• Storage protein 2 (SP2) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis. (hindawi.com)
  • Many factors, such as peroxide, ox-low density lipoprotein (LDL), angiotensin I, and tumor-necrosis-factor-(TNF-) α can induce the production of reactive oxygen species (ROS) by NADPH oxidase in endothelium and vascular smooth muscle [ 2 ], which results in oxidative stress to the endothelial cells (ECs) and, thus, the induction of cell apoptosis. (hindawi.com)
  • Additional studies have also shown that hemolymph from the silkworm ( Bombyx mori ) can inhibit insect and mammalian cell apoptosis that is induced by viruses and several chemical inducers, such as staurosporine, camptothecin, and actinomycin D [ 6 - 8 ]. (hindawi.com)
  • A recent study showed that another protein in silkworm hemolymph, storage protein 2 (SP2), can also inhibit staurosporine-induced HeLa cell apoptosis and ROS generation [ 8 ]. (hindawi.com)
  • Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. (mdpi.com)
  • CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. (thermofisher.com)
  • The proliferation and apoptosis of CaSki, SiHa and HeLa cells by the treatment of miR2911 or miR2911-containing exosomes were examined by CCK8, colony formation and flow cytometry assays. (bvsalud.org)
  • Furthermore, both miR2911 and miR2911-containing exosomes inhibited cell proliferation of SiHa, CaSki and HeLa cells, meanwhile inducing the cell apoptosis through E6/E7-p53/Caspase3 axis. (bvsalud.org)
  • CONCLUSION: Our findings indicate that miR2911, an active component present in Lonicera japonica exosomes, inhibits proliferation and induces apoptosis of cervical cancer cells by targeting the E6/E7 genes of HPV16/18. (bvsalud.org)
  • Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. (molcells.org)
  • To prevent these detrimental consequences, eukaryotic cells have evolved an elaborate and complex system, so called DNA damage response (DDR) comprising of DNA DSB repair, cell cycle arrest, apoptosis, and transcriptional regulation ( Jackson and Bartek, 2009 ). (molcells.org)
  • Flow cytometric analysis and western blot were taken to analyze cell apoptosis. (biomedcentral.com)
  • Cell proliferation was inhibited after cisplatin treatment when ERp44 was knocked down and ERp44 strengthened cisplatin resistance by influencing cell apoptosis and pyroptosis. (biomedcentral.com)
  • Jurkat cells treated by apoptosis inducing reagent, Staurosporine, were stained with JC-1 MitoMP Detection Kit. (dojindo.com)
  • The cell line was derived from cervical cancer cells taken from Henrietta Lacks, in 1951. (abcam.com)
  • The mechanism of miR2911 action on HPV and the effect of exosomal miR2911 on HPV-induced cervical cancer cells were investigated. (bvsalud.org)
  • The effects of miR2911 on endogenous E6/E7 mRNA and protein levels were detected in HPV16/18-positive cervical cancer cells by RT-qPCR and Western blotting. (bvsalud.org)
  • In addition, the endogenous E6/E7 mRNA and protein levels were significantly decreased by using miR2911 treatment in HPV16/18-positive cervical cancer cells. (bvsalud.org)
  • The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)
  • The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. (wikipedia.org)
  • Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)
  • In this study, we discover a previously unknown type of SBD and identify its causal gene, TMEM53 , which encodes nuclear envelope transmembrane (NET) protein 53 (TMEM53, also known as NET4). (nature.com)
  • In addition, the expressed protein in the silkworm baculovirus system was used to study the anti-apoptotic effects of SP2 on human umbilical vein ECs (HUVECs) induced by peroxidation. (hindawi.com)
  • Synthetic peptide derived from the central portion of the ZO-2 protein. (thermofisher.com)
  • CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
  • When cells were transfected with GFP-HIF-1α, treatment with TSA increased the number of green fluorescence protein (GFP)-positive cells. (oncotarget.com)
  • TSA also enhanced the nuclear translocation of HIF-1α protein, as assessed by immunoblotting and as evidenced by increased nuclear localization of GFP-HIF-1α. (oncotarget.com)
  • It is predicted to disrupt an exon splice enhancer (ESE) motif recognized by the human SR protein SC35. (elifesciences.org)
  • Human SREBP2 protein (amino acids 48-403). (novusbio.com)
  • A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins. (embl-heidelberg.de)
  • hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes. (embl-heidelberg.de)
  • We have identified and characterised human and mouse cDNAs that encode proteins homologous to yPop4p, a protein subunit of both the yeast RNase MRP and RNase P complexes. (embl-heidelberg.de)
  • The human Pop4 cDNA encodes a highly basic protein of 220 amino acids. (embl-heidelberg.de)
  • Immunoprecipitation assays using extracts from transfected cells expressing epitope-tagged hPop4 revealed that this protein is associated with both the human RNase MRP and RNase P particles. (embl-heidelberg.de)
  • Polyclonal rabbit antibodies raised against recombinant hPop4 recognised a 30 kDa protein in total HeLa cell extracts and specifically co-immunoprecipitated the RNA components of the RNase MRP and RNase P complexes. (embl-heidelberg.de)
  • Taken together, these data show that we have identified a protein that represents the human counterpart of the yeast Pop4p protein. (embl-heidelberg.de)
  • In some conditions, especially in tumor microenvironment, cells undergo nutrient deprivation, hypoxia or drug-induced toxicity, protein folding is interfered. (biomedcentral.com)
  • We therefore asked what role JMJD1B plays in newly synthesized histone maturation by exploiting the knockdown of JMJD1B by treating HeLa cells with siRNA against JMJD1B (siJMJD1B) and observed the reduction of both JMJD1B protein on cytosolic extracts (Fig. 1 b) and mRNA levels (Fig. 1 c) 72 h after the treatment. (biomedcentral.com)
  • Thus, the control of ribosome assembly and protein synthesis is essential for the survival of cancer cells. (biomedcentral.com)
  • In this context, during any sort of stress condition the alternative reading frame protein p14ARF subtracts MDM2, an E3 ubiquitin ligase, from the interaction with p53 in manner to free and stabilise p53 level in the nucleolus of the cell where it inhibits RNA polymerase I activity [ 3 ]. (biomedcentral.com)
  • The spike protein of coronaviruses mediates virus binding and cell entry. (cdc.gov)
  • Using this method, we examined the genomic positions of 6mA in bacteria ( E. coli ), green algae ( C. reinhardtii ), and mammalian cells (HEK239T, Huh7, and HeLa cells). (nature.com)
  • Several major species of E2 enzymes have been characterized in mammalian cells, plants, and yeast. (justia.com)
  • These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)
  • In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
  • Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
  • Cell-based and in vitro assays show that Retro-2 blocks delivery of newly-synthesized TA-proteins to the ER-targeting factor ASNA1 (TRC40). (elifesciences.org)
  • Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins. (justia.com)
  • Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)
  • and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
  • Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)
  • The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)
  • Proteins that control the CELL DIVISION CYCLE. (lookformedical.com)
  • Proteins found in the nucleus of a cell. (lookformedical.com)
  • The objective of this study was to evaluate the global effect of EGCG on IL-1β-induced expression of proteins associated with OA pathogenesis in human chondrocytes. (biomedcentral.com)
  • We show that this united ExM (uniExM) protocol can be used to preserve and visualize RNA transcripts, proteins in biologically relevant ultrastructures, and sets of RNA transcripts in patient-derived xenograft (PDX) cancer tissues and may support the visualization of other kinds of biomolecular species as well. (plos.org)
  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. (nih.gov)
  • Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)
  • HeLa cells are human epithelial cells from a fatal cervical carcinoma. (abcam.com)
  • The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
  • CSEC216 was an uncontaminated cell line, exhibited epithelial cell features with polygonal morphology and adherent growth as monolayer. (biomedcentral.com)
  • Horizontal gene transfer from human papillomavirus 18 (HPV18) to human cervical cells created the HeLa genome which is different from either parent genome in various ways including its number of chromosomes. (abcam.com)
  • In contrast to bacteria and green algae, human cells possess a very limited number of 6mA sites which are sporadically distributed across the genome of different cell types. (nature.com)
  • Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome stability. (biomedcentral.com)
  • Moreover, around 95% of the human genome contains non-coding DNA. (lidsen.com)
  • Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
  • After nuclear transplantation, oocyte-derived H3.3 but not H3.2, is deposited on several regions of the genome including rDNA, major satellite repeats, and the regulatory regions of Oct4. (biomedcentral.com)
  • In 1952 Robert Briggs and Thomas J. King published their article, "Transplantation of Living Nuclei from Blastula Cells into Enucleated Frogs' Eggs," in the Proceedings of the National Academy of Sciences, the culmination of a series of experiments conducted at the Institute for Cancer Research and Lankenau Hospital Research Institute in Philadelphia, Pennsylvania. (asu.edu)
  • This study demonstrates that the incorporation of histone H3.3 is an early and necessary step in the direct reprogramming of somatic cell nuclei by oocyte. (biomedcentral.com)
  • While those observed in eggs may well be related to DNA synthesis and cell replication coupled events during the cell cycle, those that take place in somatic nuclei transplanted to oocytes which do not replicate DNA and are arrested in prophase I of meiosis are associated essentially with new transcription and are independent of cell cycle progression. (biomedcentral.com)
  • pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
  • PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. (lookformedical.com)
  • In our previous research, we have also reported that ERp44 was highly expressed in NPC and associated with patients' survive state and clinical stages, it also participated in promoting cells proliferation and migration [ 22 ]. (biomedcentral.com)
  • IL-8 is a chemoattractant factor involved in synovial inflammation in the joint [ 4 ] and IL-6 reportedly plays a contributory role to the OA pathogenesis by increasing the number of inflammatory cells in synovial tissue, stimulating proliferation of chondrocytes, and inducing amplification of IL-1 effects [ 6 ]. (biomedcentral.com)
  • Instead ErbB3 silencing or nucleolar stress reduce cell proliferation and affect cell cycle progression. (biomedcentral.com)
  • These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. (biomedcentral.com)
  • Nucleolar activity is also influenced by the interaction between pathways activated from extracellular signals in order to coordinate ribosome synthesis and cell proliferation [ 6 ]. (biomedcentral.com)
  • Both cell-derived microstructures and extracellular matrix components play critical roles in the preorganization and oriented deposition of calcium phosphate and serve as passive supports in dentine and enamel. (researchsquare.com)
  • Fucan represents a family of water soluble, SP rich in sulfated l -fucose, extracted from extracellular matrix of these weeds (Li et al. (springer.com)
  • The extracellular matrix of the cartilage is maintained by equilibrium between anabolic and catabolic activities of the chondrocytes - the only cell type present in the cartilage [ 1 , 2 ]. (biomedcentral.com)
  • However, the mechanism by which nuclear translocation is regulated remains unclear. (nature.com)
  • Activation and nuclear translocation of NF-κB occurs following signal-induced phosphorylation of IκB, which leads to proteolysis via the ubiquitin pathway. (justia.com)
  • This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
  • Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)
  • HeLa cells have a modal chromosome number of 82, with 4 copies of chromosome 12 and 3 copies of chromosomes 6, 8, and 17. (abcam.com)
  • Barbara McClintock conducted experiments on corn (Zea mays) in the United States in the mid-twentieth century to study the structure and function of the chromosomes in the cells. (asu.edu)
  • We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)
  • Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
  • PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. (molcells.org)
  • HeLa cells are adherent cells (they stick to surfaces) and maintain contact inhibition in vitro. (abcam.com)
  • As observed with the 74 nucleotide second intron of the Drosophila white gene, the wild-type myosin intron is accurately spliced in a homologous extract, and increasing the size by 16 nucleotides both eliminates splicing in the Drosophila extract and allows accurate splicing in the human extract. (umd.edu)
  • we noted that a naturally larger (150 nucleotide) intron from the ftz gene is efficiently spliced in Kc cell extracts that do not splice enlarged introns (of 84, 90, 150 or 350 nucleotides) derived from the 74 nucleotide white intron. (umd.edu)
  • RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene. (wikipedia.org)
  • NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
  • Synthetic miR2911 and GFP-E6/E7 plasmids were transfected into HEK293T cells to examine the effect of miR2911 on E6/E7 gene expression. (bvsalud.org)
  • Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
  • For example, the human Bcl-x gene can be processed to generate several isoforms with markedly different activities. (berkeley.edu)
  • The human H2A and H2B histone gene complement. (nih.gov)
  • PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
  • Nuclear reprogramming is characterized by a global shift in gene expression. (biomedcentral.com)
  • In nuclear transfer to Xenopus eggs, histone H3.3 participates in the transmission of an active state of a gene, even in embryonic lineages where genes should be silenced [ 4 ]. (biomedcentral.com)
  • Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. (researchgate.net)
  • A study showed that ganoderic acids C and D isolated from G. lucidum inhibit the release of histamine from mast cells [81] . (researchgate.net)
  • CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. (thermofisher.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • This is due to acute alterations in the tissues surrounding the tumor and in the environment as a result of treatment with anticancer therapeutics, which facilitate the drug resistance of tumor cells. (oncotarget.com)
  • RESULTS: MiR2911 is found to be enriched in various Lonicera japonica tissues, and is stably present in Lonicera japonica-derived exosomes. (bvsalud.org)
  • uniExM may find many uses in the simple, multimodal nanoscale analysis of cells and tissues. (plos.org)
  • Nanoscale imaging enables the analysis of biological systems, such as cells and tissues, at the fundamental length scales of biomolecules and biomolecular interactions, but classically has required expensive equipment and advanced skillsets to perform, e . g ., via super-resolution microscopy [ 1 ]. (plos.org)
  • We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
  • The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
  • Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
  • By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)
  • The lowest four in tissues are FAM32A, ABCB7, MRPL21 and PCBP1, while the lowest three in cell lines are SF3B2, NXF1 and RBM45. (biorxiv.org)
  • Subcellular localization results showed that SP2 is located mainly on the cell membrane. (hindawi.com)
  • CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (thermofisher.com)
  • Mitophagy was not detected in untreated cells and the membrane potential was normal. (dojindo.com)
  • However, reduction of membrane potential and mitophagy were observed in treated cells. (dojindo.com)
  • The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. (biomedcentral.com)
  • We show that TMEM53 acts as an inhibitor of BMP-SMAD signaling by preventing SMAD accumulation in the cell nucleus and that its deficiency enhances osteogenic differentiation by overactivating the BMP signaling pathway. (nature.com)
  • Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. (biomedcentral.com)
  • Tumor suppressors, oncogenes and alternatively deregulated upstream signalling pathways can directly influence the RNA polymerase I activity inducing hyper activation of rRNA transcription in cancer cells. (biomedcentral.com)
  • In contrast to previous results, however, an upstream cryptic 5' splice site is activated when the wild-type myosin intron is tested in a human HeLa cell nuclear extract, resulting in the removal of a 98 nucleotide intron. (umd.edu)
  • Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)
  • ncRNAs contribute by far the majority of human transcriptional units, and the functions of the most are yet unknown. (lidsen.com)
  • In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
  • Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
  • CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. (thermofisher.com)
  • Initial characterization of SARS-CoV-2 spike indicates that it binds the same receptor as SARS-CoV angiotensin-converting enzyme, which is expressed in both upper and lower human respiratory tracts ( 8 ). (cdc.gov)
  • Bmdsx pre-mRNA transcribed derived from transgene was sex-specifically spliced. (bioone.org)
  • 2003. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. (berkeley.edu)
  • C) Results of DNA sequencing analysis of each cDNA derived from MO-injected embryos. (echinobase.org)
  • As your recommendaion, the Jurkat cells treated with anti Fas antibody to induce cleavage is positive control. (abcam.com)
  • This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Western Blot: SREBP2 Antibody (1D2) [NBP1-54446] - Lane1: HEp-2 cells. (novusbio.com)
  • Immunocytochemistry/ Immunofluorescence: SREBP2 Antibody (1D2) [NBP1-54446] - SREBP2 (1D2) antibody was tested in HeLa cells with DyLight 488 (green). (novusbio.com)
  • We investigated its cellular localization and found it in both cytosolic and nuclear extracts derived from HeLa cells (Fig. 1 a). (biomedcentral.com)
  • Eukaryotic cells destroy many endocytosed pathogens by targeting them to the lysosome. (elifesciences.org)
  • In the eukaryotic cells the production of ribosomes takes place in the nucleolus, a specialized subnuclear compartment where the RNA Polymerase I (RNA Pol I) catalyses the ribosomal RNA synthesis (rRNA). (biomedcentral.com)
  • IHC-P: Human placenta tissue. (abcam.com)
  • Altogether there are four main datasets, namely 409 "SLCs" in 59 tissue types and 56 cell lines, and 48 ABCs in the same tissue types and cell lines. (biorxiv.org)
  • AIM OF THE STUDY: In this study, Lonicera japonica-derived exosomes was extracted and exosomal miR2911 was identified. (bvsalud.org)
  • We performed differential centrifugation to isolate exosomes from serum or conditioned media of cells and analyzed the impact of exosomal ERp44 on cells cisplatin sensitivity. (biomedcentral.com)
  • Our data suggested that exosomal ERp44 derived from ER-stressed NPC cells took an inevitable role in NPC chemoresistance and might act as a treatment target. (biomedcentral.com)
  • The purpose of this study was to investigate the expression pattern of Mage-D1 in rat tooth germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. (researchsquare.com)
  • Our results suggest a mechanism by which Chlamydia can tailor its growth rate to the conditions within the host cell. (plos.org)
  • Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. (biomedcentral.com)
  • Nuclear transfer to eggs and oocytes attempts to identify the mechanism of this direct route towards reprogramming by natural components. (biomedcentral.com)
  • Mutation signatures, genes with SNA or CNA of CSEC216 and published ESCC cell lines were similar with the mutation spectrum of original ESCC tumors. (biomedcentral.com)
  • Alternative splicing has been shown to affect more than one-third of all human genes. (berkeley.edu)
  • Recent reports have shown that more than one third of all human genes may be affected by alternative splicing[ 4 - 9 ]. (berkeley.edu)
  • The survival rates of tumor patients are decreasing because of tumor cell resistance to anticancer chemotherapies [ 1 ]. (oncotarget.com)
  • The karyotype demonstrated tumor cell patterns with aneuploidy and complex chromosomal aberrations. (biomedcentral.com)
  • 1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)
  • HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)
  • We isolated virus from nasopharyngeal and oropharyngeal specimens from this patient and characterized the viral sequence, replication properties, and cell culture tropism. (cdc.gov)
  • It suggests that the incorporation of histone H3.3 is necessary during global changes in transcription that accompany changes in cell fate. (biomedcentral.com)
  • A number of histone changes are already known to be associated with nuclear reprogramming by eggs and oocytes. (biomedcentral.com)
  • Hanachi P, Sadeghi Ali Abadi H, Ghorbani N, Zarringhalami R, Kiarostami K. Evaluation of antioxidant and anticancer effects of Lavandula angustifolia and Melissa officinalis on HeLa, OVCAR-3 and MCF-7 cancer cell lines. (ac.ir)
  • Untreated cells showed red fluorescence, while FCCP treated cells showed little red fluorescence. (dojindo.com)
  • C . trachomatis only replicates from inside a host cell, and has evolved to acquire a variety of nutrients directly from its host. (plos.org)
  • We found that the virus replicates to high titer in Vero-CCL81 cells and Vero E6 cells in the absence of trypsin. (cdc.gov)
  • Automatically-derived, secondary literature is also avaliable. (embl-heidelberg.de)
  • Initially, two observations prompted the present study: i) previous results revealed down-regulation of p68 RNA helicase resulting from overexpression of the IDX hairpin loop in HeLa cells, and ii) the secondary structure of the IDX hairpin loop resembles pri-miRNAs, implying that an miRNA could be processed from the hairpin loop-containing pri-miRNA and regulate 68 RNA helicase. (lidsen.com)
  • Comparison of nuclear splicing extracts from human HeLa and Drosophila Kc cells has revealed species-specificity, consistent with the observed size differences. (umd.edu)
  • Antiallergic activity has been demonstrated by G. lucidum extracts, as well as some compounds isolated from this species, such as ganoderic acids, oleic acid, and cyclooctasulfur acid belonging to triterpenes [80]. (researchgate.net)
  • Celastrol showed a potent inhibitory activity against HIF-1 activation induced by hypoxia in various human cancer cell lines. (spandidos-publications.com)
  • A cell viability assay demonstrated that SP2 could significantly enhance the viability of HUVEC. (hindawi.com)
  • Then we also collected exosomes and cell viability was increased after the addition of NPC-derived-exosomes with cisplatin treatment. (biomedcentral.com)
  • Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. (nih.gov)
  • Hypomethylation of ATG4A and HIST1H2BN in ovarian tumor-initiating cells predicts a poor prognosis for ovarian cancer patients. (nih.gov)
  • Mol Cell Proteomics, 2006 Jul. (nih.gov)
  • More importantly, our results showed under ERS, NPC cells secreted exosomes containing ERp44 and could transfer them to adjacent cells to strengthen chemoresistance. (biomedcentral.com)
  • Our results suggest that the potential of EGCG in OA treatment/prevention may be related to its ability to globally suppress the inflammatory response in human chondrocytes. (biomedcentral.com)
  • Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. (rupress.org)
  • 1979. Chemicals and industrial processes associated with cancer in humans. (cdc.gov)
  • The effect of hairpin loop overexpression on cell growth and cancer processes was also investigated by analyzing cell-cycle phases and miR-206 expression. (lidsen.com)
  • Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. (biomedcentral.com)
  • Sustainable and uncontaminated cancer cell lines provide available resources for researchers to utilize. (biomedcentral.com)
  • CSEC216 was established from an endoscopic biopsy sample derived from a 45-year-old male patient who underwent esophageal endoscopy in the Cancer Hospital of Shantou University Medical College. (biomedcentral.com)
  • The current study also reported the genomic similarity of 28 ESCC cell lines and original ESCC tumors. (biomedcentral.com)
  • Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. (biomedcentral.com)
  • Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. (biomedcentral.com)
  • Misidentifying and cross-contaminations of cell lines also hamper the way of producing solid and reproductive data. (biomedcentral.com)
  • Background information and genomic mutation data of published ESCC cell lines were obtained from online databases. (biomedcentral.com)
  • Genomic mutation features of CSEC216 and 28 ESCC cell lines were characterized which provided thorough cytogenetic background that facilitated future usage. (biomedcentral.com)
  • Human cell lines are now widely used in laboratories worldwide. (biomedcentral.com)
  • reported that many cell lines had been switched or cross-contaminated with Hela cells. (biomedcentral.com)
  • Therefore, authorization of newly established cell lines is utterly needed. (biomedcentral.com)
  • There are abundant esophageal squamous cell carcinoma (ESCC) cell lines around the world. (biomedcentral.com)
  • Quantitative proteomic analysis of post-translational modifications of human histones. (nih.gov)
  • Many recent studies in both animal models and humans have revealed that renin-angiotensin system (RAS) activation is one of the most vital mechanisms involved in atrial fibrosis [ 1 , 4 ] . (medsci.org)
  • Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. (justia.com)
  • The present invention relates generally to compositions and methods for modulating the activation of nuclear factor κB (NF-κB). (justia.com)
  • 1997. Metabolic activation of aromatic amines by human pancreas. (cdc.gov)
  • The inhibitory effects of EGCG were mainly mediated by inhibiting the activation of NF-κB and c-Jun N-terminal Kinase (JNK)-MAPK in human chondrocytes. (biomedcentral.com)