• In this study, equine collagen scaffolds (TissueFleece) were modified by coating fetal bovine serum proteins, before human bladder smooth muscle cells were seeded. (nih.gov)
  • Human being ovarian tumor Ovca420 cells had been taken care of in RPMI moderate supplemented with 10% fetal bovine serum. (accessibletech4all.org)
  • Human being breasts cancers MDA-MB-231 cells had been cultured in Improved Eagle's Moderate, supplemented with nonessential proteins, sodium pyruvate and 10% fetal bovine serum. (accessibletech4all.org)
  • Cells were grown in RPMI1640 medium supplemented with 10% foetal bovine serum. (viamedica.pl)
  • Inclusion of fetal bovine serum in stem cell media further contributes to an illdefined culture system. (ddw-online.com)
  • Homeobox (HOX) genes encode proteins that are important in normal foetal development. (endocrine-abstracts.org)
  • After testing several different genes, they were able to improve reprogramming efficiency by adding a viral protein known as SV40 large T antigen. (hopkinsmedicine.org)
  • Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
  • These effects of choline are correlated with modifications in histone and DNA methylation in brain, and with alterations in the expression of genes that encode proteins important for learning and memory processing, suggesting a possible epigenomic mechanism of action. (mdpi.com)
  • This approach can greatly increase the number of potential annotated genes that can be studied beyond that which is currently available, particularly for species that do not have comprehensively characterised genomes. (cambridge.org)
  • Besides demonstrating that the probe selection method can be used to study the ovine transcriptome, the benefits of this approach are that it can greatly increase the number of annotated and novel genes that can be studied beyond those currently possible using ovine- or bovine-specific microarrays. (cambridge.org)
  • The ~1.5 Mb candidate region was shown to contain five protein-coding genes. (biomedcentral.com)
  • We also identified several genes that do not appear to be protein coding, and generated 17 kb of novel transcript sequence data from re-sequencing 97 EST clones. (biomedcentral.com)
  • The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
  • Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
  • And yet deleting or increasing the expression of genes in the womb to understand why is both impossible and unethical. (sciencedaily.com)
  • Until now we've relied on studies in mice to understand human germ cell differentiation, but the reproductive genes are not the same. (sciencedaily.com)
  • Members of what's called the DAZ family, the genes are unusual in that they encode RNA-binding proteins rather than the DNA transcription factors more commonly known to regulate cellular events. (sciencedaily.com)
  • In the current study, the researchers treated human embryonic stem cells with proteins known to stimulate germ cell formation and isolated those that began to express germ-cell-specific genes -- about 5 percent of the total. (sciencedaily.com)
  • In their current Disease Models & Mechanisms article , Mitchell Weiss and colleagues from St. Jude Children's Research Hospital, Memphis, USA, investigated a promising new treatment that is being developed in Weiss' lab and works by editing genes to switch on the production of this healthy, foetal haemoglobin in adult red blood cells. (eurekalert.org)
  • Therefore, the team sequenced the haemoglobin genes and surrounding DNA of the Berkeley mice and discovered that instead of having a single copy of the mutated human gene, the mice had 22 randomly arranged, broken-up copies of the mutated human sickle cell disease gene and 27 copies of the human foetal haemoglobin that the team had hoped to activate to cure the mice of the disease. (eurekalert.org)
  • GO-AgNPs induced significant cytotoxicity by the loss of cell viability, production of reactive oxygen species (ROS), cell cycle arrest, increasing leakage of lactate dehydrogenase (LDH) and level of Malondialdehyde (MDA), increasing expression of pro-apoptotic genes and decreasing expression of anti-apoptotic genes. (researchsquare.com)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. (wikidoc.org)
  • By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult-specific expression, these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. (biomedcentral.com)
  • We also identified 1,000 genes specific to fetal liver, which were enriched for GATA1, STAT5A, STAT5B and YY1 binding sites. (biomedcentral.com)
  • Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. (ucsf.edu)
  • Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture. (ucsf.edu)
  • Several congenital and acquired diseases of the human genito-urinary tract may need, due to lack or destruction of functional tissues, mechanically stable biomaterials as cell carriers for the engineering of these tissues. (nih.gov)
  • This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. (thermofisher.com)
  • IHC-P: Human tonsil, Human bladder cancer, mouse stomach and rat cerebrum tissues. (abcam.com)
  • In this study, we demonstrate that gDNA-based probe selection on the Affymetrix Human U133+2 GeneChip array can be used to study gene expression profiles in sheep tissues. (cambridge.org)
  • Emerging evidence indicates that the placenta controls the development and function of several fetal tissues through nutrient sensing, modulation of trophoblast nutrient transporters and by altering the number and cargo of released extracellular vesicles. (bvsalud.org)
  • In the present study, researchers assessed the effects of coronavirus disease 2019 (COVID-19) on fetal brain tissues. (news-medical.net)
  • The study was conducted between July 2020 and mid-April 2022 in the United Kingdom (UK), wherein human fetal tissues aged 9.0 to 21.0 pcw (post-conception weeks) were obtained from the HDBR (human development biology resource). (news-medical.net)
  • Next, the team examined the counts of cleaved caspase-3+ cells to determine whether the older or recent hemorrhages were related to increased cell deaths within cortical tissues. (news-medical.net)
  • In addition, SARS-CoV-2 was present sparsely in the placental, umbilical cord and amniotic tissues, indicating SARS-CoV-2 presence in maternal and fetal tissues. (news-medical.net)
  • Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. (medlineplus.gov)
  • ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)
  • Human chorionic gonadotropin (hCG) is also a glycoprotein secreted by the syncytiotrophoblastic cells of the normal placenta. (aacc.org)
  • SP-C mRNA was detected in mouse uterus, placenta and fetal membranes and in human placenta, amnion and chorion. (bmj.com)
  • An increase in the expression of SP-C was detected in placenta, uterus and fetal membranes after LPS challenge. (bmj.com)
  • SP-C mRNA and proSP-C were detected in mouse uterus, placenta and fetal membranes and LPS increased the expression. (bmj.com)
  • The System L amino acid transporter, particularly the isoform Large Neutral Amino Acid Transporter Small Subunit 1 (LAT1) encoded by SLC7A5, is believed to mediate the transfer of essential amino acids in the human placenta. (bvsalud.org)
  • Furthermore, SARS-CoV-2 spike (S) protein expression was investigated in cells of the placenta, amnion, and umbilical cord. (news-medical.net)
  • In solubility of the placenta has the fetal age, a group of the exopodites. (goldenowlhunt.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
  • Importin 13 (IPO13), a member of the importin-β superfamily, was originally identified in the fetal rat lung and differentially expressed in cells of epithelial and mesenchymal origin. (molvis.org)
  • Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
  • The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
  • Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," says Cheng, who explains that rigorous follow-up tests are required to determine if the reprogrammed cells really behave like pluripotent embryonic stem cells. (hopkinsmedicine.org)
  • Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)
  • Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)
  • Cells had been infected using the ALK5QD-expressing adenovirus 100.A Stream of human being ESTs using the 1st coding exon of TRIII revealed the current presence of 80 ESTs, 75 which contained sequences homologous towards the proximal 5 UTR (A). message and proteins amounts in ovarian (Ovca420) and breasts cancers (MDA-MB-231) cell lines in both a dosage- and time-dependent way. (accessibletech4all.org)
  • We first optimized a serum-free, miniature erythroid differentiation system starting from primary human CD34 cells, the exact type of cells we would ultimately like to target in vivo ( Figure 1 ). (haematologica.org)
  • Human CD34 + hematopoietic stem and progenitor cells purified from umbilical cord or adult peripheral blood were cultured in a two-phase liquid culture system in a serum-free medium for 21 days. (haematologica.org)
  • The aim of our work was to examine the influence of retinoic acid on the phenotype of human pheochromocytoma cells in primary culture. (viamedica.pl)
  • Retinoic acid appears to have an influence on some phenotype parameters of human pheochromocytoma cells. (viamedica.pl)
  • Furthermore, none of the 6 diatom species tested were toxic on normal human cells. (frontiersin.org)
  • Stem cells, and in particular human embryonic stem (ES) cells, have earned a reputation for being labour intensive and difficult to grow and control in culture. (ddw-online.com)
  • F urther complicating matters, human ES cells are typically co-cultured with feeder layers of mouse fibroblast cells. (ddw-online.com)
  • Several growth factors have been identified that promote growth of human ES cells in culture, most notably basic fibroblast growth factor (bFGF). (ddw-online.com)
  • However, the use of bFGF for human ES cell culture, particularly at the high levels used by some for 'feeder-free' culture, must be considered carefully, as bFGF may drive ES cells towards differentiation. (ddw-online.com)
  • Xeno-free media that do not rely upon high levels of bFGF have been developed that contain only humanised or synthetic components and are engineered to support the undifferentiated growth and expansion of human ES cells. (ddw-online.com)
  • Use of progenitor cell lines can eliminate the need to culture challenging human ES cells. (ddw-online.com)
  • For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)
  • In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
  • In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
  • Here, we combined overexpression approaches with protein analysis and functional studies in cultured primary human trophoblast (PHT) cells to test the hypothesis that SLC7A5 overexpression increases the uptake of essential amino acids and activates mTOR signaling in PHT cells. (bvsalud.org)
  • Overexpression of SLC7A5 resulted in a marked increase in protein expression of LAT1 in the PHT cells microvillous plasma membrane and System L amino acid transporter activity. (bvsalud.org)
  • This is the first report showing that overexpression of LAT1 is sufficient to increase the uptake of essential amino acids in PHT cells, which activates mTOR, a master regulator of placental function. (bvsalud.org)
  • Human embryonic stem cells derived from excess IVF embryos may help scientists unlock the mysteries of infertility for other couples struggling to conceive, according to new research. (sciencedaily.com)
  • Researchers at the school have devised a way to efficiently coax the cells to become human germ cells -- the precursors of egg and sperm cells -- in the laboratory. (sciencedaily.com)
  • Figuring out the genetic 'recipe' needed to develop human germ cells in the laboratory will give us the tools we need to trace what's going wrong for these people. (sciencedaily.com)
  • And because germ cells begin to form very early in embryonic development (by eight to 10 weeks), there's been a dearth of human material to work with. (sciencedaily.com)
  • This is the first evidence that you can create functional human germ cells in a laboratory. (sciencedaily.com)
  • Overexpressing the three proteins together allowed the researchers to generate haploid cells -- those with only one copy of each chromosome -- expressing proteins found in mature sperm. (sciencedaily.com)
  • When treated in this manner, about 2 percent of the differentiated human embryonic stem cells were haploid after 14 days of differentiation. (sciencedaily.com)
  • Overexpression of BOULE increased the relative proportion of putative germ cells from 2 to 12 percent in female, but not male, cell lines. (sciencedaily.com)
  • This suggests that BOULE may play a larger role than the other proteins in the development of female germ cells. (sciencedaily.com)
  • This disease is caused by a mutation in a gene that makes haemoglobin, the protein that carries oxygen in red blood cells, with the damaged haemoglobin distorting the shape of red blood cells, causing painful and potentially life-threatening blockages in blood vessels. (eurekalert.org)
  • First, they removed stem cells - cells in the bone marrow programmed to become red blood cells - from the mice and used gene editing to modify part of the stem cells' DNA to switch on the healthy foetal haemoglobin gene. (eurekalert.org)
  • Surprisingly, 70% of the Berkeley mice died from the therapy and it only activated production of the healing foetal haemoglobin gene in 3.1% of mouse's stem cells. (eurekalert.org)
  • In contrast, the experimental treatment activated the foetal haemoglobin gene in 57% of red blood cells in the Townes mice and did not affect the animals' survival. (eurekalert.org)
  • However, the levels of foetal haemoglobin produced in the red blood cells of Townes mice were 7- to 10-times lower than seen when this approach is used in human cells grown in the laboratory and not high enough to reduce clinical signs of sickle cell disease. (eurekalert.org)
  • These effects of KLB on muscle cells occur in both pigs and humans, suggesting the gene plays a vital role in regulating muscle development and function in mammals. (ed.ac.uk)
  • SARS-CoV-2 spike (S) expression was sparse in cortical microtubule-associated protein 2 (MAP2)-positive and HuC/D-positive neurons and the nestin-positive and Hopx (homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and subventricular zone progenitor cells. (news-medical.net)
  • The abnormal protein is toxic to the kidney cells that normally produce renin. (medlineplus.gov)
  • which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • We have investigated the potential function of 1,25D3 across gestation using human tissue obtained after l. (endocrine-abstracts.org)
  • CEA was first identified in 1965 by Phil Gold and Samuel O. Freedman in human colon cancer tissue extracts. (wikidoc.org)
  • During embryo development, Beta adrenergic receptors are involved in fetal growth, tissue differentiation and axonal outgrowth. (proteopedia.org)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • Fetal and neonatal edition. (lu.se)
  • hnRNPA2/B1 is found to activate cyclooxygenase-2 and promote tumor growth in human lung cancers. (wikipedia.org)
  • Surfactant protein-C (SP-C) increases the surface adsorption and lowers surface tension of lung surfactant. (bmj.com)
  • Lately, we have proven that TRIII manifestation is considerably downregulated at both message and proteins levels in a wide spectrum of human being malignancies, including malignancies of the breasts, lung, ovary, pancreas and prostate (11C15). (accessibletech4all.org)
  • Diabetic patients with and without chronic lung disease are at increased risk of respiratory infection. (ersjournals.com)
  • Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)
  • In vitro studies in resistive human lung epithelial cell monolayers grown at an air-liquid interface have supported these in vivo observations. (ersjournals.com)
  • Glucocorticoid and cAMP increase fatty acid synthetase mRNA in human fetal lung explants. (ucsf.edu)
  • Hormonal regulation of cholinephosphate cytidylyltransferase in human fetal lung. (ucsf.edu)
  • This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. (thermofisher.com)
  • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
  • Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
  • Transforming growth factor-beta(1) regulation of surfactant protein B gene expression is mediated by protein kinase-dependent intracellular translocation of thyroid transcription factor-1 and hepatocyte nuclear factor 3. (ucsf.edu)
  • These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. (wikipedia.org)
  • The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (bmj.com)
  • We also discuss how maternal diet and stress influences fetal development and metabolism and how fetal growth restriction can result in susceptibility to developing chronic disease later in life. (bvsalud.org)
  • Given the substantial inter-individual variation seen in metabolism, regulation of nutrients, protein synthesis, and detoxification of xenobiotics. (biomedcentral.com)
  • Working together with a hormone called FGF21, the gene suppresses the activity of a protein, known as mTOR, which is crucial to normal cell growth, survival and metabolism. (ed.ac.uk)
  • Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • METHODS: Fetal nuchal translucency thickness (fetal NT), maternal serum free beta-human chorionic gonadotrophin (free beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) were measured at 11 weeks 0 days to 13 weeks 6 days of gestation in all women. (who.int)
  • Improved methods using mass spectrometry to monitor OP-adducted biomarker proteins are needed and will be extremely helpful in early life biomonitoring, while measurement of PON1 status as a biomarker of susceptibility will help identify mothers and children highly sensitive to OPs. (cdc.gov)
  • METHODS: In maternal, umbilical cord plasma and placentas from obese women (11 female/5 male infants) and normal weight women (9 female/7 male infants), all PC and PE species containing DHA and ARA were analyzed by LC-MS/MS. Placental protein expression of enzymes involved in phospholipid synthesis, were determined by immunoblotting. (bvsalud.org)
  • Relative levels of heat shock protein (Hsp)70 were measured in developing and diapausing embryos of A. limnaeus using quantitative Western blots. (bioone.org)
  • The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. (cdc.gov)
  • At least in experimental animals, genetical y modified strains, because on the differential effects of a wide greater susceptibility to chemical in these species the interval between variety of carcinogens in humans at carcinogens in utero and during birth and sexual maturity is only a different stages of life, including var early postnatal life is usual y man few weeks. (who.int)
  • When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. (portlandpress.com)
  • In the present study, five groups of Wistar rats were provided during pregnancy with one of five diets: a control diet containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MLPU). (portlandpress.com)
  • The decreased placental System L activity in human IUGR and the increased placental activity of this transporter system in some cases of fetal overgrowth may directly contribute to changes in fetal amino acid availability and altered fetal growth in these pregnancy complications. (bvsalud.org)
  • Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. (medscimonit.com)
  • however, increased attention was paid to the patient during her pregnancy secondary to elevated hormonal levels of progesterone, which any residual disease would have a heightened sensitivity to. (hindawi.com)
  • From the onset of presenting with her pregnancy, her care was managed with input from maternal fetal medicine, endocrinology, and general surgery. (hindawi.com)
  • This was the first study to suggest that smoking tension and vascular defects (8,9), altered fetal pancreatic during pregnancy is linked to adverse changes in the lipo- development and structure (10), altered glucose tolerance protein levels of children (19). (cdc.gov)
  • Erythromycin crosses the placental barrier, but fetal plasma levels are low. (nih.gov)
  • Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (bmj.com)
  • Placental System L amino acid transporter expression and activity is decreased in pregnancies complicated by IUGR and increased in fetal overgrowth. (bvsalud.org)
  • Here, we review evidence suggesting that altered placental function may, at least in part, mediate the link between the maternal environment and changes in fetal growth and development. (bvsalud.org)
  • In this Review, we discuss the development and functions of the maternal-placental-fetal interface (in humans and mice) and how cross-talk between these compartments may be a mechanism for in utero programming, focusing on mechanistic target of rapamycin (mTOR), adiponectin and O-GlcNac transferase (OGT) signaling. (bvsalud.org)
  • BACKGROUND: We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA), a preferred form for transfer of DHA (omega 3) to the fetal brain, but only in male fetuses. (bvsalud.org)
  • On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained. (portlandpress.com)
  • Moreover, mTOR signaling was activated, and System A amino acid transporter activity increased following SLC7A5 overexpression, suggesting coordination of trophoblast amino transporter expression and activity to ensure balanced nutrient flux to the fetus. (bvsalud.org)
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
  • The mutations involved in REN -related kidney disease either change or remove a protein building block (amino acid) in the renin protein. (medlineplus.gov)
  • Maternal PON1 status (PON1 activity levels, the most important measurement, and functional Q192R phenotype) modulates the detrimental effects of exposure to the OP chlorpyrifos oxon on fetal brain gene expression and biomarkers of exposure. (cdc.gov)
  • MAIN OUTCOME MEASURES: Fetal NT, maternal serum free beta-hCG, PAPP-A and cotinine measurements. (who.int)
  • In cases of pregnant patients with a history of pancreatic tumors, a multidisciplinary approach with maternal fetal medicine, medicine, and general surgery is appropriate and can result in a healthy mother and healthy term infant. (hindawi.com)
  • Fetal origins of. (bmj.com)
  • The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (bmj.com)
  • glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
  • The spectra represent samples with both high and low protein abundance, and it is shown that peak sets selected by human operators have a considerable variability and that it is impossible to speak of a single true peak set. (lu.se)
  • So far it is not clear, to which extent such cancer-related or experimentally induced epigenetic alterations correspond to the natural epigenetic variability in human livers. (biomedcentral.com)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for methyl parathion. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • In humans, low protein intake by women in late but intrauterine exposure was (20). (cdc.gov)
  • Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
  • High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
  • The high levels of SALSA in AF and the infant intestine suggest a robust and important function for SALSA during the fetal development and in the mucosal innate immune defense of infants. (researchgate.net)
  • Over the past decade, studies on human hosted Campylobacter species strongly suggest that Campylobacter concisus plays a role in the development of inflammatory bowel disease (IBD). (frontiersin.org)
  • By charting the milestones of gamete development, they hope to identify potential problems that would lead to infertility or fetal disability. (sciencedaily.com)
  • It is normally produced during fetal development, but the production of CEA stops before birth. (wikidoc.org)
  • [1] Interestingly, overstimulation of B2ARs during critical periods of prenatal development can cause a permanent increase in the sympathetic to parasympathetic tone. (proteopedia.org)
  • Scientists identify mechanism linked to decreased muscle development in pigs and potentially in humans. (ed.ac.uk)
  • Muscle development during foetal growth in mammals is impaired by abnormal regulation of a gene, a study led by scientists at the Roslin Institute shows. (ed.ac.uk)
  • The findings, which are published in the Journal of Physiology, may be significant for humans, experiments with cell cultures suggest, but further research is needed to establish the full effects of IUGR on early muscle development in people. (ed.ac.uk)
  • Previous studies have reported that maternal SARS-CoV-2 infections and immunological responses elevate the risk of altered fetal brain development, fetal death, growth restrictions and severe pathologies such as intraventricular hemorrhages and pneumonia. (news-medical.net)
  • Only two similar cases with cortical hemorrhages were observed among 300 randomly chosen specimens out of 4,917 specimens sourced from the human development biology resource between September 1999 and December 2019. (news-medical.net)
  • Because of low blood pressure, the flow of blood is reduced (hypoperfusion), and the body does not get enough oxygen during fetal development. (medlineplus.gov)
  • Transcriptional regulation of surfactant proteins SP-A and SP-B by phorbol ester. (ucsf.edu)
  • The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (bmj.com)
  • The HNRNPA2 and HNRNPB1 proteins are involved in packaging nascent mRNA, in alternative splicing, and in cytoplasmic RNA trafficking, translation, and stabilization. (wikipedia.org)
  • 2 RNase protection assay and RT-PCR were used to quantitatively determine SP-C mRNA and protein was detected by the Western blot. (bmj.com)
  • Challenge of rGMCs with 1 or 10 μM HgCl 2 or Pb 2 acetate increased HSPA5 mRNA and protein levels. (bioone.org)
  • but an increase enormously in human embryo is only the thalamic plates of the region of individuals. (goldenowlhunt.com)
  • In the canonical Wnt/β-catenin signaling, a Wnt ligand binds to a cell surface receptor complex consisting of the members of Frizzled family and the transmembrane protein LRP 5 and 6 to prevent phosphorylation and degradation of β-catenin by the GSK3β/APC/Axin destruction complex. (oncotarget.com)
  • The described method therefore allows automated user-independent protein identification using peptide mass fingerprints. (lu.se)
  • Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)
  • Glucose-induced activation of DAG/PKC signaling in microsomes was not associated with a change in the translocation of Glut-4 transporters from microsomes to the plasma membrane, a biological response that is known to be stimulated by agonists, e.g., phorbol esters, which increase DAG/PKC signaling in plasma membranes, as well as in microsomes. (jci.org)
  • Cell growth was evaluated by WST-1 proliferation assay and improved when using modified collagen scaffolds. (nih.gov)
  • In the fetal period, from nine weeks after conception onwards, there begins the phase of rapid growth that continues until after birth. (bmj.com)
  • The main feature of fetal growth is cell division. (bmj.com)
  • Foetal growth restriction is an important cause of newborn disease and death in humans and domestic animals, particularly in pigs. (ed.ac.uk)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • An evaluation of the phenotype change was performed by estimating the expression levels of F-actin, MAP-2 protein, and chromogranin, with the use of a confocal microscopy. (viamedica.pl)
  • It provides insights into the genetic contribution to metabolite levels and potential implications for human disease. (news-medical.net)
  • Lewy bodies which are intraneuronal aggregates composed mainly of misfolded alpha synuclein (a-syn) protein is a pathological hallmark seen in both sporadic and genetic forms of PD. (lu.se)
  • Estimates of levels posing minimal risk to humans (minimal risk levels or MRLs) may be of interest to health professionals and citizens alike. (cdc.gov)
  • This concentration decreases to low levels or becomes undetectable after birth, although it may increase in some malignancies, such as hepatocellular carcinoma. (aacc.org)
  • Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
  • RESULTS: Compared with nonsmoking women, fetal NT was significantly increased and free beta-hCG and PAPP-A levels were significantly decreased in both cigarette and sheesha smokers. (who.int)
  • Heterocellular hereditary persistence of fetal hemoglobin (HPFH) is a common multifactorial trait characterized by a modest increase of fetal hemoglobin levels in adults. (biomedcentral.com)
  • Use of human feeders derived under xeno-free conditions can maintain the xeno-free nature of the culture system and allow for the use of low levels of bFGF. (ddw-online.com)
  • A new study shows that total RPE65 protein levels in mice with autosomal dominant retinitis pigmentosa were doubled following subretinal delivery of adeno-associated virus (AAV)-RPE65 gene supplementation. (news-medical.net)
  • HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)
  • The recovery of human SFRP1 spiked to levels throughout the range of the assay in various matrices was evaluated. (cusabio.com)
  • Even after successful resection of the tumor, attention needs to be paid to patients who subsequently become pregnant, secondary to any residual disease having a heightened sensitivity to increased levels of progesterone. (hindawi.com)
  • These variations can affect the liver's metabolic properties, leading to high levels of metabolites, either in the forms of lipids, proteins or xenobiotics, which can result in serious diseases or toxic side-effects. (biomedcentral.com)
  • When testing the treatment in mice, the researchers found that even though the lab mice had the symptoms of sickle cell disease, the foetal haemoglobin gene and surrounding DNA were not properly configured, making the revolutionary stem-cell treatment ineffective or even harmful in the animals and raising concerns for future research testing new gene-based therapies in these laboratory mice. (eurekalert.org)
  • In contrast, the Townes mice only had single copies of the mutated human haemoglobin gene and the gene that makes human foetal haemoglobin. (eurekalert.org)
  • However, these mice likely lacked crucial pieces of DNA that normally regulate the production of the foetal haemoglobin gene in humans. (eurekalert.org)
  • Additionally, this work provides a reminder for scientists to carefully consider the genetics of the mice that they are using to study human diseases and find the right mouse for the job. (eurekalert.org)
  • for complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and DNA isolation. (exposed-skin-care.net)
  • Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
  • Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4-10% of the total protein amount in meconium, making it one of the most abundant proteins. (researchgate.net)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
  • Cortical hemorrhages were associated with reduced integrity of blood vasculature and increased immunological cell infiltration in the fetal brain. (news-medical.net)
  • Sodium transport across the human ocular non-pigmented ciliary epithelium (NPE) is fundamental to the production aqueous humour and maintenance of intraocular pressure. (endocrine-abstracts.org)
  • Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)
  • Environmental injury has been associated with endoplasmic reticulum (ER) stress, a response characterized by activation of the unfolded protein response, proteasomal degradation of proteins, and induction of HSPA5, also known as GRP78 or BiP. (bioone.org)
  • Erythromycin acts by inhibition of protein synthesis by binding 50S ribosomal subunits of susceptible organisms. (nih.gov)
  • This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. (medlineplus.gov)
  • Cancer, inflammation, and the evolution of antibiotic-resistant pathologies, together with other human diseases, are continuously stimulating the search for new bioactive molecules from natural sources. (frontiersin.org)
  • Several Campylobacter species utilize humans as their natural host and accumulated evidence supports their role in chronic inflammatory diseases of the human intestinal tract. (frontiersin.org)
  • They survive as commensal bacteria in their hosts, and some species, such as C. jejuni and C. coli , can cause human diseases. (frontiersin.org)
  • It is one of the oncofetal antigens produced during fetal life and has a high concentration in the sera of fetuses. (aacc.org)
  • Adenylyl cyclase subsequently converts ATP into cAMP, which functions as a downstream signaling molecule activating effectors like cAMP-dependent protein kinases, resulting in various bodily responses. (proteopedia.org)
  • Prolactin receptors have been found on human T lymphocytes and B lymphocytes, and some data support T-lymphocyte dependence on prolactin for maintenance of immune competence. (medscape.com)
  • Reijo Pera is a professor of obstetrics and gynecology at the medical school and the director of Stanford's Center for Human Embryonic Stem Cell Research and Education. (sciencedaily.com)
  • Replication of human noroviruses in stem cell-derived human enteroids. (cdc.gov)
  • Furthermore, recent studies possess broadened the jobs of TRIII, including regulating TGF- receptor amounts through relationships with GAIP-interacting and -arrestin2 proteins, C terminus (GIPC) and possibly signaling individually (9,10). (accessibletech4all.org)
  • Beta-2 Adrenergic Receptor s (B2ARs) are a type of G Protein-Coupled Receptor (GPCR) . (proteopedia.org)
  • Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • We hypothesized that ether and plasmalogen PC and PE containing DHA and ARA are reduced in maternal-fetal unit in pregnancies complicated by obesity and these differences are dependent on fetal sex. (bvsalud.org)
  • The attachment of extracellular matrix or serum proteins to their surfaces does further improve these characteristics, mimicking a close to natural cell environment. (nih.gov)
  • Blood pressure was significantly increased in the MLP, MLPA and MLPU groups compared with the CON group, but for the MLPG group blood pressure was not significantly different from CON. (portlandpress.com)
  • IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium. (molvis.org)
  • CONCLUSIONS: Cigarette and sheesha smoking significantly affect first-trimester markers of Down syndrome (fetal NT, free beta-hCG and PAPP-A). Correction for this effect in women who smoke might improve the effectiveness of first-trimester screening for Down syndrome in these women. (who.int)