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  • Laboratory
  • The process was essentially the same as that used by the Wells' lab in a landmark 2010 Nature study, which reported the first-ever generation of three-dimensional human intestinal organoids in a laboratory. (eurekalert.org)
  • Advances
  • It has allowed for advances in production, transportation, and even entertainment, but never in history will science be able to so deeply affect our lives as genetic engineering will undoubtedly do. (avsabonline.org)
  • The goal of this review is to provide an overview of the advances made in the development of human defensins as well as the cathelicidin LL-37 and their derivatives as antimicrobial agents against bacteria, viruses and fungi for clinical use. (pubmedcentralcanada.ca)
  • Researchers
  • To engineer a nervous system for the intestinal organoids already growing in one petri dish, researchers generated embryonic-stage nerve cells called neural crest cells in a separate dish. (eurekalert.org)
  • Now, researchers have engineered an artificial bone marrow niche, in which the stem and progenitor cells are able to multiply for a period of several days. (eurekalert.org)
  • These findings were reported by researchers working under Professor Ivan Martin from the Department of Biomedicine at the University of Basel and University Hospital Basel and Professor Timm Schroeder from ETH Zurich's Department of Biosystems Science and Engineering. (eurekalert.org)
  • As they did with the lysins, the researchers combined the binding region from one of these remodeling enzymes with a piece of human antibody. (eurekalert.org)
  • Observing the remarkable capacity of this mechanism to identify and excise short sequences of DNA, researchers proposed to turn the naturally-occurring gene-splicing system into an intentionally-engineered tool for gene editing. (culture-of-life.org)
  • Principles
  • A recent book discussed a serious medication overdose that occurred in part due to confusing displays in the institution's CPOE system-a vivid example of how failing to use human factors engineering principles in user interface design can potentially harm patients. (ahrq.gov)
  • The author provides an overview of skeletal anatomy and the effects of pain and deterioration in order to put the engineering principles into a medical context. (ecampus.com)
  • focuses
  • In essence, human factors engineering focuses on how systems work in actual practice, with real-and fallible-human beings at the controls, and attempts to design systems that optimize safety and minimize the risk of error in complex environments. (ahrq.gov)
  • regulatory
  • This workshop will cover the regulatory requirements for human factors work on medical devices, comparisons between the regulatory requirements between the US and the EMEA region, and discuss when, and how, to go about planning human factors activities. (smi-online.co.uk)
  • diseases
  • A growing body of evidence suggests a correlation between changes in a microbiome and onset of diseases in humans, but in most cases, causality is not yet established. (nanohub.org)
  • The fundamental importance of understanding transcriptional regulation is evident from the large number of human developmental defects and diseases, including cancer and AIDS, that arise when cellular transcription factors are altered by mutation or commandeered by viral proteins. (pitt.edu)
  • mice
  • Recently our group used severe combined immunodeficient (SCID)-hu mice bearing human thymus/liver (thy/liv) implants ( 27 - 29 ) to generate HIV-specific cytotoxic T lymphocytes (CTLs) from transduced hHSC ( 30 ). (pnas.org)
  • limitations
  • It is the discipline that takes into account human strengths and limitations in the design of interactive systems that involve people, tools and technology, and work environments to ensure safety, effectiveness, and ease of use. (ahrq.gov)
  • 917 words - 4 pages limitations it could lead the human race into a future that one may not even be able to picture. (avsabonline.org)
  • Manipulation
  • Rehabilitation Engineering Applied to Mobility and Manipulation and Wheelchair Selection and Configuratio n, and co-editor of An Introduction to Rehabilitation Engineering, Care of the Combat Amputee , and the Warrior Transition Leader Medical Rehabilitation Handbook . (pitt.edu)
  • Following tumor challenge, these transgenic CD8 + T cells, in the absence of additional manipulation, limited and cleared human melanoma tumors in vivo. (pnas.org)
  • These autologous T cells have been generated either by ex vivo manipulation of antigen-specific T cells with cytokines or by genetically engineering T cells to exhibit strong antitumor responses ( 5 - 16 ). (pnas.org)
  • factors
  • The Space Station (SS) presents a plethora of human factors engineering opportunities. (sae.org)
  • This paper will address the human factors engineering effort undertaken to aid in the early-on design of the Space Station structure, with particular emphasis on structural assembly operations. (sae.org)
  • This opens up a whole host of possibilities, from researching factors that influence blood formation in humans, to drug screening with a view to predicting how individual patients will respond to a certain treatment. (eurekalert.org)
  • Human factors engineering is the discipline that attempts to identify and address these issues. (ahrq.gov)
  • A human factors engineer examines a particular activity in terms of its component tasks, and then assesses the physical demands, skill demands, mental workload, team dynamics, aspects of the work environment (e.g., adequate lighting, limited noise, or other distractions), and device design required to complete the task optimally. (ahrq.gov)
  • Human factors engineering has long been used to improve safety in many industries outside of health care-it has been employed to analyze errors in aviation, automobiles, and the Three Mile Island nuclear power plant accident. (ahrq.gov)
  • pioneering studies of human factors in anesthesia were integral to the redesign of anesthesia equipment, significantly reducing the risk of injury or death in the operating room. (ahrq.gov)
  • The very nature of human factors engineering precludes 'one size fits all' solutions, but several tools and techniques are commonly used as human factors approaches to addressing safety issues. (ahrq.gov)
  • UserWise consultants also perform safety assessments to comply with U.S. and international regulations related to Human Factors. (smi-online.co.uk)
  • Before UserWise, Shannon was a Human Factors Engineer at Intuitive Surgical, where she worked on da Vinci surgical systems, instruments, and accessories including the da Vinci Xi System. (smi-online.co.uk)
  • Core's human factors methodologies uniquely address this balance. (smi-online.co.uk)
  • design
  • The Engineering of Human Joint Replacements bridges the divide between engineering and orthopaedic surgery, offering an introductory text to young engineers entering the field, as well as a reference for medical staff who will benefit from an understanding of the materials and methods used in their design, engineering and manufacture. (ecampus.com)
  • enhancement
  • But I am not optimistic in this regard as the argument takes advantage of a slippery slope which has been established through all sorts of human enhancement procedures which people have voluntarily adopted. (blogspot.com)
  • Evolution
  • Charles Darwin, when drafting his theory of evolution, presented imperfections in humans' anatomic structures and functions as the strongest evidence for his theory. (the-scientist.com)
  • vectors
  • Our group has focused on recombinant adenoviral vectors (AdV) as vehicles for antigen engineering of DC in order to harness their immunostimulatory ability and activate multiple tumor antigen-specific T cell specificities. (jimmunol.org)
  • cells
  • A coordinated network of molecular processes providing cells with nearly flawless surveillance, maintenance, and repair capabilities exemplifies the "perfection" of the human body. (the-scientist.com)
  • Importantly, we could do this in an environment that consists exclusively of human cells and which incorporates conditions tailored to the specific individual," explain Ivan Martin and Timm Schroeder. (eurekalert.org)
  • The first involves altering the genome of "somatic cells" (i.e., any cell that makes up the human body). (culture-of-life.org)
  • The use of human progenitors to generate human transgenic T cells has been restricted mainly to in vitro studies. (pnas.org)
  • body
  • Anyone who understands how time takes its toll on the body and mind, however, will recognize that designing a human body built to last requires far more substantive changes than meddling with simple anatomy. (the-scientist.com)
  • The gastrointestinal tract contains the second largest number of nerves in the human body, according to Wells. (eurekalert.org)
  • order
  • There is a forthcoming article in Ethics, Policy and the Environment which proposes to consider human engineering, alongside other tools, in order to reduce our impact on the climate. (blogspot.com)
  • technology
  • One day this technology will allow us to grow a section of healthy intestine for transplant into a patient, but the ability to use it now to test and ask countless new questions will help human health to the greatest extent," said Michael Helmrath, MD, co-lead study investigator and surgical director of the Intestinal Rehabilitation Program at Cincinnati Children's. (eurekalert.org)
  • development
  • We asked experts in gerontology, neuroscience, genetics, cell biology, development, and health and fitness science to devise a human that would stand the test of time. (the-scientist.com)
  • Components
  • In this study we have investigated the effects of AdV transduction on APM component expression levels in human DC and have compared these values to the level of APM components in immature (iDC) and in IFN-γ/LPS-matured (mDC) DC. (jimmunol.org)
  • help
  • These separation methods, coupled with other tools such as 3D in vitro cell-based models, will help us in understanding host-microbiome interactions and act as stepping stones for engineering human microbiomes. (nanohub.org)