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  • Tumor
  • Such tumor cells, either "resting" or slowly cycling, may have an increased resistance to therapeutic agents, and some of them are probably potential stem cells. (springer.com)
  • Subsequently we demonstrated that several members of LILRB family are expressed by tumor cells, including certain hematopoietic and solid cancer cells, and may directly regulate cancer development and relapse as well as the activity of cancer stem cells. (utsouthwestern.edu)
  • His research program is focused on understanding how human effector T cells are regulated in the context of autoimmune disease, alloimmunity, and tumor immunity. (sciencemag.org)
  • It has also shown expression on tumor-initiating cells from a number of different tissues. (fluidigm.com)
  • These cells appear to be more resilient to treatment than bulk tumor cells. (springer.com)
  • however, other surface markers, characteristics, and intracellular signaling have been found to be unique to this population of tumor cells. (springer.com)
  • New studies also indicate that CSCs may also have a distinct metabolic profile that distinguishes them from non-CSC tumor cells. (springer.com)
  • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (springer.com)
  • Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer. (springer.com)
  • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. (springer.com)
  • Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells. (springer.com)
  • engraftment
  • The expression of CD62L, HLA-DR and CD117 was modulated after culture, particularly with TPO + FL + KL, explaining differences between the adhesion and engraftment of primary and cultured candidate stem cells. (scielo.br)
  • adhesion
  • We determined if the altered expression of adhesion molecules during stem cell expansion could be a reason for the discrepancy. (scielo.br)
  • endothelial
  • Brain endothelial cells (BECs) form a major component of the blood-brain barrier (BBB). (physiology.org)
  • Tight junctions and adheren junctions form between brain endothelial cells (BECs) and limit paracellular movement of proteins and large hydrophilic molecules across the BBB (Abbott et al. (physiology.org)
  • cellular
  • They enable the rapid, selective movement of potassium ions through cellular membranes, thereby regulating physiological processes such as transmembrane ion passage and hormone secretion, vesicle cycling, and cell excitability. (frontiersin.org)
  • Histological examination showed acute focal tubular necrosis, the renal corpuscles showed thickened membranes, changes in Bowman's capsule parietal cells and effacement of podocyte foot processes and the interstitium showed mononuclear cellular infiltration. (lww.com)
  • Tissues
  • and (3) experimental approaches have usually neither allowed for any correlation between the structure of neoplastic tissues and therapeutic responses nor revealed the kinetic status of various Cell. (springer.com)
  • Voltage-gated potassium channels (Kv) are ubiquitously expressed in human tissues. (frontiersin.org)
  • tumors
  • Considering effective therapy, relatively slowly growing tumors possessing a large fraction of "nonproliferating" cells are of substantial concern. (springer.com)
  • Atkin , N. B. , 1970, Cytogenetic studies on human tumors and premalignant lesions: The emergence of aneuploid Cell. (springer.com)
  • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. (springer.com)
  • modulates
  • DNA methylation modulates HERV-E expression in CD4+ T cells from systemic lupus erythematosus patients," Journal of Dermatological Science , vol. 77, no. 2, pp. 110-116, 2015. (hindawi.com)
  • differentiate
  • EryP proliferate and differentiate synchronously to generate large nucleated red cells, which enter the circulation as the heart begins to beat at approximately E9.0. (bloodjournal.org)
  • gene
  • Delivery of ZFNs and donor templates results in high levels of gene correction in human CD34+ cells from multiple sources, including SCD BM. (bloodjournal.org)
  • Sickle-cell disease (SCD) is characterized by a single point mutation in the seventh codon of the beta-globin gene. (bloodjournal.org)
  • Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches. (nih.gov)
  • A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. (semanticscholar.org)
  • Anti-c-met U1/ribozyme gene transfer inhibited the ability of SF/HGF to protect against single-strand DNA breakage, DNA fragmentation, and glioblastoma cell death caused by DNA-damaging agents, demonstrating a requirement for c-met receptor function. (aacrjournals.org)
  • samples were collected
  • Five weeks after the start of the experiment, urine and blood samples were collected for biochemical investigation and kidney tissue was used for histological examination. (lww.com)
  • Journal
  • Thank you for sharing this Blood Journal article. (bloodjournal.org)
  • Message Body (Your Name) thought you would be interested in this article in Blood Journal. (bloodjournal.org)
  • HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates," The Journal of Clinical Investigation , vol. 122, no. 12, pp. 4473-4489, 2012. (hindawi.com)
  • Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation," The New England Journal of Medicine , vol. 360, no. 7, pp. 692-698, 2009. (hindawi.com)
  • malignant
  • At this time of increased efforts and promising results in the therapy of malignant neoplasias, it seems appropriate to review critically some principal aspects of Cell. (springer.com)
  • ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. (springer.com)