• Comparison of our mouse exon-skipping events to previously detected human exon-skipping events on chromosome 22 by Hide et al.2001, has revealed that mouse and human exon-skipping events were never observed together within an orthologous gene-pair. (uwc.ac.za)
  • People get one of each pair of chromosomes from their mother and one of each pair from their father. (cdc.gov)
  • The chromosomes that form the 23rd pair are called the sex chromosomes. (cdc.gov)
  • The 23rd pair is composed of the sex chromosomes, either two X's, in the cases of females, or an X and a Y, in the case of males. (sciencedaily.com)
  • The close genomic locations of these two genes as well as their functional similarity have hindered efforts to define whether each gene independently influences human triglyceride concentrations. (doe.gov)
  • A low number (5/72 multi-exon genes) of mouse exon-skipped genes were captured through alignments of mouse ESTs to mouse genomic contigs. (uwc.ac.za)
  • These factors resulted in a large number (112/269) of mouse transcripts lacking matches to mouse genomic contigs and nearly half (12/25) of the mouse multi-exon genes, which have matching Ensembl transcript identifiers, have under-predicted exons. (uwc.ac.za)
  • HACs were first constructed de novo in 1997 by adding alpha-satellite DNA to telomeric and genomic DNA in human HT1080 cells. (wikipedia.org)
  • We have identified chromosomes with a xi 2-xi 1 rather than a xi 2-psi xi 1 arrangement by genomic mapping and oligonucleotide analysis. (ox.ac.uk)
  • Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (ox.ac.uk)
  • End sequence generated in the construction of the BAC/PAC contig identified a previously unmapped EST and served to order genomic sequence contigs from the publicly available Celera Genomics (CG) and Human Genome Project (HGP) efforts. (elsevierpure.com)
  • and the University of California, Santa Cruz, Genome Browser, to look for genes or genomic regions of chromosomes 1 and 19 thought to produce proteins that interact with Xist. (sciencedaily.com)
  • Our study identified 10 genomic regions affecting the average fibre diameter, coefficient of variation of the average fibre diameter, percentage of fibres with diameters over 30 µm, greasy fleece weight, staple length, average curvature of fibres, percentage of continuous medullated fibres and percentage of kemp fibres located on five goat chromosomes (1, 2, 5, 13 and 19). (cambridge.org)
  • Genomic DNA copy number variation is a hallmark of cancer and can lead to alteration in the expression and functions of genes residing within the affected chromosomal region [ 5 ]. (biomedcentral.com)
  • Search for antimicrobial resistance genes and replicon/plasmid sequence types run using Center for Genomic Epidemiology website ( https://genomicepidemiology.org ) and local BLAST. (cdc.gov)
  • Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections. (cdc.gov)
  • The sequence of the human genome. (nih.gov)
  • Although the transcript identity between mouse and human orthologous transcripts were high (greater than 80% sequence identity), the exon order in these gene-pairs may be different between mouse and human orthologous genes. (uwc.ac.za)
  • In 2000, researchers working on the Human Genome Project announced that they had determined the sequence of base pairs that make up this chromosome. (medlineplus.gov)
  • The pins and white diamonds on this illustration show where changes were made in the native sequence of yeast chromosome III to produce a custom-designed synthetic chromosome. (nbcnews.com)
  • We have isolated and analyzed the sequence of bacterial artificial chromosome clones from the syntenic mouse chromosome 5 region that contains Gtf2ird1 and Gtf2i as well as a neighboring gene, Ncf1. (elsevierpure.com)
  • The DNA sequence of a cloned downstream xi-like gene provides direct evidence for the conversion of a psi xi 1----xi 1 gene, by a xi 2 gene. (ox.ac.uk)
  • These unique sequence probes thus allowed each tRNA(i)(Met) gene to be analyzed individually in cell hybrids. (uthscsa.edu)
  • The sequence was used to map 110 ESTs and to predict new genes, including two GenScan gene predictions that overlapped ESTs and were shown to be differentially expressed in tumorigenic and suppressed A549 cell lines. (elsevierpure.com)
  • His Ensembl software and data allow researchers to find information on the Web on any known or predicted gene and to automatically match pieces of genes they have sequenced with other genes-without tediously combing through endless raw-sequence data. (technologyreview.com)
  • The work is part of the ongoing Human Genome Project, an international effort to sequence (read) the genetic make-up of humans. (bbc.co.uk)
  • Once again, we are seeing the fruits of the two key commitments of the Human Genome Project: to make the sequence freely available and to produce a quality finished sequence. (bbc.co.uk)
  • The sequence of chromosome 22 was revealed two years ago. (bbc.co.uk)
  • The sequence, the genes and the variations between people in the population is the tool to start dissecting complex common diseases like diabetes, obesity and eczema. (bbc.co.uk)
  • Human Chromosome 15 pac pDJ138o23, complete sequence. (lu.se)
  • Sequence of BLM gene is a reverse complement. (lu.se)
  • 100 kb on mouse chromosome 5 and is located between Cyln2 and Gtf2i. (elsevierpure.com)
  • The new mouse model, known as Ts66Yah, has a minichromosome with over a hundred genes from mouse chromosome 16 attached to the centromere region of mouse chromosome 17. (nih.gov)
  • The previous mouse model has an additional region of mouse chromosome 17 that contains 45 extra genes not found on human chromosome 21. (nih.gov)
  • Humans normally have 46 chromosomes in each cell, divided into 23 pairs. (medlineplus.gov)
  • Two copies of chromosome 21, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
  • Chromosome 21 is the smallest human chromosome, spanning about 48 million base pairs (the building blocks of DNA) and representing 1.5 to 2 percent of the total DNA in cells. (medlineplus.gov)
  • Human cells typically contain 23 pairs of chromosomes. (nbcnews.com)
  • The researchers started out with 316,617 base pairs in the natural chromosome, and slimmed the code down to 272,871 base pairs. (nbcnews.com)
  • Every human cell contains 23 pairs of chromosomes. (cdc.gov)
  • Humans have 23 pairs of chromosomes. (kidshealth.org)
  • In each cell, most humans have 23 pairs of chromosomes, for a total of 46. (sciencedaily.com)
  • fChromosome 9 is one of the 23 pairs of chromosomes in humans . (wikipedia.org)
  • Chromosome 9 spans about 150 million base pairs of nucleic acids (the building blocks of DNA ) and represents between 4.0 and 4.5% of the total DNA in cells . (wikipedia.org)
  • We have successfully used a DNA.cDNA molecular hybridization assay to directly determine the presence or absence of human beta globin gene sequences in 20 human-mouse somatic cell hybrids, each of which contained a different subset of human chromosomes. (eurekamag.com)
  • DNA extracted from a panel of 12 independent human‐rodent somatic cell hybrids was analysed by Southern blot hybridization with the cloned cDNA. (elsevierpure.com)
  • Two nonallelic human tRNA(i)(Met) genes were assigned to chromosome 6 by filter hybridization of DNA from human-rodent somatic cell hybrids by using probes containing unique sequences from the regions flanking each tRNA(i)(Met) gene. (uthscsa.edu)
  • Allelic loss at 11q13 was detected in 13 tumors, and 6 of them demonstrated previously unrecognized somatic missense and frameshift deletion mutations of the MEN1 gene. (lu.se)
  • In a very small percentage of cases, Down syndrome results from an extra copy of chromosome 21 in only some of the body's cells. (medlineplus.gov)
  • In most cases, these babies have a third copy of chromosome 21. (nih.gov)
  • Do Parents Pass Gene Mutations to Children? (kidshealth.org)
  • Do All Gene Mutations Cause Health Problems? (kidshealth.org)
  • Most gene mutations have no effect on health. (kidshealth.org)
  • As a scientist she has been involved in mapping the human genome and identifying genes and mutations, which give rise to heritable disorders. (bepress.com)
  • Frequency of mutations in PIK3CA gene is higher in tumors without lymph node metastasis, than those with in gastric cancer. (sigmaaldrich.com)
  • Thus, it might be essential to evaluate the mutations in this gene to determine cetuximab treatment in gastric cancer patients. (sigmaaldrich.com)
  • Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected. (portlandpress.com)
  • Mutations in the recently identified MEN1 gene at chromosome 11q13 have been found in parathyroid tumors of nonfamilial pHPT. (lu.se)
  • Clinical and biochemical characteristics of HPT were apparently unrelated to the presence or absence of LOH and the MEN1 gene mutations. (lu.se)
  • However, the demonstration of LOH at 11q13 and MEN1 gene mutations in small parathyroid adenomas of patients with slight hypercalcemia and normal serum PTH levels suggest that altered MEN1 gene function may also be important for the development of mild sporadic pHPT. (lu.se)
  • Achondroplasia is caused by mutations in the fibroblast growth factor receptor-3 ( FGFR3 ) gene. (medscape.com)
  • The two mutations, G1138A and G1138C, cause increased function of the FGFR3 gene. (medscape.com)
  • A study by Di Rocco et al using murine and human subjects indicated that FGFR3 mutations in achondroplasia also affect membranous ossification. (medscape.com)
  • Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. (bvsalud.org)
  • When a person's FMR1 gene has more than 200 repeats, so that it can't make FMRP, the person has FXS. (cdc.gov)
  • Each person is in one of the four groups shown below based on the number of CGG repeats in the person's FMR1 gene. (cdc.gov)
  • Genes also play a role in a person's risk for some diseases and health conditions. (kidshealth.org)
  • An additional chromosome 21 adds an extra copy of over 200 protein-coding genes to that person's genome, which causes difficulties with learning, speech and motor skills. (nih.gov)
  • Overview of Chromosome and Gene Disorders Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)
  • Analysis of human metaphase chromosomes by in situ hybridization localizes this cytochrome P‐450 gene family further to the long arm of chromosome 19 in the region q13.1→qter. (elsevierpure.com)
  • [ 9 ] The antithrombin gene is found on the long arm of chromosome 1. (medscape.com)
  • A genetic rearrangement (translocation) involving chromosome 21 is associated with a type of blood cancer known as core binding factor acute myeloid leukemia (CBF-AML). (medlineplus.gov)
  • In the present study, we report on the mapping of a second MKS locus (MKS2) to chromosome 11q13, by homozygosity mapping in seven families that do not show linkage to chromosome 17q21-q24 (maximum LOD score 4.41 at recombination fraction .01). (nih.gov)
  • This is consistent with previous mapping of the BCP gene to chromosome 7q31-35. (ox.ac.uk)
  • Introduction of a 1.1 Mb fragmented yeast artificial chromosome (YAC) mapping to this region completely suppresses the tumorigenic properties of a human NSCLC cell line, A549. (elsevierpure.com)
  • Until ten years ago, it was hoped that the mapping of the human genome - all our genes - would enable us to better understand the course of different diseases. (lu.se)
  • Only one section of the human genome fit the bill with these criteria -- a stretch of DNA on the short arm of chromosome 19. (sciencedaily.com)
  • [ 10 ] FGFR3 has been mapped to the short arm of chromosome 4, p16.3 (4p16.3). (medscape.com)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • The protein encoded by this gene is one of a family of related proteins that transports glucose into cells by facilitated diffusion. (pearson.com)
  • This gene, MPO, located at 17q23.1, encodes an enzyme that is found in white blood cells and increases the ability of these cells to kill microorganisms. (pearson.com)
  • The assay is specific for the individual human globin genes and will detect the presence of a globin gene if the relevant chromosome is present in only 10% of the cells of a hybrid population. (eurekamag.com)
  • A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. (wikipedia.org)
  • 21HAC was also able to be transferred into cells from a variety of species (mice, chickens, humans). (wikipedia.org)
  • Using 21HAC, researchers were able to insert a herpes simplex virus thymidine kinase coding gene into tumor cells. (wikipedia.org)
  • The RUNX1-ETO fusion protein forms CBF and attaches to DNA, but instead of turning on genes that stimulate the development of blood cells, it turns those genes off. (medlineplus.gov)
  • This change in gene activity blocks the maturation (differentiation) of blood cells and leads to the production of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
  • Less commonly, Down syndrome occurs when part of chromosome 21 becomes attached (translocated) to another chromosome during the formation of reproductive cells (eggs and sperm) or very early in fetal development. (medlineplus.gov)
  • They were relieved to find that the yeast cells with the synthetic chromosome, called SynIII, generally functioned as well as cells with the natural chromosome. (nbcnews.com)
  • Both tRna(i)(Met) genes segregated in the hybrid cells with the chromosome 6 enzyme markers, soluble malic enzyme and the mitochondrial form of superoxide dismutase, and also with a karyotypically normal chromosome 6. (uthscsa.edu)
  • In addition, genes have instructions for making proteins in the cells. (cdc.gov)
  • A chromosome (KRO-muh-sohm) is an X-shaped thread-like structure in the body's cells. (kidshealth.org)
  • To identify the likely location of the repressor protein and the gene that codes for it, the researchers started by looking at cells from human embryos with different forms of chromosomal trisomy, a condition in which cells carry three copies of a particular chromosome instead of two. (sciencedaily.com)
  • Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. (portlandpress.com)
  • DNA Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or the code for functional ribonucleic. (msdmanuals.com)
  • We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to single-walled carbon nanotube s (SWCNT). (cdc.gov)
  • HACs are useful in expression studies as gene transfer vectors, as a tool for elucidating human chromosome function, and as a method for actively annotating the human genome. (wikipedia.org)
  • While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally. (news-medical.net)
  • To understand how FXS is inherited, it helps to know about the changes in the FMR1 gene that cause FXS and other fragile X-associated disorders . (cdc.gov)
  • They narrowed their search to a few candidate regions, then turned to a third database, Decipher, which makes it possible to compare human genome variants on tens of thousands of patients with genetic disorders worldwide. (sciencedaily.com)
  • Here, we profile eight genomes of the bivalve mollusc family of Pectinidae in a phylogenetic context and show 350 million years sex-chromosome homomorphy, which is the oldest known sex-chromosome homomorphy in the animal kingdom, far exceeding the ages of well-known heteromorphic sex chromosomes such as 130-200 million years in mammals, birds and flies. (nature.com)
  • This is significant as an example of synthetic genomes aimed well beyond making mere copies of chromosomes," Harvard geneticist George Church, who was not involved in the project, told NBC News. (nbcnews.com)
  • Several attempts have been made toward identification of S/MARs in genomes of various organisms including human. (researchgate.net)
  • Humans and mice have very similar genomes, but the chromosomes that make up those genomes do not precisely align across those two species. (nih.gov)
  • The gene that appears to make some people more susceptible to contracting vCJD is found on chromosome 20. (bbc.co.uk)
  • [ 6 ] The human TFPI gene is found on chromosome 2. (medscape.com)
  • To further localize the gene(s) responsible for this partial suppression, a bacterial artificial chromosome (BAC) and P1-based artificial chromosome (PAC) contig was constructed, completely spanning the candidate region. (elsevierpure.com)
  • On the basis of these results, the human beta and gamma globin genes have been assigned to human chromosome 11. (eurekamag.com)
  • The duplicated human embryonic alpha-like globin genes encode a 5' functional zeta (xi 2) gene and a highly homologous pseudogene (psi xi 1). (ox.ac.uk)
  • There are currently two accepted models for the creation of human artificial chromosome vectors. (wikipedia.org)
  • In 2010, a refined human artificial chromosome called 21HAC was reported. (wikipedia.org)
  • Truncation of chromosome 21 resulted in a human artificial chromosome that was mitotically stable. (wikipedia.org)
  • In 2011, researchers formed a human artificial chromosome by truncating chromosome 14. (wikipedia.org)
  • Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. (ox.ac.uk)
  • Loss of heterozygosity for a locus on human chromosome 11q22-23 is observed at high frequency in non-small cell lung carcinoma (NSCLC). (elsevierpure.com)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (nih.gov)
  • This region of the chromosome has a cluster of genes that encode the hard proteins, which are involved in the formation of hair and nails. (pearson.com)
  • Chromosome 21 likely contains 200 to 300 genes that provide instructions for making proteins. (medlineplus.gov)
  • It uses a free program she developed called PhyloBlast to evaluate relationships between genes by comparing their sequences and the proteins they code for. (technologyreview.com)
  • Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
  • By identifying which proteins are most important for infants, laboratories will be able to produce formula more similar to mother's milk by inserting human genes. (greens.org)
  • There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. (portlandpress.com)
  • We need to know more about the proteins that our genes produce. (lu.se)
  • We have around 20 000 genes that can produce at least 500 000 proteins. (lu.se)
  • The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 21. (medlineplus.gov)
  • Affected people have two copies of chromosome 21 plus extra material from chromosome 21 attached to another chromosome, resulting in three copies of genetic material from chromosome 21. (medlineplus.gov)
  • Researchers believe that having extra copies of genes on chromosome 21 disrupts the course of normal development, causing the characteristic features of Down syndrome and the increased risk of health problems associated with this condition. (medlineplus.gov)
  • A female has two copies of the FMR1 gene, one on each of her two X chromosomes. (cdc.gov)
  • However, says Barbara R. Migeon, M.D., professor of pediatrics at the Johns Hopkins University School of Medicine and a pioneer in X-inactivation research, she and her colleagues reported nearly four decades ago that in some human embryos with triploidy -- a condition in which there are three sets of chromosomes instead of the usual two -- two copies of the X chromosome remained active. (sciencedaily.com)
  • Humans normally have two copies of this chromosome, as they normally do with all chromosomes. (wikipedia.org)
  • Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative gene products. (nih.gov)
  • By this technique, the gene coding for restin (RSN) was assigned to chromosome region 12q24.31→q24.33, while localization of the α-2-macroglobulin receptor (A2MR) was refined to 12q13.1→q13.3. (karger.com)
  • Here we report the localization of the human orthologue of this gene, HB5, to within 150 kb of H19 on human chromosome 11p15.5. (ox.ac.uk)
  • To indicate the location of a gene on a particular chromosome, the chromosome number is followed by p or q and then a number that represents the band and sub-band. (pearson.com)
  • In mice, this gene is absolutely essential for sustained growth and expected longevity. (pearson.com)
  • The gene organization of Gtf2ird1, Gtf2i, and Ncf1 is conserved in mice and humans, although the intronic regions are more compact in the mouse genome. (elsevierpure.com)
  • In 1997, Japanese researchers reported inserting a complete human chromosome into mice to produce human antibodies. (greens.org)
  • Scientists often use different strains of mice as animal models to study human diseases because most genes in humans have similar counterparts in mice. (nih.gov)
  • How these 45 extra genes affect the brain and behavior of the previous Ts65Dn mice has not been investigated until now. (nih.gov)
  • The investigators analyzed the calvaria and skull base in mice with an achondroplasia-like mutation, as well as in humans with achondroplasia or FGFR3 -related craniosynostoses. (medscape.com)
  • This is accomplished by truncating the natural chromosome, followed by the introduction of unique genetic material via the Cre-Lox system of recombination. (wikipedia.org)
  • Identification of regions with copy number aberrations and the genes involved thus offers a basis for better understanding of cancer development [ 6 ]. (biomedcentral.com)
  • Among these latter chromosomes, only chromosome 11 was present in the six hybrid clones that contained the human beta globin gene. (eurekamag.com)
  • In fact, chromosome 11 was the only human chromosome that was present in all of the six hybrid clones found to be positive for the human beta globin gene. (eurekamag.com)
  • Two sister clones, 157-BNPT-1 and 157-BNPT-4, had similar subsets of human chromosomes except that 11 was present only in 157-BNPT-4. (eurekamag.com)
  • In this study, the BCP gene has been localised to chromosome 7q31.3-32 by fluorescent in situ hybridisation of cosmid clones containing the gene. (ox.ac.uk)
  • By using hybrid clones containing translocations that divide chromosome 6 into five segments, both tRNA(i)(Met) genes were assigned to the p23→q12 region. (uthscsa.edu)
  • We have recently isolated a cloned cDNA coding for a cytochrome P‐450 of human liver microsomal membranes, which corresponds to a major phenobarbital‐inducible cytochrome P‐450 of rat liver. (elsevierpure.com)
  • The gene consists of six exons. (ox.ac.uk)
  • Using microsatellite analysis for loss of heterozygosity (LOH) at 11q13 and DNA sequencing of coding exons, the MEN1 gene was studied in 49 parathyroid lesions of patients with divergent symptoms, operative findings, histopathological diagnosis, and biochemical signs of nonfamilial pHPT. (lu.se)
  • BLM gene contains 21 exons, that comprise bases from bp 42373 to bp 135314. (lu.se)
  • Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)
  • However, the mouse exon-skipping frequency may represent the highest estimate that can be obtained given that the current number (87) of mouse genes orthologous to chromosome 22 in Ensembl (v1 30th Jan. 2002) does not deviate significantly from our total number (72) of mouse multi-exon genes. (uwc.ac.za)
  • Then the researchers used a technology called SCRaMbLE (Synthetic Chromosome Recombination and Modification by LoxP-mediated Evolution) to shuffle the genes in the synthetic chromosome. (nbcnews.com)
  • Chromosome 21 abnormalities can cause intellectual disability, delayed development, and characteristic facial features. (medlineplus.gov)
  • Down syndrome is a chromosome disorder caused by an extra chromosome 21 that results in intellectual disability and physical abnormalities. (msdmanuals.com)
  • The evolutionary dynamics of sex chromosomes suggest a mechanism for 'inheritance' turnover of sex-determining genes that is mediated by translocation of a sex-determining enhancer. (nature.com)
  • The translocation, written as t(8;21), fuses part of the RUNX1 gene from chromosome 21 with part of the RUNX1T1 gene (also known as ETO ) from chromosome 8. (medlineplus.gov)
  • Located on the X chromosome itself, Xist produces a protein that spreads up and down the chromosome during female embryonic development, turning off its genes. (sciencedaily.com)
  • We identified 20 chromosomal imbalance regions harboring 459 genes for Caucasian and 17 regions containing 476 genes for Asian lung cancer patients. (biomedcentral.com)
  • Three methods including MetaCore analysis for disease and pathway correlations, concordance analysis between array-CGH database and the expression array database, and literature search for copy number variation genes were performed to select novel lung cancer candidate genes. (biomedcentral.com)
  • DNA (deoxyribonucleic acid is the carrier of all our genes. (kidshealth.org)
  • A gene is a segment of deoxyribonucleic acid ( DNA) and contains the code for a specific protein that functions in one. (msdmanuals.com)
  • Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. (wikipedia.org)
  • Yeast artificial chromosomes and bacterial artificial chromosomes were created before human artificial chromosomes, which were first developed in 1997. (wikipedia.org)
  • Scientists say they've built a yeast chromosome from the bottom up for the first time - a feat that could open the way for custom-made biofactories. (nbcnews.com)
  • He's even looking into creating entirely new yeast chromosomes that incorporate human genetic code for medical screening purposes. (nbcnews.com)
  • The Science paper describes the reconstruction of yeast chromosome III, which regulates mating behavior and other functions. (nbcnews.com)
  • They "scrambled" the genes to turn a sterile yeast cell into a yeast cell that could mate. (nbcnews.com)
  • These results raise the possibility that other tRNA(i)(Met) genes may be syntenic with the two described in this study and illustrate the utility of using unique lanking sequences to identify members of a multigene family. (uthscsa.edu)
  • This was followed, in May 2000, by chromosome 21. (bbc.co.uk)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • Because researchers use different approaches to genome annotation , their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikipedia.org)
  • two lines positive for human beta globin gene sequences also contained human gamma globin gene sequences while one line was negative for both beta and gamma gene sequences. (eurekamag.com)
  • By leaving existing telomeric and sub-telomeric sequences, researchers were able to amplify expression levels of genes coding for erythropoietin production over 1000-fold. (wikipedia.org)
  • Studying a subset of Middle Eastern and northern African MKS families, we have recently excluded the chromosome 17 region and have suggested a genetic heterogeneity. (nih.gov)
  • The genes of human chromosome 21 identified by the genome efforts were investigated, and the success rates for de novo cloning, protein production, and antibody generation were 85, 76, and 56%, respectively. (nih.gov)
  • Changes involving chromosome 21 can include a missing segment of the chromosome in each cell (partial monosomy 21) and a circular structure called ring chromosome 21. (medlineplus.gov)
  • The following is a partial list of genes on human chromosome 9. (wikipedia.org)
  • Scientists have deciphered the complete genetic instructions of a third chromosome, one of the 24 distinct bundles of DNA that carry our genetic material. (bbc.co.uk)
  • Just as people are unlikely to agree on how much genetic material constitutes "humanness," they are likely to differ on the conditions under which it is moral or immoral to consume food with human components. (greens.org)
  • Therefore, identification and characterization of the chromosome regions with DNA copy number alteration in Western and Asian countries is important to unravel the mechanism underlying lung tumorigenesis. (biomedcentral.com)
  • Naylor, SL , Sakaguchi, AY & Shows, TB 1983, ' Two nonallelic tRNA(i)(Met) genes are located in the p23→q12 region of human chromosome 6 ', Proceedings of the National Academy of Sciences of the United States of America , vol. 80, no. 16 I, pp. 5027-5031. (uthscsa.edu)
  • The team reasoned that if the repressor was in a region that was duplicated, it would work overtime and turn off Xist on both X chromosomes, leaving both the X chromosomes active and selectively changing the survival of male vs. female embryos. (sciencedaily.com)
  • Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense. (wikipedia.org)
  • HACs have been used to create transgenic animals for use as animal models of human disease and for production of therapeutic products. (wikipedia.org)
  • It could also give an insight into variant Creutzfeldt-Jakob disease (vCJD), the human form of mad cow disease. (bbc.co.uk)
  • These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. (researchgate.net)
  • The gene for Machado-Joseph disease maps to human chromosome 14q. (bvsalud.org)