SkinFibroblastsDermisKeratinocytesUltraviolet RaysCells, CulturedEpidermisMelanocytesSkin AgingMatrix Metalloproteinase 1Skin Physiological PhenomenaSkin NeoplasmsCollagenDose-Response Relationship, RadiationKeloidScleroderma, SystemicWound HealingCollagen Type ISkin, ArtificialRNA, MessengerMateria MedicaCicatrix, HypertrophicCell LineCollagenasesSignal TransductionDermatologic AgentsExtracellular MatrixGene Expression RegulationMatrix Metalloproteinase 3Gene ExpressionFibroblast Growth Factor 2Dose-Response Relationship, DrugCell DivisionCell ProliferationSkin DiseasesTransforming Growth Factor betaCollagen Type IIISkin PigmentationUp-RegulationInterleukin-1FibrosisProcollagenCell SurvivalCell DifferentiationTissue Inhibitor of Metalloproteinase-1Transforming Growth Factor beta1Induced Pluripotent Stem CellsProto-Oncogene Proteins c-sisFibronectinsGene Expression Regulation, EnzymologicOxidative StressFibroblast Growth FactorsCell Culture TechniquesProto-Oncogene Protein c-ets-1Blotting, WesternSmad3 ProteinBase SequenceSkin AbsorptionNucleic Acid Synthesis InhibitorsDNAHyaluronic AcidProtein Kinase C-deltaSunlightCell CommunicationReverse Transcriptase Polymerase Chain ReactionCell MovementMicroscopy, FluorescenceCoculture TechniquesTumor Necrosis Factor-alphaEnzyme InhibitorsPlatelet-Derived Growth FactorActinsDown-RegulationCell AdhesionMice, HairlessInterleukin-8Reactive Oxygen SpeciesEnzyme PrecursorsTransfectionTissue EngineeringTranscription, GeneticPhosphorylationMolecular Sequence DataCulture Media, ConditionedPromoter Regions, GeneticCysteamineCytokinesScleroderma, DiffuseReceptors, Fibroblast Growth FactorDNA DamageMetalloendopeptidasesRecombinant ProteinsMelaninsImmunohistochemistryCell Line, TransformedFibroblast Growth Factor 1Mitogen-Activated Protein Kinase 3ApoptosisSkin TestsEnzyme Activation