Human gene gene cell cycle. Medical search. Frequent questions

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. (wikipedia.org)
This gene encodes two proteins, p16 and p14ARF, which are transcribed from the same second and third exons but alternative first exons: p16 from exon 1α and ARF from exon 1β. (wikipedia.org)
Here, we analyze the expression signature associated with all 687 RNA-binding proteins (RBPs) and identify 39 that significantly correlate with cell cycle mRNAs. (iric.ca)
hPSC-enriched essential genes mainly encode transcription factors and proteins related to cell-cycle and DNA-repair, revealing that a quarter of the nuclear factors are essential for normal growth. (nature.com)
Here, we review the available structural and functional data on RCC1 superfamily members, paying special attention to the human proteins and their involvement in disease. (nih.gov)
The protein encoded by this gene is one of a family of related proteins that transports glucose into cells by facilitated diffusion. (pearson.com)
This region of the chromosome has a cluster of genes that encode the hard proteins, which are involved in the formation of hair and nails. (pearson.com)
Second, it appears to block cell cycle progression, possibly via a down-regulation of CDK proteins. (rndsystems.com)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
8 9 This lack of an absolute phenotype:genotype concordance could be attributed to incomplete screening of the p53 gene, inactivation of the p53 protein through interaction with other cellular proteins or viruses, or defects in other genes involved in p53 mediated cell cycle regulatory pathways. (bmj.com)
p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)

Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
In the present study, we analyzed the proliferation and apoptosis of trophoblasts and human decidual cells in patients with recurrent spontaneous abortion and the related cellular pathway mechanism. (spandidos-publications.com)
The mechanism of recurrent abortion is considered to be related to the proliferation and apoptosis of human decidual cells and cytotrophoblasts ( 4 ). (spandidos-publications.com)
Expression of the SIL gene is correlated with growth induction and cellular proliferation. (proteopedia.org)
Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
Protein 53 is very important in protecting against cancer given that it prevents cancer-causing mutations from accumulating and its inactivation is closely linked to the proliferation of tumour cells. (scienceblog.com)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
Genes clustering in the categories fatty acid beta oxidation, cell adhesion, DNA replication and polyamine biosynthesis were up-regulated indicating increased lipolysis, cell attachment, proliferation and growth. (wada-ama.org)
Uncontrolled cell proliferation is the hallmark of cancer, and genes that directly regulate the cell cycle are typically damaged in tumor cells ( 10 ). (jcancer.org)
During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)

and regulation of cell cycle process. (nih.gov)
Interestingly, in eight cases with p53 wild-type gene, 6 cases (75%) showed a marked down-regulation of p14ARF mRNA, and three cases (37.5%) over-expressed MDM2 mRNA. (nih.gov)
While BRCA2 expression is involved in cell cycle checkpoints and DNA repair, the mechanisms of cell cycle-dependent regulation of BRCA2 gene expression remains elusive. (biomedcentral.com)
P14ARF is a central actor of the cell cycle regulation process as it participates to the ARF-MDM2-p53 pathway and the Rb-E2F-1 pathway. (wikipedia.org)
Intriguingly, some of the top-ranked transcripts are noncoding splicing isoforms, which imply diverse gene regulation mechanisms. (nature.com)
gene loci structures and their regulation. (nature.com)
Dies und die Tatsache, dass LIN-9 mit pRB in der Aktivierung differenzierungspezifischer Gene kooperiert, ließ vermuten, dass humanes LIN-9 einen bedeutenden Einfluss auf die transkriptionelle Regulation Das humane LIN-9 wurde zuerst als pRB-interagierendes Protein beschrieben und spielt eine Rolle als Tumorsuppressor im Kontext des pRB-Signalweges. (uni-wuerzburg.de)
Dies und die Tatsache, dass LIN-9 mit pRB in der Aktivierung differenzierungspezifischer Gene kooperiert, ließ vermuten, dass humanes LIN-9 einen bedeutenden Einfluss auf die transkriptionelle Regulation von Genen haben könnte. (uni-wuerzburg.de)
The homologs of LIN-9 in D. melanogaster and C. elegans are required for the transcriptional regulation of different genes. (uni-wuerzburg.de)
This and the fact, that LIN 9 cooperates with pRB in the activation of differentiation specific genes let to the hypothesis, that human LIN-9 could play an important role in the transcriptional regulation of genes. (uni-wuerzburg.de)
Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
Focus of my research for the last 10 years has been on gene regulation, initially based on transcription factors, promoters and enhancers, but increasingly also including epigenetics, in particular histone modifications. (ntnu.edu)
This gene, DCP1, located at 17q23, codes for an enzyme that plays an important role in blood pressure regulation. (pearson.com)
These modifications have been shown to be important in gene regulation. (neb.com)
The epigenetic regulation of spatiotemporal gene expression is crucial for human development. (researchgate.net)
Genes for non-apoptotic cell death and regulation of osmotic pressure were down-regulated. (wada-ama.org)
Endogenous regulation of the cell cycle depends on phosphorylation and dephosphorylation of the cyclin- cyclin-dependent kinase (CDK)-cyclin-dependent kinase inhibitor (CDKI) pathway. (jcancer.org)
More recently, cyclins are being shown to have additional functions not restricted to cell cycle regulation. (bdbiosciences.com)
Group 3 cyclins (G1, G2 and I) may play a role distinct from either cell cycle or transcriptional regulation. (bdbiosciences.com)
For the current Regulation with respect to cancer evaluation, the Working Group elected to change patients the agent name to "night shift work" in order to better reflect the main evidence base for the Regulations on shift work are in place in studies of cancer in humans, and to avoid mixing many countries. (who.int)

Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. (nih.gov)
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. (wikipedia.org)
The CDKN2A gene resides on chromosome 9 at the band 9p21 and contains 8 exons. (wikipedia.org)
The CDKN2A gene is located on the chromosome 9p21 locus, which is intriguing for several reasons. (wikipedia.org)
Title: Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. (genscript.com)
The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. (nih.gov)
The Human Genome Project: Genes on Human Chromosome 17 The location of genes is designated by an established labeling system for chromosomes. (pearson.com)
Here is a drawing of human chromosome 17 showing its characteristic major banding pattern as it appears after staining. (pearson.com)
To indicate the location of a gene on a particular chromosome, the chromosome number is followed by p or q and then a number that represents the band and sub-band. (pearson.com)
388 genes have been identified on human chromosome 17. (pearson.com)
A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
Many individuals affected by these disorders possess a shortened form of chromosome 20 that lacks a number of genes. (elifesciences.org)
This deletion is only ever seen in one of their two copies of the chromosome-suggesting that at least some of these genes are essential for survival-but the identity of the gene(s) that are associated with the increased risk of myeloid malignancies is unknown. (elifesciences.org)
have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)

Mutations of p53 tumor suppressor gene increase with tumor progression in colorectal cancers. (nih.gov)
The mutations of BRCA2 gene predispose the cells towards neoplastic development. (biomedcentral.com)
Calmodulin Mutations in Human Disease. (nih.gov)
Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. (wikipedia.org)
At least 82 mutations in the TREX1 gene have been identified in people with Aicardi-Goutières syndrome, a disorder that involves severe brain dysfunction (encephalopathy), skin lesions, and other health problems. (medlineplus.gov)
Mutations in the TREX1 gene have also been identified in people with another disorder involving the immune system. (medlineplus.gov)
People with TREX1 gene mutations may develop a rare form of SLE called chilblain lupus that mainly affects the skin. (medlineplus.gov)
TREX1 gene mutations have also been found in people with a disorder called autosomal dominant retinal vasculopathy with cerebral leukodystrophy, which affects the brain and the blood vessels in the specialized light-sensitive tissue that lines the back of the eye (the retina). (medlineplus.gov)
It is not clear why mutations in the same gene cause several different disorders. (medlineplus.gov)
The disease is caused by mutations affecting the gene represented in this entry. (proteopedia.org)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
The majority of classical LFS families harbour germline mutations of the p53 tumour suppressor gene. (bmj.com)
13 14 Although p16 INK4a is most frequently inactivated by homozygous deletion, point mutations or somatic methylation of 5′ regulatory regions are also important mechanisms of gene inactivation. (bmj.com)

Only one case with wild-type p53 gene showed normal level expression of p53 regulatory-factors (p33ING1, p14ARF, and MDM2). (nih.gov)
BRCA2 gene expression is tightly regulated during the cell cycle in human breast cells. (biomedcentral.com)
The expression of BRCA2 gene is silenced at the G0/G1 phase of cell growth and is de-silenced at the S/G2 phase. (biomedcentral.com)
Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
In the G0/G1 growth phase ZAR2 is predominantly located inside the nucleus of the breast cells, binds to the BRCA2 promoter and inhibits the expression of BRCA2. (biomedcentral.com)
Subcellular location of ZAR2 and its expression from the reverse promoter of the BRCA2 gene are stringently regulated in a cell cycle dependent manner. (biomedcentral.com)
ZAR2 binds to BRCA2/ZAR2 bi-directional promoter in vivo and is responsible, at least in part, for the silencing of BRCA2 gene expression in the G0/G1 phase in human breast cells. (biomedcentral.com)
The notion could be that unique cellular mechanisms are triggered in the breast cancer cells to stimulate BRCA2 gene expression as a temporary measure to regulate the growth of the breast cancer cells. (biomedcentral.com)
One potential mechanism of BRCA2 involvement in breast cancer progression may be through deregulation of the BRCA2 gene expression. (biomedcentral.com)
BRCA2 gene expression is stringently regulated during the cell cycle. (biomedcentral.com)
However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene expression data processing and interpretation. (nature.com)
In order to investigate representative mRNA transcript isoforms to be utilized as transcriptome analysis references, we utilized GTEx data to establish a top-ranked transcript isoform expression data resource for human protein-coding genes. (nature.com)
Distinctive tissue specific expression profiles and modulations could be observed for individual top-ranked transcripts of protein-coding genes. (nature.com)
Protein-coding transcripts or genes do occupy much higher expression fraction in transcriptome data. (nature.com)
These studies provided us more information on the spliced transcript isoforms of protein-coding genes as well as more understanding on their expression profiles and translated protein products in human tissues and diseases. (nature.com)
Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer. (genscript.com)
Data show that acetyltransferase Esco1 colocalizes with cohesin throughout the cell cycle and down-regulates expression of neighboring genes. (genscript.com)
In dieser Arbeit konnte erstmals gezeigt werden, dass der Verlust von LIN-9 zu einer verminderten Expression einer Gruppe G2/M-spezifischer Gene führt, deren Produkte für den Eintritt in die Mitose benötigt werden. (uni-wuerzburg.de)
Dies lässt vermuten, dass LIN-9 und B-MYB gemeinsam die Expression der G2/M-Gene kontrollieren. (uni-wuerzburg.de)
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)
In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. (iric.ca)
The maintenance of pluripotency requires coordinated expression of a set of essential genes. (nature.com)
Three gene expression datasets including GSE116959, GSE74706, and GSE85841 downloaded from the Gene Expression Omnibus (GEO) database were used in this study. (hindawi.com)
In recent years, gene expression profiling chips have been widely used in the research fields of various diseases to reveal the association between diseases and genes and provide valuable clues for the pathogenesis of diseases to determine the diagnosis and prognosis of cancer [ 5 ]. (hindawi.com)
Differentially expressed genes were obtained by comparing gene expression between lung adenocarcinoma samples and normal samples. (hindawi.com)
TP53 protein can induce cell growth arrest, apoptosis, differentiation and DNA repair, and activate or inhibit the expression of downstream genes such as Bax and CDKN1A ( 5 ). (spandidos-publications.com)
This study aims to explore its mechanism by defining changes in gene expression between neoplastic and normal tissue samples before and after treatment. (karger.com)
687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
Using RNA deep sequencing, we found that raltegravir specifically boosts the expression of anti-angiogenic factors and promotes metabolic homeostasis in FHV-1-infected cells. (microbiologyresearch.org)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
1994 Expression of Clara cell 10-kD gene in the human endometrium and its relationship to ovarian menstrual cycle. (kelsey-seybold.com)
However, it has much broader effects mediated by genomic (vitamin D directly or indirectly influences expression of up to 2,000 genes) as well as non-genomic mechanisms [ 1 ]. (karger.com)
Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Study of the cytotoxicity, genotoxicity, cell cycle monitoring, induction of apoptosis, and gene expression of Rubus rosaefolius leaves and stems extracts in human cultured cells. (fapesp.br)
In addition, this study will to investigate the possible mechanism of action of the both extracts, through the analysis of the gene expression of some of the main genes of these biochemical pathways. (fapesp.br)
The second stage of the research will include, through real-time qRT-PCR analysis, the investigation of the relative expression of genes involved in the above-mentioned processes that have had some interesting biological effect after exposure to the extracts. (fapesp.br)
The development of this project will allow the formation of qualified human resources at doctoral level and scientific initiation, as well as the implantation in the laboratory, the molecular techniques involving the analysis of gene expression (qRT-PCR), and flow cytometry, which have the potential to elucidate the Mechanisms of action of the phytotherapeutics (and its constituents) routinely investigated in the Toxicological Genetics Laboratory. (fapesp.br)
The introduction of complementary DNA (cDNA) microarray technology in 1995 has helped to facilitate the identification and classification of DNA sequence information and the assignment of functions to these new genes by allowing investigators to analyze expression of thousands of genes simultaneously in a single experiment. (medscape.com)
Microarrays may be used to assay gene expression within a single sample or to compare gene expression in 2 different cell types or tissue samples, such as in healthy versus diseased tissue. (medscape.com)
[ 5 ] Because a microarray can be used to examine the expression of hundreds or thousands of genes at once, it promises to revolutionize the way gene expression is examined. (medscape.com)
Because the locations of the probes are known, the intensity and pattern of the labeled mRNA can be used to measure the expression of the targeted gene. (medscape.com)
The intensity of fluorescence is analyzed and correlates with expression of the gene. (medscape.com)
[ 6 ] Both technologies use hybridization of labeled nucleic acid transcripts to measure the gene expression. (medscape.com)
By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
Myeloid malignancy patients lacking one copy of this gene showed levels of MYBL2 expression that were less than 50% of those in healthy individuals. (elifesciences.org)
This suggests that additional mechanisms must be acting to reduce expression of their remaining copy of the gene. (elifesciences.org)
Hence, this finding reveals a more general role for MYBL2 as it indicates that more patients are likely to be affected by altered expression of this gene. (elifesciences.org)
used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
As ChIP-seq cannot establish physical co-occurrence of two marks on the same allele, admixture of cells that either express (green) or do not express (red) the gene in focus could explain the occurrence of both marks as well as the low expression level in the overall population. (researchgate.net)
In contrast, in the case of ''true'' bivalency, virtually all cells in the population carry both marks simultaneously at the promoter in question, leading to low, if any, expression for that gene in all cells. (researchgate.net)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
Gene expression profile in response to potassium dichromate-induced toxicity in human dermal fibroblasts. (cdc.gov)
To understand the molecular mechanisms responsible for the dermal toxicity of chromium , a differential gene expression profile of human skin fibroblasts exposed to a cytotoxic concentration of hexavalent potassium dichromate [Cr(VI)] was studied. (cdc.gov)
Skin fibroblasts were exposed to 5 micromolar Cr(VI) for time intervals up to 24-hours and a differential gene expression profile was studied using the human Toxicology and Drug Resistance Microarray (Super Array Inc.). Of the 280 genes represented on the array, 32 were found differentially expressed in the fibroblasts exposed to Cr(VI). (cdc.gov)
The molecular mechanisms responsible for the Cr(VI)-induced differential gene expression were investigated using heme oxygenase 1 (HO-1) as the model gene. (cdc.gov)
HO-1 gene expression was significantly higher in the Cr(VI) exposed cells compared with the control cells. (cdc.gov)
Similarly, modulating the intracellular glutathione level by pre-treating cells with either BSO or glutathione significantly influenced the potential of Cr(VI) to induce the expression of the HO-1 gene. (cdc.gov)
Similar results were obtained when experiments were conducted using a luciferase reporter gene expression system containing the HO-1 gene promoter. (cdc.gov)
The researchers have worked together with Professor Barbara Bakker's lab (University Medical Centre Groningen), where they could compare the expression of human genes in yeast and in their native human muscle environment using lab-grown human tissue cells. (tudelft.nl)
Microarray technology will be used to search for changes in leukocyte gene expression which are directly related to the application of human growth hormone (hgh). (wada-ama.org)
Whole genome cDNA microarrays as well as oligonucleotide microarrays including leukocyte-relevant genes will be used to characterize potential hgh-specific genes by comparing gene expression profiles of treated and untreated cells. (wada-ama.org)
After confirming SSH-genes to be differentially expressed in a series of microarray experiments, oligonucleotide probes will be designed for both SSH-genes and the candidate genes identified along gene expression profiling using whole genome/leukocyte relevant arrays. (wada-ama.org)
The "hgh-chip" will then be thoroughly evaluated by performing numerous gene expression experiments on hgh-treated and untreated leukocyte subsets, cultured PBMCs as well as PBMCs obtained from hgh-patients. (wada-ama.org)
During the proposed project new, nucleic acid-based analytical techniques will be used to gain insight into specific effects of hgh on gene expression of leukocytes. (wada-ama.org)
Results obtained from gene expression profiling utilising whole genome arrays were in accordance with published data. (wada-ama.org)
Recently, reduced expression of CDK10 has been observed in several cancerous human tissue, suggesting that CDK10 is a tumor suppressor gene. (jcancer.org)
Like many cyclins, the expression of cyclin C oscillates throughout the cell cycle, with a peak observed during G1 phase. (bdbiosciences.com)
Because Cdc2 kinase is important for cell entry into mitosis, cyclin C's ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36 kD. (bdbiosciences.com)
Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. (lu.se)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
gene expression and secretion. (lu.se)
bioethanol, pathogenesis and expression of human hormones. (lu.se)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
Therefore, Rb remains associated with transcription factor E2F1, preventing transcription of E2F1 target genes which are crucial for the G1/S transition. (wikipedia.org)
Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. (genscript.com)
In contrast, few changes in host gene transcription were found in uninfected cells. (microbiologyresearch.org)
Taken together, these results indicate that raltegravir has profound and specific effects on the host transcription profile of herpesvirus-infected cells that may contribute to the overall antiviral activity of the drug and could provide therapeutic benefits in vivo . (microbiologyresearch.org)
Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. (karger.com)
The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
Preexposure of dermal fibroblasts to actinomycin D (inhibitor of transcription) and Nacetyl cysteine (scavenger of reactive oxygen species) blocked the Cr(VI)-induced overexpression of the HO-1 gene. (cdc.gov)
Cyclin C may play a dual role within the cell in its ability to regulate both cell cycle progression as well as gene transcription. (bdbiosciences.com)
Cyclin C associates with Cdk8, forming a complex which can induce gene transcription of Cdc2 (Cdk1). (bdbiosciences.com)

In this study, we obtained the hub genes and pathways related to LUAD, revealing the molecular mechanism and pathogenesis of LUAD, which is helpful for the early detection of LUAD and provides a new idea for the treatment of LUAD. (hindawi.com)
In the present study, we comparatively analyzed the cell apoptosis and cell signaling pathways of healthy patients and those with recurrent spontaneous abortion, providing a theoretical basis for clinical treatment. (spandidos-publications.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
From there, they wanted to see how far they could go with adding multiple human genes and entire metabolic pathways, and if the cells would still function as a whole. (tudelft.nl)

Through the service and infrastructure activities the group has also been involved in several other projects, like research on prokaryotes, including oil well metagenomics, biodegradation, pathogenic bacteria, and characterization of novel bacterial genes. (ntnu.edu)

The differentially expressed genes (DEGs) related to LUAD were screened by using the limma package. (hindawi.com)
The protein-protein interaction (PPI) of differentially expressed genes was drawn by the STRING website, and the results were imported into Cytoscape for visualization. (hindawi.com)
The PPI network of differentially expressed genes consists of 269 nodes and 625 interactions. (hindawi.com)
In general, genes involved in stress response, cell cycle control, drug metabolism, apoptosis and growth were found differentially expressed in the Cr(VI) exposed fibroblasts. (cdc.gov)

It is essential to exhaustively interrogate complex mRNA isoforms of protein-coding genes with an unified data resource. (nature.com)
One major difficulty confronted is complex alternatively spliced transcript isoforms in human protein-coding genes. (nature.com)
Therefore, information regarding reference annotated mRNA transcripts of respective human protein-coding genes would be beneficial for biomedical researches and pathological sequence variation analyses. (nature.com)
Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)

Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)

Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Gene Ontology (GO) and KEGG analysis of DEGs were carried out through the DAVID website. (hindawi.com)

We then transferred the HSV-TK gene to target cells SW1990 using these progeny virions, and treated these gene-modified tumor cells with GCV to study the sensitivity of the cells to GCV and their bystander effects by routine MTT-method. (wjgnet.com)
The Rubus rosaefolius plant recently have been some of its therapeutic properties confirmed by scientific analysis, among them the analgesic, antimicrobial, antihypertensive, antioxidant, antiproliferative effects in tumor cells, diuretic, gastroprotective and antidepressant. (fapesp.br)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

[ 1 ] the Cancer Genome Anatomy Project index of tumor genes has classified more than 40,000 genes directly or indirectly involved in one or more cancers. (medscape.com)

Daran-Lapujade's lab took human DNA (in red) encoding core functions in muscle cells, and inserted it into the DNA (chromosomes in purple) of a yeast cell (in yellow). (tudelft.nl)

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. (nature.com)
Principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics, notes that most of the genes involved in the RNA signature have not previously been linked to breast cancer and that unlike many other prognostic signatures, this one does not contain genes involved in the cell cycle or tumor grade. (sciencedaily.com)
Most of these prognostic genes are newcomers, and therefore they might represent novel drug targets," says Croce, who is also the John W. Wolfe Chair in Human Cancer Genetics. (sciencedaily.com)

In addition to p16 and ARF, this gene produces 4 other isoforms through alternative splicing. (wikipedia.org)
Thus, we established a web tool to examine top-ranked transcript isoforms in various human normal tissue types, which provides concise transcript information and easy-to-use graphical user interfaces. (nature.com)
We identified genes, isoforms and transposable element fa. (researchgate.net)

In human cancer cell lines derived from various tumor types, a high frequency of genetic and epigenetic alterations (e.g., promoter hyper-methylation, homozygous deletion or mutation) in the CDKN2A gene has been observed. (wikipedia.org)
Prevalence of prothrombin gene mutation (G-A 20210 A) in general population: a pilot study. (cdc.gov)

With this we could allude to an intrinsic bias of essentiality across cellular compartments, uncover two opposing roles for tumour suppressor genes and link autosomal-recessive disorders with growth-retardation phenotypes to early embryogenesis. (nature.com)

Our screen also led to the identification of growth-restricting genes whose loss of function provides a growth advantage to hPSCs, highlighting the role of the P53-mTOR pathway in this context. (nature.com)
[ 2 , 3 ] Conventional techniques of gene investigation in cancer rely on the identification of single genetic alterations associated with disease. (medscape.com)
This one-hundred-and-twenty-fourth volume of the IARC Monographs on the Identification of Carcinogenic Hazards to Humans contains evaluations of the carcinogenic hazard to humans of night shift work. (who.int)
Theories of drug development, including identification of genes for diagnostics, protein and drug interactions, models for 'knock-out' and 'knock-down' of genes, gene therapy, cancer and stem cell biology, as well as clinical assessment. (lu.se)

In this way, it breaks down unneeded DNA molecules or fragments that may be generated during copying (replication) of cells' genetic material in preparation for cell division. (medlineplus.gov)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
We used a replication defective recombinant retrovirus vector GINaTK (bearing HSV-TK gene) to make packaging cell PA317 produce progeny virions. (wjgnet.com)
Histone H3.3, an H3 variant that is found in all eukaryotes from yeast to human, is replication and cell cycle phase-independent and is the most common H3 in non-dividing cells. (neb.com)

We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. (lu.se)

The purpose of this study is to identify the hub genes associated with LUAD by bioinformatics methods. (hindawi.com)

Overall, we have constructed an atlas of essential and growth-restricting genes in hPSCs, revealing key aspects of cellular essentiality and providing a reference for future studies on human pluripotency. (nature.com)
2021). The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells . (essex.ac.uk)
However, before the commercial exploitation of R. rosaefolius as a herbal remedy, it is necessary to carry out tests evaluating the biosafety of the use of this plant by humans, ascertaining if it is free of cellular and genetic toxicity. (fapesp.br)
Thus, it has been argued that the observed bivalency simply reflects cellular heterogeneity arising from the averaging of cells that carry either, but not both, marks at a given locus (Fig. 2). (researchgate.net)
With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure from the molecular and cellular levels to developmental and physiological processes. (cshlpress.com)
they contain the blueprint for a so-called metabolic pathway - a process that breaks down sugar to capture energy and construct cellular building blocks inside muscle cells. (tudelft.nl)

Raltegravir is a human immunodeficiency virus (HIV)-integrase inhibitor that has been shown to alter the host immune response to HIV in addition to its direct antiviral effect. (microbiologyresearch.org)
13 p16 INK4a is a cyclin dependent kinase inhibitor that is frequently mutated or deleted in many human cancer cell lines 14-16 and some sporadic malignancies, including sarcomas, breast cancer, leukaemia, and brain tumours, which are all component tumours of LFS. (bmj.com)

In the first phase of the project cell lines of specific leukocyte subsets (THP-1/monocyte, IM-9/T lymphocyte, H9/B lymphocyte), PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively will be treated in vitro with hgh to identify candidate genes influenced by hghapplication. (wada-ama.org)
To find additional hgh-candidate genes, suppression subtractive hybridization (SSH) technology will be applied on hgh-treated PBMCs and on those cultured leukocyte subsets which showed a response to hgh before during in vitro studies. (wada-ama.org)
Geographical characteristics of single nucleotide polymorphism of candidate genes associated with coronary artery disease in Chinese Han population]. (cdc.gov)

A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. (proteopedia.org)

The gene BLMH is located at 17q11.2, and the gene encodes an enzyme. (pearson.com)
This gene, MPO, located at 17q23.1, encodes an enzyme that is found in white blood cells and increases the ability of these cells to kill microorganisms. (pearson.com)

It is ubiquitously expressed in many tissues and cell types. (wikipedia.org)
As compared to human cells or tissues, yeast is a fantastic organism for its simplicity to grow and its genetic accessibility: its DNA can be easily modified to address fundamental questions. (tudelft.nl)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

DNA microarrays are simply platforms that consist of small solid supports onto which the sequences from thousands of different genes are attached at fixed locations. (medscape.com)

Here, we used felid alphaherpesvirus 1 (FHV-1), a close relative of human alphaherpesvirus 1 (HHV-1) that similarly causes ocular herpes, to characterize the host-targeted effects of raltegravir on corneal epithelial cells during an alphaherpesvirus infection. (microbiologyresearch.org)
We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
After the slide was gram stained the slide was scanned under a microscope using low power objective to locate clusters of epithelial cells. (cdc.gov)

Among the sequenced organisms, the human genome project was declared complete in 2003 as a celebration of the 50th anniversary of the DNA double helix structure unveiling 3 . (nature.com)

E ditor -The Li-Fraumeni syndrome (LFS) is a rare familial cancer syndrome that predisposes gene carriers to the development of diverse early onset malignancies, including soft tissue sarcomas, osteosarcomas, adrenocortical carcinomas, brain tumours, breast carcinomas, and leukaemia, 1-3 with other cancer types occurring less frequently. (bmj.com)
p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
A growing number of publications are based on results from the Human Tissue Laboratory. (lu.se)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

The only known function of the enzyme encoded in this gene is the inactivation of a protein (BLM) that's toxic to the lungs. (pearson.com)
In view of the comparable biological and phenotypic features of p53 and p16 INK4a inactivation, we proposed that germline inactivation of the p16 INK4a gene could account for the predisposition to cancer development in a proportion of LFS families that harboured wild type p53 . (bmj.com)
This causes the gene encoding the protein, which in humans is the TP53 gene, to be seen as a tumour suppressor since its inactivation can make it easier for many types of tumour cells to develop. (scienceblog.com)
In recent decades, it has been confirmed that tumor progression of GC is a multi-step process that involves the activation of oncogenes and the inactivation of tumor suppressor genes at different stages ( 7 , 8 ). (jcancer.org)

CDK10 can may serve as a valuable prognostic marker and a potential target for gene therapy. (jcancer.org)
Recently, a series of studies revealed the diagnostic and prognostic value of CDKs (mainly CDK1-7) in different types of human cancer, including oral cancer, medulloblastoma, pancreatic cancer ( 11 - 14 ). (jcancer.org)

These DNA and RNA molecules may be mistaken by cells for the genetic material of viral invaders, triggering immune system reactions that damage the brain, skin, and other organs and systems and result in the signs and symptoms of Aicardi-Goutières syndrome. (medlineplus.gov)
Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
Genetic engineering has been used to clone this growth hormone gene, which has enabled the production of growth hormone used in the treatment of pituitary dwarfism. (pearson.com)
The human sperm is one of the smallest cells in the body, but also one of the most important, as it serves as the entire paternal genetic contribution to a child. (researchgate.net)
Purpose Next-generation sequencing has implicated some risk variants for human spina bifida (SB), but the genome-wide contribution of structural variation to this complex genetic disorder remains largely unknown. (researchgate.net)
Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population. (cdc.gov)
1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
The technology exists to take genetic code and manipulate it in a way that can improve human health and prevent disease. (medlineplus.gov)

We show that depletion of SMD components increases the binding of mitotic mRNAs to the NF45-NF90 complex and rescues cells from mitotic defects. (iric.ca)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

Cyclin-dependent kinase (CDK) 10, is reported to play an essential role in the progression from the G2 to M phase of the cell cycle. (jcancer.org)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
The identity of the higher molecular weight band (~ 45 kD) has not been determined, but may represent an alternative splice product of the cyclin C gene. (bdbiosciences.com)
Human Cyclin C polypeptide fragment aa. (bdbiosciences.com)
The identity of this protein has not been determined, but may represent an alternative splice product of the cyclin C gene, as has been identified in other species. (bdbiosciences.com)
Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate progression of the cell cycle. (bdbiosciences.com)
Cyclin C has been identified in both human and chicken species. (bdbiosciences.com)
The polyclonal antiserum reacts with human and mouse cyclin C. A polypeptide fragment containing amino acids 290-303 (QGPNGSQNSSYSQS) at the C-terminus of human cyclin C, with the addition of a C-terminal cysteine (C) residue to facilitate conjugation to KLH, was used as immunogen. (bdbiosciences.com)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)

The gene TP53 is located at 17p13.1. (pearson.com)

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. (genscript.com)

Here, we present whole-genome chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) analyses of a wide variety of histone markers in the brain, heart, and liver of early human embryos shortly after their formation. (researchgate.net)

Our data demonstrate that HSV-TK/GCV suicide gene therapy system is effective for treating experimental human pancreatic cancer, which is largely resistant to the common therapies, so the suicide gene therapy system may be a potential treatment approach for pancreatic cancer. (wjgnet.com)

The research describes for the first time the physiological role of p53 in the development of meiosis and suggests that the function of the tumour suppressor gene can be result of an evolution of primitive activities related with the progression of meiosis. (scienceblog.com)

Blood cells are produced within bone marrow by specialized stem cells and progenitor cells. (elifesciences.org)
Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)

Expansions of TRs are responsible for approximately 50 monogenic diseases, compared to over 4,300 disease causing genes disrupted by single nucleotide variants and small indels. (researchgate.net)

We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)

Methodology for evaluating oxidative DNA damage and metabolic genotypes in human trabecular meshwork. (cdc.gov)

Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. (lu.se)

Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)

26-29 Where available, samples from more than one family member were examined to determine whether a germline gene alteration occurred de novo or was inherited. (bmj.com)
Both p53 wild type and p53 mutant samples were included in the p16 INK4a analysis to determine whether germline alterations of one gene precluded the occurrence of alterations of the other. (bmj.com)

We model central nervous system development using organoids, and select three histone modifications as proxies for dynamic epigenetic change and validate our findings in a primary developing human brain. (researchgate.net)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

The following ESCO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. (nature.com)

We are also the home of the National Center on Sleep Disorders Research, so add sleep and circadian biology (the study of your body's 24-hour cycles). (medlineplus.gov)

Association of GSTM1 and GSTT1 gene deletions with susceptibility to DNA damage in the pesticide-exposed workers of Punjab. (cdc.gov)

We identified 67 upregulated genes and 277 downregulated genes from three LUAD datasets. (hindawi.com)

Cell Stem Cell 19 , 569-572 (2016). (nature.com)
Cell Stem Cell 9 , 563-574 (2011). (nature.com)
Cell Stem Cell 14 , 404-414 (2014). (nature.com)
I am especially interested in the role of mesenchymal stem cells (MSCs) in this process. (essex.ac.uk)
and effects on the cell cycle progression, action on the apoptosis induction, of leaf and stem extracts of R. rosaefolius, in HepG2/C3A cells (Human hepatoma). (fapesp.br)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)

Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest. (cshlpress.com)

18-20 p16 INK4a shares functional similarities with p53 in that it blocks progression through the cell cycle at G1/S by inhibiting CDK 4/6 mediated phosphorylation of Rb. (bmj.com)

This induces dimerization with ARNT, translocation to the nucleus, and activation of P450 genes such as CYP1A1 and UGT1A6. (rndsystems.com)

Anatomy22

Organisms14

Diseases4

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes99

Disciplines and Occupations3

Information Science7

Health Care3

Proteins16

Proliferation16

Regulation20

Chromosome16

Mutations13

Expression77

Transcription10

Pathways4

Characterization1

Differentially expressed4

Protein-codin4

Signaling pathway1

Differentiation5

Ontology1

Tumor cells4

Cancers1

Chromosomes1

Genetics3

Isoforms3

Mutation2

Phenotypes1

Identification4

Replication5

Mitochondrial1

Associated with LU1

Cellular6

Inhibitor2

Candidate genes3

MRNA1

Encodes2

Tissues3

Different genes1

Epithelial3

Genome project1

Tissue5

Inactivation4

Prognostic2

Genetic9

Defects2

Cyclin9

TP531

Regulate1

Whole genome1

Pancreatic cancer1

Tumour supp1

Bone marrow4

Variants1

Ovarian cancer1

Metabolic1

Secretion1

Promoters1

Germline2

Epigenetic1

Autologous stem cell trans1

NCBI1

Embryonic stem4

Biology1

Susceptibility1

Datasets1

Stem6

Tumors3

Genomics1

Progression through the cell cycle1

UGT1A61