Human hematopoietic stem and progenitor cells human hematopoietic stem cells blood stem cells. Medical search. Frequent questions

I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
and HCT/P establishments to help ensure the safety of the HCT/P supply and reduce the risk of Zika virus transmission through implantation, transplantation, infusion, or transfer of HCT/Ps to a human recipient. (cdc.gov)
These studies reveal potentially new therapeutic targets for recovery from anemia and regeneration of blood cells for transplantation. (ca.gov)
The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies Eds. (anthonynolan.org)
Both cells have common applications in various cell-based therapies such as tissue regeneration and transplantation. (differencebetween.com)
FYLNETRA is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation. (tarsadia.com)
However, sustained engraftment of the expanded cells was not observed after transplantation, suggesting ineffective expansion of hematopoietic stem cells with long-term repopulating activity (LTR-HSCs). (confex.com)
At optimal coating densities of Delta1, the frequency of LTR-HSCs measured by limiting dilution analysis 16 weeks after transplantation into NSG mice was 4.9- and 4.2-fold higher in hypoxic cultures (1 in 1,586 CD34+ cells) compared with uncultured cells (1 in 7,706) and the normoxia group (1 in 5,090), respectively. (confex.com)
Conversely, we observed no difference in expression of the homing CXCR4 receptor between cells cultured under normoxic and hypoxic conditions, indicating that hypoxia increased the absolute numbers of LTR-HSCs but not their homing potential after transplantation. (confex.com)
The occurrence of an immunologically mediated and injurious set of reactions by cells genetically disparate to their host, otherwise known as graft versus host disease (GVHD), is a phenomenon that has been described as the age of bone marrow and solid organ transplantation has emerged. (medscape.com)
Cord blood (CB) transplants offer several advantages namely the reduced need for HLA matching [thereby extending transplantation availability to nearly all patients (2)] and the decreased risk of chronic graft-versus-host disease the most important determinant of long-term quality of life in transplant patients. (gasyblog.com)
Created during the early stages of human development they have the potential to become specialised cells - such as red or white blood cells - which could be used to replace damaged or abnormal blood cells in an alternative to bone marrow transplantation. (planer.com)
The potential benefits of stem cell transplantation are that the cells are immediately available and, in the case of patient banking, genetically identical. (planer.com)
Moreover, HSPCs are of Major relevance for the establishment of successful hematopoietic stem cell transplantation (HSCT) strategies. (stemcell-lab-mk1dresden.de)
Transplantation of human organs and tissues1 saves many lives and restores essential functions in circumstances when no medical alternative of comparable effectiveness exists. (who.int)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Culture conditions of CD34(+) cells - either with or without mesenchymal stromal cells (MSCs) - had relatively little impact on DNAm, although proliferation is greatly increased by stromal support. (nih.gov)
This Technical Bulletin provides instructions for CRISPR-Cas9 genome editing and maintenance of human CD34 + cells, including optimized pre- and post-editing culture conditions and methods to evaluate genome editing efficiency. (stemcell.com)
While CRISPR-Cas9 technology has been successfully applied in numerous cell lines, its application in primary human CD34 + cells has been hampered by challenges in efficient expression and delivery of CRISPR-Cas9 components. (stemcell.com)
The ArciTect™ CRISPR-Cas9 RNP is then prepared and delivered into CD34 + cells using electroporation, and cells are plated in StemSpan™ SFEM II supplemented with StemSpan™ CD34 + Expansion Supplement post-electroporation. (stemcell.com)
Additionally, edited CD34 + cells can be further cultured in conditions stimulating lineage-specific differentiation by combining StemSpan™ media with expansion supplements designed for the expansion and differentiation of progenitors to erythroid, myeloid, megakaryocyte, natural killer (NK), or T cell lineages. (stemcell.com)
13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
We first optimized a serum-free, miniature erythroid differentiation system starting from primary human CD34 cells, the exact type of cells we would ultimately like to target in vivo ( Figure 1 ). (haematologica.org)
Human CD34 + hematopoietic stem and progenitor cells purified from umbilical cord or adult peripheral blood were cultured in a two-phase liquid culture system in a serum-free medium for 21 days. (haematologica.org)
CD135 is a 130-160 kD type III tyrosine kinase receptor expressed on CD34 + hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. (biolegend.com)
Expressed on CD34 + hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. (biolegend.com)
Expression of CD49d, CD184, and CD133 on CD34 + cells. (jamanetwork.com)
A, Representative fluorescence-activated cell-sorting dot plots showing the expression of CD49d on CD34 + cells from the peripheral blood (PB) and bone marrow (BM) of patients with multiple sclerosis treated with natalizumab (NAT). (jamanetwork.com)
For comparison, dot plots of granulocyte colony-stimulating factor (G-CSF)-mobilized CD34 + cells and BM-derived CD34 + cells of healthy control (HC) patients are shown. (jamanetwork.com)
B, Percentage of CD34 + cells expressing CD49d, CD184, and CD133 as measured by fluorescence-activated cell sorting. (jamanetwork.com)
Gray and black bars on the left side represent G-CSF-mobilized CD34 + cells from 5 HCs and PB-derived CD34 + cells from 17 patients with multiple sclerosis receiving NAT therapy. (jamanetwork.com)
Gray and black bars on the right side represent BM-derived CD34 + cells from 7 HCs and from 9 patients with multiple sclerosis treated with NAT. (jamanetwork.com)
Gray bars represent G-CSF-mobilized CD34 + cells and BM-derived CD34 + cells of HCs. (jamanetwork.com)
Black bars represent CD34 + cells of patients with multiple sclerosis treated with NAT. (jamanetwork.com)
Zohren F, Toutzaris D, Klärner V, Hartung HP, Kieseier B, Haas R. The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34 + hematopoietic progenitor cells in humans. (jamanetwork.com)
CD34 + progenitor cells mobilized by natalizumab are not a relevant reservoir for JC virus. (jamanetwork.com)
The expansion of HSPCs was evaluated through the total number of UCB mononuclear cells (MNCs) produced, their repopulating potential with the colony-forming unit assay (CFU-Cs) and CD34(+) phenotypic analysis with flow cytometry. (ox.ac.uk)
At the end of 7 days of culture, the UCB-MNCs, CFU-Cs and CD34(+) cells had achieved 18.7 +/- 1.6, 11.6 +/- 0.9 and 23.4 +/- 2-fold expansions, respectively, in the test groups. (ox.ac.uk)
Control (dimethyl sulfoxide DMSO) fed-batch cultures contained mostly differentiated cells (Fig. 2A DMSO) and a reduced frequency of CD34+CD45RA? (gasyblog.com)
Colony Forming Cell (CFU) Assay CD34+ cells were selected from HPDSCs with a human CD34 positive selection kit and isolated using automated cell separator RoboSep (StemCell Technologies, Inc., Vancouver, Canada). (ebat2018.org)

Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)
erythroid cells after in vitro differentiation, despite having similar frequencies of phenotypic HSC initially. (lu.se)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
TGF-β affects development and differentiation of human natural killer cell subsets. (sunnybrook.ca)
HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation. (sunnybrook.ca)
Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
Experiments revealed that the fusion protein activates unusual signaling pathways during PSC differentiation leading to changes in cycling and survival of the red cells. (ca.gov)
Unlimited self renewal capacity and differentiation potential make human pluripotent stem cells (PSC) a promising source for the ex vivo manufacture of red blood cells (RBC) for safe transfusion. (ca.gov)
We present here evidence that ic-MPL dimerization induces erythropoietin (EPO)-independent erythroid differentiation from hESC by inducing the generation of erythroid progenitors and by promoting more efficient erythroid maturation with increased RBC enucleation as well as increased gamma:epsilon globin ratio and production of beta-globin protein. (ca.gov)
Stromal cell CD9 regulates differentiation of hematopoietic stem/progenitor cells. (bdbiosciences.com)
Leucocyte Typing III: White Cell Differentiation Antigens. (bdbiosciences.com)
CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. (biolegend.com)
These cells evolve from the differentiation of neural progenitor cells (NPCs). (differencebetween.com)
They play a role in cell development and differentiation. (differencebetween.com)
In phase 2 (Donor-T-cell activation, differentiation, and migration), the infused donor T lymphocytes are responsible for triggering GVHD and proliferate after activation by the recipient antigens expressed on host cells. (medscape.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)

HSCs develop into different types of blood cells in lines called myeloid and lymphoid , which are involved in dendritic cells formation. (differencebetween.com)
Lymphoid cells include T cells, B cells, innate lymphoid cells, and natural killer cells. (differencebetween.com)
These multipotent progenitor cells differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor cells (CLP). (differencebetween.com)
Hematopoiesis is disrupted profoundly, with a reduction of hematopoietic stem cells and common lymphoid progenitors causing a severely depleted acquired immune system. (ox.ac.uk)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)

It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Arrow in first panel points to an endothelial cell induced to become hematopoietic stem cell (HSC). (nih.gov)
In the second, researchers employed another approach to convert mature mouse endothelial cells, which line the inside of blood vessels, directly into self-renewing HSCs. (nih.gov)
As reported in Nature , both teams took advantage of earlier evidence showing that HSCs are formed during embryonic development from budding endothelial cells in the aorta. (nih.gov)
However, the biochemical signals, or recipes, driving that natural conversion of endothelial cells into HSCs weren't known. (nih.gov)
To test them out, the researchers first used a previously defined protocol to convert human iPSCs into endothelial cells similar to those known to produce HSCs during development. (nih.gov)
They then tested the capacity of those 26 transcription factors in different combinations to coax endothelial cells into producing HSC-like cells. (nih.gov)
They ultimately narrowed down the recipe to a combination of seven transcription factors that were sufficient to convert the iPSC-derived endothelial cells to immature HSC-like cells. (nih.gov)
In the parallel study, Raphael Lis and Shahin Rafii from Weill Cornell Medicine, New York, began with readily accessible endothelial cells taken from the organs of adult mice. (nih.gov)
Bypassing the pluripotent state, in which stem cells are still capable of producing several different cell types, the researchers showed that expression of only four transcription factors was sufficient to convert the adult endothelial cells into long-lasting HSCs. (nih.gov)
Lis and Rafii instead grew the emerging mouse HSCs on a layer of endothelial cells in a dish, where they acquired the attributes of fully functional HSCs, and later were transplanted into mice. (nih.gov)
Among the remaining cells, several different cell types are recognized, including hematopoietic stem cells, mesenchymal stem cells (MSCs), megakaryocytic precursors, and endothelial progenitors. (ebat2018.org)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)

Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses stemness during culture. (nih.gov)
In brief, my research team uses cutting edge imaging, clonal tracking (cellular barcoding), genomics technologies, and functional assays (in vivo and in vitro) to tackle long-standing questions about the biology of blood production. (edu.au)
A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
Progenitor cell function may be measured post-modification by in vitro CFU assays. (stemcell.com)
Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors. (sunnybrook.ca)
Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. (sunnybrook.ca)
The Procleix® Ultrio Elite Assay is a qualitative in vitro nucleic acid amplification test to screen for human immunodeficiency virus type 1 (HIV-1) RNA,hepatitis C virus (HCV) RNA, and/or hepatitis B virus (HBV) DNA, and detect human immunodeficiency virus type 2 (HIV-2) RNA in plasma and serum specimens from individual human donors, including donors of whole blood, blood components, and source plasma, and from other living donors. (fda.gov)
Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
An ideal transduction protocol should determine high gene marking in long-term self -renewing hematopoietic stem cells (HSCs), preserving their repopulation potential during in vitro manipulation. (bvsalud.org)
The addition of PGE2 shortly before transduction of human CD34+ cells determined a significant transduction increase in the in vitro cell progeny paralleled by a significant reduction of their clonogenic potential. (bvsalud.org)
02:47 and red blood cells in vitro. (yale.edu)
Latest studies demonstrated that aryl hydrocarbon receptor (AhR) antagonists and a notch ligand agonist promote the in vitro enlargement of individual CB cells with repopulating activity long lasting up to 16 weeks in immunodeficient mice (7 8 We created an computerized and continuous moderate delivery program that creates an equivalent enlargement of CB cells with equivalent repopulation properties (9). (gasyblog.com)

The ability to genetically manipulate hematopoietic stem and progenitor cells (HSPCs) in particular has significantly advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. (stemcell.com)
Melinda Tursky has specialised in the field of normal and malignant human hematopoiesis and has a strong translational interest in the pathogenesis of hematological cancers. (edu.au)
CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function. (jamanetwork.com)

HCT/Ps such as amnion/chorion hematopoietic stem/progenitor cells from cord blood and peripheral blood, and reproductive tissues such as semen and oocytes, have the potential for harboring Zika virus. (cdc.gov)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
This assay is not intended for use on cord blood specimens. (fda.gov)
It is also intended for use in testing pools of human plasma and pools of human serum composed of equal aliquots of not more than 16 individual specimens from donors of whole blood, blood components, hematopoietic stem/progenitor cells sourced from bone marrow, peripheral blood or cord blood, and from donors of donor lymphocytes for infusion. (fda.gov)
We have previously shown that homo-dimerization of the intracellular component of MPL (ic-MPL) induces erythropoiesis from human cord blood progenitors. (ca.gov)
Notably, autologous cord blood mononuclear cells (ACBMNCs) can substantially prevent severe BPD and decrease the inflammatory response in surviving very preterm neonates. (spandidos-publications.com)
Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
Subsequently, the association between cord blood Angptl7 levels and BPD incidence in a cohort of very preterm neonates was assessed (cohort 2). (spandidos-publications.com)
In cohort 2, the cord blood Angptl7 levels were significantly lower in infants who later developed BPD. (spandidos-publications.com)
In conclusion, the anti‑inflammatory and proangiogenic effects of Angptl7 derived from cord blood stem cells may ameliorate BPD severity. (spandidos-publications.com)
Our previous study demonstrated that autologous cord blood mononuclear cells (ACBMNCs), which are rich in stem cells, could substantially prevent moderate or severe BPD in surviving very preterm neonates, and that the immunomodulatory effect of MNCs contributed in mitigating the severity of BPD ( 13 ). (spandidos-publications.com)
Stem cell work is still quite experimental but is very promising as many beneficial therapies are thought to exist with much scientific value being ascribed to cord blood and its cells. (ndtv.com)
Human cord blood contains a large number of haematopoietic progenitor cells that can be used as a source of stem cells for treatment of blood disorders and cancers. (ndtv.com)
Kilbride P, Meneghel J, Lamb S, Morris J, Pouzet J, Jurgielewicz M, Leonforte C, Gibson D, Madrigal A. Recovery and Post-Thaw Assessment of Human Umbilical Cord Blood Cryopreserved as Quality Control Segments and Bulk Samples. (anthonynolan.org)
Effective expansion of umbilical cord blood hematopoietic stem/progenitor cells by regulation of microencapsulated osteoblasts under hypoxic condition. (ox.ac.uk)
The expansion of hematopoietic stem/progenitor cells (HSPCs) from umbilical cord blood (UCB) with the support of microencapsulated osteoblasts under hypoxia environment was investigated. (ox.ac.uk)
The small amount of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. (gasyblog.com)
The cord blood sample is tested for bacterial and fungal infections, and the mother's blood is also tested. (planer.com)
The cord blood is tested for antigens, unique immune system markers, and is then controlled rate frozen prior to cryo storage at -196 C. Transplanted cord blood stem cells theoretically pose a lower risk of graft versus host problems because cord blood stem cells will not yet have fully developed antigen markers. (planer.com)
Over twenty public tissue storage banks have been established in the United States to collect, store, and distribute donated cord blood and there are some thirty private ones. (planer.com)
In the UK there are some six principle private companies that offer cord blood banking. (planer.com)
A leading UK independent bio storage facility, BioVault, insists on accurate controlled rate freezing in the preparation of cord blood samples before liquid nitrogen storage. (planer.com)
Human stem-progenitor cells from neonatal cord blood have greater hematopoietic expansion capacity than those from mobilized adult blood. (musc.edu)
Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells. (ox.ac.uk)
The intrinsic functional differences between quiescent and dividing CD34+ HSPCs prompted us to determine whether fresh or cytokine-induced cord blood-derived CD34+ HSPCs are a more appropriate normal control compared to AML blasts. (ox.ac.uk)

The CD9 antibody, clone M-L13, is derived from the hybridization of mouse myeloma cells with spleen cells isolated from mice immunized with common acute lymphoblastic leukemia (cALL) cells. (bdbiosciences.com)
Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
Bone marrow transplants offer a way to cure leukemia, sickle cell disease, and a variety of other life-threatening blood disorders.There are two major problems, however: One is many patients don't have a well-matched donor to provide the marrow needed to reconstitute their blood with healthy cells. (nih.gov)
Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells. (utsouthwestern.edu)
In my first paper, we describe the entire antibody discovery process where we developed antibodies capable of depleting chronic lymphocytic leukemia (CLL) cells using primary cells obtained from patients. (lu.se)
CLL is considered the most common form of leukemia in adults and is a type of cancer that starts in white blood cells, known as lymphocytes. (lu.se)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
The Working Group was not aware of any good rodent models that simulate the occurrence of acute myeloid leukemia in humans. (who.int)
Therefore, on the basis of the data available at this time, it was not possible to identify a mechanism for the induction of myeloid leukemia in humans. (who.int)
Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms related to cytopenias. (msdmanuals.com)
The current approach to classifying leukemia is based on the 2016 World Health Organization (WHO) system ( classification for hematopoietic neoplasms ). (msdmanuals.com)
People with PDGFRA -associated chronic eosinophilic leukemia can also have an enlarged spleen (splenomegaly) and elevated levels of certain chemicals called vitamin B12 and tryptase in the blood. (medlineplus.gov)
Some people with PDGFRA -associated chronic eosinophilic leukemia have an increased number of other types of white blood cells, such as neutrophils or mast cells. (medlineplus.gov)
Occasionally, people with PDGFRA -associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (medlineplus.gov)
When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in blood cell precursors, the growth of eosinophils (and occasionally other blood cells, such as neutrophils and mast cells) is poorly controlled, leading to PDGFRA -associated chronic eosinophilic leukemia. (medlineplus.gov)

Stored blood from umbilical cords is also a promising source of haematopoietic progenitor cells - the type of stem cells found in bone marrow and peripheral blood. (planer.com)

Notch activation in human CD34+ hematopoietic stem/progenitor cells (HSPCs) by treatment with Delta1 ligand has enabled clinically relevant ex vivo expansion of short-term HSPCs. (confex.com)
Hematopoietic stem and progenitor cells (HSPCs) are crucial for the maintenance of homeostasis of all blood lineages in human. (stemcell-lab-mk1dresden.de)
Hematopoietic stem and progenitor cells (HSPCs) isolated from human blood are frequently used as a normal comparator in AML studies. (ox.ac.uk)
This was confirmed by comparing the cell cycle status of the AML blasts and the HSPCs. (ox.ac.uk)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

Hematopoietic stem cells (HSCs) are immature cells found in the peripheral blood and bone marrow. (differencebetween.com)
Here, a combination of different cell surface markers is used to separate the rare HSCs. (differencebetween.com)
To corroborate these findings molecularly, we performed transcriptomic analyses and found significant upregulation of a distinct HSC gene expression signature in cells cultured with Delta1 in hypoxia (Fig. A). Collectively, these data show that hypoxia supports a superior ex vivo expansion of human HSCs with LTR activity compared with normoxia at optimized densities of Delta1. (confex.com)
To clarify how hypoxia improved Notch-mediated expansion of LTR-HSCs, we performed scRNA-seq of CD34+ cells treated with Delta1 under normoxic or hypoxic conditions. (confex.com)
Hypoxia lessened the cellular stress response in both progenitors and HSCs, but the mitigation was more apparent in the HSC population (Fig. C, grey plots), and decreased apoptosis was observed only within the HSC-enriched cluster 5 (Fig. D). These findings are consistent with several reports indicating that HSCs are more vulnerable to strong ER stress than downstream progenitors due to their lower protein folding capacity. (confex.com)
However CB transplants suffer from limited progenitor cell dose leading to delayed neutrophil engraftment and increased mortality (3 4 Recent studies in immunodeficient mice have confirmed the presence of human CB-derived long-term-repopulating hematopoietic stem cells (LT-HSCs) capable of regenerating the lifelong production of all mature blood cells (5). (gasyblog.com)
These LT-HSCs show a delayed engraftment pattern in opposition to short-term HSCs (ST-HSCs) that produce short-lived progenitors responsible for the production of mature blood cells and prompt neutrophil recovery (3 5 Hence there is great interest in the development of conditions for robustly expanding these progenitor cells while maintaining or expanding LT-HSCs. (gasyblog.com)
mobilized peripheral bloodstream (mPB) cells that are enriched in LT-HSCs (10) (fig. S1 B) and A. Seven hits had been determined after excluding the autofluorescent substances (Fig. 1A and fig. S1C) five which had been known [four (11 12 or previously unidentified (one UM125454 fig. S2) suppressors from the AhR pathway (Fig. 1B). (gasyblog.com)
cells (10) (Fig. 1D and fig. S3 B) and A. UM729 didn't broaden mouse HSCs (fig. S4). (gasyblog.com)
To address this challenge, researchers have been trying to develop reliable, lab-based methods for making the vital, blood-producing component of bone marrow: hematopoietic stem cells (HSCs). (nih.gov)
When these HSCs were transplanted into mice, they fully reconstituted the animals' blood systems with healthy red and white blood cells. (nih.gov)
Those HSCs ultimately find their way into the bone marrow, where they produce a lifetime supply of blood cells. (nih.gov)
Both groups relied on external signals to encourage the immature HSCs or HSC-like cells to mature into self-renewing stem cells that no longer needed any assistance from the researchers to continue growing and producing various types of blood cells. (nih.gov)

MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. (sunnybrook.ca)
These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and cell survival. (medlineplus.gov)
As a result, the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells. (medlineplus.gov)

Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. (lu.se)
03:06 cell functionally in FINA? (yale.edu)

D) Representative flow cytometry plots of cells stained with fluorescein isothiocyanate (FITC)-conjugated anti-CD71 and phycoerythrin (PE)-conjugated anti-CD235a antibodies, demonstrating sequential expression of CD71 followed by CD235a and subsequent loss of CD71. (haematologica.org)
Results HPDSCs Are Rich in Both Hematopoietic and Nonhematopoietic Stem Cells The overall cell types as determined by flow cytometry analysis are comparable between HPDSCs and UCB. (ebat2018.org)

are a group of clonal hematopoietic stem cell disorders unified by the presence of distinct mutations of hematopoietic stem cells. (msdmanuals.com)
The somatic mutation occurs initially in a single cell, which continues to grow and divide, producing a group of cells with the same mutation (a clonal population). (medlineplus.gov)

Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. (wikipedia.org)
The International Journal of Biochemistry & Cell Biology. (wikipedia.org)
In 2011, I started my own laboratory at WEHI with a consistently innovative research program focused on the biology of blood production and function. (edu.au)
Currently, the majority of in vivo investigations to understand malaria biology are dependent upon rodent malaria species ( P. berghei and P. yoelii ) which are used as surrogates to study human malaria ( 3 - 6 ). (frontiersin.org)
Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)
CRISPR-Cas9, an RNA-guided genome editing technology, is revolutionizing cell biology due to the ease and efficiency by which it enables genetic manipulation of mammalian cells. (stemcell.com)

Fatal sickle cell crises: Serious sickle cell crises have been reported in patients with sickle cell disorders receiving FYLNETRA. (tarsadia.com)
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders. (nature.com)
The precise pathophysiology of inherited single cell and multilineage cytopenias has not been elucidated despite the identification of many of the genes mutated in these disorders. (medscape.com)

The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. (sunnybrook.ca)
Context-dependent regulation of hematopoietic lineage choice by HEBAlt. (sunnybrook.ca)
Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)

Progenitor cells are an intermediary step in the development of mature cells in tissues, organs, blood, and the central nervous system. (differencebetween.com)
Therefore, progenitor cells are necessary for repairs and to maintain tissues after an injury. (differencebetween.com)
They can create new tissues and even whole organs from a few stem cells. (differencebetween.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
We show that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues. (ox.ac.uk)
In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. (biolegend.com)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
50 × 10 9 /L) not caused by malignant transformation of a hematopoietic stem cell. (msdmanuals.com)

Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)

Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
Angptl7 has been shown to be one of the most abundant paracrine cytokines secreted by stem cells, which is capable of stimulating human hematopoietic stem and progenitor cell expansion ( 15 , 16 ). (spandidos-publications.com)
In our previous study, it was revealed that Angptl7 was capable of stimulating human hematopoietic stem and progenitor cell expansion, and increasing the repopulation activities of human hematopoietic progenitors ( 15 , 16 ). (spandidos-publications.com)

Once transplanted in vivo in a competitive repopulation assay, human CD34+ cells transduced with PGE2 contributed significantly less than cells transduced with a standard protocol to the repopulation of recipient mice , indicating a relative repopulation disadvantage of the PGE2 -treated CD34+ cells and a counter-selection for the PGE2 -treated cell progeny in vivo. (bvsalud.org)
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. (nature.com)
To investigate the in vivo trafficking of HPDSCs, peripheral blood and organs including lung, spleen, bone marrow, GI, and skin were isolated from your recipient RDEB mice on different days Fraxinellone after HPDSC administration. (ebat2018.org)
In addition there is a lack of information regarding the presence of mast cells in dental pulp of rats, which are animals used to study important aspects of the pathophysiology of dental pulp in vivo 6 . (bvsalud.org)

The Human Pluripotent Stem Cell facility continuously evaluates emerging technologies and is now offering both feeder-based and feeder-free cultures in chemically defined mTeSR or in N2/B27 media. (einsteinmed.edu)
Reprogramming of fibroblasts or blood cells into Induced human pluripotent stem cell (iPSCs). (einsteinmed.edu)

Fig. 1 Identification of previously unknown compounds promoting human CD34+ cell growth AZD6244 (Selumetinib) Optimization of fed-batch culture period indicated that the highest growth of multipotent progenitors and long-term culture-initiating cells (LTC-ICs) was obtained on day 12 (fig. S3 C AZD6244 (Selumetinib) to E). Similarly the proportion of apoptotic cells was lower at that time when compared with day 16 (fig. S3F). (gasyblog.com)

Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). (lu.se)
The cells gave rise to all major blood lineages, including red blood cells, B cells, and T cells. (nih.gov)
These may be classified into those that result in pancytopenia and those limited to failure of 1 or 2 hematopoietic lineages. (medscape.com)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. (sunnybrook.ca)
HEBAlt enhances the T-cell potential of fetal myeloid-biased precursors. (sunnybrook.ca)
1 The accumulation of free excess α-globin chains in red blood cells and their precursors, as a result of the decreased production of β-globin, is believed to be the main pathophysiological mechanism leading to hemolytic anemia and ineffective erythropoiesis in β-thalassemia. (haematologica.org)

Graft-versus-host reaction occurs when donor immune cells recognize disparate host antigens. (medscape.com)

CD133+ melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence. (wikipedia.org)
Most clusters could be computationally assigned to a defined hematopoietic subpopulation, including progenitor cells (clusters 0 to 4) and a single transcriptionally defined HSC population (cluster 5). (confex.com)
Specifically, a subpopulation of cells with a phenotype of CD34+/CD45? (ebat2018.org)

Significant human RBC engraftment was achieved by ameliorating the residual non-adaptive immune response using clodronate-loaded liposome treatment. (frontiersin.org)
Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells. (bvsalud.org)
Autologous graft versus host disease (GVHD) involving the skin of a patient's arm shortly after showing signs of engraftment after an autologous peripheral blood stem cell transplant for ovarian cancer. (medscape.com)
UM729 and AZD6244 (Selumetinib) UM171 treatment improved the engraftment potential of Compact disc34+ macaque cells by threefold when compared with controls (fig. S5). (gasyblog.com)

Balassa K, Danby R, Rocha V. Haematopoietic stem cell transplants: principles and indications. (anthonynolan.org)
Autologous bone marrow transplants in cancer treatment have been used for some thirty years - and Planer, of Sunbury, UK, pioneered controlled rate freezing of the cells - an essential step prior to cryogenic storage. (planer.com)
In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)

The key difference between hematopoietic stem cells and progenitor cells is that hematopoietic stem cells have the ability to differentiate into different types of cells while progenitor cells are more specific and they differentiate into target cells. (differencebetween.com)
Progenitor cells are descendants of stem cells that further differentiate into specialized cell types. (differencebetween.com)
Progenitor cells are the cells that originate from stem cells and further differentiate to create specialized cell types. (differencebetween.com)
Some cells differentiate into targeted cells, while other cells have the ability to differentiate into more than one type of cell. (differencebetween.com)
Hematopoietic stem cells differentiate into multipotent progenitor cells. (differencebetween.com)
On the other hand, progenitor cells are more specific than hematopoietic stem cells and can differentiate into target cells. (differencebetween.com)

In addition, the red cells produced are of an immature type, expressing mostly embryonic rather than adult hemoglobin. (ca.gov)
Human adult mobilized CD34+ cells were cultured for 21 days under normoxia (21% O 2 ) or hypoxia (2% O 2 ) in vessels coated with optimized concentrations of Delta1. (confex.com)

Chronic leukemias have more mature cells than do acute leukemias. (msdmanuals.com)

AKT activation upregulates the GATA-1 and FOXO3 transcriptional pathways with resulting inhibition of apoptosis, modulation of cell cycle and enhanced maturation of erythroid cells. (ca.gov)
CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis. (bdbiosciences.com)
Accelerated hematopoietic cell apoptosis has been demonstrated in virtually all IBMFS. (medscape.com)

CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. (wikipedia.org)
The study is an interdisciplinary effort to generate safe and effective chimeric antigen receptor (CAR)-T cell therapy for cancer that will be done by doing a deep-dive into understanding the relationship between the metabolism and anti-tumor functions of CAR-T cells. (uclahealth.org)
Ashton JJ, Latham K, Beattie RM, Ennis S. Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease. (anthonynolan.org)
These cytokines further activate host antigen-presenting cells (APCs). (medscape.com)

Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. (nature.com)
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. (nature.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. (ca.gov)
The goal of the present study was to investigate the potential of ic-MPL dimerization to induce erythropoiesis from human embryonic stem cells (hESC) and to identify the signaling pathways activated by this strategy. (ca.gov)
The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)

Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Clinical efficacy is currently limited to bone marrow transplant, grafting new skin cells to treat burns, regenerating cornea in visually impaired, etc. (ndtv.com)
Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone imaging changes. (tarsadia.com)
Bone-marrow-derived progenitors actively engage DNA repair but also imprint a formaldehyde-driven mutation signature similar to aging-associated human cancer mutation signatures. (ox.ac.uk)
Daley's team matured those human HSC-like cells by transplanting them directly into the bone marrow of living mice. (nih.gov)
In the mice, stem cells generated using both approaches took up residence in the bone marrow as expected. (nih.gov)
The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
[ 1 , 2 ] The remainder of the blood supply is through nutrient vessels that pierce the cortex and supply the marrow cavity and the inner two thirds of the cortical bone. (medscape.com)
15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)

Approximately half of congenital SNHL is hereditary and is the result of genetic mutations causing improper development of cochlear hair cells. (intechopen.com)
Genetic rearrangements and point mutations affecting the PDGFRA gene are somatic mutations, which are mutations acquired during a person's lifetime that are present only in certain cells. (medlineplus.gov)

Mechanistically, we identified dysregulated erythropoiesis with reduced numbers of reticulocytes, the preferred host cells of P. yoelii , in Ac-deficient mice. (elifesciences.org)
The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
During erythropoiesis, the cells start to produce hemoglobin, lose nuclei and organelles, and induce plasma membrane remodeling. (elifesciences.org)

[ 2 ] In 1966, Billingham proposed 3 conditions required for the development of GVHD, as follows: (1) the graft must contain immunologically competent cells, (2) the host must possess important transplant alloantigens that are lacking in the donor graft so that the host appears foreign to the graft, and (3) the host itself must be incapable of mounting an effective immunologic reaction against the graft. (medscape.com)

We identified 6 distinct clusters (clusters 0 to 5) in dimension-reduction (UMAP) analysis, with a comparable distribution of cells per cluster between normoxic and hypoxic cultures. (confex.com)

In both cell sources, greater than 80% of the cells are lymphocytes, monocytes, or granulocytes. (ebat2018.org)

Macrophages are strongly adherent and are not effectively dislodged from culture surfaces by standard enzymatic cell dissociation reagents. (sigmaaldrich.com)
It was especially designed for the gentle release of adherent macrophages and guarantees the best possible cell viability, even after prolonged exposure times. (sigmaaldrich.com)

Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. (bdbiosciences.com)
GVHD from passive transmission of immunocompetent maternal cells has also been described in neonates with severe immunodeficiency. (medscape.com)

Hematopoietic progenitor cells (HPCs) are also intermediates in the development of blood cells. (differencebetween.com)

The human malaria parasite was accountable for 4,45,000 deaths in the 2016 ( 1 ). (frontiersin.org)
Cell Stem Cell 19 , 569-572 (2016). (nature.com)

In mice the vaccination with CD133+ melanoma cells mediated strong anti-tumor activity that resulted in the eradication of parental melanoma cells. (wikipedia.org)
Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. (frontiersin.org)
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans. (ox.ac.uk)

Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
Therefore, C9-M and C9-C (Rescued phenotype of wild-type growth by genetic complementation) parasites ( 26 ) showed the attenuation in PF13_0027 knock-out parasites (C9-M) growth, which in turn resulted in the irregular cell cycle. (frontiersin.org)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)

Bonig H, Wundes A, Chang KH, Lucas S, Papayannopoulou T. Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab. (jamanetwork.com)

We observed enhanced progenitor cell activity within the CD34+ cell population treated with Delta1 in hypoxia, but the benefits provided by low-oxygen cultures were most notable in the primitive HSC compartment. (confex.com)
To assess the relative impact of normoxia and hypoxia on the HSC compartment, we performed gene set enrichment analysis (GSEA) of cells within HSC cluster 5 from each culture condition. (confex.com)

The CD9 antibody recognizes a 24-kilodalton (kDa) cell surface glycoprotein belonging to the tetraspanin family. (bdbiosciences.com)
Anti-CD9 monoclonal antibody activates p72syk in human platelets. (bdbiosciences.com)

In this paper we found that if we introduced a synthetic "fusion" protein into PSC, we could produce significantly more red cells in culture and that those cells were also more mature. (ca.gov)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)

Hematopoietic stem cells are immature cells that develop into all types of blood cells. (differencebetween.com)
consist of predominantly immature, poorly differentiated cells (usually blast forms). (msdmanuals.com)

Anatomy47

Organisms15

Diseases27

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Named Groups5

Health Care7

Transplantation21

CD3425

Differentiation19

Lymphoid5

Endothelial22

Vitro12

Hematopoiesis3

Cord25

Leukemia15

Umbilical1

HSPCs4

Abstract1

HSCs13

Proliferation3

Functionally2

Flow cytometry2

Clonal2

Biology6

Disorders3

Lineage6

Tissues6

Malignant4

Allogeneic3

Expansion3

Vivo4

Pluripotent stem2

Multipotent progenitors1

Lineages4

Precursors3

Antigens1

Subpopulation3

Engraftment4

Transplants3

Differentiate6

Adult2

Acute1

Apoptosis3

Antigen4

Embryonic11

Marrow14

Myeloid cells6

Mutations2

Erythropoiesis3

Donor1

Distinct1

Lymphocytes1

Macrophages2

Immunodeficiency2

HPCs1

20162

Mice4

Genetic3

Chronically1

Hypoxia2

Antibody2

Significantly2

Immature2