Human gene silencing. Medical search. Frequent questions

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (nih.gov)
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. (nih.gov)
NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. (senescence.info)
The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
The project is based on our recent findings describing that the transcriptional co-repressor TRIM28 binds to TEs in neural progenitor cells (NPC s) and mediates transcriptional silencing by depositing H3K9me3. (lu.se)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (nih.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)

In this respect, they match the miRNAs much better than the natural gene transcripts that the miRNAs evolved to target. (scripps.edu)
De confirmed that decoy RNAs designed to match miRNAs this way can greatly hasten the miRNAs' "unloading" from Argonautes, thus effectively dialing down these miRNAs' normal gene-silencing activities. (scripps.edu)
MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
From the list of genes that were targeted by the 73 diagnostic miRNAs, DGKE and WDR47 had significant associations with responses to both systemic therapies and radiotherapy in lung cancer. (cdc.gov)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)

Since genes use RNA molecules to make proteins, these snippets effectively "silence" genes that carry the same sequence. (newscientist.com)
The ability to silence gene expression is an invaluable tool for elucidating the importance of intracellular signaling proteins which contribute to the effector functions of mast cells and basophils. (kent.ac.uk)
The gene-silencer in question is Argonaute 2, a molecular machine in cells that can grab and destroy the RNA transcripts of specific genes, preventing them from being translated into proteins. (scripps.edu)
Argonaute 2 and other Argonaute proteins regulate the influence of about a third of the genes found in humans and other mammals-and thus are among the most important modulators of our cells' day-to-day activities. (scripps.edu)
they are taken up by Argonaute proteins as guide RNAs and lead to the silencing of targeted gene transcripts. (scripps.edu)
SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or "" T cells. (tcd.ie)
This was followed-up in his post-doctoral research at UC Santa Cruz (1996-2001) where he was awarded the prestigious Human Frontier Science Program fellowship and published breakthrough work characterizing the key RNA sequences and the cellular proteins that modulate the alternative splicing of the HIV-1 messenger RNA (mRNA). (fau.edu)
His work on RNA binding proteins and SRSF1 has been continuously funded by the NIH and has recently expanded to the study of the role played by multiple RNA binding proteins on cellular gene transcription and T cell development and functions. (fau.edu)
It is caused by inactivating predominantly biallelic mutations involving >20 genes encoding proteins with roles in the FA/BRCA DNA repair pathway. (bvsalud.org)

Eighty-five healthy adults were given a nasal spray containing either a placebo or siRNA designed to silence one of the genes of respiratory syncytial virus (RSV), which is the leading cause of infant hospitalisation in the US but fairly harmless in healthy adults. (newscientist.com)
Here, we describe a method using lipofection which has been successfully employed to silence gene expression using siRNA in human LAD2 mast cells as well as primary human basophils. (kent.ac.uk)
Gene silencing through the use of small interfering RNA (siRNA) has become a primary tool for identifying disease-causing genes. (labettor.com)
There are several aspects for preparing and delivering effective siRNA to knockdown a target gene. (labettor.com)
If a validated siRNA sequence for your target gene is not available, use siRNA generated against the entire target gene ORF. (labettor.com)
An arrayed collection of siRNA reagents for RNAi screening, targeting human phosphatases. (horizondiscovery.com)
With the Human Accell Phosphatases siRNA library, researchers receive siRNAs targeting enzymes with known or predicted phosphatase activity. (horizondiscovery.com)
For a complete list of target genes in this siRNA Library, please contact Technical Support or your local Sales Representative. (horizondiscovery.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

Now, for the first time, RNA interference (RNAi) has been proven effective against a human disease - a common respiratory virus. (newscientist.com)
Researchers around the world are achieving targeted gene silencing in cells that had previously been beyond the reach of conventional RNAi products due to toxicity caused by transfection reagents or undesirable viral responses. (horizondiscovery.com)
Sigma-Aldrich® Advanced Genomics RNAi Single Clones deliver powerful, long term, and stable gene silencing. (sigmaaldrich.com)
As an exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC), our comprehensive offering consists of nearly 200,000 pre-cloned shRNA constructs targeting more than 22,500 human and 20,000 mouse genes. (sigmaaldrich.com)
These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. (sigmaaldrich.com)
From gene expression knockdown with CRISPRi and RNAi to overexpression with CRISPRa and ORF, we have everything you need for your target discovery research. (sigmaaldrich.com)
Silencer Predesigned and Validated siRNAs are designed for maximum potency and specificity using a proprietary algorithm ( see: RNAi has become a powerful tool for understanding gene function ). (thermofisher.com)

1. Role of the cytokine-signal transduction pathways and epigenetic gene silencing in pathogenesis of T-cell lymphoma. (upenn.edu)

In April 4 Nature, Ina Rhee and colleagues from Johns Hopkins University School of Medicine, show that two enzymes (DNMT1 and DNMT3b) cooperate to silence genes and maintain DNA methylation in human cancer cells.Rhee et al. (the-scientist.com)
These results "establish that methylation is essential for silencing tumor suppressor genes in human cancer cells. (the-scientist.com)
When DNA methylation is removed, researchers found that they could selectively turn on previously silenced genes in the underlying genome of the plant. (newswise.com)
We saw repeatedly that lots of genes are silenced by DNA methylation and thought it was kind of curious," said Schmitz. (newswise.com)
Introducing this human protein allows researchers to remove DNA methylation and thereby turn on previously silenced genes. (newswise.com)
The silencing of NDRG1 in SW620 was not due to promoter hyper-methylation as bisulfite sequencing of the NDRG1 promoter showed minimal DNA methylation in both cell lines. (nih.gov)
Scoccianti C, Ricceri F, Ferrari P, Cuenin C, Sacerdote C, Polidoro S, Jenab M, Hainaut P, Vineis P, Herceg Z. (2011) Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study. (who.int)

Glioblastoma multiforme (GBM) is the most malignant human primary brain tumor, and its infiltrative nature represents the leading cause for the failure of therapies and tumor recurrences. (nih.gov)
Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. (the-scientist.com)
N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. (nih.gov)
miR-205 expression in humans was validated by Landgraf et al ( 8 ), however, its role in tumor progression is contradictory ( 9 - 12 ). (spandidos-publications.com)

A subset of Silencer siRNAs to human targets have been functionally tested in-house and verified to reduce target mRNA levels by 70% or greater, enabling us to guarantee that these Silencer Validated siRNAs will knock-down their target genes. (thermofisher.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. (nature.com)
Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)
Target a single gene or screen a whole genome with fully customizable products. (sigmaaldrich.com)
Whether you're targeting specific genes or performing a genome-wide screen, we offer extensive pooled and arrayed formats to meet your needs. (sigmaaldrich.com)
1 The idea that the field of molecular biology needed to move from studying isolated biological molecules towards a broad analysis of large sets of biological molecules was underscored with the completion of the human genome project (HGP) in 2001. (bmj.com)
2 3 The HGP demonstrated that a relatively limited number of genes could be identified in the human genome, which substantiated the theory that complex biological processes were regulated on other levels than DNA sequence alone. (bmj.com)
Transposable elements have the unique ability to move within our DNA, causing or reversing mutations, altering genes, and even affecting the size of our genome. (lu.se)
The challenge has been to determine what these elements do and how they affect human tissues, given their abundant and repetitive presence in the human genome. (lu.se)

Epigeneitc silencing of ribosomal RNA genes by Mybbp1a. (nih.gov)
Here we generate a synthetic sex distortion system by exploiting the specificity of the homing endonuclease I-PpoI, which is able to selectively cleave ribosomal gene sequences of the malaria vector Anopheles gambiae that are located exclusively on the mosquito's X chromosome. (nature.com)
Further studies confirmed, in humans and mice, that germline mutations affecting TP53 or its regulator MDM4 may cause short telomeres and alter hematopoiesis, but also revealed features of Diamond-Blackfan anemia (DBA) or Fanconi anemia (FA), two BMFSs, respectively, caused by defects in ribosomal function or DNA repair. (bvsalud.org)
Similarly, ribosomal dysfunction and DNA lesions cause p53 activation, and p53-DREAM targets include the DBA-causal gene TSR2, at least 9 FA-causal genes, and 38 other genes affecting ribosomes or the FA pathway. (bvsalud.org)

The exposure of humans to ionizing radiation (IR) induces several types of genetic and somatic mutations leading to several types of cancers including breast cancer [ 1 ]. (biomedcentral.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
Argonautes' gene-silencing functions also help cells cope with rogue genetic activity from invading viruses or cancer-promoting DNA mutations. (scripps.edu)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Database of human genetic variants associated with longevity. (senescence.info)
a) Gene expression profiling is performed in healthy and Type 2 diabetic subjects and defined genetic models to create a fingerprint of dysregulated genes associated. (ki.se)
Rarely, small deletions of genetic material from the AFF2 gene are associated with fragile XE syndrome, although how these deletions affect the protein and lead to intellectual disability is unknown. (medlineplus.gov)
Researchers at Lund University have discovered that a specific group of genetic elements in our DNA influence the development of the human brain, their study was published in Science Advances. (lu.se)
Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. (lu.se)
Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

The effectiveness of approximately 1,100 algorithm-designed siRNAs was measured in the silencing of almost 400 endogenously expressed human transcripts. (thermofisher.com)
His doctoral work led to the discovery of splicing silencing elements within the transcripts of human messengers utilizing the fibronectin gene as a model. (fau.edu)
These elements appear to influence the expression of both protein-coding genes and non-coding transcripts in the human brain through various mechanisms," says Raquel Garza. (lu.se)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations in the AFF2 gene cause fragile XE syndrome, a condition characterized by mild intellectual disability and learning difficulties. (medlineplus.gov)
Interestingly, mutations in any DC-causal gene will cause telomere dysfunction and subsequent p53 activation to further promote the repression of p53-DREAM targets. (bvsalud.org)
Molecular diagnosis of FA is challenging due to the wide spectrum of the contributing gene mutations and structural rearrangements. (bvsalud.org)
Variegate porphyria (VP) is an inherited disorder of porphyrin-heme metabolism arising from mutations of the gene encoding the enzyme protoporphyrinogen oxidase. (medscape.com)
To date, there have been 184 different mutations in the protoporphyrinogen oxidase gene that results in variegate porphyria. (medscape.com)

According to the World Cancer Report, colorectal cancer (CRC) is one of the most dangerous malignant tumors in humans. (hindawi.com)
This study may result in novel therapies for lymphoma based on selective inhibition of the elements of the IL-2R signal transduction pathway(s) which are preferentially utilized by malignant T cells and/or on induction of re-expression of the epigenetically-silenced SHP-1 gene. (upenn.edu)
Our most recent work focuses on the molecular mechanisms of the aberrant gene silencing in the malignant lymphoid cells. (upenn.edu)
Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)
However, its role in malignant transformation and tumorigenesis of human lung cells is not well understood. (cdc.gov)
Using a gene silencing approach, we showed that Bcl-2 plays an important role in the malignant properties of Cr(VI)-transformed cells. (cdc.gov)
The role of Bcl-2 in malignant transformation and tumorigenesis was confirmed by gene silencing experiments using human lung carcinoma NCI-H460 cells. (cdc.gov)
Knockdown of Bcl-2 in the H460 cells inhibited malignant and tumorigenic properties of the cells, indicating the general role of Bcl-2 in human lung tumorigenesis. (cdc.gov)
Together, our results indicate the novel and multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of human lung epithelial cells chronically exposed to Cr(VI). (cdc.gov)

Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)

In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)

We found that silencing of the protein by small interfering RNAs (siRNAs) abrogated the migratory and invasive capacity of three different human GBM cell lines both in 2-dimensional (2-D) and 3-dimensional (3-D) in vitro assays. (nih.gov)

A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
ICE research includes a wide portfolio of aim to evaluate the role of infectious study designs that are tailored to specific agents in human cancers through The overall strategy of ICE is to improve infectious agents across a spectrum of biological and epidemiological studies. (who.int)
2012) Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. (who.int)

Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
Twenty-two of the pairs, chromosome numbers 1 to 22, the autosomes, are normally homologous (identical in size, shape, and position and number of genes). (msdmanuals.com)
the smaller Y chromosome carries genes that initiate male sex differentiation, as well as a few other genes. (msdmanuals.com)
The genes that occupy the same locus on each chromosome of a pair (one inherited from the mother and one from the father) are called alleles. (msdmanuals.com)
A chromosome contains many genes. (msdmanuals.com)

The objective of this study was to investigate the potential mechanisms involved in silencing of the NDRG1 gene. (nih.gov)
His doctoral and post-doctoral work focused on the mechanisms that control the splicing of eukaryotic genes. (fau.edu)

Aberrant cell signaling and epigenetic regulation of gene expression in human lymphomas. (upenn.edu)

Humans have about 20,000 to 23,000 genes depending on how a gene is defined. (msdmanuals.com)

Gene silencing approaches in mast cells and primary human basophils. (kent.ac.uk)
However, primary mast cells and their terminally differentiated blood counterpart, namely basophils, pose a difficult challenge for gene silencing approaches given not only their state of maturation and difficulty to transfect, but also because their functions are readily altered by cell-handling conditions. (kent.ac.uk)
This study evaluated the effect of matrix metalloproteinases-2 (MMP-2) gene silencing using MMP-2 shRNA expression plasmids (pMMP-2) on IR induced cytotoxicity and DNA damage by MTT, dead green, γH2AX and comet assays in human normal dermal fibroblasts (HDFs) and MCF-7 human breast cancer cells. (biomedcentral.com)
In addition, MMP-2 gene silencing using pMMP-2 decreased comet tail length in irradiated HDFs but increased in irradiated MCF-7 cells. (biomedcentral.com)
The aim of the present investigation is to study the effect of MMP-2 gene silencing by transfection of MMP-2 shRNA expression plasmids (pMMP-2on radiation-induced DNA damage in human normal dermal fibroblasts (HDFs) and MCF-7 cells. (biomedcentral.com)
Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. (medicaldaily.com)
A team led by scientists at The Scripps Research Institute (TSRI) has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells' activities. (scripps.edu)
Cells have built in machinery to turn off and on gene expression permanently. (aacrjournals.org)
Silencing of Chl1 in INS-1 cells was done to assess its impact on the insulin secretion, content, cell viability, and apoptosis. (lu.se)
Silencing of Chl1 in INS-1 cells markedly reduced insulin content and secretion. (lu.se)
GSEA showed that the insulin-signaling pathway was influenced in Chl1 -silenced cells. (lu.se)
a) high-through-puts screen in human skeletal muscle cells to silence or overexpress candidate genes to establish the functional impact on metabolism. (ki.se)
The AFF2 gene provides instructions for making a protein that is found in the nucleus of cells but whose function is not well understood. (medlineplus.gov)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
The abnormal wound healing is due to impaired limbal epithelial stem cells, and the new research, published online July 18 in Diabetologia , involved isolation of those cells from 30 donor eyes of humans with and 23 without diabetes. (medscape.com)
Specifically, the WNT5A gene was hypermethylated at the promotor region in the diabetic cells and its protein was markedly repressed. (medscape.com)
Most of us have learnt in school that our DNA is the same in all our cells that we cannot influence our genes. (lu.se)
the cells of the body can activate and deactivate genes, which means that the function of the cells can be altered. (lu.se)

b) medium-through-put screens (electroporation) to determine the consequence of gene silencing or overexpression on the whole-body metabolic phenotype at tissue (organ) level. (ki.se)

c) tissue-specific gene knockout or transgenic models to provide proof-of concept that the identified gene(s) and the pathway(s) they regulate play a causative or preventive role in the development of type 2 diabetes. (ki.se)
p53 downregulates several genes mutated in DC, either by binding to promoter sequences (DKC1) or indirectly via the DREAM repressor complex (RTEL1, DCLRE1B), and the p53-DREAM pathway represses 22 additional telomere-related genes. (bvsalud.org)
Biology Group (ICB) and the Infections evaluate the role of infections in human the pathway from discovery to public and Cancer Epidemiology Group (ICE). (who.int)

With decades of gene editing experience and an unsurpassed portfolio of CRISPR and ZFN technology patents, Sigma-Aldrich® Advanced Genomics delivers the highest quality reagents for your entire workflow, from early-stage discovery to translational research. (sigmaaldrich.com)

Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. (nih.gov)
Database of human genes associated with cellular senescence. (senescence.info)
His research expanded to the mechanism regulating the transcription of cellular and viral genes and characterized the protein SRSF1 as a strong inhibitor of HIV-1 replication. (fau.edu)
2017) Tat is a multifunctional viral protein that modulates cellular gene expression and functions. (fau.edu)

The discovery does not affect gene sequence but entails specific DNA modifications altering gene expression - what are known as epigenetic alterations," he said. (medscape.com)

Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench. (sigmaaldrich.com)

NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. (senescence.info)
70% silencing of their target. (thermofisher.com)
1) Development of target identification platforms using microarray, proteomics and bioinformatics to identify dysregulated genes in healthy and diabetic patients or genetically modified model systems. (ki.se)
c) Proteomics is being developed to validate the target genes identified in the gene expression profile. (ki.se)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

Predesigned Invitrogen Silencer siRNAs are available for all human, mouse, and rat gene targets in the RefSeq database. (thermofisher.com)

Silencing of Chl1 impairs β-cell function by disrupting the activity of key signaling pathways of importance for insulin biosynthesis and secretion. (lu.se)

By introducing a human protein into the model plant species Arabidopsis thaliana, researchers found that they could selectively activate silenced genes already present within the plant. (newswise.com)

The low Pol II binding at the NDRG1 promoter in SW620 was associated with gene-wide decrease in histone H4 acetylation and increase in histone H3 serine 10 phosphorylation. (nih.gov)

Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsible for genomic instability, altered gene expression, and cell death. (biomedcentral.com)

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. (nature.com)
Finally, we show that the generated episignature includes CpG sites that do not undergo functional selective pressure, allowing diagnosis of FA in individuals with reverted phenotype due to gene conversion. (bvsalud.org)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
The 23rd pair, the sex chromosomes (X and Y), determines a person's sex as well as containing other functional genes. (msdmanuals.com)

Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. (senescence.info)

The founder gene mutation common among South Africans encodes an enzyme with little or no residual activity that may be lethal in homozygotes. (medscape.com)

RNA-sequencing was used to investigate the expression of CHL1 in human adipose, liver, muscle, and human islets. (lu.se)

These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)

Cytosine exists in all living species, ranging from bacteria to plants to humans. (hmdb.ca)

Our goal was to identify any distinct characteristics that could help to explain unique traits specific to humans," says Johan Jakobsson. (lu.se)

according to their Panther/Gene Ontology Classification. (thermofisher.com)

Salistick detects pregnancy by identifying a hormone called human chorionic gonadotropin (hCG), which is present in the body of a pregnant person. (medicaldaily.com)

Their application in human observational studies (HOS) has become feasible in recent years due to a spectacular increase in the sensitivity, resolution and throughput of OMICS-based assays. (bmj.com)

Each gene has a specific location (locus), which is typically the same on each of the 2 homologous chromosomes. (msdmanuals.com)

And third, it blocks apoptosis by interacting with E2F1, thus silencing TP73 and Apaf1 genes. (rndsystems.com)

Learning to control natural gene silencing processes will allow an entirely new approach to treating human disease," said Ian J. MacRae, associate professor in TSRI's Department of Integrative Structural and Computational Biology and principal investigator for the study, which appears as the cover story in the May 9, 2013 issue of the journal Molecular Cell . (scripps.edu)

Anatomy42

Organisms18

Diseases4

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes128

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science18

Health Care4

Transcriptional7

MiRNA2

MiRNAs8

Proteins9

SiRNA9

RNAi7

Epigenetic gene1

Methylation7

Tumor4

MRNA2

Genome8

Ribosomal4

Genetic10

Transcripts3

Mutations6

Malignant9

Aberrant gene1

Expressed genes associated1

RNAs1

Cancers3

Chromosome5

Mechanisms2

Regulation1

20,0001

Cells18

Overexpression1

Pathway3

Translational1

Cellular4

Sequence1

Knockdown1

Target5

Targets1

Pathways1

Activate1

Histone1

Altered gene expression1

Functional4

Selectively1

Encodes1

Adipose1

Composition1

Species1

Johan Jakobsson1

Ontology1

Chorionic gonadotropin1

Assays1

Locus1

Apoptosis1

Processes1