• Previous studies have shown association of the multifunctional hepatic protein α2HS-glycoprotein/human fetuin A with insulin resistance, type 2 diabetes mellitus, metabolic syndrome, obesity, and atherosclerosis. (nih.gov)
  • Reports of contribution of α2HS-glycoprotein/human fetuin A rs4917 single-nucleotide polymorphism to the development of these pathologic processes are inconsistent. (nih.gov)
  • Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists as a single-copy gene in the human and mouse genomes. (wikipedia.org)
  • Fetuin relatives within this superfamily are the histidine-rich glycoprotein (HRG) and kininogen (KNG). (wikipedia.org)
  • [ 2-5 ] Of these molecules, fetuin-A is a serum glycoprotein produced primarily in the liver that circulates at high levels. (medscape.com)
  • Binding assay: used to assess the amount of pertussis toxin/toxoid binding activity to the glycoprotein fetuin. (nih.gov)
  • With the use of bovine fetuin as a standard glycoprotein, the incubation time was determined for each major step of glycopeptide isolation. (nih.gov)
  • Fetuin-A, also referred to as α2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. (ox.ac.uk)
  • Fetuin-A is a glycoprotein that acts as a protective factor for vascular calcification in end-stage kidney disease (3). (ankaratipfakultesimecmuasi.net)
  • The human Alpha-2-HS-Glycoprotein containing 349 a.a was purified from the human plasma.The total molecular mass is 37.3kDa (calculated without glycosylation). (assaygenie.com)
  • HN - 2012 MH - alpha-2-HS-Glycoprotein UI - D060749 MN - D12.776.124.790.106.304.500 MN - D12.776.157.125.283.500 MN - D12.776.215.625.500 MN - D12.776.377.715.85.304.500 MN - D12.776.395.86 MS - A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. (nih.gov)
  • Fetal bovine serum contains more fetuin than albumin, while adult serum contains more albumin than fetuin. (wikipedia.org)
  • Conclusions: The results of this study advance current knowledge of the human cord blood serum proteome. (nih.gov)
  • With the use of commercially available human serum, multiple parallel isolations of glycopeptides were performed using hydrazide tips with a liquid handling robotic system. (nih.gov)
  • OEG 2 ) 2 -IP4 potently stabilizes calciprotein particle (CPP) growth, consistently demonstrates low micromolar activity in different in vitro models of VC (i.e., human serum, primary cell cultures, and tissue explants), and largely abolishes the development of VC in rodent models, while not causing toxicity related to serum calcium chelation. (nature.com)
  • Under non-pathological conditions, surges of plasma phosphate or calcium, or local drops in the concentration of circulating calcification inhibitors are buffered by acidic serum proteins, notably fetuin-A, via the formation of colloidal calciprotein particles (CPPs) 19 . (nature.com)
  • 9, 10] Chronic inflammatory conditions may predispose to calciphylaxis by reducing serum levels of fetuin-A, an important inhibitor of calcification produced in the liver. (medscape.com)
  • The performance of the pipeline is also demonstrated in a biological human serum dataset for the identification of gender-related proteins. (biomed.news)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Metallothionein 2 (MT2) in serum, plasma, tissue homogenates and other biological fluids. (agctsequencing.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Metallothionein 2 (MT2) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
  • Description: A sandwich ELISA kit for detection of Metallothionein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)
  • Description: A sandwich ELISA kit for detection of Jumping Translocation Breakpoint Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • Description: A competitive ELISA for quantitative measurement of Human Translocation protein SEC62(SEC62) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (2sars.com)
  • Description: A competitive ELISA for quantitative measurement of Human Cytochrome P450 2A13(CYP2A13) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
  • Description: For quantitative detection of human MIA in cell culture supernates, serum, plasma(heparin, EDTA) and saliva. (cromauv.org)
  • Description: For quantitative detection of human ADA in cell culture supernates, serum and pleural fluid. (cromauv.org)
  • Description: For quantitative detection of human PAM in cell culture supernates, serum and plasma (heparin, EDTA, citrate). (cromauv.org)
  • Description: For quantitative detection of human RET in cell culture supernates, serum and plasma (heparin). (cromauv.org)
  • Description: For quantitative detection of human LY9 in cell culture supernates, serum and plasma (heparin, EDTA). (cromauv.org)
  • Feeding a mineral-rich diet to fetuin-A-deficient mice resulted in widespread calcification (ectopic mineralization) of lung, heart, and kidneys in these mice. (wikipedia.org)
  • The calcification became drastically exacerbated when the fetuin-A knockout was combined with the genetic background DBA/2. (wikipedia.org)
  • Fetuin-A deficiency dramatically increased the calcification proneness of these mice in that all mice spontaneously calcified throughout their body even without a mineral-rich diet or surgical tissue trauma. (wikipedia.org)
  • Fetuin-A is therefore regarded as a potent inhibitor of systemic calcification. (wikipedia.org)
  • Fetuin-A was originally discovered to be an inhibitor of vascular calcification in early 1990s. (wikipedia.org)
  • Here we summarize the functional link between vascular calcification and autophagy in both animal models of and human cardiovascular disease. (biomedcentral.com)
  • Fetuin-A is a major carrier protein of free fatty acids in the circulation. (wikipedia.org)
  • Free fatty acids cause Fetuin-A overexpression by increasing the pro-inflammatory protein NF-κB. (wikipedia.org)
  • When the alive and deceased groups were compared age (p=0.001), diabetes mellitus (p=0.041), GNRI (p=0.019), AAC score (p=0.009), cf-PWV (p=0.003), albumin (p=0.030), C-reactive protein (p=0.003), mean systolic BP before dialysis (p=0.018), and mean diastolic BP before dialysis (p=0.045) were significantly different between two groups, whereas Fetuin-A and FGF-23 were not. (ankaratipfakultesimecmuasi.net)
  • Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains.Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. (assaygenie.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Jumping Translocation Breakpoint Protein (JTB) in Tissue homogenates, cell lysates and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Jumping Translocation Breakpoint Protein (JTB) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • The work, supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), suggests that the protein fetuin-A (a known anti-mineralization protein) could be a therapeutic target in PXE. (nih.gov)
  • The rs4686434 variant in the fetuin B (FETUB) locus is associated with intrahepatic triglyceride content in obese Chinese adults. (cdc.gov)
  • Xenopus tropicalis fetuin B (fetub), mRNA. (genscript.com)
  • Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer. (ox.ac.uk)
  • The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. (ox.ac.uk)
  • 1. Fetuin-A deficiency is associated with infantile cortical hyperostosis (Caffey disease). (nih.gov)
  • Avrameas S, Guilbert B, Dighiero G. Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities Ann Immunol (Paris). (ukrbiochemjournal.org)
  • Plasma Levels of Fetuin-A and Hepatic Enzymes and Risk of Type 2 Diabetes in Women in the U.S. (medscape.com)
  • From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses'Health Study, for whom levels of plasma fetuin-A, alanine transaminase (ALT), and γ-glutamyltranspeptidase (GGT) were measured. (medscape.com)
  • These findings suggest that plasma fetuin-A levels were independently associated with higher risk of developing type 2 diabetes. (medscape.com)
  • Plasma concentration of fetuin-A and insulin was determined. (bmj.com)
  • Plasma fetuin-A concentration in GDM cases was significantly higher than controls in both the first trimester and the second trimester and notably increased from the first to the second trimester. (bmj.com)
  • To address this challenge, nanoflow liquid chromatography, ion mobility spectrometry, and mass spectrometry (nLC-IMS-MS) were combined with the Individuality Normalization when Labeling with the Isotopic Glycan Hydrazide Tags (INLIGHT™) strategy to study a series of glycan standards and those enzymatically released from the glycoproteins horseradish peroxidase, fetuin, and pooled human plasma. (nih.gov)
  • Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. (ox.ac.uk)
  • Do Nonalcoholic Fatty Liver Disease and Fetuin-A Play Different Roles in Symptomatic Coronary Artery Disease and Peripheral Arterial Disease? (wikipedia.org)
  • Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. (medscape.com)
  • The scientists also looked at the blood concentration of the fetuin-A in PXE mice, and found it to be significantly lower than that of unaffected mice. (nih.gov)
  • Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults. (cdc.gov)
  • Here, we examined whether the mRNA-expression of pancreatic extracellular matrix (ECM)-forming and -degrading components differ in PPAs from individuals with normal glucose regulation (PPAs-NGR), prediabetes (PPAs-PD), and type 2 diabetes (PPAs-T2D), and whether fetuin-A/palmitate impacts ECM-formation/degradation and associated monocyte invasion. (bvsalud.org)
  • Fetuin-A/palmitate reduced fibronectin, decorin, TIMP-1/-2 and TGF-ß1 mRNA levels. (bvsalud.org)
  • Fetuin-A/palmitate increased MMP-1, usherin and dermatopontin mRNA-levels in co-cultured islets. (bvsalud.org)
  • Increased fetuin-A has also been linked to increased occurrence of non-alcoholic fatty liver disease and cardiovascular events, believed to be due to its proinflammatory effects. (wikipedia.org)
  • The function of Fetuin-A in the body was determined by gene knockout technology in mice. (wikipedia.org)
  • Previously, we found that human pancreatic preadipocytes (PPAs) and islets influence each other and that the crosstalk with the fatty liver via the hepatokine fetuin-A/palmitate induces inflammatory responses. (bvsalud.org)
  • Although a recent study ( 22 ) reported enhanced avidity of H5N6 viruses for human-type receptors, recombinant clade 2.3.4.4 highly pathogenic influenza A virus H5 proteins from virus isolates in North America show a strict avian receptor-binding preference ( 23 ). (cdc.gov)
  • A transmigration assay showed increased monocyte migration towards PPAs, which was enhanced by fetuin-A/palmitate. (bvsalud.org)
  • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance" (PDF). (wikipedia.org)
  • The present invention relates to the lower molecular weight subunit of the human transferrin receptor of a strain of N. meningitidis, in purified form, as well as to a vaccinal pharmaceutical composition intended for the prevention or attenuation of the effects of an N. meningitidis infection, containing the said subunit in purified form. (justia.com)
  • Se asocia con la calcificación vascular y con una gran mortalidad cuando sus niveles en sangre son elevados. (revistanefrologia.com)
  • The Human Secretoneurin ELISA is a sandwich Enzyme-linked Immunoassay (ELISA). (ibl-america.com)
  • These results confirm that EPA is a tumor suppressor in human ovarian clear cell carcinoma cells and functions through a novel fatty acid receptor, GPR30, indicating a mechanistic linkage between omega-3 fatty acids and cancers. (e-crt.org)
  • There are still ongoing experiments to see how it reacts and helps cancer tumors by witnessing the progression of the tumor by hypnotizing the fetuin as the cell types do not have the ability to express fetuin on its own. (prospecbio.com)
  • The fetuin surrounds the tumor cell. (prospecbio.com)
  • Knocking out the gene for fetuin-A rendered the mice completely fetuin-A deficient. (wikipedia.org)
  • Fetuin-A has been shown to facilitate the binding of free fatty acids to TLR4 receptors, thereby inducing insulin resistance in mice. (wikipedia.org)
  • In contrast, mice heterozygous for this allele, thus mimicking human carriers of LoF alleles, show markedly increased endocrine and exocrine zinc content (1.6-fold increase for both compared to WT), as measured by LA-ICP-MS. Both endocrine and exocrine manganese contents were also sharply increased in R138X+/- mice, with smaller increases observed in R138X+/+ mice. (bvsalud.org)
  • Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice. (nih.gov)
  • Decreased fetuin-A is a predictor of increased disease activity in obstructive lung disease, Crohn's disease, and ulcerative colitis. (wikipedia.org)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. (ox.ac.uk)
  • Description: For quantitative detection of human P53 in cell lysates. (cromauv.org)
  • Activity: ACL agglutinates human ABO and sheep, goat, rat, rabbit and guinea-pig erythrocytes. (glycomatrix.com)
  • Hence fetuin-A is a predictor of adverse glycemic outcomes in pre-diabetes. (wikipedia.org)
  • Only fibronectin was strongly downregulated by fetuin-A/palmitate independently of the glycemic status. (bvsalud.org)
  • When results from this study were pooled with those in three prior prospective investigations of the same association, a consistent, positive association was observed between high fetuin-A levels and diabetes risk: the relative risk (95% CI) comparing high versus low fetuin-A levels was 1.69 (1.39-2.05) ( P for heterogeneity = 0.45). (medscape.com)
  • Several cross-sectional studies documented a positive association between fetuin-A and prevalent diabetes, [ 14 , 15 ] although a temporal relationship cannot be extrapolated from these studies. (medscape.com)
  • Thus far, only three prospective studies have been conducted and all reported a positive association between fetuin-A levels and diabetes risk. (medscape.com)
  • Therefore, we performed a prospective, nested, case-control study among the Nurses'Health Study (NHS) participants to examine the association between fetuin-A and diabetes risk and to explore whether this association is explained or modified by alanine transaminase (ALT) and γ-glutamyltranspeptidase (GGT), two liver enzymes that serve as surrogate markers of NAFLD. (medscape.com)
  • The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development. (ox.ac.uk)
  • The binding pattern to fetuin was identical among all isolates tested (association constant K ass ≈ 5.8 ± 0.5, 1/μM sialic acid). (cdc.gov)
  • The study of the association between diet and human cancer has drawn considerable attention in recent decades, especially which and how dietary factors might influence cancer risk. (e-crt.org)
  • Fetuin-A in contrast has also been demonstrated to have anti-inflammatory properties. (wikipedia.org)
  • In contrast, our human ancestors did not have continuous access to a food supply. (nature.com)
  • In response to various metabolic needs, the human body has developed an interorgan communication system where individual tissues can affect the metabolic pathways of distant tissues. (scientificarchives.com)
  • However, so far, limited research on the correlation of fetuin-A and GDM yielded inconsistent findings and none of them assessed the impact of the dynamic change in fetuin-A levels on GDM. (bmj.com)
  • however, the role of fetuin-A in the development of colorectal cancer is unclear. (ox.ac.uk)
  • In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 µg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. (ox.ac.uk)
  • In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 µg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). (ox.ac.uk)
  • Identification and characterization of metabolically benign obesity in humans. (research.com)
  • Since then many more roles have been attributed to fetuin-A. Fetuin-A has been demonstrated to play an important role in free fatty acid induced insulin resistance in the liver. (wikipedia.org)
  • Studies of human-derived and other macrophages in vitro and ex vivo showed that M2-macrophages (stimulated by CSF-1, IL-4, and IL-13) can phagocytose CaOx crystals, which suppresses stone development. (frontiersin.org)
  • Increased fetuin-A in patients with pre-diabetes is associated with increased progression to diabetes and decreased reversal to normoglycemia. (wikipedia.org)
  • [ 12 , 13 ] Human observational studies regarding fetuin-A levels in relation to insulin resistance or diabetes are scarce. (medscape.com)
  • Objective To examine the effects of dynamic change in fetuin-A levels before the diagnosis of gestational diabetes mellitus (GDM) on insulin resistance and GDM. (bmj.com)
  • Fetuin-A has been shown to contribute to the onset of type 2 diabetes mellitus, indicating that it might also be an important biomarker involved in the pathogenesis of gestational diabetes mellitus (GDM) development. (bmj.com)
  • Conclusions The dynamic change in fetuin-A levels was associated with the changes in insulin resistance and β-cell function from the first to the second trimester, and was associated with an increased risk of the development of GDM, indicating that fetuin-A could be a biomarker to predict the risk of GDM. (bmj.com)
  • Fetuin-A and FGF-23 levels were measured. (ankaratipfakultesimecmuasi.net)
  • Primary CPPs (CPP1) are spherical complexes of amorphous calcium and phosphate with fetuin-A with a hydrodynamic radius ( R h ) of less than 100 nm 20 . (nature.com)
  • The receptors for NRG ligands are all members of the EGF receptor (EGFR) family, and include EGFR (or ErbB1), ErbB2, ErbB3, and ErbB4, also known as HER1 through HER4, respectively, in humans (Meyer et al. (justia.com)
  • Like fetuin-A, fetuin-B is made predominantly by the liver and to a lesser extent by a number of secretory tissues. (wikipedia.org)
  • FGF-21 is preferentially expressed in liver and regulates glucose uptake in human fat cells. (biovendor.com)
  • Emergence of new viruses with clade 2.3.4.4 hemagglutinin (HA) that infect poultry and humans emphasizes the need for detailed characterization of molecular properties of these viruses. (cdc.gov)
  • The currently circulating human and pandemic influenza (H1N1) viruses showed a preference for 6′SLN and negligible binding to the avian-type 3′SL. (cdc.gov)
  • Find MGP Antibodies for a variety of species such as anti-Human MGP, anti-Rat MGP, anti-Mouse MGP. (antibodies-online.com)
  • We first tested species-specific erythrocyte agglutination by the pandemic (H1N1) 2009 isolates A/California/04/2009 and A/Tennessee/1-560/2009 and by other isolates from humans, swine, and birds ( Table 1 ). (cdc.gov)
  • Furthermore, co-cultures with human islets and monocyte migration assays in Transwell plates were conducted. (bvsalud.org)
  • Human and swine H1N1 viruses were agglutinated by turkey, guinea pig, chicken, and goose erythrocytes, and all erythrocytes we tested except those of swine were agglutinated by avian isolates ( Table 1 ). (cdc.gov)