Alpha-smooth musclNeonatalFetusVentricularCardiacSerumBovineMaternalAscitesAccumulationCardiomyocytesAdultVenousTissueCardiovascularCellsProteinsRegenerationAtrialGrowthPleuralAlterationsIncidenceAdjacentImmuneDevelopmentHeartEmbryonicVivoInfectionMuscleMechanismInsulinLifeBrainBodyPatientsModelDeathBloodLeadLevelMediumHeartsFoundMolecularCases
Alpha-smooth muscl3
- METHODS AND RESULTS: Expression of structural protein (desmin, desmoplakin, titin, cardiotin, alpha-smooth muscle actin, lamin-A/C, and lamin-B2) in viable dysfunctional myocardium was analyzed by immunohistochemistry. (amsterdamumc.org)
- We tested the hypothesis that these arose secondary to elevations in preload rather than ischemia.METHODS AND RESULTS: Expression of structural protein (desmin, desmoplakin, titin, cardiotin, alpha-smooth muscle actin, lamin-A/C, and lamin-B2) in viable dysfunctional myocardium was analyzed by immunohistochemistry. (amsterdamumc.org)
- fcc co-ordinating director mark howell said in his letter that the united states center for consumer rights statement was a setback in efforts to.The expression of human fibrillin-1 in vascular smooth muscle cells requires interaction with the alpha smooth muscle actin cytoskeleton. (clubonlineusacasino.com)
Neonatal4
- Hydrops fetalis has been a well-recognized fetal and neonatal condition throughout history. (medscape.com)
- Intrahepatic cholestasis of pregnancy (ICP) is liver disease which could lead to premature birth, fetal distress and neonatal asphyxia, and increasing risk of fetal morbidity and mortality [ 1 ]. (hindawi.com)
- TMEM70 gene mutations turned out to represent the most frequent cause of ATP synthase deficiency resulting in a severe mitochondrial disease, neonatal encephalo-cardiomyopathy in humans (OMIM 604273). (cas.cz)
- The expression of HCN channel is age-related, the expression has difference in distinct growth stages, HCN genes are inactivated in ventricular myocytes cells following maturation whereas they expressed in these cells in the fetal and/or neonatal heart [5-8] . (bjcvs.org)
Fetus1
- A human fetus forms in a very precise order. (farinelliandthekingbroadway.com)
Ventricular11
- ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. (wikipedia.org)
- ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases. (wikipedia.org)
- MYL4 expression in ventricular myocardium has shown to abnormally persist in neonates up through adulthood in patients with the congenital heart disease, tetralogy of Fallot. (wikipedia.org)
- CONCLUSIONS: Qualitative cardiomyocyte remodeling similar to that in humans with chronic hibernation occurs rapidly after a critical coronary stenosis is applied, as well as after transient elevations in left ventricular end-diastolic pressure in the absence of ischemia. (amsterdamumc.org)
- Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
- Based on fetal echocardiography distinguishment of the different conditions causing a membranous ventricular septal protrusion is often challenging, in particular in the setting of various clinical presentations and prenatal imaging [3,5,6]. (fortuneonline.org)
- Only after assessment of fetal left ventricular mass with left-hand topology. (lowerbricktown.com)
- 8 hlh 29 pi ns abbreviations: Coa, coarctation of the ventricular myocardium, a locally restricted reentrant circuit usually includes allowing the infant in a patient with vt. (lowerbricktown.com)
- During hypertension and heart failure, If activity is observed in the ventricular myocardium due to re-expression of HCN genes [18,21-23] , several studies proved that If current density and occurrence is significantly greater in hypertrophic cardiomyocytes and end-stage failing hearts and this is directly related to the arrhythmias [18,21,24-27] . (bjcvs.org)
- Basing on the presence of If current in ventricular myocytes isolated from severely hypertrophied rat hearts, the current arrhythmogenic role in cardiac hypertrophy and failure has been inferred [25] , and its density is larger in human ventricular myocytes isolated from the hearts of patients with ischemic than in those with dilated cardiomyopathy [21] . (bjcvs.org)
- [18] demonstrated for the first time comparing the mRNA and protein expression of HCN subunits in the human atrial and ventricle under normal and heart failure conditions in human heart failure, an upregulation of ventricular HCN2 and HCN4 underlies the increase in functional If current, Michael et al. (bjcvs.org)
Cardiac5
- Following the 3 R's principles of animal research-replacement, reduction, and refinement-a high-performance computational framework was produced to generate a platform to perform human cardiac in-silico clinical trials as means to assess the pro-arrhythmic risk after the administrations of one or combination of two potentially arrhythmic drugs. (bvsalud.org)
- The proposed workflow for in silico clinical drug cardiotoxicity trials allows for reproducing the complex behavior of cardiac electrophysiology in a varied population, in a matter of a few days as compared to the months or years it requires for most in vivo human clinical trials. (bvsalud.org)
- In zebrafish, cardiac regeneration is thought to require at least in part, reactivation of foetal gene programs. (ox.ac.uk)
- In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: (1) reduction in resting and exercise heart rate and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia, and (4) reduction in reflex orthostatic tachycardia. (nih.gov)
- Cardiac pumping revisited: quantitative blood flow analysis in the human heart. (lu.se)
Serum8
- However, in the sheep model, a 41% reduction in total serum protein accompanied by a 44% decline in colloid osmotic pressure failed to produce fetal hydrops. (medscape.com)
- [ 2 ] Furthermore, a study in humans showed that, despite a significant negative correlation between the fetal serum albumin level and the degree of fetal hydrops, most fetuses with hydrops had albumin levels within the reference range. (medscape.com)
- Groups A and B intervened with BA showed significant higher level of TBA in both maternal and fetal serum, more mortality rate of fetal rats, more concentration of SP-A in fetal serum, and wider alveolus mesenchyme of fetal rats than the control Group C. Higher level of BA associated with increased fetal risk and lower numerical density of mitochondria in type II alveolar epithelial cells. (hindawi.com)
- The levels of TBA in maternal serum were found to have significant positive correlation with those in fetal serum and SP-A level but negatively with the area of alveolus and the numerical density of lamellar body. (hindawi.com)
- The TBA level in maternal serum showed significant association with lung pathological changes in fetal rats. (hindawi.com)
- Howard and Murphy found that fetal serum TBA was higher than that of the maternal level during late stage of normal pregnancy [ 4 ]. (hindawi.com)
- However, whether the level of TBA in maternal serum caused perinatal abnormality of pulmonary surfactant and fetal lung tissue morphological structure remains largely unknown. (hindawi.com)
- Here we show that in the differentiated rat aortic smooth muscle cell line A10, in which CT-1 is expressed constitutively, expression of fibrillin-1 is maintained by mitogenic stimulation with fetal bovine serum or platelet-derived growth factor-BB. (clubonlineusacasino.com)
Bovine1
- A commercialized cell line of HDPCs was cultured with 10% fetal bovine serumcontaining Dulbecco's Eagle medium. (hairloss-research.org)
Maternal3
- To determine the correlation between maternal bile acid (BA) level and fetal pulmonary surfactant in rats and study the effects of BA on fetal lung in rat model of intrahepatic cholestasis of pregnancy. (hindawi.com)
- While ICP occurs, high bile acid level in maternal blood made damage to placental transport, leading to bile acid deposition in fetal body [ 5 ]. (hindawi.com)
- Chagas disease is infection with Trypanosoma cruzi , transmitted by Triatominae bug bites or, less commonly, via ingestion of sugar cane juice or foods contaminated with infected Triatominae bugs or their feces, via blood transfusion or an organ transplant from an infected donor, or via maternal-fetal transmission. (msdmanuals.com)
Ascites3
- Hydrops fetalis (fetal hydrops) is a serious fetal condition defined as abnormal accumulation of fluid in two or more fetal compartments, including ascites , pleural effusion , pericardial effusion , and skin edema. (medscape.com)
- The patient was a 29-year-old G1P0 pregnant woman hospitalized at 23 weeks' gestation after routine ultrasonography because of fetal ascites and minor ventriculomegaly. (cdc.gov)
- It also detected ascites, a minor pericardial effusion, and cardiomegaly with a hyperechogenic myocardium. (cdc.gov)
Accumulation2
- BACKGROUND: Dysfunctional and normally perfused remote regions show equal myolysis and glycogen accumulation in pig hibernating myocardium. (amsterdamumc.org)
- and Source patients, supporting congestive GPCRs, external fetal adjacent failure, diuretics with autoimmune determinants, certain accumulation, clinical treatment for fabricated due clinical and medical sources, written portions, and female persons with CHF. (siriuspixels.com)
Cardiomyocytes2
- During fetal life the myocardium expands through replication of cardiomyocytes. (elsevierpure.com)
- Growth factors that stimulate proliferation of fetal cardiomyocytes include angiotensin II, cortisol and insulin-like growth factor-1. (elsevierpure.com)
Adult1
- Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. (lu.se)
Venous1
- HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
Tissue3
- Although widely reported as a ban on abortion after 6 weeks, the Texas anti-abortion law bans abortions once a fetal myocardium-the muscle tissue that becomes the human heart-begins to contract. (prinz-lawfirm.com)
- However, it is shown that tissue injury can result in the activation of the immune, regenerative processes in the myocardium. (highwire.org)
- IHC-P: Human liver tissue. (abcam.com)
Cardiovascular1
- Fetal cardiovascular system alterations in sleeping pattern, sleeplessness, or hypersomnia some states of sleep is too harsh for the next step. (lowerbricktown.com)
Cells8
- I also designed and constructed sgRNAs in preparation for the use of the CRISPR/Cas9 system to target the CD40 gene in human induced pluripotent stem cells as a rational approach to the production of tolerogenic dendritic cells. (ox.ac.uk)
- It has previously been demonstrated in Xenopus that gata6 overexpression holds embryonic myocardial cells in a precursor state, but once normal levels are resumed, development continues, but the myocardium is thicker. (ox.ac.uk)
- An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)
- Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
- Fetal myocardium in the kidney capsule: an in vivo model of repopulation of myocytes by bone marrow cells. (umn.edu)
- The heart derives from embryonic mesodermal germ layer cells that differentiate after gastrulation into mesothelium, endothelium, and myocardium. (farinelliandthekingbroadway.com)
- In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
- Cells of the reticuloendothelial system, myocardium, muscles, and nervous system are most commonly involved. (msdmanuals.com)
Proteins1
- Thus, reorganization of cytoskeletal proteins in patients with viable dysfunctional myocardium appears to reflect chronic and/or cyclical elevations in preload associated with episodes of spontaneous regional ischemia. (amsterdamumc.org)
Regeneration1
- Mechanical forces have an important role in regeneration of tissues, such as bone, cartilage, blood vessels, and myocardium. (hairloss-research.org)
Atrial1
- Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. (wikipedia.org)
Growth1
- Tmem70 ablation resulted in profound growth retardation and embryonic lethality at 9.5 days of fetal development. (cas.cz)
Pleural1
- Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. (cusabio.com)
Alterations1
- Alterations progressed with the transition to hibernating myocardium, in which desmin, cardiotin, and titin were globally reduced. (amsterdamumc.org)
Incidence1
- Nevertheless, in developing countries, the incidence of immune fetal hydrops is still high. (medscape.com)
Adjacent1
- Thus, simultaneous information about electrical ac-tivity, oxygenation, and contractility in lo-cally altered myocardium and adjacent, un-disturbed muscle became available. (1library.net)
Immune1
- With the introduction of widespread immunoprophylaxis for red blood cell alloimmunization and the use of in-utero transfusions for immune hydrops therapy, nonimmune causes have become responsible for at least 85% of all cases of fetal hydrops. (medscape.com)
Development1
- During development of the vasculature, fibrillin-1 expression increases during differentiation of the myocardium and is induced by the cardiotrophin-1 (CT-1) cytokine. (clubonlineusacasino.com)
Heart3
- The framework employs electrophysiology simulations on high-resolution three-dimensional, biventricular human heart anatomies including phenotypic variabilities, so as to determine if differential QT-prolongation responds to drugs as observed clinically. (bvsalud.org)
- During the fetal heart's developmental stages, the heart actually takes on several distinct appearances. (farinelliandthekingbroadway.com)
- conduct of hyperinsulinism from been house into the depression and of E-mail heart from the myocardium into the species. (siriuspixels.com)
Embryonic1
- These results thus showed that Tmem70 knockout in the mouse leads to embryonic lethality due to the lack of ATP synthase and impairment of mitochondrial energy provision and fully confirmed the expected mechanism of human TMEM70 disease. (cas.cz)
Vivo1
- To this end, four anatomically normal, human, biventricular geometries (two male, two female), with identifiable trabeculations, were obtained from high-resolution, ex-vivo MRI and represented by detailed and smoothed geometrical models (with and without the trabeculations). (bvsalud.org)
Infection1
- Infection is transmitted to humans when bitten by Triatominae (reduviid, kissing, or assassin) bugs in South and Central America, Mexico, and very rarely in the US. (msdmanuals.com)
Muscle1
- congestive care: external, weak division that invades known with the extracellular muscle which is in human or elderly thrombosis. (siriuspixels.com)
Mechanism1
- The basic mechanism for the formation of fetal hydrops is an imbalance of interstitial fluid production and the lymphatic return. (medscape.com)
Insulin1
- Some dcms may be interchangeable, but human insulin as the failure of the vertebral bodies gradually separate so that the fcv and great vessels and trachea view will be compromised at birth. (lowerbricktown.com)
Life2
- 4 hours about the history of efforts to achieve suspended animation and radical extension of the human life span from 1968 through the present. (extropy.org)
- During fetal life, hemodynamic appearance remain asymptomatic and diagnosis is more likely to be an incidental finding [7-9]. (fortuneonline.org)
Brain1
- A) Fetal brain at 23 weeks' gestation. (cdc.gov)
Body1
- The viscera of the human body : including the organs of digestion, respiration, secretion, and excretion : in a series of plates, with references and physiological comments. (utoronto.ca)
Patients2
- With Diastolic myocardium, central part of patients, and double post-implant, the trial will primarily highly trigger longer but secondarily be a better discharge of circulation. (siriuspixels.com)
- The underlying myocardium is not involved in most patients. (medscape.com)
Model1
- The electrophysiology finite element model (FEM) simulations were carried out, using O'Hara-Rudy human myocyte model with sex phenotypes of Yang and Clancy. (bvsalud.org)
Death1
- How Much to Query 12 V. Levels of Querying 13 Priority Level 1 15 Priority Level 2 18 Priority Level 3 18 Priority Level 4 19 Priority Level 5 19 Priority Level 6 20 Fetal death 20 Sample letters 21 VI. (cdc.gov)
Blood1
- A fetal blood sample showed moderate anemia. (cdc.gov)
Lead2
- Several hypotheses regarding the pathophysiologic events that lead to fetal hydrops have been suggested. (medscape.com)
- We have developed a technique for ampli-fication and recording of oxygen-reduction currents and electrocardiograms simultane-ously from the same lead-point2'4 in the myocardium. (1library.net)
Level1
- The best biomarker for diagnosis and follow-up of ICP is up to knowing percentage levels of bile acids (taurocholic and glycocholic acids) over 40% with TBA 14 mmol/L. The level of bile acid is found to be associated with fetal complications [ 1 , 4 ]. (hindawi.com)
Medium1
- The medium cerebral artery peak systolic velocity was 1.98 multiples of median, which indicated fetal anemia. (cdc.gov)
Hearts2
- The aim of this work was to analyze the influence of sex hormones and anatomical details (trabeculations and false tendons) on the electrophysiology of healthy human hearts. (bvsalud.org)
- Unlike humans, zebrafish can fully regenerate their hearts after injury. (ox.ac.uk)
Found1
- Recently, bile acid was found to cause surfactant inactivation by enhancing the activity of secretory phospholipase A2 (sPLA2) and induce inflammatory response of fetal lung [ 5 , 8 ]. (hindawi.com)
Molecular1
- Animal models of human mitochondrial diseases enable detailed insight into pathogenic mechanisms, from molecular to organismal levels. (cas.cz)
Cases1
- More recent recognition of factors other than isoimmune hemolytic disease that can cause or be associated with fetal hydrops led to the use of the term nonimmune hydrops to identify those cases in which the fetal disorder was caused by factors other than isoimmunization. (medscape.com)