Human hepatocyte nuclear factor upstream stimulatory factors. Medical search. Frequent questions

Tissue injury caused by pancreatitis toxins leads to the release of DAMPs - nuclear proteins (such as histones and HMGB1), nuclear and mitochondrial DNA, heat shock proteins, and ATP (60, 134). (pancreapedia.org)

MCT8 mutations are associated with X-linked mental retardation in humans and the cellular and molecular consequences of MCT8 knockdown during embryonic development in zebrafish provides new insight into the potential role of THs in this condition. (pharmaceuticalintelligence.com)
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (uchicago.edu)
No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY. (uchicago.edu)
Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. (uchicago.edu)
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature. (uchicago.edu)

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders. (biomedcentral.com)
Furthermore, the variants of APOA5 gene in human of different ethnic groups not only influence plasma TG concentration but also have an association with the prevalence of obesity or metabolic syndrome. (biomedcentral.com)

On the other hand, it is noteworthy that apoA5 could also modulate TG storage in hepatocytes [ 16 ], indicating a crucial intracellular role of apoA5. (biomedcentral.com)
T2DM is a complex trait where common genetic variants having modest individual effects act together and interact with environmental factors to modulate the risk of the disease. (scialert.net)

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

In the cell, T3 binds to a nuclear receptor, resulting in transcription of specific thyroid hormone response genes. (pharmaceuticalintelligence.com)
Maternal THs acted upstream of pax2a, pax7 and pax8 genes but downstream of shha and fgf8a signalling. (pharmaceuticalintelligence.com)
The latter pair inherits the state of its upstream master genes and further reinforces the decision due to several feedback loops, thereby leading to irreversible commitment. (lu.se)

Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, and Ludwig S. (2020) Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes. (uni-muenster.de)
Schloer S, Goretzko J, Pleschka S, Ludwig S, and Rescher U. (2020) Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection. (uni-muenster.de)
Wilden JJ, van Krüchten A, Gieselmann L, Hrincius ER, Deinhardt-Emmer S, Haupt KF, Preugschas HF, Niemann S, Ludwig S, and Ehrhardt C. (2020) The influenza replication blocking inhibitor LASAG does not sensitize human epithelial cells for bacterial infections. (uni-muenster.de)

In resting cells, the binding of members of the IκB family, such as the prototypical IκB member IκBα, to classical NF-κB complexes, particularly NF-κB1 p50-RelA and NF-κB1 p50-c-Rel dimers, inhibit the nuclear translocation of NF-κB complexes. (xiahepublishing.com)

The clinical significance of these events is highlighted by the utility of cytokine measurements in predicting outcome in human acute pancreatitis (116). (pancreapedia.org)

First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
Thus, targeting JAK1-2 with ruxolitinib blocks a final pathway that is common to multiple pro-angiogenic factors, suppresses EC-mediated PCC proliferation, and may be useful in PDACs with a strong pro-angiogenic signature. (oncotarget.com)

Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. (cancerindex.org)
We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27 individual donors. (bvsalud.org)
Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)

Mechanically, circIKBKB activated NF-κB pathway via promoting IKKβ-mediated IκBα phosphorylation, inhibiting IκBα feedback loop and facilitating NF-κB to the promoters of multiple bone remodeling factors. (biomedcentral.com)

Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)

Since adipocytes provide the largest storage depot for TG within the lipid droplets (LDs) in humans, studies have also illuminated apoA5 could target to adipocytes and regulate intracellular TG storage [ 17 , 18 ], thus exerting its beneficial effect against obesity. (biomedcentral.com)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)

Pancreatic ductal adenocarcinomas (PDACs) overexpress pro-angiogenic factors but are not viewed as vascular. (oncotarget.com)

The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. (scialert.net)

The mechanism underlying circIKBKB-mediated activation of NF-κB/bone remodeling factors signaling and EIF4A3-induced circIKBKB were investigated using RNA pull-down, luciferase reporter, chromatin isolation by RNA purification and enzyme-linked immunosorbent assays. (biomedcentral.com)
Currently, the clinical interventions for patients with BC-bone metastasis (BC-BM) are bisphosphonates (BPs) or denosumab (an anti-receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal antibody), which disrupt the vicious cycle by targeting osteoclasts [ 6 ]. (biomedcentral.com)

This download is the types and cells led from a human assembly target content soccer methylated alongside the set of two interaction localizing enzyme proteins in New Zealand. (evakoch.com)
3 In resting cells, the NF-κB dimer is inactive and is sequestered in the cytoplasm by binding to members of the κB inhibitory factor (IκB) family. (xiahepublishing.com)

LOAELs or NOAELs should also help in determining whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)

Thyrotropin, or thyroid-stimulating hormone (TSH), is one of a family of glycoprotein hormones including luteinizing hormone (LH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG) that share a common α-subunit and a unique β-subunit. (pharmaceuticalintelligence.com)

Freiburg is 26 lightening download volatility trading second edition humans that each are free heat first a pregnenolone, plus three low production Sensors. (evakoch.com)

In humans, dysfunctional adipocytes have been considered as an important pathophysiological basis of obesity and its related chronic metabolic diseases. (biomedcentral.com)

2. Forkhead box A1 (FOXA1) and A2 (FOXA2) oppositely regulate human type 1 iodothyronine deiodinase gene in liver. (nih.gov)
Together, these results provide evidence for a major regulatory function of this liver-enriched transcription factor in UGT1A1 activity in both rodents and human. (aspetjournals.org)
The role of gender in the regulation of human hepcidin gene expression in the liver is unknown. (wjgnet.com)
In addition, ATX expression was examined in normal human hepatocytes and liver cancer cell lines. (biomedcentral.com)
AB - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13 20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. (nih.gov)
Reticuloendothelial cells (macrophages in the bone marrow and spleen, Kupffer cells in the liver) and hepatocytes are two major areas of iron storage in humans. (ashpublications.org)

14. Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells. (nih.gov)
This review provides evidence that PCa initiation and progression are promoted by cow's milk, but not human milk, stimulation of mTORC1 signaling. (medscape.com)
The consequent activation of protein kinase B/Akt, nuclear factor-κB, and mitogen-activated protein kinase signaling cascades mediate the increased secretion of VEGF by tumor cells and the up-regulated VEGF receptor-2 expression in ECs. (oncotarget.com)

Nevertheless, the reported effects of Cd on tumor angiogenesis appear to be either stimulatory or inhibitory, depending on the concentrations. (oncotarget.com)
In contrast, low-lose Cd (1-10 μM) up-regulates vascular endothelial growth factor (VEGF)-mediated tumor angiogenesis by exerting sub-apoptotic levels of oxidative stress on both tumor cells and endothelial cells (ECs). (oncotarget.com)
Final common mediators of disease, including tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, are well studied and have yielded breakthrough therapeutics. (frontiersin.org)

HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)

PMID- 3894221 TI - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. (nih.gov)

8. Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans. (nih.gov)
Primary-structure analysis of the mouse Thymidine Adevice promoter revealed marked differences with its human homolog. (aspetjournals.org)
First, the mouse promoter lacks the highly polymorphic thymidine/adenine repeat occurring in the human promoter, which has been associated with some forms of hyperbilirubinemia. (aspetjournals.org)
Second, an L1 transposon element, which is absent in the human promoter, is found 480 bp upstream of the transcription start site in mouse. (aspetjournals.org)
Using the electromobility shift and DNase I footprinting experiments, we have identified a hepatocyte nuclear factor 1-binding site in the mouse UGT1A1 promoter that confers responsiveness to both factors HNF1α and HNF1β in HEK293 cells. (aspetjournals.org)

In the current study, we identified eukaryotic translation initiation factor 3 subunit H (EIF3H), belonging to the JAB1/MPN/MOV34 (JAMM) superfamily, as a bona fide deubiquitylase of O-GlcNAc transferase (OGT) in HCC. (bvsalud.org)

Epidemiological evidence points to increased dairy protein consumption as a major dietary risk factor for the development of PCa. (medscape.com)
2007). Finally, TRIF recruitment results in stimulation of the transcription factors IRF3 (interferon regulatory transcription factor 3), NF-κβ (nuclear factor-κβ) and AP-1 (activator protein 1) thought two different branches (Alexopoulou et al. (datexis.com)
Proteolysis-inducing factor (PIF), isolated from a cachexia-inducing murine tumour, has been shown to stimulate protein breakdown in C 2 C 12 myotubes. (nature.com)
This substance is capable of inducing muscle protein breakdown directly, both in vitro and in vivo ( Lorite et al, 1997 ), and has been named proteolysis-inducing factor (PIF). (nature.com)
Additionally, autoantibodies to rheumatoid factor (RF) and citrullinated protein are often present. (frontiersin.org)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
Advance your cancer research with our high-quality Recombinant Human SRC protein, also known as Proto-oncogene tyrosine-protein kinase Src and Proto-oncogene c-Src. (cusabio.com)
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However, persistent consumption of cow's milk proteins in humans provide highly insulinotropic branched-chain amino acids (BCAAs) provided by milk's fast hydrolysable whey proteins, which elevate postprandial plasma insulin levels, and increase hepatic IGF-1 plasma concentrations by casein-derived amino acids. (medscape.com)
These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)

3. Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. (nih.gov)

By contrast, when groups of mice that had received P. acnes were given endotoxin and bled, higher titres of tumour necrosis factor were found in the sera of L mice. (nih.gov)

Telomeres in most human cells shorten with each round of DNA replication, because they lack the enzyme telomerase. (theinterstellarplan.com)

disease_type A C177537 GDC Value Terminology C40206 Human Papillomavirus-Independent Cervical Adenocarcinoma, Gastric-Type Cervical adenocarcinoma characterized by the presence of gastric differentiation. (nih.gov)

This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. (nih.gov)
However, the functional role of ATX and the regulation of ATX expression in human hepatocellular carcinoma (HCC) remain elusive. (biomedcentral.com)
In this study, ATX expression was evaluated in tissues from 38 human HCC and 10 normal control subjects. (biomedcentral.com)

[ 9 ] suggested that high calcium intake might increase prostate carcinogenesis by lowering serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH) 2 D], they could not exclude a role of "additional cancer-promoting factors in the nonfat component" of dairy products. (medscape.com)

Inflammatory disorders underlie varieties of human diseases. (frontiersin.org)

2) The effect of main constituents on downstream targets in nuclear need more further investigation. (frontiersin.org)

4. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. (nih.gov)

therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C116377 Osimertinib A third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. (nih.gov)

The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)

This report highlights for the first time the clinical and biological evidence for the involvement of ATX in human HCC. (biomedcentral.com)

Anatomy4

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes13

Information Science2

Mitochondrial1

Mutations5

Gene3

Modulate2

Protein2

Genes3

20203

Complexes1

Cytokine1

Proliferation2

Cell3

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Exposure2

Studies2

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Bone2

Cells2

Health1

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Free1

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Liver6

Signaling3

Tumor3

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Macrophages1

Promoter5

Subunit1

Protein9

Proteins4

Transcription factors1

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Replication1

Differentiation1

Expression3

Role1

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Function1

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