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  • insulin
  • In summary, the results indicated that the insulin resistance observed in human muscle when plasma FFA levels were elevated during euglycemic-hyperinsulinemic clamping was associated with increases in DAG mass and membrane-associated PKC-βII and -δ and a decrease in IκB-α. (diabetesjournals.org)
  • Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-β/IκB/NFκB pathway remains to be established. (diabetesjournals.org)
  • chromosome
  • The chromosome mapping of the genome for PtdIns 4-kinase was attempted in cooperation with Dr.D.M.Hunt and started. (nii.ac.jp)
  • Exclusion of the human collagen type XVII (COL17A1) gene as the cause of Thiel-Behnke corneal dystrophy (CDB2 on chromosome 10q23-q25. (uth.edu)
  • activity
  • This effect required DGK η catalytic activity, as assessed using a kinase-dead (G389D) mutant and multiple truncation constructs. (aspetjournals.org)
  • The ED50 as determined by a cell proliferation assay using human A375 cell line is less than 5 μg/ml, corresponding to a specific activity of >200 IU/mg. (cusabio.com)
  • Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. (nih.gov)
  • Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity . (genecards.org)
  • gene knockout
  • Such an increase in the gene expression after axotomy was observed in a similar time course for PI3 kinase and skin type-fatty acid binding protein (FABP), suggesting a functional relation between PI-signal and FABP.Thus the gene knockout for s-FABP is under way in co-operation with Dr.F.Spener. (nii.ac.jp)
  • cell proliferation
  • This increase resulted in concomitant transactivation of the EGF receptor and sustained activation of extracellular signal related kinase (ERK) 1/2, culminating in enhanced cell proliferation. (rupress.org)
  • regard
  • This finding is closely similar to that of arachidonoyl-diacylglycerol kinase (DGK) and in this regard we discussed with Dr.J.A.Glomset who first id … More entified the DGK and attempted to examine the colocalization of the two molecules by immunohistochemistry by Drs.K.Goto. (nii.ac.jp)