• One beta subunit, produced from the KCNE1 gene, binds to the channel and regulates its activity. (medlineplus.gov)
  • Ehmke H. Physiological functions of the regulatory potassium channel subunit KCNE1. (medlineplus.gov)
  • 10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
  • 11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
  • 13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)
  • Bulk Order Inquiry for Anti-Kv2.1 Potassium Channel Subunit Antibody FL490 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
  • This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. (antikoerper-online.de)
  • The human ether-a-go-go-related gene (hERG) encodes for the pore-forming subunit of the channel that conducts the rapidly activating delayed K+ current (IKr) in the heart. (bvsalud.org)
  • 7) Zheng YM , Park SW , Stokes L , Tang Q , Xiao JH , Wang YX 。Distinct activity of BK channel β1 subunit in cerebral and pulmonary artery smooth muscle cells. (tjmu.edu.cn)
  • This delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mRNA for genes implicated in neuronal differentiation such as delta-like homolog 1 (DLK1), gamma-aminobutyric acid type B receptor subunit 2 (GABABR2), nuclear receptor related 1 protein (NURR1), G-protein-regulated inward-rectifier potassium channel 2 (GIRK-2) and tyrosine hydroxylase (TH). (mpg.de)
  • Up to now, it has been thought that therapeutic compounds causing QT prolongation are associated with direct block of the cardiac potassium channel human ether a-go-go-related gene (hERG), which encodes the α subunit of cardiac I Kr currents. (aspetjournals.org)
  • These results show that gintonin-mediated enhancement of I Ks channel currents is achieved through binding of the [Ca 2+ ] i /CaM complex to the C terminus of KCNQ1 subunit. (molcells.org)
  • Channels formed from KCNQ proteins consist of homomeric tetramers or heteromeric tetramers containing KCNQ as the α-subunit, and each KCNQ subunit is composed of six α-helical transmembrane segments (S1-S6). (molcells.org)
  • Subunit stoichiometry associated with altered channel gating induced by hERG1 agonist RPR-260243. (ucsd.edu)
  • Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K + channels. (ucsd.edu)
  • 12] Sayad A,Ghafouri-Fard S,Noroozi R,et al.Association study of sequence variants in voltage-gated Ca 2+ channel subunit alpha-1C and autism spectrum disorders[J].Rep Biochem Mol Biol,2019,8(1):56-62. (magtech.com.cn)
  • This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. (nih.gov)
  • The KCNE1 protein regulates a channel made up of four parts, called alpha subunits, which are produced from the KCNQ1 gene. (medlineplus.gov)
  • Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits. (ucdenver.edu)
  • Probing molecular identity of native single potassium channels by overexpression of dominant negative subunits. (ucdenver.edu)
  • The slowly activating delayed rectifier K + ( I Ks ) channel is a cardiac K + channel composed of KCNQ1 and KCNE1 subunits. (molcells.org)
  • KCNQ channel proteins also co-assemble with KCNE1-4 subunits ( McCrossan and Abbott, 2004 ). (molcells.org)
  • Voltage gated potassium channel subunits (K V ) were found to be related to hyperexcitability of injured nerves and pain transduction The predominant K V 1 channels in myelinated nerve fibers comprise of co-assembled K V 1.1 , K V 1.2 , and K V 2.1 that form dendrotoxin (DTX)-sensitive delayed-rectifier channels. (alomone.com)
  • In the heart, KCNQ1 associates with KCNE1 subunits to form I Ks channels that regulate heart rhythm. (elifesciences.org)
  • The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2.1 and Kv2.2, mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central neurons. (jneurosci.org)
  • 7-9 Specifically, I Ca,L , as with most other ion currents in mammals, displays considerably larger amplitudes at higher than at lower temperature in human cardiac cells. (asahq.org)
  • The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. (ox.ac.uk)
  • We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed rectifier currents. (ox.ac.uk)
  • 12)Li G R, Wang HB, Qin GW, Jin MW, Tang Q , et al.Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. (tjmu.edu.cn)
  • Mutant EGL-2( gf ) channels exhibited a negative shift in voltage dependence of activation, and both wild-type (WT) and mutant currents were blocked by imipramine. (jneurosci.org)
  • We found that gintonin enhances I Ks channel currents in concentration- and voltage-dependent manners. (molcells.org)
  • It has recently been demonstrated that a selective KCNQ/K V 7 channel opener (Retigabine), which mediates M-currents, selectively reduces the activity of axotomized Aδ/C-fibers, but not uninjured axons and human C-fiber axons. (alomone.com)
  • ML277 provides insights and a tool to investigate the gating mechanism of KCNQ1 channels, and our study reveals a new strategy for treating long QT syndrome by specifically enhancing the AO state of native I Ks currents. (elifesciences.org)
  • Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different. (silverchair.com)
  • The KCNE1 gene provides instructions for making a protein that regulates the activity of potassium channels. (medlineplus.gov)
  • Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. (wikipedia.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
  • 9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)
  • Primary sensory neurons express a Shaker-like potassium channel gene. (ucdenver.edu)
  • LQT2 is the second most common subtype of LQTS caused by loss of function mutations in the potassium voltage-gated channel subfamily H member 2 (KCNH2) gene. (bvsalud.org)
  • 11) Tang Q, Li ZQ, Li W, et al.The 5-HT(2) antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.Br J Pharmacol. (tjmu.edu.cn)
  • Background: The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. (current-pharmaceutical-design.com)
  • We show that the Caenorhabditis elegans egl-2 gene encodes an eag K + channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. (jneurosci.org)
  • Potassium voltage-gated channel subfamily A member 2 (KCNA2), also known as Kv1.2, is a shaker-related voltage-gated potassium channel that is encoded by the KCNA2 gene in human. (bicellscientific.com)
  • This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
  • Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. (uc.edu)
  • In the present study, we used the Xenopus oocyte gene expression system to investigate the molecular mechanisms underlying how gintonin-mediated [Ca 2+ ] i transients are coupled to the regulation of I Ks channel activity. (molcells.org)
  • Wu W , Dong MQ, Wu XG, Sun HY, Tse HF, Lau CP, Li GR. Human ether-à-go-go gene potassium channels are regulated by EGFR tyrosine kinase. (ucsd.edu)
  • 9] Lu AT,Dai X,Martinez-Agosto JA,et al.Support for calcium channel gene defects in autism spectrum disorders[J].Mol Autism,2012,3(1):18. (magtech.com.cn)
  • The human ether-a-go-go related gene (hERG, KCNH2) encodes for a voltage dependent K + ion channel (Kv11.1). (springer.com)
  • Lundquist AL, Turner CL, Ballester LY, George AL Jr. Expression and transcriptional control of human KCNE genes. (medlineplus.gov)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
  • 2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
  • 5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)
  • Research progresson voltage-gated calcium channel-encoding genes in autism spectrum disorders[J]. journal1, 2021, 29(1): 47-51. (magtech.com.cn)
  • Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). (antibodiesinc.com)
  • Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. (antibodiesinc.com)
  • The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al. (antibodiesinc.com)
  • Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids. (ucsd.edu)
  • 3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
  • In this study, we investigated the molecular mechanisms of gintonin-mediated activation of human I Ks channel activity by expressing human I Ks channels in Xenopus oocytes. (molcells.org)
  • Alomone Labs Jingzhaotoxin-IX blocks Na V 1.5 channels heterologously expressed in Xenopus oocytes. (alomone.com)
  • Here, we tested modulations of human KCNQ1 channels by an activator ML277 in Xenopus oocytes. (elifesciences.org)
  • The KCNE1 protein is also produced in the kidneys, testes, and uterus, where it probably regulates the activity of other channels. (medlineplus.gov)
  • Wu W , Wang Y, Deng XL, Sun HY, Li GR. Cholesterol down-regulates BK channels stably expressed in HEK 293 cells. (ucsd.edu)
  • Wu W , Sun HY, Deng XL, Li GR. EGFR Tyrosine kinase regulates small conductance Ca 2+ -activated K + (hSKCa1) channels expressed in HEK 293 cells. (ucsd.edu)
  • This conduction system of the human heart is intrinsic i.e. the myocytes produce the impulse themselves without the involvement of neurons. (microbenotes.com)
  • Neurons of different cortical layers express diverse populations of ion channels and possess distinct intrinsic membrane properties. (jneurosci.org)
  • Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy. (ucsd.edu)
  • An altered KCNE1 protein cannot regulate the flow of potassium ions through channels in the inner ear and cardiac muscle. (medlineplus.gov)
  • KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. (medlineplus.gov)
  • 8)Dong MQ, Sun HY, Tang Q , Tse HF , Lau CP, Li GR . Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase. (tjmu.edu.cn)
  • KCNE1 suppresses the IO state so that the I Ks channel opens only to the AO state. (elifesciences.org)
  • Kuo, 1998 ), but the molecular identities of these channels are unknown. (jneurosci.org)
  • New insights into the mechanisms underlying AF have identified promising new approaches, including the modulation of atrium-specific ion channels, connexins and the ryanodine receptor, the prevention of remodelling processes that lead to the arrhythmia as well as specific molecular events involved in arrhythmia generation. (nature.com)
  • These results identify a molecular mechanism that contributes to heterogeneity in cortical neuron ion channel function and regulation. (jneurosci.org)
  • Wu HJ, Sun HY, Wu W , Zhang YH, Qin GW, Li GR. Properties and molecular determinants of the natural flavone acacetin for blocking hKv4.3 channels. (ucsd.edu)
  • A series of 172 molecular structures that block the hERG K + channel were used to develop a classification model where, initially, eight types of PaDEL fingerprints were used for k -nearest neighbor model development. (springer.com)
  • Xiao GS, Zhang YH, Wu W , Sun HY, Wang Y, Li GR. Genistein and tyrphostin AG556 decrease human atrial ultra-rapidly activating delayed rectifier potassium current by inhibiting EGFR tyrosine kinase. (ucsd.edu)
  • Zhang YH, Wu W , Sun HY, Deng XL, Cheng LC, Li X, Tse HF, Lau CP, Li GR. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. (ucsd.edu)
  • Zhang DY, Wu W , Deng XL, Lau CP, Li GR. Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition. (ucsd.edu)
  • Anti-KCNA2 (Kv1.2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. (bicellscientific.com)
  • The specific function of a potassium channel depends on its protein components and its location in the body. (medlineplus.gov)
  • A novel oligosaccharide compound AVR-25 selectively binds to the TLR4 protein (IC 50 = 0.15 µM) in human peripheral blood monocytes and stimulates IL-10 production. (nature.com)
  • The C terminus of the KCNQ1 channel protein has two calmodulin-binding sites that are involved in regulating I Ks channels. (molcells.org)
  • Although it is not clear whether anesthetics interact directly with the C-terminus, which is thought to reside intracellularly, this portion of the channel protein clearly influences the actions of both anesthetics. (silverchair.com)
  • Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K+ current in human atrial myocytes. (tjmu.edu.cn)
  • The hERG channel is important for cardiac repolarization, and reduction of its expression in the plasma membrane due to mutations causes long QT syndrome type 2 (LQT2). (bvsalud.org)
  • It is categorized as a Vaughn-Williams Class IC agent based upon its properties of causes a strong degree of sodium channel blockage with slowing cardiac conduction and a minimal effect on ventricular repolarization. (encyclopedia.pub)
  • In addition, some clinically used drugs may act via K + channel blockade ( Sanguinetti and Jurkiewicz, 1990 ). (jneurosci.org)
  • 1 As one major target of volatile anesthetics in the heart, the L-type Ca 2+ channel, responsible for the L-type Ca 2+ current (I Ca,L ), has been identified. (asahq.org)
  • However, remdesivir decreased while lumacaftor increased the current and cell-surface expression of heteromeric channels formed by WT hERG and mutant G601S or R582C hERG. (bvsalud.org)
  • Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes. (tjmu.edu.cn)
  • This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
  • B. Superimposed traces of channel current in the absence (black) and presence (green) of 1 µM Jingzhaotoxin-IX (taken from experiment in A). (alomone.com)
  • Halothane accelerated the time constant of current inactivation, whereas ketamine affected this parameter minimally in both channel types. (silverchair.com)
  • These findings extend our understanding of drug-channel interaction and may have clinical implications for patients with hERG mutations. (bvsalud.org)
  • SIGNIFICANCE STATEMENT: Various naturally occurring mutations in a cardiac potassium channel called hERG can impair channel function by decreasing cell-surface channel expression, resulting in cardiac electrical disturbances and even sudden cardiac death. (bvsalud.org)
  • Mutations that activate K + channels can lower cellular excitability, whereas those that inhibit K + channels may increase excitability. (jneurosci.org)
  • Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
  • Mutations in the KCNQ1 [Ca 2+ ] i /CaM-binding IQ motif sites (S373P, W392R, or R539W)blocked the action of gintonin on I Ks channel. (molcells.org)
  • Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. (nih.gov)
  • KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. (nih.gov)
  • Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
  • We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson's disease patient with a triplication of the human SNCA genomic locus. (mpg.de)
  • This project aims to delineate the neurobiology underlying TSPO overexpression in the human brain together with projects A2 and A3. (uni-regensburg.de)
  • In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
  • Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. (elifesciences.org)
  • Similar inhibition is observed with the mouse homolog MEAG, suggesting that inhibition of EAG-like channels may mediate some clinical side effects of this class of antidepressants. (jneurosci.org)
  • The KCNQ family of channel proteins (also known as Kv7) form K + -selective, voltage-gated channels ( Hille, 2001 ) that are slowly activating delayed rectifier K + ( I Ks ) channels. (molcells.org)
  • Activity Jingzhaotoxin-IX blocks Na V 1.4, Na V 1.5 and K V 2.1 voltage-gated channels 1 . (alomone.com)
  • 12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)
  • our unpublished data), suggesting a specific interaction between tricyclics and EGL-2 channels. (jneurosci.org)
  • In the present study, we applied patch clamp, western blots, immunocytochemistry, and quantitative reverse transcription polymerase chain reaction techniques to investigate the rescue effects of two drugs, remdesivir and lumacaftor, on trafficking-defective mutant hERG channels. (bvsalud.org)
  • We concluded that drugs can differentially affect homomeric WT and heteromeric WT+G601S (or WT+R582C) hERG channels. (bvsalud.org)
  • Promotion of cell-surface expression of mutant hERG channels represents a strategy to rescue channel function. (bvsalud.org)
  • This work demonstrates that drugs such as remdesivir and lumacaftor can differently affect homomeric and heteromeric mutant hERG channels, which have biological and clinical implications. (bvsalud.org)
  • We conclude that pentamidine prolongs the cardiac action potential by block of hERG trafficking and reduction of the number of functional hERG channels at the cell surface. (aspetjournals.org)
  • There is increasing evidence that direct interactions between volatile anesthetics and channel proteins may result in general anesthesia. (silverchair.com)
  • Recent evidence is in favor of direct interactions between volatile anesthetics and channel proteins as the underlying mechanism of general anesthesia. (silverchair.com)
  • 13) Tang Q, Jin MW , Xiang JZ , Dong MQ , Sun HY , Lau CP , L i GR. The membrane permeable calciumchelator BAPTA-AMdirectly blocks human ether a-go-gorelatedgene potassium channels stably expressed in HEK 293 cells.Biochemical Pharmacology2007,74(11):1596-1607. (tjmu.edu.cn)
  • Gintonin-mediated activation of the I Ks channels was blocked by an LPA1/3 receptor antagonist, an active phospholipase C inhibitor, an IP 3 receptor antagonist, and the calcium chelator BAPTA. (molcells.org)
  • 4] Andrade A,Brennecke A,Mallat S,et al.Genetic associations between voltage-gated calcium channels and psychiatric disorders[J].Int J Mol Sci,2019,20(14):E3537. (magtech.com.cn)
  • 8] Splawski I,Timothy KW,Sharpe LM,et al.Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism[J].Cell,2004,119(1):19-31. (magtech.com.cn)
  • 15] Calorio C,Gavello D,Guarina L,et al.Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers[J].J Physiol,2019,597(6):1705-1733. (magtech.com.cn)
  • 7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
  • 8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)
  • It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. (wikipedia.org)
  • TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
  • Sig1R-modulatory activity was first found for phenytoin, an anticonvulsant drug that primarily acts by blocking the voltage-gated sodium channels. (frontiersin.org)
  • My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
  • Use dependence of ketamine and halothane action was observed in both Kv2.1 and the mutant channel, attributable to augmentation of C-type inactivation. (silverchair.com)
  • The link between inactivation and high affinity block of hERG1 channels. (ucsd.edu)
  • PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
  • It collects the cardiac impulses from the atrium, delays the impulse by about 0.09s, and sends the impulse down the other structures and fibers for contraction of the ventricles. (microbenotes.com)
  • TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)