Human cyclin gene. Medical search. Frequent questions

13 p16 INK4a is a cyclin dependent kinase inhibitor that is frequently mutated or deleted in many human cancer cell lines 14-16 and some sporadic malignancies, including sarcomas, breast cancer, leukaemia, and brain tumours, which are all component tumours of LFS. (bmj.com)
Endogenous regulation of the cell cycle depends on phosphorylation and dephosphorylation of the cyclin- cyclin-dependent kinase (CDK)-cyclin-dependent kinase inhibitor (CDKI) pathway. (jcancer.org)

This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. (nih.gov)
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
Humans have evolved elaborate mechanisms to activate p53 in response to insults that lead to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) RPL5 and RPL11. (nih.gov)
Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
Cyclins are a group of proteins that play a key role in the control and regulation of the cell cycle. (iiarjournals.org)
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
8 9 This lack of an absolute phenotype:genotype concordance could be attributed to incomplete screening of the p53 gene, inactivation of the p53 protein through interaction with other cellular proteins or viruses, or defects in other genes involved in p53 mediated cell cycle regulatory pathways. (bmj.com)
The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis. (sciencedaily.com)
Finally, IGF‑1R protein, phosphoinositide 3‑kinase/Akt signaling pathway‑associated proteins and cyclin pathway‑associated proteins were differentially expressed between miR‑497‑overexpressing cells and miR-497-silenced cells. (spandidos-publications.com)
These results suggest that alterations in the cell cycle proteins, cyclin D1, cdk4, p16INK4a, and Rb, may play a role in the acquisition of autonomous growth by adenomas. (jax.org)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

Mutations in the CDKN1B gene have also been found to cause tumors in single endocrine glands, such as the pituitary gland or the parathyroid glands. (medlineplus.gov)
Somatic CDKN1B gene mutations have been identified in sporadic (nonfamilial) pituitary adenomas and in sporadic parathyroid adenomas, which are noncancerous tumors of the parathyroid glands. (medlineplus.gov)
Apart from multiple endocrine neoplasia, the CDKN1B gene is rarely mutated in cancerous tumors. (medlineplus.gov)
However, compared to normal ovarian tissues, overexpression of cyclin D1 and c-Myc was observed in 42.6% (20/47) and 65.9% (31/47) of tumors examined, respectively. (bmj.com)
Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis and deserve further study. (bmj.com)
The identification and cloning of the PRAD 1 gene, a novel cyclin gene overexpressed in a subset of parathyroid and other tumors. (massgeneral.org)
Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compared to normal lung tissues. (jax.org)
The expression of cyclin D1, cdk4, p16INK4a, and Rb protein was examined by immunohistochemistry in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mouse lung tumors. (jax.org)
Western blot analysis confirmed the increased expression of cyclin D1 and cdk4 in lung tumors compared to normal lung. (jax.org)
Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
At least eight mutations in the CDKN1B gene have been found to cause a relatively rare form of multiple endocrine neoplasia called type 4. (medlineplus.gov)
Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
Mutations of p53 tumor suppressor gene increase with tumor progression in colorectal cancers. (nih.gov)
The accumulation of mutations in the human genome is at the origin of cancers, as well as the development of resistance to treatments. (phys.org)
The majority of classical LFS families harbour germline mutations of the p53 tumour suppressor gene. (bmj.com)
13 14 Although p16 INK4a is most frequently inactivated by homozygous deletion, point mutations or somatic methylation of 5′ regulatory regions are also important mechanisms of gene inactivation. (bmj.com)
These databases provide resources to analyze the effect of mutations on human health. (hindawi.com)
Either at genomic or at proteomic level, mutations have significant impact on normal gene or protein function, and human diseases could be associated with mutations like nonsynonymous single-nucleotide variations (nsSNVs) on amino acids. (hindawi.com)
Yet how gene mutations affect protein activities through posttranslational modification sites have not been widely studied. (hindawi.com)
Although data of both gene mutations and PTMs are increasing fast, the proteome-wide analysis on the relationship between damaged PTMs and human diseases is not well studied. (hindawi.com)
Frequent inactivating mutations of the ATM gene have been reported in patients with rare sporadic T cell prolymphocytic leukaemia (T-PLL), B cell chronic lymphocytic leukaemia (B-CLL), and most recently, mantle cell lymphoma (MCL). (bmj.com)
The presence of inactivating mutations, together with the deletion of the normal copy of the ATM gene in some patients with T-PLL, B-CLL, and MCL, establishes somatic inactivation of the ATM gene in the pathogenesis of lymphoid malignancies, and strongly suggests that ATM functions as a tumour suppressor. (bmj.com)
Genetic testing for mutations in the VHL gene is performed at many laboratories throughout the United States and the world. (medscape.com)

Western Blot: Cyclin H Antibody (1B8) [H00000902-M01] - CCNH monoclonal antibody (M01), clone 1B8 Analysis of CCNH expression in HeLa. (novusbio.com)
Western blot analysis of cyclin C in NIH 3T3 mouse fibroblasts. (bdbiosciences.com)
Western blot analysis in human cell line SK-MEL-30. (atlasantibodies.com)

In recent decades, it has been confirmed that tumor progression of GC is a multi-step process that involves the activation of oncogenes and the inactivation of tumor suppressor genes at different stages ( 7 , 8 ). (jcancer.org)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Cyclins function as regulators of CDK kinases. (novusbio.com)
They are able to build complexes with cyclin-dependent kinases (CDKs) and regulate their activity ( 2 ). (iiarjournals.org)
The ATM gene encodes a large protein that belongs to a family of kinases possessing a highly conserved C-terminal kinase domain related to the phosphatidylinositol 3-kinase domain. (bmj.com)

Background/Aim: Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. (iiarjournals.org)
Cyclin D1, a 45-kDa protein encoded by the cyclin D1 gene ( CCND1 ) on 11q13, is one such molecule. (iiarjournals.org)
Expression of cyclin D1 has been reported to be a strong predictor for the clinical outcome of OSCC ( 4 ), and amplification of CCND1 was found significantly more frequently in patients with OSCC than in healthy controls ( 5 ), suggesting the predictive and prognostic value of this molecule and its potential as a therapeutic target. (iiarjournals.org)
another is mutation of T286 in cyclin D1 (CCND1) causing the loss of phosphorylation of T286 is involved in nuclear accumulation of cyclin D1 in esophageal cancer [ 14 ]. (hindawi.com)
The wild type alleles of the Ccnd1, Cdk4, Cdkn2a, and Rb1 genes were reported to be expressed in the lungs of these mice. (jax.org)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)

it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
OCT4 as a Target of miR-34a Stimulates p63 but Inhibits p53 to Promote Human Cell Transformation. (nih.gov)
We show that, in primary CTB, p63 levels are reduced as cells differentiate into STB, and that forced expression of p63 maintains cyclin B1 and inhibits STB differentiation. (ca.gov)
Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. (neobiotechnologies.com)

The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. (wikipedia.org)
Unexpectedly, we found that their depletion in primary human lung fibroblasts failed to induce cell cycle arrest but strongly suppressed cell cycle progression. (nih.gov)
We show that the effects on cell cycle progression stemmed from reduced ribosome content and translational capacity, which suppressed the accumulation of cyclins at the translational level. (nih.gov)
Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate progression of the cell cycle. (bdbiosciences.com)
Cyclin C may play a dual role within the cell in its ability to regulate both cell cycle progression as well as gene transcription. (bdbiosciences.com)
Because Cdc2 kinase is important for cell entry into mitosis, cyclin C's ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36 kD. (bdbiosciences.com)
The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
Taken together, our results establish that BMP4-treated hESCs are an excellent model of human trophoblast differentiation, closely mimicking the in vivo progression from p63+ CTB stem cells to terminally differentiated trophoblast subtypes. (ca.gov)
We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
Dampening Cdk1 activation, by reducing gene expression or upon treatment with cell-permeable Cdk1 inhibitors, is also detrimental for proliferating cells, but has been associated with defects in mitotic progression, and the formation of aneuploid daughter cells. (eur.nl)
Cyclin-dependent kinase (CDK) 10, is reported to play an essential role in the progression from the G2 to M phase of the cell cycle. (jcancer.org)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
However, whether the clock genes are rhythmic expressed in mandibular condylar chondrocytes, or the clock genes have an effect on the progression of TMJOA remains unknown. (bvsalud.org)

Human herpesvirus 8 (HHV-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. (cdc.gov)

With the development of high-throughput sequencing technology, gene mutation detection has become another important resource to investigate regulatory mechanisms and cellular processes. (hindawi.com)
Au WY, Fung AT, Ma ES, Liang RH, Kwong YL: Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocytic leukemia and myelodysplastic syndrome. (karger.com)
The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. (bmj.com)
Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)
Gene Tests ( www.genetests.org ) cites 48 different laboratories in the United States that can test for the VHL gene mutation. (medscape.com)

hPTTG phosphorylation is mediated by cyclin-dependent kinase 2 (CDC2) and expression is regulated by specificity protein 1 (SP1). (endocrine-abstracts.org)
The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. (neobiotechnologies.com)

Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (nih.gov)
This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). (neobiotechnologies.com)

Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Studies have been conducted in our laboratory to determine whether exposure to TCA causes alterations in expression of cancer related genes in cultured human cells. (cdc.gov)

Immunohistochemistry-Paraffin: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on formalin-fixed paraffin-embedded human testis. (novusbio.com)
Immunohistochemistry analysis in human placenta and kidney tissues using AMAb91497 antibody. (atlasantibodies.com)
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected p16INK4a in human kidney and small intestine tissue sections. (sigmaaldrich.com)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

Cyclin C associates with Cdk8, forming a complex which can induce gene transcription of Cdc2 (Cdk1). (bdbiosciences.com)
Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. (neobiotechnologies.com)

The more aggressive basal-like subtype of breast cancers, however, exhibited lower levels of cyclin D1 and Dicer, which would in turn globally reduce the level of mature miRNA. (sciencedaily.com)
Indeed, lower levels of miRNAs have been observed in a number of human cancers. (sciencedaily.com)
Because the cyclin D1 gene has been implicated in a variety of other human cancers these findings may have broad implications for processing of non coding RNA in human tumorigenesis. (sciencedaily.com)
In this study, we elucidated the proteome wide relationship of eight damaged PTMs to human inherited diseases and cancers. (hindawi.com)
Some human inherited diseases or cancers may be the consequences of the interactions of damaged PTMs, rather than the result of single damaged PTM site. (hindawi.com)
In this work, we chose eight experimentally demonstrated damaged PTMs to elucidate their association to human diseases including inherited diseases and cancers (somatic diseases). (hindawi.com)

also known as CDK4I, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, MTS-1, p16-INK4, p16-INK4a, p16INK4A) is encoded by the CDKN2A (also known as CDKN2, MTS1) gene (Gene ID 1029) in human. (sigmaaldrich.com)
Conversely, SMMC‑7721 human HCC cells transfected with a miR‑497 inhibitor exhibited enhanced colony formation and tumor growth. (spandidos-publications.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (novusbio.com)
Group 3 cyclins (G1, G2 and I) may play a role distinct from either cell cycle or transcriptional regulation. (bdbiosciences.com)
Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions. (neobiotechnologies.com)

Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization. (ihcworld.com)
HHV-8 latency-associated nuclear antigen-1 and HHV-8 viral cyclin gene were identified in the lung tissue of 10 (62.5%) of 16 patients with IPAH, whereas only 1 (7.1%) of 14 patients with associated pulmonary hypertension (PH) had HHV-8 gene sequences in lung tissue ( 2 ). (cdc.gov)

There was no significant difference of overexpression of cyclin D1 or c-Myc gene products between these four histologic subtypes of ovarian adenocarcinomas. (bmj.com)
We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
In addition, overexpression of miR‑497 was observed to inhibit colony formation and tumor growth in MHCC‑97H human HCC cells. (spandidos-publications.com)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)

Synthesis of the nuclear protein cyclin and DNA in quiescent mouse fibroblasts is coordinately induced by serum and purified growth factors. (ihcworld.com)
Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. (ihcworld.com)
Immunohistochemical staining revealed exclusive nuclear staining of both cyclin D1 and cdk4 that was light to moderate in normal mouse lung tissues, but intense in lung adenomas and adenocarcinomas. (jax.org)
4 - 7 The ATM gene encodes a nuclear phosphoprotein of approximately 350 kDa (3056 amino acids) and is ubiquitously expressed. (bmj.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

Alterations in expression include metabolic genes (CYP11B1, MGMT), cell cycle control and DNA repair genes (GADD45, Cyclin G2, Cyclin D3, Cyclin A) and transcription factors (IF2, IF3). (cdc.gov)

Immunocytochemistry/ Immunofluorescence: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on HeLa cell. (novusbio.com)
SDS-PAGE Analysis Purified Cyclin B2 Mouse Monoclonal Antibody (X29.2). (neobiotechnologies.com)

GST-tagged recombinant human p16INK4a internal fragment. (sigmaaldrich.com)
Cyclin D1 dysregulation and differential inactivation of p16INK4a and Rb have been observed in human lung cancer. (jax.org)

INK4a and INK4b (encoded by the CDKN2A and CDKN2B gene, respectively) constitute the INK4 subfamily of CDKis. (sigmaaldrich.com)
Inactivation of CDKN2A and CDKN2B are found in a wide variety of human malignancies and murine tumor models. (sigmaaldrich.com)

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes. (mousephenotype.org)

The identity of this protein has not been determined, but may represent an alternative splice product of the cyclin C gene, as has been identified in other species. (bdbiosciences.com)
Cyclin C has been identified in both human and chicken species. (bdbiosciences.com)
The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species. (sciencedaily.com)
Find CDK3 ELISA Kits for a variety of species such as anti-Human CDK3, anti-Mouse CDK3. (antibodies-online.com)

Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)

No abnormal expression of cyclin D1 or c-Myc was demonstrated in any of the 12 normal ovarian specimens. (bmj.com)
This study shows that cyclin D1 and c-Myc are frequently overexpressed in epithelial ovarian carcinomas, but they are not correlated with a particular histologic subtype. (bmj.com)

Recently, a series of studies revealed the diagnostic and prognostic value of CDKs (mainly CDK1-7) in different types of human cancer, including oral cancer, medulloblastoma, pancreatic cancer ( 11 - 14 ). (jcancer.org)
The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)

The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. (sigmaaldrich.com)

To identify the most predictive genes we used a variable selection strategy. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)

However, a comprehensive genome-wide map of human S/MARs is yet not available. (researchgate.net)
The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. (sciencedaily.com)
In prior work, they showed that cyclin D1 regulates the non coding genome, and that the non-coding genome, in turn, regulates expression of cyclin D1. (sciencedaily.com)
Furthermore, the group showed that many cancer patients encode a form of cyclin D1 that evades negative feedback from the non coding genome. (sciencedaily.com)
1,000 human miRNAs have been identified that regulate ~1/3 of the coding genes in the human genome ( 9 ). (spandidos-publications.com)
In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)

Modern molecular methods, including genetic markers, cytokines, proliferation indexes, and cyclins, are all undergoing study to help determine which atypical moles may progress to melanoma, although no single marker has been determined. (medscape.com)
The identity of the higher molecular weight band (~ 45 kD) has not been determined, but may represent an alternative splice product of the cyclin C gene. (bdbiosciences.com)
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted. (sciencedaily.com)

This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
This gene encodes a member of the cyclin-dependent protein kinase family. (antibodies-online.com)

The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
Uncontrolled cell proliferation is the hallmark of cancer, and genes that directly regulate the cell cycle are typically damaged in tumor cells ( 10 ). (jcancer.org)

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER. (mousephenotype.org)

Cyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. (bmj.com)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
More recently, cyclins are being shown to have additional functions not restricted to cell cycle regulation. (bdbiosciences.com)
Like many cyclins, the expression of cyclin C oscillates throughout the cell cycle, with a peak observed during G1 phase. (bdbiosciences.com)
In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. (sciencedaily.com)
They arise from pituitary cell types due to both cell cycle trophic dysruptions leading to adenomatous growth, as well as a coupling of specific hormone gene over-expression. (endocrine-abstracts.org)
By applying the random forests algorithm, a supervised machine learning approach, we show how a multi-gene signature that classifies individual cells into their correct cell cycle phase and cell size can be generated. (frontiersin.org)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

More than 90% of oral malignant neoplasms are squamous cell carcinomas (OSCC), which are among the ten most frequent malignancies in humans and this entity is the eighth leading cause of cancer-related death worldwide ( 1 ). (iiarjournals.org)
E ditor -The Li-Fraumeni syndrome (LFS) is a rare familial cancer syndrome that predisposes gene carriers to the development of diverse early onset malignancies, including soft tissue sarcomas, osteosarcomas, adrenocortical carcinomas, brain tumours, breast carcinomas, and leukaemia, 1-3 with other cancer types occurring less frequently. (bmj.com)
p16 INK4a is a candidate gene that could account for the cancer predisposition in p53 wild type LFS families. (bmj.com)
In view of the comparable biological and phenotypic features of p53 and p16 INK4a inactivation, we proposed that germline inactivation of the p16 INK4a gene could account for the predisposition to cancer development in a proportion of LFS families that harboured wild type p53 . (bmj.com)
They found that patients with the luminal A subtype of breast cancer had increased levels of expression of both cyclin D1 and Dicer. (sciencedaily.com)
These models are being used to explore the roles of this human SNP in modulating cancer susceptibility and the response to DNA damaging agents, including chemotherapeutic drugs. (mdanderson.org)
Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network vat recente ontwikkelingen samen en beschrijft hoe het Preagnant netwerk een professionele infrastructuur creeërt voor patiënten en professionals, artsen en onderzoekers. (kanker-actueel.nl)
After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
The aim of the present study was to evaluate the influence of Ang II on human endometrial cancer cells. (spandidos-publications.com)
Biological assays were performed on well-[Ishikawa (ISH)] moderately (MFE-296) and poorly (MFE-280) differentiated human adenocarcinoma cancer cell lines, representing the G1, G2 and G3 stage of EC. (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Although TCE is classified as a probable carcinogen to humans by International Agency for Research on Cancer, inadequate evidence limits classifying TCA as a probable carcinogen. (cdc.gov)

Both p53 wild type and p53 mutant samples were included in the p16 INK4a analysis to determine whether germline alterations of one gene precluded the occurrence of alterations of the other. (bmj.com)
Whether alterations in the expression pattern of these genes, particularly transcriptional factors, is associated with carcinogenic potential of TCA needs to be elucidated. (cdc.gov)

MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs, which act as key post-transcriptional regulators of target-gene expression. (spandidos-publications.com)
Transcriptional changes in normal human liver cells exposed to tetrachloroethylene metabolite using microarray analysis. (cdc.gov)

Sandwich ELISA: Cyclin H Antibody (1B8) [H00000902-M01] - Detection limit for recombinant GST tagged CCNH is approximately 1ng/ml as a capture antibody. (novusbio.com)

This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)

We have developed mouse models that mimic this human SNP and have demonstrated that the humanized p53 variants are functional and display the expected difference in apoptotic capacity in mouse tissues. (mdanderson.org)
Here, we show that BMP4-treated hESCs differentiate into bona fide CTB by direct comparison with primary human placental tissues and isolated CTB through gene expression profiling. (ca.gov)

The polyclonal antiserum reacts with human and mouse cyclin C. A polypeptide fragment containing amino acids 290-303 (QGPNGSQNSSYSQS) at the C-terminus of human cyclin C, with the addition of a C-terminal cysteine (C) residue to facilitate conjugation to KLH, was used as immunogen. (bdbiosciences.com)

methylation at certain residues of histones can regulate gene expression [ 4 ], and glycosylation is responsible for targeting substrates and changing protein half-life [ 2 ]. (hindawi.com)

HeLa human cervical carcinoma (ATCC CCL 2) and NIH 3T3 mouse fibroblasts (ATCC CRL 1658) are suggested as a positive controls for these applications. (bdbiosciences.com)

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. (nih.gov)

The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

In the current study, the group sought to investigate the mechanism by which cyclin D1 regulates the biogenesis of non coding miRNA. (sciencedaily.com)
However, whether miR-497 regulates other target genes in HCC is unknown. (spandidos-publications.com)

Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population. (cdc.gov)

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. (wikipedia.org)

They bind primarily to 3′-untranslated regions (3′-UTRs) of target gene mRNAs. (spandidos-publications.com)

Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. (nih.gov)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)

Anatomy15

Organisms7

Diseases3

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes43

Disciplines and Occupations1

Information Science3

Dependent kinase inhibitor2

Proteins11

Tumors14

Mutations16

Western Blot3

Tumor Suppr5

Kinases3

CCND16

Inhibits4

Progression13

Antibodies1

Mutation5

Phosphorylation2

Regulatory subunit2

Expression of cancer-related genes2

Immunohistochemistry4

Cdc22

Cancers6

Inhibitor3

Distinct4

Antigen2

Overexpression4

Nuclear5

Repair genes1

Monoclonal Antibody2

P16INK4a2

CDKN2A2

Phenotypes1

Species4

CDK21

Ovarian2

CDKs2

Inhibitors1

Predictive2

Genome6

Molecular3

Induce1

Encodes2

Proliferation3

OMIM1

Cell cycle8

Cancer12

Alterations2

Transcriptional2

Recombinant1

Chromosome1

Tissues2

Immunogen1

Methylation1

Mouse fibroblasts1

Activator1

Apoptosis1

Regulates2

Predisposition1

Protein encoded by this gene1

Target Gene1

Poor prognosis2