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  • HSCT
  • A case of pulmonary infiltrates and fever of unknown origin occurring in a hematopoietic stem cell transplant (HSCT) recipient was investigated using a modified version of the generic virus detection assay after conventional methods failed to identify a pathogen. (pubmedcentralcanada.ca)
  • MicroBeads
  • Cells are first labeled with a cocktail of biotin-conjugated antibodies against lineage-specific antigens (CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a (Glycophorin A)). These cells are subsequently magnetically labeled with Anti-Biotin MicroBeads. (miltenyibiotec.com)
  • functional
  • The resulting murine transgenic T cells were functional against murine tumor cell lines transduced with HLA-DR4, but it is unclear how this approach would work in human cells and on human tumors. (pnas.org)
  • Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. (aacrjournals.org)
  • Homing of HSPCs from bloodstream to bone marrow (BM) is an important aspect of HSPC biology that has remained unaddressed in efforts to derive functional HSPCs from human PSCs. (jci.org)
  • However, glycoengineered hiPS-HSPCs did not engraft long-term, indicating that additional functional deficiencies exist in these cells. (jci.org)
  • biology
  • However, translation of these findings into effective therapies for human diseases has been limited by the gap that exists between murine and human biology. (jimmunol.org)
  • stable
  • The goal of cancer immunotherapy is the generation of an effective, stable, and self-renewing antitumor T-cell population. (pnas.org)
  • system
  • Seven decades ago, scientists working on the Manhattan Project in the United States discovered that the hematopoietic system was the most radiation-sensitive tissue. (frontiersin.org)