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  • inhibit
  • We have examined the interaction of dexamethasone with the ZR75-1 human breast cancer cell line to determine if glucocorticoids might directly inhibit growth of breast cancer cells. (aacrjournals.org)
  • en] Glucocorticoids have been shown to inhibit the activity of the human prolactin (hPRL) promoter. (ac.be)
  • Glucocorticoids act to inhibit feedback of both the hypothalamus, decreasing corticotropin-releasing hormone [CRH], and corticotrophs in the anterior pituitary gland, decreasing the amount of adrenocorticotropic hormone [ACTH]. (wikipedia.org)
  • synthesis
  • We suggest that this change in PI/IRI with glucocorticoid and growth hormone treatment may be due to an alteration in B-cell synthesis or release of PI. (diabetesjournals.org)
  • For this reason, glucocorticoid analogue drugs such as prednisone down-regulate the natural synthesis of glucocorticoids. (wikipedia.org)
  • Based on these antiandrogen and antiglucocorticoid effects, ketoconazole has been used with some success as a second-line treatment for certain forms of advanced prostate cancer and for the suppression of glucocorticoid synthesis in the treatment of Cushing's syndrome. (wikipedia.org)
  • pharmacological
  • They also suggest that glucocorticoids have a direct inhibitory effect on proliferation of human breast cancer cells, which may help explain breast tumor regression following pharmacological glucocorticoid therapy. (aacrjournals.org)
  • Physiological vs. pharmacological effects of glucocorticoids on human monocytes. (grantome.com)
  • Pharmacological glucocorticoids (GCs) have been effectively used to treat inflammation for over a half century, resulting in the established paradigm of GC action that addresses only mechanisms that lead to suppression of inflammation and immunity. (grantome.com)
  • Our study is designed to test the hypothesis that preparative phenotypic and molecular changes induced by physiological concentrations of cortisol in human monocytes and macrophages, lead to functionally opposing consequences compared with pharmacological GC doses. (grantome.com)
  • genes
  • Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • In humans and many other tetrapods, the RLN/INSL-encoding genes exist in 4 distinct clusters. (wikipedia.org)
  • The 23 pairs of DNA molecules called chromosomes contain the approximately 21,000 genes comprising the "human blueprint. (wikipedia.org)
  • endogenous
  • Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. (wikipedia.org)
  • hippocampus
  • Scientific studies have mainly focused on the impact of glucocorticoids on the hippocampus because of its role in memory processes and on the prefrontal cortex for its role in attention and executive function. (wikipedia.org)
  • Considerable expansion of the cerebral cortex in higher mammals (e.g. humans) displaces the hippocampus ventrally where it protrudes inferiorly into the lateral ventricles. (wikipedia.org)
  • chromosome
  • The largest cluster contains 4 loci: RLN1, RLN2, INSL4 and INSL6, situated in tandem on human chromosome 9 (chromosome 9). (wikipedia.org)
  • Human HSP90AA1 is encoded on the complement strand of Chromosome 14q32.33 and spans over 59 kbp. (wikipedia.org)
  • Human GLUD1 contains 13 exons and is located on the 10th chromosome. (wikipedia.org)
  • physiologic
  • Based on established concepts of hemoglobin (Hb) toxicity and physiologic Hb scavenger systems, we evaluated whether glucocorticoids could support an adaptive response to extracellular Hb independently of their immunosuppressive activities. (uzh.ch)
  • These observations suggest a multitude of less-dramatic physiologic roles for glucocorticoids. (wikipedia.org)
  • immune
  • We therefore propose a pilot human study to obtain data that will support a new paradigm, one addressing the mechanisms by which a transient in vivo increase in cortisol to stress-associated levels (e.g., levels that follow trauma) prepares for an enhanced innate immune response when a subsequent activation event occurs (e.g., an infection). (grantome.com)
  • Identify specific cellular and molecular changes that distinguish stress-cortisol enhancement from pharm- cortisol suppression of human monocyte/macrophage innate immune activation pathways. (grantome.com)
  • The studies proposed are novel in that, to the best of our knowledge, we will be the first to examine mechanisms by which physiological stress-associated levels of hydrocortisone enhance immune and inflammatory pathways within human monocytic white blood cells in vivo. (grantome.com)
  • these are widely utilized in general medical practice and numerous specialties either as replacement therapy in glucocorticoid deficiency or to suppress the immune system. (wikipedia.org)
  • In healthy situations, the human immune system is biased towards anti-viral readiness. (wikipedia.org)
  • airway
  • These methods confirmed CCL2 mRNA targeting by GR in human primary airway epithelial cells. (jimmunol.org)
  • In this study we investigated whether smoking and chronic obstructive pulmonary disease (COPD), both characterized by airway inflammation with increased levels of inflammatory mediators , affect GR characteristics in cultured human bronchial epithelial cells (HBEC). (hindawi.com)
  • lineage
  • Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood. (wikipedia.org)
  • antagonists
  • Aside from discontinuation of glucocorticoid medication, potential treatments discussed in the research literature include:[citation needed] anti-glucocorticoids psychoactive drugs that up-regulate the GRII glucocorticoid receptor:tricyclic antidepressants: Desipramine, Imipramine, and Amitriptyline (SSRIs do not ) serotonin antagonists: Ketanserin mood stabilizers: Lithium corticotropin-releasing hormone (CRH) antagonists glutamate antagonists dehydroepiandrosterone (DHEA) small molecule brain-derived neurotrophic factor (BDNF) analogs stress reduction therapies and exercise. (wikipedia.org)
  • acute
  • Glucocorticoids (GCs) are a crucial component in all protocols for the treatment of human lymphoid malignancies, including childhood acute lymphoblastic leukemia (ALL). (aacrjournals.org)
  • 2001) presented a 10-year-old male patient, with no prior psychiatric history, who showed significant declines in academic performance that began during a 5-week course of glucocorticoid treatment for acute asthma flare. (wikipedia.org)