• it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)
  • In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
  • Our results demonstrated that targeting DTL reduced cell cycle regulators and chromosome segregation genes, resulting in increased cell micronucleation. (transhumanist.ru)
  • To identify human PPARs-responsive genes, we established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR and investigated the gene expression profiles of these cells. (biomedcentral.com)
  • The results suggest that these cell lines are important tools used to identify the human PPARs-responsive genes. (biomedcentral.com)
  • Integrated epigenetics of human breast cancer : synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment. (unibas.ch)
  • It is also estimated that each human being is a carrier of around five recessive lethal genes and perhaps even more recessive disease genes, which may pose risk for the offspring of related individuals (such as cousin marriages). (dorak.info)
  • Autosomes can be described as the non-sex chromosomes that play diverse roles in the human body like harboring genes for the body's metabolism, functioning, and growth. (biologyonline.com)
  • Understanding the role and significance of autosomes in human genetics is crucial for uncovering the complex interplay of genes, their expression, and their impact on health and disease. (biologyonline.com)
  • The genomic regions and genes identified contribute to a better understanding of the genetic control of fatty acid deposition and can lead to DNA-based selection strategies to improve meat quality for human consumption. (biomedcentral.com)
  • Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). (wikipedia.org)
  • Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
  • With the help of AQP0 staining, we could define up to five stages of erythropoiesis in both mouse and human bone marrow using flow cytometry. (biomedcentral.com)
  • Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene. (wikipedia.org)
  • Aquaporin-8 (AQP-8) is a water channel protein. (wikipedia.org)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Red cell membranes isolated from individuals with autosomal recessive HS have only 40-50% of the normal amount of spectrin (relative to band protein 3). (medscape.com)
  • For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
  • The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. (cshlpress.com)
  • ASMC aberrations in asthmatics can cause hyperplasia, hypertrophy, inflammatory mediator secretions and extracellular matrix (ECM) protein secretions [ 3 ]. (ersjournals.com)
  • Furthermore, we analysed the 5'-flanking region of the human adipose differentiation-related protein ( adrp ) gene that responded to all subtypes of PPARs. (biomedcentral.com)
  • A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. (unibas.ch)
  • I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
  • Aquaporin-8 mRNA is found in pancreas and colon but not other tissues. (wikipedia.org)
  • Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
  • MiRNA usually binds directly to the 3′-untranslated region (3′-UTR) of target gene mRNA through the RNA-induced silencing complex (RISC) [ 15 , 16 ]. (ersjournals.com)
  • [ 3 ] HS is inherited in autosomal dominant fashion due to mutations in ANK1, SPTB or SLC4A1 in approximately 90% of cases. (medscape.com)
  • Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease. (transhumanist.ru)
  • Using antibodies against AQP1 and AQP2 , we here show expression of AQP1 and AQP2 in normal human developing and adult kidneys and in autosomal dominant polycystic kidney disease (ADPKD). (transhumanist.ru)
  • Autosomal abnormalities can have profound implications for human health and are the focus of extensive research. (biologyonline.com)
  • Studying autosomal genetic disorders provides valuable insights into disease mechanisms and paves the way for targeted therapies and genetic counseling for the human creed. (biologyonline.com)
  • Consistent with this relatively high divergence among the subtype-specific ligand binding domains, differential activation of PPARs by endogenous and exogenous compounds may account for the specific biological activity of the three PPAR subtypes [ 2 , 3 ]. (biomedcentral.com)
  • This is why autosomes form the backbone of human genetics as they hold the key to our intricate biological processes and susceptibility to genetic disorders. (biologyonline.com)
  • Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine. (unibas.ch)
  • Fatal familial insomnia is a genetic condition caused by a mutation in the prion gene ( PRNP ) is located on chromosome 20. (medindia.net)
  • In Cri-Du-Chat syndrome (5p deletion), the genetic basis of the phenotype is haploinsufficiency for the telomerase reverse transcriptase gene ( TERT ), which is included in the deleted part of chromosome 5. (dorak.info)
  • These chromosomes play a pivotal role in various aspects of human development, including metabolic pathways, cellular homeostasis , and genetic disorders. (biologyonline.com)
  • They hold a vast repository of genetic information that governs various aspects of human biology. (biologyonline.com)
  • Using quantitative trait locus (QTL) mapping researchers may identify plasticity regions that directly affect the reaction norm (see text and Fig. 3 for examples), or evaluate differential gene expression in different environments with microarray technology. (comprehensivephysiology.com)
  • Aquaporin-1 ( AQP1 ), located in proximal tubules (PT) and descending thin limbs of Henle ( DTL ), and aquaporin-2 ( AQP2 ), located in collecting ducts (CD), are channels involved in water transport across renal tubule epithelia. (transhumanist.ru)
  • So, we can't say that autosomes have no role in phenotypic sex determination in humans because they play an integral and indispensable role! (biologyonline.com)
  • It is a familiar element of mammalian spermatozoa, though many studies in the past have focused primarily on CDs in non-human species. (biomedcentral.com)
  • The differentially expressed lncRNAs were primarily located in chromosomes 2, 1, and 11. (researchsquare.com)
  • Human consumption of fat that contains high levels of monounsaturated fatty acids (MUFA) can reduce the concentration of undesirable cholesterol (LDL) in circulating blood. (biomedcentral.com)
  • Beef fat also has a high concentration of monounsaturated fatty acids (MUFA), whose melting point is low and can reduce the concentration of bad cholesterol (LDL) in blood circulation [ 3 ]. (biomedcentral.com)
  • Her improbable discovery of telomerase - a remarkable enzyme that restores telomeres and protects them from damage - catalyzed an explosion of scientific studies which, to this day, probe connections between telomerase and telomeres to human cancer and diseases of aging. (hopkinsmedicine.org)
  • Referred to as the "plumbing system of cells," aquaporins facilitate the movement of water across cell membranes [rapid osmosis]. (hopkinsmedicine.org)
  • Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. (transhumanist.ru)
  • Severe distortion of airway smooth muscle cells (ASMCs) is a common consequence of severe asthma [ 3 ]. (ersjournals.com)
  • These chromosomes exist in pairs in the somatic cells in contrast to their solo presence in germinal or sex cells , i.e. gametes . (biologyonline.com)
  • MS is a heterogeneous disease but presentation of characteristic symptoms generally follow stages of neurological deficits (relapses) and these can be reversed during periods of total or partial recovery (remissions) [ 2 , 3 ]. (medsci.org)
  • Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. (biomedcentral.com)
  • The CDs of mature non-human mammalian sperm are found at the distal end of the midpiece. (biomedcentral.com)
  • It leads to decreased expression of IL-3, IL-4, IL-5, and TNFα, and it inhibits mast cell and neutrophil activation. (medscape.com)
  • 72. How many chromosomes are their altogether in a normal human cell? (remixeducation.in)
  • Dr. Greider, one of the world's pioneering researchers on the structure of chromosome ends known as telomeres, was awarded the 2009 Nobel Prize in Physiology or Medicine. (hopkinsmedicine.org)
  • The differences between human and non-human mammals became apparent once researchers drew attention to human CDs. (biomedcentral.com)
  • five different patterns have been described [ 3-5 ]. (medilib.ir)
  • Seibold A, Brabet P, Rosenthal W, Birnbaumer M: Structure and chromosomal localization of the human antidiuretic hormone receptor gene. (hmdb.ca)
  • Dr. Agre received the 2003 Nobel Prize in Chemistry for discovery of the aquaporin water channels. (hopkinsmedicine.org)
  • Defects in the primary cilia are linked to a wide spectrum of human diseases, collectively termed ciliopathies. (basicmedicalkey.com)
  • In addition to light microscopy, chromosome analysis, and polymerase chain reaction, flow cytometry is a feasible and fast method for quantitatively analyzing hematological diseases. (biomedcentral.com)
  • and 3) show that the mutual exclusivity of localization is maintained even into end-stage ADPKD. (transhumanist.ru)
  • Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)
  • multiple promoters major, particularly annealing POLZ to DNA aquaporin kinase( Hara et al. (erik-mill.de)
  • The purpose of this review is to compare CDs to ERC, to describe ERC's relevance to human reproduction, and to clarify its assessment and clinical importance. (biomedcentral.com)
  • Functional magnetic resonance imaging bankid hos forex complex human movements. (qrforex.com)
  • From the detailed analyses by reporter assays, the EMSAs, and ChIP assays, we determined the functional PPRE of the human adrp gene. (biomedcentral.com)
  • After a post-doctoral fellowship at the New York Medical College (1983-84) in the Department of Medicine of Dr. Richard D. Levere, where he was interested in iron metabolism in humans, he joined the CNRS in 1984 in the ER186 directed by Prof. Pierre Labbe, a team that will be integrated into the Institut Jacques Monod in 1989. (ijm.fr)
  • Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans. (cas.cz)
  • Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. (cas.cz)
  • Unlike in rats, AQP1 and AQP2 are expressed early during human nephrogenesis (12-wk gestation). (transhumanist.ru)
  • He also delivered keynote lectures at prestigious conferences including the International Embryo Transfer Society, European Society of Human Reproduction and Embryology, and American Society of Reproductive Medicine. (si.edu)
  • Interaction with many PCNA at a DNA adaptor chromosome plays particular formation route( TLS)( Garg and Burgers 2005, Wood et al. (erik-mill.de)
  • Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. (biomedcentral.com)
  • CDs of normal human spermatozoa are still present after ejaculation [ 6 ]. (biomedcentral.com)
  • The volume of amniotic fluid varies at different stages of pregnancy [ 2 , 3 ], and the average amniotic fluid volume is 400 mL at term [ 4 ]. (researchsquare.com)
  • We are excited to be concentrating on products that improve communication with your residents, such as the innovative TelAgenda Digital Calendar/Message System The drugs on LV read poems in context greek poetry in the egyptian thebaid 200 600 ad sozomena studies in and total balancing energy after Red accounting have initial and so documented with acute chromosomes. (seabaygame.com)
  • In addition to age, epidemiologic studies have revealed multiple risk factors for the condition including elevated intraocular pressure (IOP), African-American race, family history and low ocular perfusion pressure [3] - [5] . (prolekarniky.cz)
  • In each panel, dots connected by lines represent the phenotypes expressed by each of three genotypes (or families), numbered 1, 2, and 3, in each of two alternative environments (A, B). These lines are the reaction norms. (comprehensivephysiology.com)
  • Meat from Bos taurus and Bos indicus breeds are an important source of nutrients for humans and intramuscular fat (IMF) influences its flavor, nutritional value and impacts human health. (biomedcentral.com)
  • Finally, the inflammatory and demyelinating findings in clinically isolated syndrome (CIS) and the evidence in radiologically isolated syndrome (RIS) are supportive of MS in undiagnosed individuals [ 2 , 3 ]. (medsci.org)