Human chondrosarcoma cells. Medical search. Frequent questions

The cells in EMC tumors do not express specific tumor marker proteins that would help in diagnosing this disease. (wikipedia.org)
Based on the stable culturing properties of these cell lines and their genotypic profile resembling the original tumors, these cell lines should provide useful functional models to further characterize chondrosarcoma and to evaluate new treatment strategies. (biomedcentral.com)
Chondrosarcoma represents a heterogeneous group of tumors. (biomedcentral.com)
The research paper presented by the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development say that anti-cancer treatments might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease though quite often they effectively shrink the size of tumors. (medindia.net)
The researchers first determined that Nanog and BMI1 stem cell markers were more highly expressed in metastatic tumors compared to primary tumors. (medindia.net)
They then applied various therapies - from VEGF inhibitors such as Avastin to the proteasome inhibitor Velcade - in mice implanted with human MSC, and analyzed the effects on tumors. (medindia.net)
But analysis of stem cell expression before and after treatment revealed that even as some anti-cancer treatments shrank tumors, they increased expression of Nanog and BMI1. (medindia.net)
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
Mast cell tumors are the most common cancers of the skin. (embracepetinsurance.com)
Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)
Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. (cdc.gov)

Bone sarcomas such as osteosarcoma and chondrosarcoma are frequently refractory to conventional chemotherapy and radiotherapy that exhibit poor prognosis. (oncotarget.com)
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. (cdc.gov)
Examples include osteosarcoma and chondrosarcoma. (newsbreak.com)

Liposarcoma , a malignancy of fat cells, is the most common soft tissue sarcoma with an annual incidence of 2.5% cases per million. (drrathresearch.org)
Extraskeletal myxoid chondrosarcoma (EMC), a soft-tissue sarcoma with unique clinicopathologic features and characteristic chromosomal translocations, is extremely rare in the pediatric population. (cancer-genetics.org)
Scholars@Duke publication: Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. (duke.edu)
The SARC028 clinical trial showed that immunotherapy with a programmed cell death 1 (PD-1) and PD ligand 1 (PD-L1) inhibitor can result in responses in patients with soft-tissue sarcoma, particularly in patients with undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. (jhoponline.com)

Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. (umassmed.edu)
Benign cartilage lesions can be difficult to differentiate from slow-growing, low-grade chondrosarcomas. (medscape.com)
Chondrosarcoma: These are less common but tend to affect the cartilage. (embracepetinsurance.com)
Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma. (cdc.gov)
We previously reported that human MMP3 could translocate into cellular nuclei and control transcription in human chondrosarcoma-derived cells and in articular cartilage (Eguchi et al. (elsevierpure.com)
Effects Expression of BMP and TGFB ligands and receptors in central chondrosarcoma The expression of genes for BMP and TGFB ligands and receptors was measured in central chondrosarcoma and typical cartilage samples by quantitative RT PCR. (thrombin-inhibitor.com)
In comparison to standard cartilage, chondrosarcoma showed altered expression ranges for BMP2 and BMP7. (thrombin-inhibitor.com)
BMP2 was drastically larger expressed in normal cartilage samples than in chondrosarcoma, even though BMP7 was not detected Pracinostat chemical structure or found at pretty very low ex pression levels in typical cartilage samples and was drastically higher expressed in chondrosarcoma. (thrombin-inhibitor.com)
Chondrosarcoma develops from cartilage cells that are found between bones and joints in the legs, arms or pelvis. (cuanschutz.edu)

Activity of Smad158 and Smad2 in central chondrosarcoma samples As a way to set up irrespective of whether the BMP and TGFB signal ing pathways are lively in central chondrosarcoma, the presence of nuclear phosphorylated Smad158 and Smad2 was evaluated by immunohistochemical evaluation. (thrombin-inhibitor.com)

IDH1 gene mutations have been found in some cells of enchondromas and hemangiomas in people with Maffucci syndrome, as well as in the bone marrow or blood of a few affected individuals. (medlineplus.gov)
IDH1 gene mutations have been found in enchondroma cells in most people with Ollier disease, but the relationship between the mutations and the signs and symptoms of the disorder is not well understood. (medlineplus.gov)
The IDH1 gene mutations involved in CN-AML are somatic mutations, found only in cells that become cancerous. (medlineplus.gov)
Instead of becoming normal mature cells, immature blood cells with somatic IDH1 gene mutations divide uncontrollably, leading to CN-AML. (medlineplus.gov)
Within the past few years, novel mutations in the human P3H1 gene and genes encoding P3H1-associated proteins were shown to cause reces- sive forms of osteogenesis imperfecta (8 -11). (documents.pub)
Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma. (cdc.gov)
Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. (cdc.gov)
IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. (cdc.gov)
IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma. (cdc.gov)

Chondrosarcoma is the second most common primary sarcoma of bone. (biomedcentral.com)
We investigated the effect of micronutrient synergy in vitro on human rhabdosarcoma, liposarcoma and chondrosarcoma cell lines and, in vitro and in vivo on human osteosarcoma, synovial sarcoma and fibrosarcoma cell lines. (drrathresearch.org)
Here we demonstrate aberrant activation of Wnt/β-catenin signaling in bone sarcoma cells, involving an autocrine Wnt signaling loop with upregulation of specific Wnt ligands and receptors. (oncotarget.com)
Activation of Wnt/β-catenin signaling with Wnt3a or GSK-3β inhibitor drives the proliferation of bone sarcoma cells, whereas downregulation of activated Wnt signaling with dnTCF4 or siLEF1 suppresses bone sarcoma proliferation and induces cell cycle arrest. (oncotarget.com)
Taken together, our findings establish the evidence that aberrant activation of Wnt/β-catenin pathway involving an autocrine Wnt singaling drives the proliferation of bone sarcoma cells, and identify the autocrine activation of the Wnt/β-catenin signaling as a potential novel therapeutic target for bone sarcomas. (oncotarget.com)
The low levels of methotrexate polyglutamates formed is likely the major cause of intrinsic methotrexate resistance in these new sarcoma cell lines. (duke.edu)
Though one immunohistochemical research observed no BMPs in human typical chondro sarcoma tissue, one particular RT PCR based gene expression analysis detected expression of BMP2, four, six and BMPRII. (thrombin-inhibitor.com)
In order to uncover a potential implication in chondro sarcoma, the aim of this venture was to carry out a sys tematic quantitative examine in the expression of BMPs, TGFBs and their receptors and also to assess activity of the corresponding signaling pathways in central chondrosar coma cells. (thrombin-inhibitor.com)
Primary bone cancer, also known as bone sarcoma , is a tumor that develops from the cells forming the bone. (cuanschutz.edu)
The most common types of bone cancers are osteosarcoma, Ewing sarcoma, chondrosarcoma and chordoma. (cuanschutz.edu)
Osteosarcoma and Ewing sarcoma are especially frequent in children and teenagers, while chondrosarcoma and chordoma are mostly seen in adult patients. (cuanschutz.edu)
Other types of sarcoma such as leiomyosarcoma, angiosarcoma, pleomorphic sarcoma, giant cell tumor of bone and other can also rarely arise in the bone. (cuanschutz.edu)

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma. (cdc.gov)
In addition, the whole exon analysis results revealed isocitrate dehydrogenase 1 ( IDH1 ) R132C mutation in chondrosarcoma lesions but not in blood DNA. (biomedcentral.com)
This case report showed MS complicated by giant chondrosarcoma in the left ankle with an IDH1 R132C mutation, which is appropriate to monitor the development of MS pathology and other concomitant lesions. (biomedcentral.com)

Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent . (cardiff.ac.uk)
Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization. (nih.gov)
Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
In nucleated cells, BAD is an important target gene downstream of Akt [ 9 ] and belongs to the pro-apoptotic Bcl-2 family of proteins. (researchsquare.com)
The hemopexin-like repeat (PEX) domain of the human MMP3 was essential for transcriptional induction of the HSP70B′ gene. (elsevierpure.com)
At present, there are few studies on MS with chondrosarcoma and detailed gene analysis. (biomedcentral.com)

Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)

Subsequent in vitro studies examined the effects of allium-derived compounds on the expression of matrix-degrading proteases in SW1353 chondrosarcoma cells. (biomedcentral.com)
To assess the potential roles of HDAC4, HDAC4 expression in human chondrosarcoma cells (SW1353) was down-regulated by transfecting small interference RNA (siRNA), thereafter, cells were treated with IL-1β or TNF-α, and the expressions of several matrix-degrading enzymes and anabolic factors were examined by using quantitative PCR. (biomedcentral.com)

Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs from other sarcomas by unique histology and characteristic chromosomal translocations. (wikipedia.org)
when they discussed the different species of extraskeletal chondrosarcoma, but EMC concept was firstly proposed in 1972 by Enzinger et al. (wikipedia.org)
Systemic manifestations of extraskeletal myxoid chondrosarcoma associated with a novel t(2;22)(q34;q12) EWS translocation in a child and a review of the literature. (cancer-genetics.org)

Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation. (ebsco.com)
Background: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. (ebsco.com)
My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. (gene.com)
In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Osteosarcomas and chondrosarcomas are recognized as the most common primary bone sarcomas [ 1 ], which involve mesenchymal tissues and exhibit highly heterogeneous histologic and molecular profiles [ 2 ]. (oncotarget.com)
Primary dedifferentiated chondrosarcoma tissues were obtained at the time of surgery and subjected to primary tissue culture. (cancer-genetics.org)
Cells Tissues Organs. (cancercentrum.se)

Caspase-3 is one of the most critical effector proteases in cell apoptosis. (researchsquare.com)
Inhibition of autophagy via bafilomycin A1 aggravated H 2 O 2 -induced reactive oxygen species (ROS) accumulation and apoptosis in MAC-T cells. (biomedcentral.com)
Because apoptosis of bovine mammary epithelial cells is modulated by cellular redox state [ 11 ], developing potential strategies for maintaining redox balance is particularly important in terms of preventing oxidative damage. (biomedcentral.com)
This led us to investigate a cell-suicide process called Apoptosis-which has important roles in normal physiology as well as in disease. (gene.com)
We have discovered that the key UPR enzyme IRE1 is hijacked by certain cancer cells to avert apoptosis and resist proteotoxic stress. (gene.com)

The malignant cells are uniform and lack nuclear pleomorphism. (wikipedia.org)
Chondrosarcoma is a malignant bone neoplasm characterized by the deposition of a hyaline cartilaginous extracellular matrix. (biomedcentral.com)
Background: Although chondrosarcoma is the second most common primary malignant bone tumor, treatment options are limited due to its extensive resistance to a chemo- and radiation therapy. (ebsco.com)

There are three main subtypes of NSCLC which are adenocarcinoma (~40% of cases), squamous cell carcinoma (~25-30% of cases), and large-cell carcinoma (~10-15% of cases). (hindawi.com)

Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. (umassmed.edu)
Our results suggest that a micronutrient mixture containing vitamin C, EGCG, Lysine, Proline and other natural components is effective in inhibiting cancer cells proliferation, secretion of MMPs and cancer invasion through Matrigel in vitro and in inhibiting the tumor growth of grafted saracoma cell lines in nude mice. (drrathresearch.org)
CBS RII cells exhibited lowered survivin and XIAP expression as com pared with CBS cells in vitro. (thrombin-inhibitor.com)

To date, three Wnt signaling pathways have been characterized including the canonical Wnt/β-catenin signaling, the noncanonical planar cell polarity pathway (Wnt/PCP) and the Wnt/Ca 2+ pathway [ 7 , 8 ]. (oncotarget.com)
If scientists understood the pathways cancer stem cells use to survive treatment or increase their ranks, then therapeutic targets could be developed, Dr. Vasko said. (medindia.net)
As important regulators of usual chondrogenesis, the BMP and TGFB signaling pathways could play an energetic part inside the progression of chondrosarcoma. (thrombin-inhibitor.com)

Tumor-tissue derived from three resected specimens derived from one conventional and two dedifferentiated chondrosarcomas were used for culture. (biomedcentral.com)
Samples were coded and all procedures were performed according to the ethical guidelines "Code for Proper Secondary Use of Human Tissue in The Netherlands 2002" (Dutch Federation of Medical Scientific Societies http://www.federa.org/sites/default/files/bijlagen/coreon/codepropersecondaryuseofhumantissue1_0.pdf ). (biomedcentral.com)
Moreover, we conducted whole-exome sequencing of germline DNA and chondrosarcoma tissue to further explore the pathogenesis of MS. (biomedcentral.com)

These findings suggest that P2Y12 has the potential to regulate cell death, but its expression in lumbar facet joint osteoarthritis and its possible role remain unclear. (researchsquare.com)
Furthermore, diallyl disulphide, a compound found in garlic and other alliums, represses the expression of matrix-degrading proteases in chondrocyte-like cells, providing a potential mechanism of action. (biomedcentral.com)
This may help explain why the expression of stem cell markers has been associated with resistance to chemotherapy and radiation treatments and poor outcome for patients with cancers including prostate, breast and lung cancers," Dr. Vasko said. (medindia.net)
Use of the agents Velcade and Docetaxel led to the most significant increase in stem cell markers within the treated tumor, while ifosfamide and Avastin inhibited expression of the markers in this cancer subtype. (medindia.net)
We hypothesize that the tumor escapes from chemotherapy by induction of stem cell marker expression," he said. (medindia.net)
Dr. Vasko doesn't know how this happens, but theorizes that "dying cells could secrete a lot of factors that induce expression of stem cell markers in other cancer cells. (medindia.net)
In the present study, we report that baicalein significantly inhibits the expression of Cyr61 and migration and invasion of MDA-MB231 human breast cancer cells. (molcells.org)
The active, un-phosphorylated form of GSK3β maintains both (i) epithelial phenotypes by inhibiting the expression and stabilization of Snail and Slug and (ii) high E-cadherin expression ( Boble and Woodgett, 2007 ) in resting epithelial cells. (molcells.org)
CBS is known as a human colon carcinoma cell line that has attenuated TGFB signaling because of reduced expression of TGFB receptor kind II. (thrombin-inhibitor.com)
Subcellular fractionation was per formed on CBS and CBS RII cells to find out no matter whether restoration of TGFB receptor signaling resulted in sup pression of survivinXIAP expression. (thrombin-inhibitor.com)
Reintroduction of Smad dependent TGFB signaling resulted in decreased expression of cytoplasmic survivin and XIAP in CBS RII cells. (thrombin-inhibitor.com)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)

Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. (nih.gov)
TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content. (ebsco.com)
Our experiments suggest that some treatments could be producing more cancer stem cells that then are capable of metastasizing, because these cells are trying to find a way to survive the therapy," said one of the study's investigators, Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences in Bethesda, Md. (medindia.net)
The cancer stem cell markers include Nanog and BMI1, both of which contribute to stem cells' defining ability to renew themselves and differentiate into different cell types, Dr. Vasko said. (medindia.net)
Researchers have recently debated the notion that some therapies are not capable of eradicating cancer because they do not target the cancer stem cells responsible for tumor development. (medindia.net)
They selected a rare form of cancer, mesenchymal chondrosarcoma (MCS), which has not been well described and for which there is no effective treatment. (medindia.net)
These treatments were not enough to completely inhibit tumor growth, and the cancer stem cell markers were still present," Dr. Vasko said. (medindia.net)
Some novel therapies are already being tested against cancer stem cells, he added. (medindia.net)
Cancer is perhaps best defined as a disease caused by the uncontrolled division of abnormal cells. (embracepetinsurance.com)
Our research further revealed that inhibiting IRE1 activity in cancer-surveilling dendritic cells augments anti-tumor immunity. (gene.com)
We are currently developing strategies that aim to kill cancer cells by directly disrupting their inherent stress-adaptation mechanisms or by augmenting the anti-tumor immune response. (gene.com)
The Cytosol Mitochondria benefits demonstrate that liver from CBS bearing animals had significantly even more metastatic colony formation as reflected major cancer cells with minimal metastatic prospective. (thrombin-inhibitor.com)
Common types of bone cancer in adults are chondrosarcoma, giant cell tumor, and chordoma. (cuanschutz.edu)
Chondrosarcoma is the second most common bone cancer in adults after the age of 40, although it can present at any age. (cuanschutz.edu)
There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. (newsbreak.com)
The type of cancer and its severity depends on the type of cells affected, the location of the affected cells, and the stage at which it is detected and treated. (newsbreak.com)
Lymphomas: A type of cancer that originates in the immune system cells, including the lymphatic system. (newsbreak.com)
Melanomas: A type of skin cancer that begins in the cells that produce pigment. (newsbreak.com)

High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. (biomedcentral.com)
We developed and characterized three cell lines, derived from conventional grade III chondrosarcoma (L835), and dedifferentiated chondrosarcoma (L2975 and L3252) of bone. (biomedcentral.com)
L835 is derived from a grade III conventional chondrosarcoma, while L2975 and L3252 originate from dedifferentiated chondrosarcomas of bone. (biomedcentral.com)

A somatic mutation occurs in a single cell. (medlineplus.gov)
As that cell continues to grow and divide, the cells derived from it also have the same mutation. (medlineplus.gov)
cells that arise from that abnormal cell have the mutation, while the body's other cells do not. (medlineplus.gov)

Bovine mammary epithelial cells after calving undergo serious metabolic challenges and oxidative stress both of which could compromise autophagy. (biomedcentral.com)
However, effects of TFEB-mediated autophagy on the oxidative stress of bovine mammary epithelial cells remain unknown. (biomedcentral.com)
Therefore, the main aim of the study was to investigate the role of TFEB-mediated autophagy in bovine mammary epithelial cells experiencing oxidative stress. (biomedcentral.com)
H 2 O 2 challenge of the bovine mammary epithelial cell MAC-T increased protein abundance of LC3-II, increased number of autophagosomes and autolysosomes while decreased protein abundance of p62. (biomedcentral.com)
The bovine mammary epithelial cell undergoes serious metabolic challenges and excessive ROS production during the transition period. (biomedcentral.com)
Thus, TFEB-mediated autophagy in bovine mammary epithelial cells might play a positive role in response to oxidative stress. (biomedcentral.com)
[ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)

Dedifferentiated chondrosarcoma is an aggressive mesenchymal tumor of the bone, and novel therapies are needed to improve its clinical outcomes. (cancer-genetics.org)
Some types of blood cancers start in the blood-forming cells of the bone marrow but not the bone itself. (cuanschutz.edu)
The preferred location of the tumor in the human economy is the long bone, with predilection for the distal femoral metaphysis, proximal tibia, and humeral metaphysis. (isciii.es)

Secondary chondrosarcoma can occur in a previously benign cartilaginous lesion. (medscape.com)
Therefore, this article reports a case of giant chondrosarcoma secondary to MS with a long medical history. (biomedcentral.com)

Glial brain tumours originating from glial cells are intracranial solid neoplasms. (hindawi.com)

Lipotransfection and MTT were applied for proliferation assessment in U87-MG cells. (hindawi.com)
The Wnt signaling are evolutionarily conserved and implicated in cell proliferation and sarcomagenesis. (oncotarget.com)

The migratory effect of BMP2 on chondrosarcoma cell lines, even so, suggests a role of BMP signaling in progression. (thrombin-inhibitor.com)

Patient-derived cell lines are essential tools for elucidating disease mechanisms associated with poor prognosis and for developing therapies. (cancer-genetics.org)

The fusion proteins found in the neoplastic cells of EMC consist of NR4A3 in >90% of cases partnered with EWRS1 in >75% of cases or, alternatively, TAF15, TCF12, or TFG in uncommon cases. (wikipedia.org)

As in humans, these can occur in the skin, but they're not as prevalent here as they are in the oral cavity of both dogs and cats. (embracepetinsurance.com)

After washing, the cells were transferred into small collagen-coated culture flasks and cultured in RPMI1640 supplemented with 20% heat inactivated Fetal Calf Serum (Gibco, Invitrogen Life-Technologies, Scotland, UK), 1% L-glutamax, and 1% penicillin/streptomycin (100U/mL). (biomedcentral.com)
Mass spectrometry deter- mined that all the additional candidate 3Hyp substrate sites in the pN type II collagen made by these cells were highly hydroxy- lated. (documents.pub)
In the intima from normal aorta fibronectin was present in the subendothelial basal layer, along the internal and external elastic laminae, around and between the smooth muscle cells of the media and along the collagen and elastic fibres in the adventitia. (zib.de)

GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
TSAs and TAAs typically are portions of intracellular molecules expressed on the cell surface as part of the major histocompatibility complex. (msdmanuals.com)

That tells us that understanding how to target these markers and these cells could prove useful in treating these cancers. (medindia.net)
As in humans, cancers are often strongly linked to genetic factors, which makes them more prevalent in certain breeds and within specific genetic lines within those breeds. (embracepetinsurance.com)
Which means that some cancers are more common in dogs than they are in humans. (embracepetinsurance.com)
Recent studies have implicated that members of the DICKKOPF ( DKK ) were causally involved in large number of human cancers. (biomedcentral.com)
Figure 7A and 7B compares GFP fluorescence within the major cancers and liver isolated from animals orthotopically implanted with CBS RII or CBS cells, respectively. (thrombin-inhibitor.com)
Getting vaccinated: Some cancers, such as human papillomavirus (HPV)-related cancers, can be prevented through vaccination. (newsbreak.com)

TFG is also observed as a fusion transcript with ALK (2p23) in anaplastic large-cell lymphoma and with ANTRK1 (1q21) in some of the thyroid papillary carcinomas. (wikipedia.org)

The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome. (springer.com)
The NADPH produced from isocitrate dehydrogenase 1 is involved in the breakdown of fats for energy, and it also protects cells from potentially harmful molecules called reactive oxygen species. (medlineplus.gov)

NME1 Drives Expansion of Melanoma Cells with Enhanced Tumor Growth and Metastatic Properties. (umaryland.edu)

Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. (nih.gov)
These same molecules are found in embryonic stem cells. (medindia.net)
It is also found in cellular structures called peroxisomes, which are small sacs within cells that process many types of molecules. (medlineplus.gov)

Brody thought that this was a unique low-grade malignancy with a low growth rate and both clinically and histopathologically distinct anamnesis beside the typical chondrosarcomas. (wikipedia.org)
We show that the three cell lines have distinct migrative properties, L2975 had the highest migration rate and showed tumorigenic potential in mice. (biomedcentral.com)
CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties. (umaryland.edu)

Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
When between the ligands analyzed the BMP2, BMP4, BMP6, BMP7, TGFB1 and TGFB2 genes did not present substantial differences amongst chondrosarcomas of different histo logical grades, TGFB3 was appreciably larger expressed in grade III compared to grade I chondrosarcoma. (thrombin-inhibitor.com)

According to classification system of the World Health Organisation (WHO) based on histological evaluation, brain tumour grade is determined by necrotic cells in the centre of the tumour, increased mitotic activity, the presence of nuclear pleomorphism, and angiogenesis. (hindawi.com)

All the genes egf receptor inhibitor analyzed have been identified to become expressed in chondrosarcoma samples. (thrombin-inhibitor.com)

For example, less than 20% of EMC tumor cases contain cells that express the S100 protein whereas many other tumor types contain cells that express S100 protein in most or all cases (see Pathology of S100 protein). (wikipedia.org)
In the canonical Wnt/β-catenin signaling, a Wnt ligand binds to a cell surface receptor complex consisting of the members of Frizzled family and the transmembrane protein LRP 5 and 6 to prevent phosphorylation and degradation of β-catenin by the GSK3β/APC/Axin destruction complex. (oncotarget.com)
Upon nutrient deprivation, autophagy is often up-regulated in response to metabolic stress and excessive organelle damage to facilitate aggregated protein removal and provide energy for cells [ 13 ]. (biomedcentral.com)
2.Resistin Enhances Monocyte Chemoattractant Protein-1 Production in Human Synovial Fibroblasts and Facilitates Monocyte Migration. (mmh.org.tw)

However, the parental line of EMC cells remains indeterminate. (wikipedia.org)
We needed to identify the target of an antibody from a phenotypic screening approach using a difficult iPSC-derived cell line and reached-out to DualSystems and their LRC-TriCEPS technology after an earlier attempt at target deconvolution using an array of membrane targets had failed. (dualsystems.com)
The cell line was established and authenticated by assessing DNA microsatellite short tandem repeats. (cancer-genetics.org)
We pursued this possibility using the Swarm rat chondrosarcoma cell line (RCS-LTC) found to express high levels of P3H2 mRNA. (documents.pub)
P3H1 was identified as the chick homologue of rat leprecan, a glycoprotein, which was first isolated from a rat parietal yolk sac tumor cell line (7). (documents.pub)
All four new cell lines were resistant to methotrexate as determined by inhibition of thymidylate synthase in whole cells and by growth inhibition, as compared with HT-1080, a methotrexate sensitive cell line. (duke.edu)
However, levels of long chain polyglutamates (glu3-5) of methotrexate achieved after a 24-h incubation with this drug were much lower in the four new cell lines as compared to the HT-1080 cell line (5- to 20-fold lower). (duke.edu)

Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)

Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. (nih.gov)
This enzyme is primarily found in the fluid-filled space inside cells (the cytoplasm). (medlineplus.gov)

Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
Now the identified target proteins can be down regulated using siRNA and with Flow-TriCEPS or Tamra-TriCEPS reduced binding is expected of your ligand of interest compared to the wild type cells when the true target is knocked down. (dualsystems.com)
The UPR normally helps secretory cells to resolve issues with 3D shaping of newly synthesized proteins. (gene.com)

Genomic database analyses indicate the presence of three isoenzymes in the vertebrate prolyl 3-hydroxylase family, P3H1, P3H2, and P3H3, encoded by the genes LEPRE1 , LEP- REL1 , and LEPREL2 , respectively, in humans (15). (documents.pub)

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Soft tissue4

Cartilage9

Central chondrosarcoma1

Mutations9

Sarcoma12

IDH13

Gene7

Lesions1

SW13532

Extraskeletal3

Receptors4

Tissues4

Apoptosis5

Malignant3

Large cell carcinoma1

Vitro3

Pathways3

Tissue3

Expression12

Cancer20

Conventional3

Mutation3

Epithelial8

Bone3

Secondary2

Intracranial1

Proliferation2

Progression1

Mechanisms1

NR4A31

Occur1

Collagen3

Intracellular2

Cancers6

Anaplastic1

Species2

Tumor growth1

Molecules3

Distinct3

Grades2

Tumour1

Inhibitor1

Protein4

Line7

Pulmonary1

Cytoplasm2

Proteins3

Genes1