EmbryosHPSCsHPSCHomozygousInternational Stem Cell CorporationISCO'sGeneticallyPluripotentEggsOocytesBabiesBiologyResearchChromosomesTherapeuticTissueGrownProducesParthenogenesisTissuesSpeciesCaliforniaGeneticSimilarLaboratoryMiceStructuresCreationTypeNormalCultureProcessTypesFoundImportanceStudyHopeMedicinePreviously
Embryos7
- Similar to embryonic stem cells (ESCs), hpSCs are pluripotent cells that can be reproduced into any type of cell within the human body without using or destroying the viable human embryos. (pharmaceutical-technology.com)
- As the technology uses un-fertilised oocytes, it eradicates the ethical issues arising from the use of human embryos. (pharmaceutical-technology.com)
- But that's far enough to produce embryonic stem cells that can be harvested for research and medicine - without the ethical quandaries presented by taking stem cells from human embryos discarded in IVF. (chemistryworld.com)
- hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. (intlstemcell.com)
- The Case alters the patenting regime for human embryonic stem cell (hESC) applications, by stating that moral restrictions against hESC-patents are only applicable to such cells derived from embryos that had the potential to develop into a human being. (bvsalud.org)
- The law review addresses the controversy of all of the entities that are currently called embryos with regards to embryonic stem cell research legislation around the world. (wikipedia.org)
- Mature egg cells are produced by mitotic divisions, and these cells directly develop into embryos. (alchetron.com)
HPSCs4
- The stem cell facility will produce human parthenogenic stem cells (hpSCs) that are derived from parthenogenetically induced human oocytes. (pharmaceutical-technology.com)
- The new International Stem Cell Corporation (ISCO) facility will produce human parthenogenic stem cells (hPSCs). (pharmaceutical-technology.com)
- Unlike induced pluripotent stem cells (iPSs), hPSCs do not manipulate the gene expression process back to a less differentiated stage, thereby avoiding the regulatory, ethical and safety obstacles. (pharmaceutical-technology.com)
- The European Court of Justice (ECJ) has recently issued a ruling in Case C-364/13 International Stem Cell Corporation v. Comptroller General of Patents Designs and Tademarks (Case) that aims at harmonising the patenting practices regarding interpretation of Article 6.2.c of Directive 98/44/EC (Biotech Patent Directive) in respect of patentability of human parthenogenic stem cells (hpSCs). (bvsalud.org)
HPSC7
- Different cell types will be produced using hPSC technology. (pharmaceutical-technology.com)
- ISCO will simultaneously partner with leading scientists across the world to showcase the therapeutic applicability and the potential advantages of hPSC over other stem cells. (pharmaceutical-technology.com)
- The hpSC cell line will be used to treat a host of degenerative diseases. (pharmaceutical-technology.com)
- The facility will produce different cell types using the company's patented human parthenogenic stem cell (hpSC) technology, known as parthenogenesis. (pharmaceutical-technology.com)
- Unfertilised human eggs are used to produce parthenogenic stem cells (hpSC) that have the ability to be immune-matched with millions of patients. (pharmaceutical-technology.com)
- This produces either heterozygous human parthenogenetic stem cell lines that can be precisely HLA-matched or stem cell lines histocompatible with the oocyte donors or HLA homozygous hPSC that are histocompatible with the major segments of human population. (pharmaceutical-technology.com)
- ISCO has discovered and filed for patents on a cell culture process for the synthesis of fully human, cornea-like structures using either its proprietary human parthenogenic stem cell (hpSC) technology or human embryonic stem cells. (intlstemcell.com)
Homozygous1
- ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. (intlstemcell.com)
International Stem Cell Corporation2
- OCEANSIDE, CA - February 16, 2010 - International Stem Cell Corporation ( ISCO .OB), www.intlstemcell.com , announced today that multiple international meetings taking place between ISCO's executive management and researchers and clinicians from commercial entities in both Asia and Europe revealed significant clinical-commercial opportunities for the company's stem cell-derived human cornea technology in those regions. (intlstemcell.com)
- International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. (intlstemcell.com)
ISCO's4
- It will also be implemented with ISCO's parthenogenic stem cell processes. (pharmaceutical-technology.com)
- ISCO's parthenogenic stem cell technology enables synthesis of corneal tissue that is immune matched for millions of people. (intlstemcell.com)
- Brian Lundstrom, ISCO's President, says: "Given the substantial unmet medical need for human corneas in Asia and Europe, ISCO has commenced a targeted effort to partner with clinical development and commercialization partners in these regions. (intlstemcell.com)
- ISCO's core technology, parthenogenesis , results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). (intlstemcell.com)
Genetically2
- The HLA genotypes of stem cells obtained from such oocytes are heterozygous and are genetically cloned to the donors. (pharmaceutical-technology.com)
- Costagliola and her colleagues first genetically engineered embryonic stem cells to express two proteins NKX2-1 and PAX8 that are expressed together only in the thyroid. (regenerativemedicine.net)
Pluripotent1
- Francesco Antonica, a molecular embryologist in Costagliola's lab and a co-author of the latest paper, says that the team plans to use such induced pluripotent stem cells, derived from patients with hypothyroidism, to try to replicate the mouse results in humans. (regenerativemedicine.net)
Eggs4
- Situated in California, US, the new facility is located close to fertility clinics that provide donated human eggs to ISCO. (pharmaceutical-technology.com)
- The article discusses research 1 demonstrating that parthenogenesis can be induced in human eggs by a simple chemical stimulus using the compound called calcium ionophore. (chemistryworld.com)
- While eggs chemically triggered to develop don't have what it takes to make a viable embryo, it's a different story if the egg has been given the chromosomes of a cell from a more mature organism, through the technique of somatic-cell nuclear transfer used in cloning. (chemistryworld.com)
- This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. (intlstemcell.com)
Oocytes1
- In the beginning, the human oocytes are parthenogenically activated using a range of activation techniques (including electrical or chemical stimuli). (pharmaceutical-technology.com)
Babies2
- Can't you make parthenogenic babies, though? (chemistryworld.com)
- If the same technique could be applied to humans, it would help the roughly 1 in 3,000 babies born with deficient thyroid activity, or hypothyroidism, which can result in stunted physical and mental development. (regenerativemedicine.net)
Biology6
- The facility is also near leading Californian research institutions that have already collaborated with ISCO on basic stem cell biology and therapeutic applications. (pharmaceutical-technology.com)
- This report pioneered the importance of naturally occurring retrovirus sequences in human genes, now thought to be important to the genetic plasticity involved in human evolution and biology. (wikipedia.org)
- Her dual interests in virology and reproductive biology led to research in semen transmission of human immunodeficiency virus, and the creation of the first laboratory for human in vitro fertilization in Oregon in the early 1980s. (wikipedia.org)
- Expertise in human egg biology led Kiessling to develop the country's first human egg donor program for stem cell research in 2000. (wikipedia.org)
- 2014 - Oregon State University Commencement Address 2014 - Honorary Doctorate in Cell and Molecular Biology, Oregon State University[citation needed] Loutradis D, John D, Kiessling AA (September 1987). (wikipedia.org)
- Crayfish are freshwater crustaceans that have become increasingly popular in epigenetic, microbiome, stem cell and evolutionary biology research. (researchsquare.com)
Research11
- ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. (intlstemcell.com)
- This Case represents a leap forward to striking a balance between protecting human dignity and integrity whilst granting patent incentives for biomedical research. (bvsalud.org)
- The lack of consensus on a common definition of the term 'embryo' has resulted in legal uncertainty affecting the permissibility of human embryonic stem cell (hESC) research and the commercialisation prospects and patenting of inventions of hESC origin in the EU. (bvsalud.org)
- Ann A. Kiessling is an American reproductive biologist and a researcher in human parthenogenic stem cell research at The Bedford Research Foundation. (wikipedia.org)
- Kiessling conducts research at the Bedford Stem Cell Research Foundation. (wikipedia.org)
- The need to conduct biomedical research in areas not funded by the federal government led to the incorporation of the Bedford Stem Cell Research Foundation. (wikipedia.org)
- Kiessling is a member of the California (California Constitution Article XXXV) and Connecticut Stem Cell Research Advisory Boards, and a member of the Embryonic Stem Cell Research Oversight Committees for Harvard University, Joslin Diabetes Center and Children's Hospital. (wikipedia.org)
- As crayfish and other invertebrates continue to become common models in research to study human disease, it is vital that we develop universal laboratory standards and guidelines on housing and husbandry practices. (researchsquare.com)
- This prospect has been made easier in recent years by research that was recognized this week with a Nobel prize: the demonstration by Shinya Yamanaka of Kyoto University in Japan that adult skin cells can be reprogrammed to form stem cells capable of differentiating into a wide range of cell types. (regenerativemedicine.net)
- We are pleased that we have succeeded in developing a functioning nano-electrode, getting it into place, and capturing signals from nerve cells, says Professor Jens Schouenborg, who is head of the Neuronano Research Centre. (regenerativemedicine.net)
- The research group has already worked for several years to develop electrodes that are thin and flexible enough not to disturb the brain tissue, and with material that does not irritate the cells nearby. (regenerativemedicine.net)
Chromosomes1
- Normal egg cells form after meiosis and are haploid, with half as many chromosomes as their mother's body cells. (alchetron.com)
Therapeutic1
- In 2003, Kiessling wrote Human Embryonic Stem Cells: An Introduction to the Science and Therapeutic Potential, the first textbook on the controversial topic. (wikipedia.org)
Tissue2
- Small molecules, identified by screening, have been used to switch differentiated cells directly from one tissue type to another - cardiac fibroblasts to muscle, say - both outside and inside the body. (chemistryworld.com)
- The structures are grown to clear hollow spheres with a size of 8-10 mm in diameter and contain tissues and cells similar to those found in normal human corneal tissue. (intlstemcell.com)
Grown1
- When these cells were grown in Petri dishes in the presence of thyroid-stimulating hormone, they turned into thyroid cells. (regenerativemedicine.net)
Produces1
- The researchers want to try and reduce the size of the base to which the nanowires are attached, improve the connection between the electrode and the electronics that receive the signals from the nerve cells, and experiment with the surface structure of the electrodes to see what produces the best signals without damaging the brain cells. (regenerativemedicine.net)
Parthenogenesis1
- In animals , parthenogenesis means development of an embryo from an unfertilized egg cell. (alchetron.com)
Tissues1
- A series of achievements have stoked excitement about the potential of regenerative medicine, which aims to tackle diseases by replacing or regenerating damaged cells, tissues, and organs. (regenerativemedicine.net)
Species2
- The Boston Herald could not resist suggesting (without cause) that Loeb's process 'may apply to human species', adding that thereby the 'Immaculate Conception [is] explained. (chemistryworld.com)
- About 30 cockroach species out of 4,600 are associated with human habitats . (wikipedia.org)
California3
- With more than 3.0 million page views and more than 5,000 items, this blog provides news and commentary on public policy, business and economic issues related to the $3 billion California stem cell agency. (blogspot.com)
- The California Stem Cell Report is taking a break for a few weeks. (blogspot.com)
- Money, manpower and performance - all are some of the top issues facing the $3 billion California stem cell agency in 2010. (blogspot.com)
Genetic1
- Gynogenesis and pseudogamy are closely related phenomena in which a sperm or pollen triggers the development of the egg cell into an embryo but makes no genetic contribution to the embryo. (alchetron.com)
Similar1
- Remarkably, the stem-cell-derived thyroid cells spontaneously grouped into follicles similar to those in an intact thyroid gland. (regenerativemedicine.net)
Laboratory1
- At Lund University in Sweden, researchers have, for the first time, succeeded in implanting an ultrathin nanowire-based electrode and capturing signals from the nerve cells in the brain of a laboratory animal. (regenerativemedicine.net)
Mice2
- The method had already been known to work in other animals, including mice and monkeys, but it had hitherto failed in humans. (chemistryworld.com)
- Four weeks later, once hypothyroidism had been established, the mice received a graft of stem-cell-derived thyroid follicles. (regenerativemedicine.net)
Structures3
- Portions or all of these structures may be suitable for cornea transplantation in humans. (intlstemcell.com)
- Crayfish (Decapoda: Astacoidea & Parastacoidea), are amongst the few animals that have stem cells within hemolymph, with the capacity to continuously produce differentiated neuronal structures throughout life. (researchsquare.com)
- 84 , 92 , 100 As of late, researchers have found that Procambarus clarkii (Red Swamp Crayfish) has the unique ability to continuously produce neuronal structures, throughout adulthood, through selective differentiation of innate immune cells, acting as neural precursors. (researchsquare.com)
Creation1
- Yet, due to the complex and heterogeneous nature of stem cell-based ATMPs, creation of an appropriate set of potency assays is associated with a number of specific challenges ranging from intrinsic and operational to legal and regulatory ones. (bvsalud.org)
Type1
- In recent years we ve seen a number of very important studies in which mouse stem cells have been converted to a desired cell type that has then been shown to be functional in vivo, and to confer benefits in mouse models of human diseases. (regenerativemedicine.net)
Normal2
- Supply of synthetic human corneas would alleviate the problem and provide great socio-economic benefit by enabling millions of Indians to get back to work and live a more normal life. (intlstemcell.com)
- Kiessling is noted for her discovery of reverse transcriptase activity in normal human cells. (wikipedia.org)
Culture1
- Cockroaches have appeared in human culture since classical antiquity . (wikipedia.org)
Process1
- In flowering plants, cells of the gametophyte can undergo this process. (alchetron.com)
Types1
- The facility accommodates separate suites for developing and manufacturing different types of cells. (pharmaceutical-technology.com)
Found1
- Prior to this discovery, it had been assumed that reverse transcriptase was an enzyme found only in retroviruses (such as human immunodeficiency virus). (wikipedia.org)
Importance1
- Ensuring integrity of relevant potency assays for stem cell-based ATMPs is of paramount importance for safety and efficacy of clinical interventions. (bvsalud.org)
Study1
- When we started the project, our hope was to get some cells that could be used to study thyroid physiology, says Costagliola. (regenerativemedicine.net)
Hope1
- In the future, we hope to be able to make electrodes with nanostructured surfaces that are adapted to the various parts of the nerve cells parts that are no bigger than a few billionths of a meter. (regenerativemedicine.net)
Medicine1
- As with much recent work in regenerative medicine, the next challenge is to translate this to humans, says ffrench-Constant. (regenerativemedicine.net)
Previously1
- Such thin electrodes have previously only been used in experiments with cell cultures. (regenerativemedicine.net)