Sandhoff DiseaseHuntington DiseaseDisease Models, AnimalAlzheimer DiseaseMice, TransgenicPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorGaucher Diseasebeta-N-AcetylhexosaminidasesPresenilin-1Amyloidogenic ProteinsBrainRotarod Performance TestNeostriatumGlucosylceramidaseDiseaseNerve Tissue ProteinsMice, Inbred C57BLTrinucleotide Repeat ExpansionBehavior, AnimalMaze LearningGene Knock-In Techniquestau ProteinsNeuronsPhenotypeMice, Mutant StrainsMutationGlycosphingolipidsExploratory BehaviorAmyloidMicrogliaAmyloid Precursor Protein SecretasesMice, KnockoutCorpus StriatumNeuroprotective AgentsGenetic Diseases, InbornNuclear ProteinsImmunohistochemistryMotor ActivityCells, CulturedAnalysis of VarianceGene Expression RegulationBlotting, WesternAgingEnzyme-Linked Immunosorbent AssaySynapsesTime FactorsHippocampusPeptide FragmentsAge FactorsMolecular Sequence DataGenome, HumanNeoplasmsSignal TransductionImmune System DiseasesDatabases, GeneticComputational BiologyModels, GeneticModels, BiologicalNeurodegenerative DiseasesGenomicsGenetic VariationAmino Acid SequenceGenetic Predisposition to DiseaseMitochondrial DiseasesSequence Analysis, DNAPolymorphism, Single NucleotideGene Expression ProfilingBase SequenceGenome-Wide Association StudyMicroRNAsDisease ReservoirsProteinsGenotypeChromosome MappingZebrafishGenomeCell LinePhylogenyModels, AnimalSpecies SpecificityCiliaEpigenesis, GeneticOligonucleotide Array Sequence AnalysisNervous System DiseasesAllelesZoonosesGene TargetingEvolution, MolecularGenetics, MedicalCluster AnalysisMolecular MedicineProtein Structure, TertiaryModels, MolecularMembrane ProteinsAlgorithmsAnimals, Genetically ModifiedMetabolic DiseasesSequence Alignment