• Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. (rcsb.org)
  • In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
  • Studies on the major sialoglycoprotein of the human red cell membrane. (wikidata.org)
  • Isolation and characterization of a glycoprotein from human group O erythrocyte membrane. (wikidata.org)
  • Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis. (wikidata.org)
  • 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
  • Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
  • Treatment of erythrocytes with 0.5 mM thiram for 4 h increased the level of oxidative stress markers, decreased antioxidant power and lowered the activity of antioxidant and membrane bound enzymes . (bvsalud.org)
  • The characteristics of the binding of 12‐alpha‐[3H]‐digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. (ox.ac.uk)
  • Erythrocytes are susceptible to oxidative damage as a result of the high polyunsaturated fatty acid content of their membranes and the high cellular concentrations of oxygen and haemoglobin [1]. (scirp.org)
  • They have a polypeptide composition quite different from those of erythrocyte membranes or microvesicles, consisting largely of components of mol.wts. (uea.ac.uk)
  • Cyclic adenosine 3',5'-monophosphate-dependent protein kinase of human erythrocyte membranes. (elsevierpure.com)
  • Babesia divergens Shows Equal Predilection for Human ABO Blood Types in an In Vitro Erythrocyte Preference Assay. (lu.se)
  • B. divergens in human group A, B and O erythrocytes in vitro and measured rates of multiplication. (lu.se)
  • The predilection for the different erythrocyte types was also determined using an in vitro erythrocyte preference assay when the parasites were grown in group A, B or O erythrocytes over time and then offered to invade differently stained. (lu.se)
  • This method was subsequently utilized for the in vitro assessment of isosteviol's partitioning into blood compartments of humans and rats.MethodsFresh blood samples from healthy humans and Wistar rats were equilibrated with 1, 10, and 30 µM isosteviol at 37 °C in a shaking dry-bath. (tropmedres.ac)
  • The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
  • A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
  • The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). (hindawi.com)
  • The present study was conducted to investigate the in vitro dose-dependent effect of curcumin on PMRS activity of erythrocytes and validated through in vivo studies on Wistar rats. (hindawi.com)
  • By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a research team has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. (sciencedaily.com)
  • Although these erythrocytes consisted mostly of fetal-type hemoglobin, they were confirmed to have oxygen-carrying capacity and to have circulatory capacity following transfusion into mice. (sciencedaily.com)
  • Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). (ox.ac.uk)
  • Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. (ox.ac.uk)
  • Erythrocytes consist mainly of hemoglobin , a complex molecule containing heme groups whose iron atoms temporarily link to oxygen molecules in the lungs or gills and release them throughout the body. (wikidoc.org)
  • The color of erythrocytes is due to the heme group of hemoglobin. (wikidoc.org)
  • A typical erythrocyte contains about 270 million hemoglobin molecules, with each carrying four heme groups. (wikidoc.org)
  • There are three biomarkers of effect currently being applied to measure PO exposure in humans: DNA adducts, hemoglobin adducts, and sister chromatid exchanges (SCE). (who.int)
  • Products of non-enzymatic reactions between GLUCOSE and HEMOGLOBIN (occurring as a minor fraction of the hemoglobin of ERYTHROCYTES. (bvsalud.org)
  • Glycated hemoglobin A is used as an index of the average blood sugar level over a lifetime of erythrocytes. (bvsalud.org)
  • 9 In consideration of the paradoxical occurrence of eeNOS in red blood cells (RBCs), 6 which are mainly responsible for NO inactivation, 9 we attempted to measure NOS activity in RBCs freshly collected from normal healthy humans by a fully validated, highly sensitive and specific gas chromatography-mass spectrometry (GC-MS) assay. (ashpublications.org)
  • What is an Erythrocyte Sedimentation Rate (ESR)? (medlineplus.gov)
  • An erythrocyte sedimentation rate (ESR) is a blood test that that can show if you have inflammation in your body. (medlineplus.gov)
  • Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. (jabfm.org)
  • Serum or plasma C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are employed in routine clinical practice as laboratory markers of systemic inflammation. (jabfm.org)
  • Babesia divergens is an intraerythrocytic parasite with many similarities to malaria, but the impact of ABO on the susceptibility to and progression of the infection in humans is unknown. (lu.se)
  • Malaria is the deadliest among infectious diseases, accounting for approximately 429,000 human deaths in 2015 as of the latest estimate by the World Health Organization. (wikipedia.org)
  • The human malaria parasite was accountable for 4,45,000 deaths in the 2016 ( 1 ). (frontiersin.org)
  • However, the study of human malaria parasites in animal models is severely limited by ethical and technical constraints, since only a few primate species have been found to be receptive to P. falciparum infection ( 2 - 4 ). (frontiersin.org)
  • Currently, the majority of in vivo investigations to understand malaria biology are dependent upon rodent malaria species ( P. berghei and P. yoelii ) which are used as surrogates to study human malaria ( 3 - 6 ). (frontiersin.org)
  • Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)
  • In addition, the epidemiological data provided no evidence for an association between exposure of humans to nitrite and nitrate and the risk for cancer. (inchem.org)
  • The three criteria for ranking were frequency of occurrence at NPL sites, toxicity, and potential for human exposure. (cdc.gov)
  • A definitive analysis of the impact on public health of lead-contaminated soil is limited often by a lack of information on human exposure factors and soil conditions. (cdc.gov)
  • The exposure dose as measured by determination of Hb-adduct concentrations is integrated over the average life span of human erythrocytes, which is approximately 120 days. (who.int)
  • These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the host cell. (gla.ac.uk)
  • To understand these unique modifications, we used a large-scale gene knockout strategy combined with functional screens to identify proteins exported into parasite-infected erythrocytes and involved in remodeling these cells. (gla.ac.uk)
  • Larval ticks become infected while feeding on an infected rodent, then transform into nymphs that transmit the parasite to another animal or to a human. (msdmanuals.com)
  • Adult ticks ordinarily feed on deer but may also transmit the parasite to humans. (msdmanuals.com)
  • Erythrocyte (RBC) thiol methyltransferase (TMT) activity was measured in blood samples from 237 individuals from 49 nuclear families. (elsevierpure.com)
  • Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. (scirp.org)
  • An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
  • Ca2+ does not influence much the thiol content of phenylhydrazine treated erythrocytes. (scirp.org)
  • No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. (scirp.org)
  • The glycosylation of the complement regulatory protein, human erythrocyte CD59. (ox.ac.uk)
  • The CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes , erythrocytes. (lu.se)
  • An over-production of these reactive species can occur in the human body, due to oxidative stress brought about by the imbalance of the body antioxidant defense system and free radical accumulation. (scirp.org)
  • It also enhanced the generation of reactive oxygen and nitrogen species (ROS and RNS) and altered the morphology of erythrocytes . (bvsalud.org)
  • Other Babesia species transmitted by different ticks infect humans in other areas of the world. (msdmanuals.com)
  • Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis. (univalle.edu.co)
  • Therefore, adhesion of sickle erythrocytes may not be a feature of retinal vaso-occlusion in the steady state, but endothelial activation may be an important modulating phenomena. (johnshopkins.edu)
  • abstract = "A study was made of the influence of psycho-emotional strain, experienced by students when taking examinations, on the erythrocyte electrophoretic mobility (EPM). (elsevierpure.com)
  • ABSTRACT Erythrocyte indices used to differentiate between iron deficiency anaemia (IDA) and thalassaemias have been studied mainly in countries with a high prevalence of IDA or beta-thalassaemias. (who.int)
  • A. phagocytophilum infects neutrophils to cause granulocytic anaplasmosis in humans (HGA), dog, horses and sheep (in the United Kingdom and Europe). (usda.gov)
  • A. phagocytophilum, a human and veterinary pathogen, infects neutrophils to cause granulocytic anaplasmosis. (usda.gov)
  • Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)
  • Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)
  • Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
  • Therefore, the measurement of allantoin may be useful for the determination of oxidative stress in humans. (degruyter.com)
  • Significant higher levels of allantoin in both plasma and erythrocytes of patients with chronic renal failure indicate that allantoin may be used as a good marker of oxidative stress. (degruyter.com)
  • Allantoin as a marker of oxidative stress in human erythrocytes" Clinical Chemistry and Laboratory Medicine , vol. 46, no. 9, 2008, pp. 1270-1274. (degruyter.com)
  • Kand'ár, R. and Žáková, P. (2008) Allantoin as a marker of oxidative stress in human erythrocytes. (degruyter.com)
  • Ionizing radiation (IR) can pass through the human body easily, potentially causing severe damage to all biocomponents, which is associated with increasing oxidative stress. (biofullerene.com)
  • However, prior treatment of erythrocytes with rutin (0.5, 1 and 2 mM) for 2 h, followed by 4 h incubation with 0.5 mM thiram , led to a decrease in the level of oxidative stress markers in a rutin concentration-dependent manner. (bvsalud.org)
  • quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
  • Carbonic Anhydrase I from human erythrocytes is a protein which is used as a standard pI (isoelectric point) marker for isoelectric focussing experiments. (sigmaaldrich.com)
  • The catalase within normal, intact human erythrocytes was completely inactivated with amino triazole. (nih.gov)
  • Babesia is spread to humans via ticks or blood transfusions. (lu.se)
  • Currently prevention of both granulocytic and bovine anaplasmosis rely on tick control, either through careful avoidance of ticks in the case of humans, or repeated use of acaricides, which are toxic, expensive and partially effective in cattle. (usda.gov)
  • Occasional human infection was reported as a result of the consumption of homemade cheese or unpasteurized milk from cows with mastitis. (cdc.gov)
  • Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). (medscape.com)
  • It was also found that the expression of the BCL-XL gene was higher during the maturation process of erythrocyte progenitor cells than during their replication process. (sciencedaily.com)
  • These findings indicate that these genes are important for the maturation of erythrocytes. (sciencedaily.com)
  • Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. (ox.ac.uk)
  • Carbonic Anhydrase I from human erythrocytes has been used as a pI (isoelectric point) marker in two-dimensional gel electrophoresis. (sigmaaldrich.com)
  • During the differentiation process from hematopoietic progenitor cells, chromosomes in the cell nucleus aggregate and the cell becomes a mature erythrocyte by subsequently losing this nucleus (enucleation). (sciencedaily.com)
  • Erythrocytes in mammals are anucleate when mature, meaning that they lack a cell nucleus and as a result, have no DNA . (wikidoc.org)
  • Subsequently, the erythrocytes were resuspended in these plasma/RCM mixtures, incubated for 5 minutes and then examined under the microscope. (iospress.com)
  • In the US, Babesia microti is the most common cause of babesiosis in humans. (msdmanuals.com)
  • The molecular typing methods showed that human and equine isolates were identical or closely related. (cdc.gov)
  • Uric acid is the final product of purine metabolism in humans. (degruyter.com)
  • Approximately 0.05% of an applied dose (0.0026 mg/cm2) was determined in one human study (Franz 1984), and another estimated a dermal absorption rate of approximately 0.4 mg/cm2/hour under conditions of complete saturation (35-43 cm2 of skin was exposed to approximately 0.06 g/cm2 of liquid benzene for 1.25-2 hours) (Hanke et al. (cdc.gov)
  • Trypsin-treated erythrocytes can be coated with antibody and complement components and used as a specific reagent to detect the C3 receptor on human B lymphocytes, avoiding the risk of an interaction between the erythrocytes and T lymphocytes. (ashpublications.org)
  • These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
  • In this study, we used novel approaches to determine the importance of P. falciparum erythrocyte-binding Ags (EBAs), which are important invasion ligands, as targets of human invasion-inhibitory Abs and define their role in contributing to immune evasion through variation in function. (edu.au)
  • Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
  • As the c-MYC gene and BCL-XL gene are present within erythrocyte progenitor cells, methods that make use of them actually mimic the body's own system and can therefore be thought of as safer with a view to future clinical application than the previously developed systems for large-scale erythrocyte production using oncogene-derived from Human papillomavirus that are not normally expressed in the human body. (sciencedaily.com)
  • Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)
  • We measured allantoin and uric acid in human plasma and erythrocytes obtained from patients with chronic renal failure before hemodialysis (n=30) and blood donors (n=30). (degruyter.com)
  • BackgroundIsosteviol is a synthetic derivative of steviol glycosides with promising pharmacological properties and might find future use as a cardioprotective agent.ObjectiveA simple LC-MS/MS technique was developed and validated for the bioanalysis of isosteviol in plasma and erythrocytes. (tropmedres.ac)
  • The levels of isosteviol in plasma and erythrocytes partitions were determined in these samples, after separation, at intervals over a 60-minute period. (tropmedres.ac)
  • Additionally, we show that multiple proteins play a role in generating increased rigidity of infected erythrocytes. (gla.ac.uk)
  • Since the rosettes dissociate at 37°C, a method was developed to isolate human T lymphocytes with a high degree of purity and good recoveries. (ashpublications.org)
  • Rosetting of activated human T lymphocytes with autologous erythrocytes. (ox.ac.uk)
  • We find that LFA-3 is expressed on human E, and that CD2 is a receptor for LFA-3 that mediates T cell adhesion to human E. Pretreatment of T lymphocytes with CD2 mAb or of E with LFA-3 mAb inhibits rosetting. (ox.ac.uk)
  • reciprocally, binding of LFA-3 mAb to human E is inhibited by pretreatment with purified CD2. (ox.ac.uk)
  • Erythrocytes, which have the function of transporting oxygen within the body, have no nucleus and are therefore not capable of self-replication. (sciencedaily.com)
  • In humans, less than 2% of the total oxygen, and most of the carbon dioxide, is held in solution in the blood plasma ). (wikidoc.org)
  • Erythrocytes are produced in the body by progressive evolution of hematopoietic stem cells into hematopoietic progenitor cells and then erythroblasts. (sciencedaily.com)
  • These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans. (ox.ac.uk)
  • The research showed that an increase in the expression of the c-MYC gene led to an enhancement of the replication ability of erythrocyte progenitor cells. (sciencedaily.com)
  • The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. (nih.gov)
  • Hopes for the creation of a more stable transfusion system have centered on the establishment of a technology for large-scale erythrocyte production ex vivo, using for instance iPS cells or ES cells. (sciencedaily.com)
  • Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)
  • Results show that women with M(A)DD had significantly lower erythrocyte levels of total n-3 FA, EPA, DHA and DGLA, and significantly higher n-6 DPA, and n-6:n-3, AA:EPA and n-6 DPA:DHA ratios compared to healthy controls. (uu.nl)
  • After controlling for antenatal mental health, n-3/n-6 FA in maternal erythrocytes or in human milk were not significantly associated with postpartum depression. (uu.nl)
  • Simple frequency domain spectral analysis methods showed that all the acid extractable ADP (and ATP) was MR-visible in human erythrocytes. (nih.gov)
  • However, such methods gave variable estimates for 31P-NMR spectra of fresh chicken erythrocytes from which no conclusions could be drawn about the MR-visibility of ADP. (nih.gov)
  • availability of large amounts (erythrocytes in whole blood), availability of methods for chemical identification (specific and sensitive), and the well-defined life span due to absence of DNA repair (Ogawa et al. (who.int)
  • The data derived was used to estimate erythrocyte-to-plasma and blood-to-plasma coefficients.ResultsMean erythrocyte-to-plasma partition coefficients (SD) after 60 minutes of equilibration were observed to be 0.039 (0.002) and 0.040 (0.003) in humans and rats, respectively. (tropmedres.ac)
  • Derived values for the blood-to-plasma ratio (SD) were 0.576 (0.001) in humans and 0.543 (0.007) in rats, whereas plasma component binding was estimated to be more than 96%.ConclusionsThe findings suggest that isosteviol preferentially partitions into plasma compartments in humans and rats. (tropmedres.ac)
  • The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
  • In humans, S. zooepidemicus may cause glomerulonephritis and rheumatic fever, which are known sequelae of Streptococcus pyogenes infections. (cdc.gov)
  • Protective effect of rutin against thiram-induced cytotoxicity and oxidative damage in human erythrocytes. (bvsalud.org)
  • The present study was designed to evaluate the protective effect of rutin against thiram -induced damage in human erythrocytes . (bvsalud.org)
  • A significant restoration in the antioxidant power and activity of antioxidant enzymes was observed upon the treatment of erythrocytes with 1 and 2 mM rutin . (bvsalud.org)
  • Pre-incubation with rutin lowered the generation of ROS and RNS which will reduce oxidative damage in erythrocytes . (bvsalud.org)
  • These results suggest that rutin can be used to mitigate thiram -induced oxidative damage in human erythrocytes . (bvsalud.org)
  • In healthy erythrocytes, significant oxidative damage is prevented by a very efficient antioxidant system, consisting of a number of antioxidant compounds and enzymes [2]. (scirp.org)
  • The radioprotective properties of fullerenol were determined by examining the antioxidant enzymes activity in the hemolysate, the concentration of -SH groups, as well as by determining erythrocyte microviscosity. (biofullerene.com)
  • Overall, we point to the radioprotective effect of C 60 (OH) 36 manifested as the protection of the antioxidant enzymes of human erythrocytes against IR-induced damage, which has not been the subject of intense research so far. (biofullerene.com)
  • Human erythrocytes have no nucleus, mitochondria or endoplasmic reticulum, whereas chicken erythrocytes have a nucleus and mitochondria and are closer in internal morphology, to cells such as the hepatocyte. (nih.gov)
  • [4] Mammalian erythrocytes also lose their other organelles such as their mitochondria . (wikidoc.org)
  • Purified CD2 molecules bind to human E and inhibit rosetting. (ox.ac.uk)
  • In horses, S. zooepidemicus is an opportunistic pathogen, but human infections associated with S. zooepidemicus are often severe. (cdc.gov)
  • Microscopic results were cause epidemiologic records show no bacterial pneumonia complicated by absent from the available postmortem evidence of infl uenza or excess deaths abundant erythrocyte sickling in a pa- examination record. (cdc.gov)
  • There is inadequate evidence in humans for the carcinogenicity of propylene oxide. (who.int)
  • Erythrocytes are red blood cells. (medlineplus.gov)
  • The spleen acts as a reservoir of red blood cells, but this effect is somewhat limited in humans. (wikidoc.org)
  • The best analysis available from a combination of sources continues to affirm the identification of the shown biological components as being that of erythrocytes, or red blood cells. (carnicominstitute.org)
  • Halder, J. and Bhaduri, A.N. (1998) Protective role of bla- ck tea against oxidative damage of human red blood cells. (scirp.org)
  • Here, we evaluated the potential association between antenatal depression/anxiety and n-3/n-6 FA in (a) maternal erythrocytes and (b) human milk. (uu.nl)
  • n-3/n-6 FA were determined in maternal erythrocytes in gestational week 32 and in human milk in postpartum week 1. (uu.nl)
  • No significant associations between antenatal depression or anxiety and n-3/n-6 FA in human milk were found. (uu.nl)
  • However, when free radicals overwhelm the capacity of antioxidant system in the erythrocyte, oxidative damages may occur endangering the integrity of the erythrocytes [3,4]. (scirp.org)
  • However, Free radical reactions occur in the human body and food systems. (scirp.org)