an acute, fatal encephalitis. (cdc.gov)

Anatomy24

Organisms22

Diseases38

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes37

Information Science3

Named Groups3

Health Care13

Geographicals1

Antibodies11

Caprylate-chromatography purified1

Imogam Rabies-HT1

Immunization4

Subcutaneous4

Immunoglobulin4

Octagam2

Intravenous immune5

Infection11

Plasma fractionation2

IGIV2

Platelet counts3

Intramuscular1

Albumin1

Post-exposure pr1

Thrombocytopenic purpura3

HBIG2

Occur5

Efficacy1

Hepatitis2

Gamma2

Decreases1

Immunodeficiency virus2

Antibody response1

Serum1

Infectious4

Fractionation2

Antigen5

Sanofi1

Specific immune1

Patients3

KedRab2

Anthrax1

Recipients1

Protein2

Injection1

Interactions1

Infusion2

Proteins1

Treatment4

Severe2

Products2

Body's1

Vaccine1

Animals and humans2

Immunity2

Donors2

Blood4

Kidney1

System10

Fatal2