Human distinct. Medical search. Frequent questions

Epigenetic mechanisms are highly cell-type-specific requiring cell separation techniques to determine epigenomic features in a specific cell type, especially when keeping in mind that the cellular composition of the human heart is highly dynamic. (nature.com)
Transplantation of ALDHhl mixed progenitor cells or culture- expanded multipotent stromal cells (MSC) into streptozotocin-treated NOD/SCID mice revealed endogenous islet regeneration occurred via distinct mechanisms. (uwo.ca)
Happle R: Mosaicism in human skin: understanding the patterns and mechanisms. (karger.com)
Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. (plos.org)
These results indicate that USMB enhances both CME and fluid phase endocytosis through distinct signaling mechanisms, and suggest that strategies for potentiating the enhancement of endocytosis upon USMB treatment may improve targeted drug delivery. (plos.org)
Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)
Interleukin 7 and interleukin 4 stimulate human thymocyte growth through distinct mechanisms. (ox.ac.uk)
Our findings show that both IL-7 and IL-4 can act as growth factors for human thymocytes, and that these cytokines stimulate proliferation through distinct mechanisms. (ox.ac.uk)
Significance: Our method for isolating endothelial cell types from human breast tumors may be explored to (a) understand cellular and molecular mechanisms, (b) screen anti-angiogenic molecules, and (c) formulate organoid cultures to develop personalized medicine facilitating better clinical management of breast cancers. (manipal.edu)
These observations indicate that innate and adaptive immune lineages are specified by distinct epigenetic mechanisms via combinatorial and context-dependent use of key transcription factors . (bvsalud.org)

Further understanding of these endogenous angiogenic or putative neogenic programs activated by distinct human progenitor subsets may provide new approaches for combinatorial cellular therapies to treat diabetes. (uwo.ca)
In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
Two distinct subsets of BTICs were identified co-existing in human glioblastoma, both in de novo tumors and in recurrent tumors after initial complete surgical resection and chemoradiation. (cns.org)

large variety of types, still poorly classified) Note: Cephalic connective tissue and bones are derived from the Cranial neural crest which comes from the ectoderm germ layer List of human cell types derived from the germ layers Hatton IA, Galbraith ED, Merleau NS, Miettinen TP, Smith BM, Shander JA (September 2023). (wikipedia.org)

Here, we address the question of mitochondrial adaptation by examining the differentiation of human pluripotent stem cells to cardiac progenitors and further to differentiated mesodermal derivatives, including functional cardiomyocytes. (uib.no)
Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct foci. (waw.pl)
We demonstrate that silencing of human polynucleotide phosphorylase (PNPase) causes accumulation of RNA decay intermediates and increases the half-life of mitochondrial transcripts. (waw.pl)

Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. (ca.gov)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. (ca.gov)
Conversion of human embryonic stem cells (hESCs) to an epiblast-like state activates blastocyst-specific ERV elements, indicating that their activity dynamically reacts to changes in regulatory networks. (ntu.edu.sg)

This functional dissociation between the BNST and amygdala is however controversial, and human evidence scarce. (jneurosci.org)
We show strong evidence for a dissociable role of the BNST and amygdala in threat processing by demonstrating in two large participant samples that they show a distinct temporal signature of threat responding as well as a discriminable pattern of functional connections and differential sensitivity to early life threat. (jneurosci.org)
Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. (lu.se)
These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation. (lu.se)
This study provides the first evidence that different EJCs can have distinct functions, illuminating EJC-dependent gene regulation. (nature.com)
In the primate, researchers have argued from both behavioral and neural evidence that a key step in visual representation is 'figure-ground segmentation', the delineation of figures as distinct from backgrounds. (elifesciences.org)
This systematic review investigates whether current evidence supports conceptualising treatment-resistant and treatment-responsive schizophrenoa as categorically distinct subtypes. (biomedcentral.com)
Human evidence of this is provided by molecular analysis of Pneumocystis isolates obtained from groups of patients involved in hospital outbreaks. (medscape.com)
Watkins PA, Maiguel D, Jia Z, Pevsner J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (medlineplus.gov)
Evidence for multiple, distinct representations of the Human Body. (bvsalud.org)

Despite their important role in steering innate and adaptive immunity, the age- and inflammation-associated changes in the molecular identity and functional properties of human FRCs have remained largely unknown. (nih.gov)
Interactome analysis combined with ex vivo and in vitro validation revealed that T cell activity within subepithelial niches is controlled by distinct molecular pathways during PI16 + RC-lymphocyte interaction. (nih.gov)
In sum, the topological and molecular definition of the human tonsillar stromal cell landscape reveals PI16 + RCs as a specialized FRC niche at the core of mucosal immune responses in the oropharynx. (nih.gov)
The existence of distinct molecular subtypes of glioblastoma and possibility for intra-tumoral heterogeneity present significant therapeutic challenges. (cns.org)
Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)
Recent studies have found that they have clinical and molecular features of both the BRAF mutant/MSI and the conventional BRAF wild-type cancers and comprise a distinct colorectal cancer subgroup. (hindawi.com)
BRAF mutant/MSS cancers form a distinct colorectal cancer entity that shares clinical and molecular features with both BRAF mutant/MSI serrated pathway cancers and the BRAF wild-type cancers of the conventional pathway [ 9 - 11 ]. (hindawi.com)

To enrich for analogous human progenitor cells, we purified human umbilical cord blood (UCB) and BM based on high aldehyde dehydrogenase activity (ALDHhl), a conserved function in multiple progenitor lineages. (uwo.ca)

The eggs from human excreta and urine have been found in endemic water supplies. (medscape.com)

There are about 30 trillion (3×1013) human cells in the adult human body, varying from about 20 to 40 trillion depending on the sex, age and weight, and a roughly equal number of bacterial cells. (wikipedia.org)
The human cells have been categorized into about 300 cell types based on location and function within the body, of which about 230 types are listed here. (wikipedia.org)
There are many different types of cells in the human body. (wikipedia.org)
Several efforts have been made to make a list or a map of all human cells. (wikipedia.org)
The endodermal cells primarily generate the lining and glands of the digestive tube There are nerve cells, also known as neurons, present in our human body. (wikipedia.org)
How many cells are in the human body? (wikipedia.org)
Wikimedia Commons has media related to Human cells. (wikipedia.org)
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo. (lu.se)
Here, we report that depletion of Tyrosyl DNA phosphodiesterase 1 (TDP1) sensitizes human cells to alkylation damage and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitivity above that observed for TDP1 or APE1 depletion alone. (whiterose.ac.uk)
Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)
Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
Background There is increasing interest in the therapeutic potential of human mesenchymal stem cells (hMSCs), especially in diseases such as acute hepatic failure (AHF) that are predominantly caused by a variety of drugs and viruses. (bmj.com)
Conclusions Human spindle-shaped AF-MSCs or HPL cells might be valuable tools to induce liver repair and support liver function by cell transplantation. (bmj.com)
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. (ox.ac.uk)
They then used these visualizations to reconstruct dendrites and axons allowing them to identify the cell type of the recorded cells and better understand the activity of these distinct types of interneurons while the mice were completing the spatial navigation task. (medicalxpress.com)
We developed an approach combining imaging with polymer simulations to describe the chromatin structure in individual human cells," explains Christophe Zimmer, Head of the Imaging and Modeling laboratory at the Institut Pasteur. (pasteur.fr)
Their analyses suggest the simultaneous presence of tens or hundreds of thousands of loops in the genome of individual cells, indicating that the vast majority of human DNA is enclosed in loops maintained by cohesin. (pasteur.fr)
Results: We have developed a robust and reproducible method for isolating and ex vivo culture of endothelial cells (EC) derived from non-malignant (Endo-N) and malignant (Endo-T) part from clinically characterized human breast tumors. (manipal.edu)
The relationship between human immunodeficiency virus type 1 (HIV-1) viral RNA and proviral DNA load in vagina and cervix and that found in the plasma and peripheral blood mononuclear cells (PBMC) was investigated in 28 HIV-1-infected women. (ox.ac.uk)

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. (sens.org)
Here we report a hydrogel-based multi-curvature design consisting of over twenty bands of distinct parallel curvature ranges to precisely engineer neuronal networks' growth and signaling under patterns of arcs. (rsc.org)
Publisher Correction: Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus. (ox.ac.uk)
Here, we identified lineage-specific DNA methylation signatures of six immune cell types from human peripheral blood and determined their relationship to other epigenetic and transcriptomic patterns. (bvsalud.org)

In addition, our study provides a functional map of the non-coding genome of human CMs throughout life. (nature.com)
About half of the human genome consists of highly repetitive elements, most of which are considered dispensable for human life. (ntu.edu.sg)

In summary, we find that ERV expression is a hallmark of cellular identity and cell potency that characterizes the cell populations in early human embryos. (ntu.edu.sg)
In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. (ox.ac.uk)

This co-culture approach also will enable identification of other distinct hESC subpopulations, and selection for these should prove valuable in generating tissue-specific reagents for cell-based therapy. (ca.gov)
Surface markers of distinct BTIC subpopulations were validated in fluorescence-activated cell sorting (FACS) and colony forming assays. (cns.org)

Researchers compared spleen, PB, and mobilized PB to BM utilizing single-cell RNA-sequencing and/or functional tests to characterize human extramedullary HSPC compartments thoroughly. (physiciansweekly.com)

Pneumocystis is a genus of unicellular fungi found in the respiratory tracts of many mammals and humans. (medscape.com)

Third, healthy PB HSPCs have a distinct preference for erythroid-megakaryocytic differentiation. (physiciansweekly.com)
In previous studies, a distinct population termed human spindle-shaped MSCs were isolated and expanded from second trimester amniotic fluid (AF-MSCs) and characterised based on their phenotype, pluripotency and differentiation potential. (bmj.com)

This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity. (bvsalud.org)

So far it is not clear whether nevus marginatus represents a distinct entity or merely an unusual clinical variant of nevus sebaceus. (karger.com)
It is plausible that varying degrees of response to antipsychotics reflect categorically distinct illness subtypes, which would have significant implications for research and clinical practice. (biomedcentral.com)
The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. (medscape.com)

All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. (lu.se)
In terms of implications for human health, one of the most significant evolutions has been the divergence of viruses into distinct genetic groups, sometimes called clades. (who.int)

How do these differences yield distinct behaviors in these species? (elifesciences.org)
Dienekes' Anthropology Blog: Is Homo heidelbergensis a distinct species? (blogspot.com)
Is Homo heidelbergensis a distinct species? (blogspot.com)
Some researchers propose H. heidelbergensis as an Afro-European taxon that is ancestral to both modern humans and Neandertals whereas others think it is a strictly European species that is part of the Neandertal lineage. (blogspot.com)
Less prevalent species, such as S mekongi and S intercalatum , may also cause systemic human disease. (medscape.com)
This has occurred in marshlands, leading to "hybrid" species of schistosomes, which have re-infected humans, usually from the same supply sources. (medscape.com)
Whether A. suum is a distinct species from A. lumbricoides is debated. (msdmanuals.com)

The asexual cycle occurs in other mammals (including humans) and various strains of birds. (medscape.com)

Differential treatment response represents a discontinuity which could help divide schizophrenia into biologically distinct subtypes, as Farooq et al. (biomedcentral.com)
This paper will review the literature as to whether treatment-resistant and treatment-responsive schizophrenia reflect categorically distinct subtypes. (biomedcentral.com)

There are more than 50 types of immunologically distinct adenoviruses that can cause infections in humans. (cdc.gov)
Approach to Parasitic Infections Human parasites are organisms that live on or in a person and derive nutrients from that person (its host). (msdmanuals.com)

The canine virus was almost certainly derived from a virus of birds or an avian influenza virus and it didn't derive from the human influenza strain. (cdc.gov)
Colin Parrish] So, the virus is like human influenza virus, it has a very similar disease. (cdc.gov)
Colin Parrish] The symptoms, as I mentioned, are very similar to those seen for human influenza virus. (cdc.gov)
The present WHO level of pandemic influenza alert, set in place in January 2004, remains at phase 3: a novel influenza virus is causing sporadic human cases, but is poorly adapted to humans. (who.int)

Based on this method 13 , 14 , we used a nuclear staining strategy to isolate CM nuclei from intact prenatal and postnatal human heart tissue and subjected these nuclei to comprehensive analysis of the epigenome during prenatal development, postnatal maturation, and in heart failure. (nature.com)
Tangential curvatures are a key geometric feature of tissue folds in the human cerebral cortex. (rsc.org)

Transcriptome-wide RNA-seq studies revealed that ASAP and PSAP complexes regulate distinct alternative splicing events both in EJC-independent and EJC-dependent manner. (nature.com)

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)

Hafner C, van Oers JM, Vogt T, et al: Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. (karger.com)

A combination of fluorescence lifetime imaging microscopy with Förster resonance energy transfer and bimolecular fluorescence complementation (BiFC) experiments prove that PNPase and hSuv3 helicase (Suv3, hSuv3p and SUPV3L1) form the RNA-degrading complex in vivo in human mitochondria. (waw.pl)

Ammonia is a colorless gas with a very distinct odor. (cdc.gov)
Formaldehyde is a colorless, flammable gas that has a distinct, strong smell. (cdc.gov)

T gondii oocysts, tachyzoites, and bradyzoites can cause infection in humans. (medscape.com)

Their findings , outlined in Neuron , show that distinct types of interneurons fire differently while the mice are navigating an environment and remembering odors they smelled in the past. (medicalxpress.com)

The EU have attempted to map everything in the human brain, however a lot of the areas in the model which is currently available does not have cellular resolution available. (wikipedia.org)

Among the five esters that were found to distinguish humans from pigs were propyl hexanate, a chemical used to recreate the smell of pineapples and blackberries. (dailymail.co.uk)

Sites of lineage-specific hypomethylation were associated with distinct combinations of transcription factors in each cell type. (bvsalud.org)

There are 14 distinct viruses associated with haemorrhagic fever in humans. (who.int)
the only exception is the four dengue viruses, which may circulate continually among humans. (who.int)

Here, we show that human tonsillar FRCs undergo dynamic reprogramming during life and respond vigorously to inflammatory perturbation in comparison to other stromal cell types. (nih.gov)
Previous work of Professor Thomas Klausberger and other researchers has revealed that neurons in the hippocampus express a high diversity, consisting of distinct neuron types," Thomas Forro, co-author of the paper, told Medical Xpress. (medicalxpress.com)
Self‐initiated foreign expatriates versus assigned expatriates Two distinct types of international careers? (deepdyve.com)
Furthermore, binding of human fibrinogen is associated with specific SzM types. (lu.se)

Here, we report that repetitive elements originating from endogenous retroviruses (ERVs) are systematically transcribed during human early embryogenesis in a stage-specific manner. (ntu.edu.sg)

reported that chronic administration of a common herbicide, rotenone, resulted in a selective destruction of the nigrostriatal dopaminergic system, formation of cytoplasmic inclusions in nigral neurons, and induction of hypokinesia and rigidity in rats, reproducing the key features of human PD. (jneurosci.org)

Here, using recombinant complex reconstitution and transcriptome-wide analysis, we showed that the EJC peripheral protein complexes ASAP and PSAP form distinct complexes with the EJC core and can confer to EJCs distinct alternative splicing regulatory activities. (nature.com)

These results suggest that SzM-mediated binding of human fibrinogen is an important virulence mechanism of zoonotic S. equi subsp. (lu.se)

The N-terminal 216 amino acids of the mature SzM were found to exhibit a high degree of diversity, but the majority of human isolates grouped in three distinct SzM clusters. (lu.se)

In contrast, primates, including humans, macaques, and mouse lemurs, could readily segment figures independent of carrier pattern using the opponent motion cue. (elifesciences.org)
In contrast, curvatures in the brain span a wide physical range, leaving it unknown which precise role distinct curvatures may play on neuronal cell signaling. (rsc.org)

zooepidemicus strains that the M-like protein SzM is crucial for the binding of fibrinogen to the bacterial surface and for survival in equine and human blood. (lu.se)

Here we describe the human CM epigenome during prenatal development and postnatal maturation of the heart from infant to adult age and in terminal failure. (nature.com)

To determine how the ASAP complex interacts with the EJC core, we performed in vitro coprecipitation assays 3 with Tandem Affinity Purification (TAP)-tagged recombinant proteins corresponding to full-length human SAP18, RNPS1 and ACINUS. (nature.com)

We provide a comparative morphological analysis using 47 anatomical traits of 36 Pleistocene fossils from Africa, Asia, and Europe and 35 extant human mandibles. (blogspot.com)
Plasma protein absorption assays and flow cytometry analysis revealed that pronounced binding of human fibrinogen is a common phenotype of human S. equi subsp. (lu.se)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
Conclusions No distinct microbial signature was observed in IBS. (bmj.com)

Researchers have found a 'cocktail' of five chemical compounds given off by decomposing bodies that are unique to human flesh when compared to other animals. (dailymail.co.uk)
The bodies of animals such as pigs, which are thought to decay in a similar way to humans, are often used when studying decomposing bodies. (dailymail.co.uk)
The pigs and human remains gave of eight distinct esters that separated them the other animals. (dailymail.co.uk)
In addition to allowing humans and animals to recall events that happened in the past, it plays a part in learning and behavioral adaptation. (medicalxpress.com)
Ammonia is found throughout the environment in the air, soil, and water, and in plants and animals including humans. (cdc.gov)
Cattle and other animals may have distinct schistosomes. (medscape.com)
Small amounts of formaldehyde are naturally produced by plants, animals, and humans. (cdc.gov)

However, this project still only mapped about 31 of the human bodies' 70 organs. (wikipedia.org)
It is often described as a stomach churning, sickly odour, but it seems the stench of death given off by human bodies has a distinctly fruity tone to it. (dailymail.co.uk)
Researchers have identified five distinct chemical compounds called esters, which have odours of ripe apple, pineapple, blackberries and cherries, that are given off by human bodies as they decompose. (dailymail.co.uk)

zooepidemicus isolates of equine and human origins were compared with regard to SzM sequences and binding of equine and human fibrinogens. (lu.se)

No health effects have been found in humans exposed to typical environmental concentrations of ammonia. (cdc.gov)
When applying for the Master's in Human Geography, you must also submit a statement of purpose with your application (instructions are found at www.keg.lu.se). (lu.se)

They show, for example, that the Caribbean islands were populated in two distinct waves and that the human population of the islands was also smaller than once believed. (artdaily.com)

These findings further confirm that the H5N1 virus is at present poorly adapted to humans. (who.int)

In human mitochondria nothing is known about the spatial organization of the RNA decay machinery, and the ribonuclease responsible for RNA degradation has not been identified. (waw.pl)

The Department of Health and Human Services (DHHS), the EPA, and the International Agency for Research on Cancer (IARC), have not classified ammonia for carcinogenicity. (cdc.gov)

Despite the significance of understanding their contributions to defensive reactions, there is a paucity of human studies that directly compared these regions on activity and connectivity during threat processing. (jneurosci.org)
Studies in human geography prepare you for a career in physical give you an excellent scientific base that can easily be combined planning, environmental issues, urban development, landscape with other academic subjects. (lu.se)

Humans are infected with A. lumbricoides when they ingest its eggs, often in food contaminated by human feces. (msdmanuals.com)
Humans can also be infected with ascaris ( A. suum ) from pigs when they ingest eggs from handling pigs or from consuming undercooked vegetables or fruits contaminated with pig feces. (msdmanuals.com)

Mechanisms10

Subsets3

20231

Mitochondrial3

Embryonic stem3

Evidence10

Molecular7

Progenitor cells1

Endemic1

Cells19

Patterns4

Genome2

Populations2

Subpopulations2

Functional1

Respiratory1

Differentiation2

Epigenetic2

Clinical3

Genetic2

Species7

Mammals1

Subtypes2

Infections2

Influenza virus4

Tissue2

Regulate1

Genetics1

Mutations1

Vivo1

Colorless2

Infection1

Mice1

Cellular1

Distinguish1

Transcription1

Viruses2

Types4

Endogenous1

Neurons1

Peripheral1

Mechanism1

Diversity1

Contrast2

Bacterial1

Describe1

Purification1

Analysis2

Conclusions2

Animals7

Bodies3

Sequences1

Found2

Show1

Findings1

Decay1

Department of Healt1

Studies2

Eggs2