• ADCs combine the targeting properties of monoclonal antibodies with the cancer-killing capabilities of cytotoxic drugs, designed to discriminate between healthy and diseased tissue. (wikipedia.org)
  • Epitope mapping of new monoclonal antibodies recognizing distinct human FcRII (CD32) isoforms. (uni-bielefeld.de)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.cn)
  • Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. (abcam.com)
  • We obtained identical results when working with three specific anti-GR monoclonal antibodies aimed against Pyrantel pamoate the N-terminal half from the cGR. (fabretp.org)
  • 2008). Time-domain optical imaging of AML xenografts with near infrared conjugated monoclonal antibodies. (uib.no)
  • Here we review the biology of the FcγRs and IgG isotypes in both humans and mice, detail the potential roles that FcγR interactions can play in the activity of monoclonal antibodies in general, and of immunomodulatory antibodies in particular, and discuss how preclinical studies on these interactions might be best interpreted and translated to a human setting. (bmj.com)
  • Some patients present azoospermia or severe oligospermia without other clinical manifestations.This antibody is a rabbit polyclonal antibody. (ptglab.com)
  • Description: A polyclonal antibody for detection of Glucocorticoid receptor from Human, Mouse, Rat. (nfkb-p65.info)
  • Description: A Rabbit Polyclonal antibody against Glucocorticoid receptor from Human/Mouse/Rat. (nfkb-p65.info)
  • Polyclonal antibody raised in rabbit against the Cas9 nuclease (CRISPR-associated protein 9) using a recombinant protein. (diagenode.com)
  • Polyclonal antibody raised in rabbit against 5-Carboxylcytosine (5ca-CMP monophosphate) conjugated to BSA. (diagenode.com)
  • Polyclonal antibody raised in rabbit against Lachnospiraceae bacterium (Lb) Cpf1 (CRISPR from Prevotella and Francisella 1) using a recombinant protein. (diagenode.com)
  • Polyclonal antibody raised in rabbit against the C-terminus of the S. aureus Cas9 nuclease (CRISPR-associated protein 9) using a recombinant protein. (diagenode.com)
  • Polyclonal antibody raised in rabbit against CEBP Alpha (CCAAT/enhancer binding protein (C/EBP), alpha), using a KLH-conjugated synthetic peptide. (diagenode.com)
  • Polyclonal antibody raised in rabbit against human CBX2 (chromobox 2), using a synthetic peptide containing a sequence from the C-terminus of the protein1. (diagenode.com)
  • Polyclonal antibody raised in rabbit against human CHD1 (Chromodomain Helicase DNA Binding Protein 1), using a synthetic peptide containing a sequence from t. (diagenode.com)
  • ST13 antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. (prospecbio.com)
  • The first immunology antibody-drug conjugate (iADC), ABBV-3373, showed an improvement in disease activity in a Phase 2a study of patients with rheumatoid arthritis and a study with the second iADC, ABBV-154 to evaluate adverse events and change in disease activity in participants treated with subcutaneous injection of ABBV-154 is ongoing. (wikipedia.org)
  • In July 2018, Daiichi Sankyo Company, Limited and Glycotope GmbH have inked a pact regarding the combination of Glycotope's investigational tumor-associated TA-MUC1 antibody gatipotuzumab and Daiichi Sankyo's proprietary ADC technology for developing gatipotuzumab antibody drug conjugate. (wikipedia.org)
  • An antibody-drug conjugate consists of 3 components: Antibody - targets the cancer cell surface and may also elicit a therapeutic response. (wikipedia.org)
  • Androgen receptor (AR) also konwn as Dihydrotestosterone receptor (DHTR), Nuclear receptor subfamily 3 group C member 4 (NR3C4).It is one of steriod hormoen receptors, which are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (ptglab.com)
  • Description: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. (nfkb-p65.info)
  • GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). (biolegend.com)
  • Monocyte Chemoattractant Protein-1 in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis: Biomarker Potential and Association with Polymorphisms in the MCP-1 and the CC Chemokine Receptor-2 Gene. (cdc.gov)
  • Clinical outcome in anti-neutrophil cytoplasmic antibody-associated vasculitis and gene variants of 11? (cdc.gov)
  • Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. (thermofisher.com)
  • Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization. (uni-bielefeld.de)
  • The cDNA synthesized by RNA reverse transcription is then used as a template for PCR amplification of the JUN antibody gene. (cusabio.com)
  • The obtained JUN antibody gene is inserted into a vector and transfected into host cells for culture. (cusabio.com)
  • His lab also identified the MIF receptor and discovered common polymorphisms in the MIF gene, which show global population stratification. (yale.edu)
  • Classically, glucocorticoids (GCs)1 exert their immunomodulatory impact by activating the cytosolic glucocorticoid receptor (cGR), which translocates towards the nucleus and regulates gene manifestation (1). (fabretp.org)
  • The lifestyle of such a receptor was also reported inside a mouse pituitary cell range (22), suggesting a second gene can be mixed up in manifestation of the GC-binding proteins at least in the central anxious system. (fabretp.org)
  • The hypothesis can be backed by These data how the mGR result from the NR3C1 gene, as the cytosolic receptor (12). (fabretp.org)
  • C: The genomic structure of the human preproapelin gene as found in the human PAC 454M7 clone (GenBank accession no. (phoenixpeptide.com)
  • Transfected Brm, expressed in cells lacking endogenous protein, can cooperate with the glucocorticoid receptor (GR) in transcriptional activation. (bdbiosciences.com)
  • MSK1 Antibody detects endogenous levels of total MSK1. (affbiotech.com)
  • Cortisol, an endogenous glucocorticoid receptor (GR) agonist, controls a broad transcriptional program that affects T-cell activation, pro-inflammatory cytokine secretion, apoptosis, and immune-cell trafficking. (bvsalud.org)
  • 1 , 2 In all cases, the majority of the ensuing glucocorticoid actions are mediated by GR and culminate in a modification of the synthesis and expression of pivotal mediators of innate and adaptive immunity. (ashpublications.org)
  • The JUN recombinant monoclonal antibody is prepared using a combination of protein technology and DNA recombinant technology. (cusabio.com)
  • The JUN recombinant monoclonal antibody is then purified from the supernatant of the cell culture through affinity chromatography. (cusabio.com)
  • FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
  • HSP 90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, Ah receptor, and some kinases. (abcam.cn)
  • The immunogen of 22576-1-AP is androgen receptor Fusion Protein expressed in E. coli. (ptglab.com)
  • An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein) that, ideally, is only found in or on tumor cells. (wikipedia.org)
  • Monoclonal antibody raised in mouse against the N-terminus of the Cas9 nuclease (CRISPR-associated protein 9) using a recombinant protein. (diagenode.com)
  • Alternative name: Csn1 Monoclonal antibody raised in mouse against the N-terminus of the Cas9 nuclease (CRISPR-associated protein 9) using a recom. (diagenode.com)
  • Human recombinant protein fragment corresponding to amino acids 1-265 of human NR3C1 produced in E.coli. (thermofisher.com)
  • 5 Since changes in de novo protein synthesis are the basis for glucocorticoid effectiveness, the lack of a modulatory effect on platelet functions is not surprising given that these cells have been regarded as incapable of synthetic activity. (ashpublications.org)
  • The human Brm protein has been reported to be a 180 kDa nuclear factor that acts as a transcriptional activator when fused to a heterologus DNA binding domain. (bdbiosciences.com)
  • Singh P, Coe J, Hong W. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. (bdbiosciences.com)
  • The IL-1 receptor type I is a 80 kDa transmembrane protein with demonstrated IL-1 signaling function. (rndsystems.com)
  • The IL-1 receptor type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail and has no signaling function. (rndsystems.com)
  • ST13 is an adaptor protein (co-chaperone) that mediates the association of HSP70 & HSP90 and appears in early receptor complexes. (prospecbio.com)
  • Anti-human ST13 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ST13 protein 1-369 amino acids purified from E. coli. (prospecbio.com)
  • ST13 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. (prospecbio.com)
  • Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
  • Rigorous verification of this antibody is conducted to ensure its accuracy, and it can be utilized for detecting human JUN protein in ELISA, WB, and IHC experiments. (cusabio.com)
  • Subsequently, a corticosterone binding proteins was determined in synapses of amphibian mind, with characteristics just like G-protein combined receptors (6C9). (fabretp.org)
  • Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation. (uib.no)
  • Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. (uib.no)
  • SGK-1 protein levels in spinal astrocytes are increased in response to glucocorticoid stimuli and enhanced ATP release by opening the pannexin-1 hemichannels. (nature.com)
  • Apelin peptides are cognate ligands for the apelin receptor, a G-protein-coupled receptor (GPCR). (phoenixpeptide.com)
  • Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. (thermofisher.com)
  • Natural and synthetic glucocorticoids bind to GR, producing major conformational changes that result in nuclear translocation or transrepression of transcription factors, including nuclear factor κB. (ashpublications.org)
  • Like Brm, Rb up-regulates glucocorticoid-receptor-mediated transcription. (bdbiosciences.com)
  • The hormone-stimulated glucocorticoid receptor (GR) modulates transcription by interacting with thousands of enhancers and GR binding sites (GBSs) throughout the genome. (bvsalud.org)
  • Glucocorticoid action in cells is mediated by the glucocorticoid receptor (GR), a member of the superfamily of ligand-inducible transcription factors that exert a variety of physiological functions, such as inflammation, autoimmune diseases, and cancer [ 4 ]. (biomedcentral.com)
  • It is the first anti-glucocorticoid-induced tumor necrosis factor receptor (GITR) drug candidate to enter human clinical trials. (biopharminternational.com)
  • TRX518 is a targeted T cell immunomodulator that activates GITR (glucocorticoid-induced tumor necrosis factor receptor) found on multiple types of T cells and other immune cells. (biopharminternational.com)
  • Human peripheral blood lymphocytes were activated for 3 days with PHA, and then stained with CD3 Alexa Fluor® 647 and CD357 (GITR) (clone 108-17) PE (top) or mouse IgG2a, κ PE isotype control (bottom). (biolegend.com)
  • GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. (biolegend.com)
  • The following product was used in this experiment: NR3C1 Monoclonal Antibody (OTI7A11), TrueMAB™ from Thermo Fisher Scientific, catalog # TA806207. (thermofisher.com)
  • MCF-7 human breast cancer cell line treated with CoCl 2 was stained with Mouse Anti-Human/Mouse HIF-1a PE-conjugated Monoclonal Antibody (Catalog # IC1935P, filled histogram) or isotype control antibody (Catalog # IC002P , open histogram). (bio-techne.com)
  • The following product was used in this experiment: CD11c Monoclonal Antibody (N418), PE-Cyanine7, eBioscience™ from Thermo Fisher Scientific, catalog # 25-0114-82, RRID AB_469590. (thermofisher.com)
  • However, while prednisolone (1-10 μM) reduced adenosine diphosphate (ADP, 4 μM) and thromboxane A 2 receptor agonist U46619 induced platelet aggregation (up to 75%), dexamethasone had no effect. (ashpublications.org)
  • EU Panel Backs Two Triple Combo Drugs for COPD Maintenance CHF 5993 and Trydonis, from Chiesi Farmaceutici SpA, combine a glucocorticoid, a long-acting beta-2 receptor agonist, and a long-acting muscarinic antagonist. (medscape.com)
  • TRX518 is a monoclonal antibody designed to enhance the immune system by enabling T cells to more effectively attack cancer cells. (biopharminternational.com)
  • Despite their extensive use in cardiovascular and immune pathologies, glucocorticoids have been reported to be largely inactive on platelet function. (ashpublications.org)
  • 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
  • GR expression in human tumor and immune cells positively correlated with PD-L1 expression and tumor infiltration of Th2 and Treg cells, and negatively correlated with Th1-cell infiltration. (bvsalud.org)
  • In the ovalbumin-expressing EG7 and MC38 immune-competent tumor models, relacorilant significantly improved anti-PD-1 antibody efficacy and showed favorable effects on antigen-specific T-cells and systemic TNFα and IL-10. (bvsalud.org)
  • HIT pathophysiology has an initiation phase, immunization to produce pathologic antibodies, then platelet activation by IgGCPF4CHep immune complexes. (immune-source.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • Multiple approaches to conjugation have been developed for attachment to the antibody and reviewed. (wikipedia.org)
  • This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. (abcam.com)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
  • Detection of HIF‑1 alpha in MCF‑7 Human Cell Line by Flow Cytometry. (bio-techne.com)
  • Progress in therapy is usually hampered by the difficulties of inadequate positive predictive value of antibody detection and clinical scores in suspected HIT, very limited availability of practical platelet activation assays, and the paucity of new agents in human clinical trials. (immune-source.com)
  • Intravenous immunoglobulin (IVIG) is a therapeutic preparation of polyspecific antibodies isolated from pools of plasma obtained from several thousand healthy blood donors [1]. (academie-medecine.fr)
  • Because human septic shock involves excessive inflammatory cytokine production, we investigated the effect of cortistatin on the production of inflammatory mediators and its therapeutic action in various murine models of endotoxemia. (rupress.org)
  • Cortistatin represents a potential multistep therapeutic agent for human septic shock, to be used in combination with other immunomodulatory agents or as a complement to other therapies. (rupress.org)
  • Methods: We constructed nanoparticles to fully encapsulate the therapeutic drug (ginsenoside Rg1), which can be transferred into brain tissue via the receptor-mediated transfer of drug-encapsulated nanoparticles. (cbinsights.com)
  • In a target identification study, compound 11 was characterized as a dual modulator binding to both peroxisome proliferator-activated receptor (PPAR) γ and glucocorticoid receptor (GR). This study provides a novel pharmacophore for PPARγ/GR dual modulators with therapeutic potential against human metabolic diseases. (bvsalud.org)
  • 1 Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba. (nih.gov)
  • The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. (biolegend.com)
  • This GABA A Receptor Alpha2 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. (bd-ibr.org)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • IL-1 is a name that designates two proteins, IL-1 alpha and IL-1 beta, that are the products of distinct genes, but recognize the same cell surface receptors. (rndsystems.com)
  • The majority of our de novo radiotracer development focuses on small molecule organic chemistry, and our antibody radiotracer development programs involves new bioconjugation chemistry, and defining and exploiting the biological mechanisms that underwrite the aberrant expression of cell surface receptors in cancer. (ucsf.edu)
  • Structure/function relationships of Fc gamma receptors in phagocytosis. (uni-bielefeld.de)
  • Most of these immunomodulatory antibodies are of IgG isotypes that have low, or no, binding to the Fc gamma receptors (FcγRs) that trigger cell-mediated cytotoxic effector functions such as antibody dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). (bmj.com)
  • Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis. (fmu.ac.jp)
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
  • A soluble version of the type II receptor is induced by anti-inflammatory agents such as glucocorticoids, IL-4 and IL-13. (rndsystems.com)
  • Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. (uni-bielefeld.de)
  • Goat Antibody Laboratories manufactures the glucocorticoid receptor goat antibody reagents distributed by Genprice. (nfkb-p65.info)
  • The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that encompasses, among others, estrogen receptor and peroxisome proliferators-activated receptor. (ashpublications.org)
  • Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)
  • Antibody-drug conjugates are an example of bioconjugates and immunoconjugates. (wikipedia.org)
  • The Proteintech guarantee covers Proteintech antibodies in any species and any application, including those not listed on the datasheet. (ptglab.com)
  • Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. (uib.no)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
  • If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
  • Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. (thermofisher.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Antibodies targeting T-cell inhibitory pathways, such as CTLA-4 and PD-1/PD-L1, are emerging as an important class of cancer therapeutics, and a next generation of immunomodulatory therapies targeting alternative inhibitory (e.g. (bmj.com)
  • The apparently anomalous binding data were clarified by the fact that washed platelets (1) contained mineralocorticoid receptor and that (2) it was associated with GR. Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. (ashpublications.org)
  • Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis . (biolegend.com)
  • Applications Reported: This N418 antibody has been reported for use in flow cytometric analysis. (thermofisher.com)
  • Applications Tested: This N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. (thermofisher.com)
  • This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. (nfkb-p65.info)
  • RU486), suggesting the functional importance of the ligand-receptor complex. (ashpublications.org)
  • In vitro, cortisol inhibited, and relacorilant restored, T-cell activation and pro-inflammatory cytokine secretion in human peripheral blood mononuclear cells. (bvsalud.org)
  • To determine the pathological relevance of the diurnal secretion of adrenal glucocorticoids in neuropathic hypersensitivity, we investigated the influence of adrenalectomy on the threshold of mechanical allodynia in nerve-injured mice. (nature.com)
  • Conceived initially for antibody replacement therapy in patients with primary and secondary immunodeficiencies, IVIG is now used in several autoimmune and inflammatory diseases. (academie-medecine.fr)
  • The Bucala group is credited with the molecular cloning of MIF and discovery of its critical role in regulating glucocorticoid immunosuppression, which opened novel approaches to therapy in autoimmune inflammatory conditions. (yale.edu)
  • Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction in which circulating antibodies cause fluctuant skeletal muscle weakness. (medscape.com)
  • Glucocorticoid Receptor Modulators (GRM) represent to most active payload class for iADCs. (wikipedia.org)
  • Other names: m1A, 1mA, m1Ado Monoclonal antibody raised in mouse against 1-methyladenosine (m1A) conjugated to KLH. (diagenode.com)
  • Monoclonal antibody raised in mouse against 6X His epitope tag, using a KLH-conjugated synthetic peptide. (diagenode.com)
  • Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-Brm antibody. (bdbiosciences.com)
  • Mature human and mouse IL-1 beta share approximately 75% amino acid sequence identity and human IL-1 beta has been found to be active on murine cell lines. (rndsystems.com)
  • Two distinct types of IL-1 receptors have been identified and cloned from human and mouse cells. (rndsystems.com)
  • Recognizes human and mouse HIF-1 alpha in direct ELISAs. (bio-techne.com)
  • Mouse Anti Human Monoclonal. (prospecbio.com)
  • Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
  • HSP 84 and HSP 86, which may be subject to estrogenic regulation, have been found as components of the non-DNA binding form of mouse glucocorticoid receptor, but dissociated from the transformed DNA-binding form. (abcam.cn)
  • The lifestyle of a glucocorticoid receptor (GR) in plasma membrane was initially reported inside a mouse lymphoma cell range (S-49) and it had been proposed to become functionally connected with glucocorticoid-induced cell loss of life (5). (fabretp.org)
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • The Glucocorticoid Receptor Goat Antibody reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (nfkb-p65.info)
  • We identify serum- and glucocorticoid-inducible kinase-1 (SGK-1) as the key molecule responsible for the glucocorticoid-enhanced release of ATP from astrocytes. (nature.com)
  • Serum- and glucocorticoid-inducible kinase-1 (SGK-1) mediates the glucocorticoid-enhanced release of ATP from astrocytes by opening the pannexin-1 hemichannels. (nature.com)
  • This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS). (ptglab.com)
  • However, evidence is now accumulating for rapid corticosteroid actions 25 , 26 , and the existence of membrane-bound steroid receptors that may mediate these rapid actions 27 , 28 . (ersjournals.com)
  • Apelin is a peptide hormone that binds to a class A GPCR (the apelin receptor/APJ) to regulate various bodily systems. (phoenixpeptide.com)
  • These peptide usually contains the epitope recognized by the antibody. (affbiotech.com)
  • For example, coxsackievirus B3 (CB3) infection of susceptible mice results in inflammation of the heart (myocarditis) that resembles myocarditis in humans. (cdc.gov)
  • Few studies have addressed the effects of classical anti-inflammatory glucocorticoids on platelet function. (ashpublications.org)
  • It is released from the cell surface by proteolysis after oxidative stress or inflammatory stimuli, including bacterial endotoxins and activation of the Toll-like receptors TLR2 or TLR5 (7‑10). (rndsystems.com)
  • It is also known that alcohol, at least in part, exerts its anti-inflammatory response via activation of the hypothalamic-pituitary-adrenal axis pathway resulting in increases of glucocorticoids [ 10 ]. (cdc.gov)
  • Antibodies attach themselves to the antigens on the surface of cancerous cells. (wikipedia.org)
  • ST13 functions to promote the efficiency of glucocorticoid receptor maturation in cells. (prospecbio.com)
  • 1 In humans, glucocorticoid receptors have been shown in many different cells, including those of the granulocyte-macrophage lineage and lympho cytes. (bmj.com)
  • 2 Erythropoietic cells also have binding sites for glucocorticoids. (bmj.com)
  • 5 In this study we started with a highly enriched population of CD34+ progenitor cells 6 obtained by incubating the mononuclear fraction of blood and bone marrow with biotinylated anti-CD34 antibodies and running the CD34 labelled cells over an avidin column (Cellpro, Inc., Bothell, Washington, USA). (bmj.com)
  • The process starts by immunizing mice with a synthesized peptide from human c-Jun, followed by extraction of spleen cells' RNA under aseptic conditions. (cusabio.com)
  • In phenotypic screening with human bone marrow mesenchymal stem cells (hBM-MSCs), (E)-4-hydroxy-3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)-6-methyl-2H-pyran-2-one (1) was identified to increase adiponectin biosynthesis during adipogenesis and simultaneously to stimulate leptin production. (bvsalud.org)
  • In CCRF-CEM cells, a human being T-cell lymphoblast-like cell range the recognition was possible just after enrichment of mGR+ cells using immunopanning strategies (19, 24, 25). (fabretp.org)
  • These isotypes were selected to minimise the risk of depleting the T cells upon which such antibodies depend for their mechanism of action. (bmj.com)
  • Current pathophysiology studies are focused on the origin of the antibody response, the nature of the antigenic complex and pathologic epitopes, the mechanisms of interindividual differences in platelet activation, and the functions of monocytes and endothelial cells. (immune-source.com)
  • This antibody is routinely tested by western blot analysis. (bdbiosciences.com)
  • This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc. (bdbiosciences.com)
  • The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. (ptglab.com)
  • Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • Temporal elevations in glucocorticoid levels enhance the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. (wikipedia.org)
  • Antibodies of the IgG sub-class are bi-functional molecules, possessing a F(ab) domain, variable in sequence and responsible for the binding of antigen, and an Fc domain, constant in sequence and responsible for mediating a range of antibody effector functions [ 1 ]. (bmj.com)