• Methods: This article examines different emotional, cognitive and discursive strategies used by neurobiologists in a foetal cell transplantation trial in Parkinson's disease research, using cells harvested from aborted embryos. (lu.se)
  • Cell transplantation studies were performed in mice with drug-induced acute liver failure to elicit benefits in hepatic support and tissue regeneration. (elsevierpure.com)
  • PURPOSE OF REVIEW: 2008 marks the 20th anniversary of the first use of umbilical cord blood (UCB) as a source of donor cells for hematopoietic stem cell transplantation. (duke.edu)
  • The findings, which could someday have implications for infertility, contraception, and stem cell transplantation therapy, will be published in the June issue of Nature Genetics. (sciencedaily.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Researchers currently explore prospects of using 3D printing or stem cells to produce organs, but some such research projects have been crictised for their use of human embryos taken through abortions, as in controversies about Planned Parenthood's selling of fetal organs and tissues for research. (wikipedia.org)
  • The 1968 UAGA set a legislative precedent for the donation of fetal organs and tissues and has been in the background of many debates regarding abortion and fetal tissue research. (asu.edu)
  • [5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
  • Background: Rich in different kind of potent cells, embryos are used in modern regenerative medicine and research. (lu.se)
  • The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. (lu.se)
  • Conclusions: The marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. (lu.se)
  • The goal of Dr. Oxburgh's research is to understand how kidney tissue can be grown from stem cells. (rogosin.org)
  • What if we could make new kidney tissue from stem cells to increase access to transplantation? (rogosin.org)
  • And what if we could make new kidney tissue from a patient's own stem cells so that we could reduce the need for immunosuppression? (rogosin.org)
  • The past 5 years have seen extremely rapid advances in efforts to generate patient-specific kidney tissue from stem cells. (rogosin.org)
  • This has enabled the development of procedures to differentiate stem cells to the building blocks for kidney tissue through a process known as directed differentiation. (rogosin.org)
  • First Global Consultation on Regulatory Requirements for Human Cells and Tissues for Transplantation, Ottawa, 29 November to 1December 2004 : report. (who.int)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • Although engraftment of irradiated C.B-17 scid/scid (SCID) mice with human progenitor cells occurred after infusion with human pediatric bone marrow cells, significant engraftment of the mouse bone marrow with human cells was dependent upon continuous treatment with exogenous human cytokines. (elsevierpure.com)
  • Furthermore, despite cytokine treatment, only minimal peripheral engraftment of these mice with human cells was observed. (elsevierpure.com)
  • In the present study, after infusion of irradiated SCID mice with pre-cultured human fetal bone marrow cells (BM-SCID-hu mice), their bone marrow became significantly engrafted with human precursor cells and their peripheral lymphoid compartment became populated with human B cells and monocytes independently of the administration of extraneous human cytokines. (elsevierpure.com)
  • Since engraftment occurs in the absence of exogenous cytokine treatment, the BM- SCID-hu mouse model described should provide a useful in vivo system for studying factors important in the maturation of human myeloid and lymphoid cells in the bone marrow and the behavior of the mature human cells after dissemination into the peripheral lymphoid tissue. (elsevierpure.com)
  • Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
  • 2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
  • Yamanaka worked to find new ways to acquire embryonic stem cells to avoid the social and ethical controversies surrounding the use of human embryos in stem cell research during the late twentieth and early twenty-first centuries. (asu.edu)
  • Other research groups such as Masako Tada's group in Japan in 2001 and Chad CowanÆs group in Massachusetts in 2005 combined embryonic stem cells with somatic cells to produce pluripotent cells. (asu.edu)
  • During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
  • The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
  • In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
  • Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
  • Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. (elsevierpure.com)
  • To determine mechanisms in these stage-specific lineage interactions, we modeled potential effects of soluble signals derived from immortalized human fetal liver parenchymal cells on stem cells, including embryonic and induced pluripotent stem cells. (elsevierpure.com)
  • These studies showed signals emanating from fetal liver cells induced hepatic differentiation in stem cells. (elsevierpure.com)
  • In stem cells exposed to signals from fetal cells, mechanistic gene networks of upstream regulators decreased pluripotency, while simultaneously inducing mesenchymal and epithelial properties. (elsevierpure.com)
  • The differentiation mechanisms involving metabolomics products could have an impact on advancing recruitment of stem/progenitor cells during tissue homeostasis. (elsevierpure.com)
  • Bandi, S , Tchaikovskaya, T & Gupta, S 2019, ' Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products ', Differentiation , vol. 105, pp. 54-70. (elsevierpure.com)
  • Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
  • In the future, it may emerge as a source of cells for cellular therapies focused on tissue repair and regeneration. (duke.edu)
  • What researchers are trying to do is unravel the mystery of the adult germ stem cells in male testicles, which are capable of producing an average of 1,500 sperm during every human heartbeat - or an average of 130 million sperm a day. (sciencedaily.com)
  • In the early embryo, embryonic stem cells give rise to all of the cell types in the organism, including adult stem cells, which continually replace cells in the adult tissues that die or differentiate into more mature cells like red blood cells. (sciencedaily.com)
  • Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
  • This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
  • The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)
  • We aimed for addressing the role of FasL expression in human intervertebral disc degeneration (IDD) and immune privilege in terms of the interaction between NP cells and immunocytes via the FasL-Fas machinery. (medsci.org)
  • FCM analysis found that human NP cells with increased FasL expression resulted in significantly increased apoptosis ratio of macrophages and CD8 + T cells. (medsci.org)
  • Moreover, studies with human disc cells, especially focusing on nucleus pulposus (NP) cells, are seldom found in the literature. (medsci.org)
  • Methods BALB/c-Rag2 null Il2rγ null SIRPα NOD (BRGS) pups were humanized through transplantation of cord blood (CB)-derived CD34+ cells. (bmj.com)
  • Finally, as observed in human colorectal patients, anti-PD-1 therapy had a strong response to a microsatellite-high CRC PDX that correlated with a higher number of human CD8+ IFNγ+ T cells in the tumor. (bmj.com)
  • Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
  • More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
  • These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
  • The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
  • This led us to question whether excessive Ca V 3 channels, retained mistakenly in engineered human-induced pluripotent stem cell-derived islet (hiPSC-islet) cells, act as an obstacle to hiPSC-islet maturation. (mdpi.com)
  • Transplantation of immature cells has been considered a potential therapeutic strategy for the damaged adult brain and spinal cord, and there is currently sustained interest in the generation of stem cell lines that could be used to treat certain CNS injuries or disorders. (hindawi.com)
  • Past studies have shown that some fetal nigral cells transplanted in this way can grow a limited number of axonal projections towards the striatum, but most are generally incapable of growing over the distance required to establish functional connections in the striatum in the adult brain [ 8 - 10 ]. (hindawi.com)
  • Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
  • The laboratory, which is supported by the National Institutes of Health, can supply tissue from normal or abnormal embryos and fetuses of desired gestational ages between 40 days and term. (blessedquietness.com)
  • There has also been controversy over the donation of embryos, which the 2006 Act addresses by stating that it neither allows or disallows the use of donated embryos for research, and that other federal laws address this topic. (asu.edu)
  • However, the success of fetal tissue transplants has been meager at best, and ethically-derived alternatives exist and are coming to dominate the field. (lozierinstitute.org)
  • The first recorded fetal tissue transplants were in 1921 in the UK, in a failed attempt to treat Addison's disease, [1] and in 1928 in Italy, in a failed attempt to treat cancer. (lozierinstitute.org)
  • That attempt also failed, as did subsequent similar fetal tissue transplants in 1959. (lozierinstitute.org)
  • Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)
  • [8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
  • A second large, controlled study published in 2003 showed similar results (funded by NIH), with over half of the patients developing potentially disabling tremors caused by the fetal brain tissue transplants. (lozierinstitute.org)
  • [12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • The Act has been consulted in discussions about abortion , fetal tissue transplants, and Body Worlds , an anatomy exhibition. (asu.edu)
  • Parkinson's (PD) and Huntington's (HD) diseases are two such instances where a substantial amount of research is being conducted to discover the potential for structural repair of neuronal circuits (via cellular transplants) when effective alternative therapies (e.g., pharmacological therapy) become ineffective [ 5 - 7 ]. (hindawi.com)
  • [2] The first fetal tissue transplant in the U.S. was in 1939, using fetal pancreatic tissue in an attempt to treat diabetes. (lozierinstitute.org)
  • Between 1960 and 1990, numerous attempts were made to transplant fetal liver and thymus for various conditions. (lozierinstitute.org)
  • One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
  • Currently, access to transplant organs is very limited, and the long-term objective of the research is to provide an abundant and reliable source of kidney tissue for patients with kidney failure. (rogosin.org)
  • The Amish will consent to transplantation if they believe it is for the well-being of the transplant recipient. (unos.org)
  • For example, a gift received by a medical school must be used for research or for the improvement of the medical field, while a gift given to an individual must be used for his or her medical treatment or tissue transplant. (asu.edu)
  • We have a close relationship with the UCSF Transplant community and with the UCSF VITAL Core which allows us access to a range of resources to define complex human immune biology. (ucsf.edu)
  • Heart valve transplantation is proposed as a new type of transplant with the potential to deliver durable heart valves, capable of somatic growth with no requirement for anticoagulation. (jove.com)
  • Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. (wjgnet.com)
  • A series of cellular and molecular events, which affect the outcome of tissue regeneration, occur after GBMs are implanted into the body. (bvsalud.org)
  • The immunomodulatory function of GBMs is considered to be a key factor influencing tissue regeneration. (bvsalud.org)
  • This review introduces the applications of GBMs in bone, neural, skin, and cardiovascular tissue engineering, emphasizing that the immunomodulatory functions of GBMs significantly improve tissue regeneration. (bvsalud.org)
  • more importantly, it contributes insights into the design of GBMs to enhance wound healing and tissue regeneration in tissue engineering. (bvsalud.org)
  • The high proliferation and differentiation capacity of fetal MSCs and the role of fetal pancreatic-derived MSCs (FPMSCs) in islet generation make them good candidates for diabetes treatment. (biomedcentral.com)
  • In our recent study, we examined the impact of the three-dimensional co-culture of FPMSCs on human embryonic stem cell-derived pancreatic progenitors' development. (biomedcentral.com)
  • Investigation of human hematopoietic maturation has been hampered by the lack of in vivo models. (elsevierpure.com)
  • thus, we developed a hematopoietic humanized mouse model, hu-CB-BRGS, and used it to study anti-tumor human immune responses to triple-negative breast cancer (TNBC) cell line and patient-derived colorectal cancer (CRC) xenografts (PDX). (bmj.com)
  • Note that fetal tissue has been taken in a number of cases from fetuses at developmental ages where fetal surgery is now used to correct problems and save lives, and at stages where science now demonstrates that the unborn fetus can feel pain. (lozierinstitute.org)
  • Between 1988 and 1994, roughly 140 Parkinson's disease patients received fetal tissue (up to six fetuses per patient), with varying results. (lozierinstitute.org)
  • As a report in The Stream indicates: "Under the NIH Revitalization Act of 1993 , the U.S. Department of Health and Human Services (HHS) should be performing audits on Planned Parenthood, since Planned Parenthood is involved in research on aborted fetuses and HHS is supporting its work with funding. (lifenews.com)
  • OHRP is in charge of overseeing any research done on human fetuses. (lifenews.com)
  • In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
  • A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
  • Intestinal organoids are three-dimensional (3D) in vitro tissue cultures that model the in vivo intestine. (stemcell.com)
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
  • Using in vivo and in vitro assays, we found that ZnO-NPs could cross the underdeveloped bloodbrain barrier and enter fetal brain tissue, where they could be endocytosed by microglia. (bvsalud.org)
  • The JPND database of Experimental Models for Parkinson's disease, developed in cooperation with the Italian Ministry of Education, Universities and Research ( MIUR ), aims to build an online network of scientists working in the field to more rapidly establish community consensus around currently available models. (neurodegenerationresearch.eu)
  • Currently, the majority of in vivo investigations to understand malaria biology are dependent upon rodent malaria species ( P. berghei and P. yoelii ) which are used as surrogates to study human malaria ( 3 - 6 ). (frontiersin.org)
  • Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)
  • 3 Epithelial Cell Biology in ENT Research Group (EpiCENTR), Developmental Biology and Cancer, Great Ormond Street UCL Institute of Child Health, University College London , London, U.K. (biorxiv.org)
  • 1997. Metabolic activation of aromatic amines by human pancreas. (cdc.gov)
  • Conclusion Hu-CB-BRGS mice represent an in vivo model to study immune checkpoint blockade to human tumors. (bmj.com)
  • Although accumulating studies have demonstrated the toxic effects of ZnO-NPs, few studies have addressed the effect of prenatal ZnO-NP exposure on fetal brain tissue development. (bvsalud.org)
  • We hope the information provided in our study will improve the understanding of the effects of prenatal ZnO-NP exposure on fetal brain tissue development and draw more attention to the daily use of and therapeutic exposure to ZnO-NPs among pregnant women. (bvsalud.org)
  • 2022. Human embryonic stem cell-derived dopaminergic grafts alleviate L-DOPA induced dyskinesia . (cardiff.ac.uk)
  • The extent of metabolic and synthetic functions in stem cell-derived hepatocytes was sufficient for providing hepatic support along with promotion of tissue repair to rescue mice in acute liver failure. (elsevierpure.com)
  • Only very few patients who are diagnosed at an early stage may benefit from cancer resection or liver transplantation. (springer.com)
  • UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38. (cdc.gov)
  • Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. (hindawi.com)
  • By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. (hindawi.com)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • Intense efforts to examine genetic alterations in human cancer have provided a catalogue of cancer-causing genes. (haematologica.org)
  • The study of functional synergism among cancer-causing genes is thus becoming one of the central issues in cancer research. (haematologica.org)
  • These genes are transcriptionally deregulated as the partner genes of IgH translocation, and are thus thought to perform crucial roles in human B-cell lymphomagenesis. (haematologica.org)
  • 2 A synergistic effect resulting from a combination of two genes from BCL2 , MYC and CCND1 has been implicated in human B-cell lymphomagenesis. (haematologica.org)
  • 7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
  • 7 That multiple genes are involved in human lymphoma formation has also been suggested by experimental mouse models. (haematologica.org)
  • 13 The identification and clarification of the multiple cooperative genes implicated in human lymphoma formation is important, although our present understanding of such genes remains scant. (haematologica.org)
  • Human embryonic and fetal tissues are available from the Central Laboratory for Human Embryology at the University of Washington. (blessedquietness.com)
  • Introduction to anatomy, general features of epithelial tissue, general organization of connective tissue, development of and hstology of cartilage and bone tissues, embryology and histology of skin, biochemistry of connective tissue, and bone tissue, skin and tissue parasites and fungi, arthropods and arthropods borne viruses. (atilim.edu.tr)
  • Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)
  • Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)
  • An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)
  • 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
  • RECENT FINDINGS: Transplantation with UCB is effective in the treatment of children with hematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. (duke.edu)
  • Bolaños-Meade, J & Brodsky, RA 2009, ' Blood and marrow transplantation for sickle cell disease: Overcoming barriers to success ', Current opinion in oncology , vol. 21, no. 2, pp. 158-161. (johnshopkins.edu)
  • The World Health Organization argues that transplantation promote health, but the notion of "transplantation tourism" has the potential to violate human rights or exploit the poor, to have unintended health consequences, and to provide unequal access to services, all of which ultimately may cause harm. (wikipedia.org)
  • Gut microbiota changes in the extreme decades of human life: a focus on centenarians " has been published in the journal Cellular and Molecular Life Sciences . (neurodegenerationresearch.eu)
  • His research interests include imaging informatics, artificial intelligence and machine learning, telemedicine, cell-based therapies and clinical trial design. (stanford.edu)
  • The awards, which include $1.5 million in seed funding for each recipient, recognize early career scientists whose innovative research has the potential to lead to improved therapies. (stanford.edu)
  • Background The success of agents that reverse T-cell inhibitory signals, such as anti-PD-1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. (bmj.com)
  • Specifically, according to HHS's own documents, 'Section 498A of the Public Health Service Act [42 USC 289g-1] requires the annual submission to Congress of a report describing research involving therapeutic transplantation of human fetal tissue supported or conducted by the NIH. (lifenews.com)
  • Ultimately, the only documents turned over were the redacted emails and several letters from HHS to Congress stating that the National Institute of Health (another part of HHS) had no required reports to give Congress about research on transplanting human fetal tissue for therapeutic purposes because NIH hadn't been involved with any such work. (lifenews.com)
  • The public clinical trials database http://clinicaltrials.gov shows 123 clinical trials using MSCs for a very wide range of therapeutic applications (Figure 1 ), the majority of which are in Phase I (safety studies), Phase II (proof of concept for efficacy in human patients), or a mixture of PhaseI/II studies (Figure 2 ). (biomedcentral.com)
  • Juliette Hordeaux, PhD, senior director of translational research for the University of Pennsylvania's gene therapy program, is cautious about the FDA's predictions, saying she'd be "thrilled" with 5 cell and/or gene therapy approvals annually. (ajmc.com)
  • He is the director of clinical and translational research and director of ophthalmic diagnostics for the Department of Ophthalmology. (stanford.edu)
  • She will establish and lead basic and translational research at the Stanford Amyloid Center, which will integrate clinical, research and training efforts related to amyloidosis. (stanford.edu)
  • It has been suggested that tissue-matched MSCs may increase the efficacy of their regenerative effects [ 7 ]. (biomedcentral.com)
  • It is suggested that MSCs isolated from each tissue may be a more appropriate source for regenerating the same tissue. (biomedcentral.com)
  • They emphasize the need to promote the teaching of ethics in medical education and to establish effective measures to protect developing countries from the risk of unregulated expatriate research involving human subjects. (who.int)
  • In recent decades, great strides have been made in biomedi- cal ethics, especially in the fields of education, research and legislation. (who.int)
  • Great Iranian Muslim scholars netics, stem cell research, and organ trans- laid huge emphasis on teaching and practis- plantation are some of the medical issues ing ethics. (who.int)
  • The perfect intersection of clinical and research objectives makes the placement of the Kidney Regenerative Medicine Laboratory within The Rogosin Institute an obvious strategic development. (rogosin.org)
  • Tissue engineering and regenerative medicine hold promise for improving or even restoring the function of damaged organs. (bvsalud.org)
  • Graphene-based materials (GBMs) have become a key player in biomaterials applied to tissue engineering and regenerative medicine. (bvsalud.org)
  • Transplantation without full human leukocyte antigen matching is possible and, despite a lower incidence of graft-versus-host disease, graft-versus-leukemia is preserved. (duke.edu)
  • This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) , where it is permissible to download and share the work provided it is properly cited. (lww.com)
  • This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. (wjgnet.com)
  • For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. (mdpi.com)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. (cdc.gov)
  • Long-term follow-up of a few of the patients in these large studies showed that even in fetal tissue that grew in patients' brains, the grafted tissue took on signs of the disease and were not effective. (lozierinstitute.org)
  • According to the National Conference of State Legislatures, one of the top ten issues that will come before state legislatures this year (2006) relates to rights of conscience in the biomedical field - stem cell experimentation and research. (consciencelaws.org)
  • Experimentation on, or using the organs or tissues from, a human or other mammalian conceptus in the postembryonic period, after the major structures have been outlined. (bvsalud.org)
  • The focus was on the effects of fetal bovine serum (FBS) replacement with pooled human serum (HS). (biomedcentral.com)
  • In practice, organ and tissue banks often choose patients in ways that secure their revenue, whereas "altruistic" clinics may not have the income necessary to fund their own needs, let alone to support research and development to improve quality and availability of care People with intellectual disabilities have historically been excluded from organ transplantation waitlists. (wikipedia.org)
  • And when faced with the decision of organ and tissue donation during the trauma of a loved one's death, a person's religion suddenly becomes very important. (unos.org)
  • As the decision is being made, the question often arises, "What is my religion's stance on organ and tissue donation? (unos.org)
  • Most people are not aware of their religious group's doctrine or position regarding organ and tissue donation. (unos.org)
  • Although this is a passive approach to affirming organ and tissue donation and transplantation, it seems to be the position of a large population of the religious community. (unos.org)
  • All faith leaders are encouraged to research their religious group's tradition and position on organ and tissue donation and transplantation, as well as other biomedical ethical issues. (unos.org)
  • It is important to be informed, since the family members who are suddenly faced with making a decision concerning organ and tissue donation of a loved one may depend on the faith leader to know the position held by their religious group. (unos.org)
  • The following summary of statements concerning various religious groups' positions on organ and tissue donation and transplantation may be of help to you. (unos.org)
  • Organ and tissue donation is viewed as an act of neighborly love and charity by these denominations. (unos.org)
  • The NCCUSL drafted the Act in August of 1967 in an attempt to unify the US states on the topic of organ and tissue donation. (asu.edu)
  • Progress: Dr. Leif Oxburgh now routinely generates human kidney tissue fragments in the laboratory that display hallmark structures of the human kidney. (rogosin.org)
  • Associated with new knowledge on the human genome, it could be used to facilitate genotype selection and encourage social and parental intolerance of disability or, potentially, perceived genetic defects. (who.int)
  • Prior Mendelian randomization (MR) studies exploring this question do not distinguish the mechanistic contributions of variants that directly influence birth weight through the foetal genome (direct foetal effects), vs. variants influencing birth weight indirectly by causing an adverse intrauterine environment (indirect maternal effects). (imperial.ac.uk)
  • 5 × 10−8) single nucleotide polymorphisms were extracted from genome-wide association studies summary statistics for birth weight overall, and after isolating direct foetal effects only. (imperial.ac.uk)
  • Unfortunately, most patients with SCD do not have a suitable human lymphocyte antigen-matched sibling donor. (johnshopkins.edu)
  • Afterward they transplanted the thawed strips into mice that, thanks to genetic engineering, lacked an immune system and so couldn't reject the foreign tissue. (discovermagazine.com)
  • Significant human RBC engraftment was achieved by ameliorating the residual non-adaptive immune response using clodronate-loaded liposome treatment. (frontiersin.org)
  • Further, the presence of mutant parasites in deep-seated tissues suggests the escape of parasites from the host's immune responses and thus extended the survival of the parasite. (frontiersin.org)
  • The immune system is a powerful tool to prevent infection and cancer, maintain tissue homeostasis, and regulate a wide range of physiologic processes. (ucsf.edu)
  • The mechanisms of immune privilege in human nucleus pulposus (NP) remain unclear. (medsci.org)
  • Our study demonstrated that FasL expression tends to decrease in degenerated discs and FasL plays an important role in human disc immune privilege, which might provide a novel target for the treatment strategies for IDD. (medsci.org)
  • The immune privilege of tissues is ascribed not only to the physiological blood-tissue barrier, but the local expression of Fas ligand (FasL). (medsci.org)
  • As the largest avascular organ in the human body, the intervertebral disc is isolated from the host immune system [ 8 ]. (medsci.org)
  • During the process of tissue healing, multiple immune responses, such as the inflammatory response, foreign body reaction, tissue fibrosis, and biodegradation of GBMs, are interrelated and influential. (bvsalud.org)
  • This will be applied to the development of methods to replicate kidney tissue from patients in the laboratory, which can be used to test treatment strategies for the individual patient. (rogosin.org)
  • Transplantation is generally a far better solution as it provides all of the complex functions of the kidney, ensuring an immense improvement in life quality for most patients. (rogosin.org)
  • Experimental models mimic the processes thought to be at play in human patients and allow researchers to assess possible treatments before moving into clinical trials. (neurodegenerationresearch.eu)
  • We thank Giuseppe Iacono and Mirella Collura for granting access to patients' files and Daniele Casulli for skilled technical assistance. (cdc.gov)
  • Under universal precautions, blood and certain body fluids of all patients are considered potentially infectious for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and other bloodborne pathogens. (cdc.gov)
  • Interestingly, we confirmed the increase in CD133 mRNA levels in the tumoral tissue of patients with ethanol-related HCC compared to other HCC etiologies. (springer.com)
  • patients underwent genetic sequencing as part of the research protocol and long-term follow-up. (imperial.ac.uk)