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  • pathogen
  • My laboratory is interested in how microbes influence human health, both in the context of host-pathogen and host-commensal interactions. (duke.edu)
  • cells
  • These observations point out to Chlamydia-mediated manipulation of LDs in infected cells, which may impact the function and thereby the protein composition of these organelles. (duke.edu)
  • We determined that LDs isolated from C. trachomatis-infected cells were enriched in proteins related to lipid metabolism, biosynthesis and LD-specific functions. (duke.edu)
  • pathogenic
  • Infections with the human pathogenic bacterium Chlamydia trachomatis, which can lead to chronic pain or infertility, were analyzed in these models. (hu-berlin.de)
  • Phylogenetic analyses suggested that a plasmid similar to the S. negevensis plasmid was originally acquired by the last common ancestor of all four families and that it was subsequently reduced, integrated into the chromosome, or lost during diversification, ultimately giving rise to the extant virulence-associated plasmid of pathogenic chlamydiae. (nih.gov)
  • primarily infect
  • We identified a surprisingly large core gene set present in all genomes and a high number of diverse accessory genes in those Chlamydiae that do not primarily infect humans or animals, including a chemosensory system in P. acanthamoebae and a type IV secretion system. (nih.gov)
  • vitro
  • The objective of this study was to develop a human urethral 3D in vitro equivalent to gain a better insight into the invasiveness of Ct in host tissue. (bmj.com)
  • Infections
  • We conclude that persistence of oncogenic HPV infections is more likely among women with a previous C. trachomatis infection. (lu.se)
  • Introduction Chlamydia trachomatis (Ct) genovars D-K cause non-invasive urogenital infections, which often remain asymptomatic. (bmj.com)
  • Moreover, these urethral equivalents could successfully be infected by a Ct genovar D strain, making this a promising life model to investigate the human pathogenesis of urogenital Ct infections. (bmj.com)
  • Researchers have used the mouse extensively as a model organism to study the pathogenesis of human infections and found that it imperfectly recapitulates many aspects of infectious disease as seen in patients. (iayork.com)
  • Although 75% of genital infections in women and 95% in men are asymptomatic, up to 40% of untreated cases of C. trachomatis infection in women progress to pelvic inflammatory disease (PID) (3-5) . (annals.org)
  • protein
  • Hence, it could be triggered by a preformed protein that the bacterium translocates into the human cell. (miami.edu)
  • genome
  • Unity in variety--the pan-genome of the Chlamydiae. (nih.gov)
  • Genome size reduction in the Chlamydiae . (nih.gov)
  • The reduction of genome size within the Chlamydiae does not correlate with a decrease in genomic G + C content, an effect observed in other bacterial groups, for example, the Gammaproteobacteria (light gray circles). (nih.gov)
  • Pathways
  • We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a. (napier.ac.uk)
  • it turned out that MCMV can't infect human cells well because its normal ability to disarm the programmed cell death (apoptosis) pathways only works against the mouse versions of the pathway. (iayork.com)
  • Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats. (amedeo.com)
  • mechanism
  • In summary, the findings might describe a novel Chlamydia-mediated HIV-1 reactivation mechanism from latently infected cells. (miami.edu)
  • genes
  • One advantage of using humans as models of their own diseases is that there are an amazing number of well-documented mutations and disease-associated genes in humans. (iayork.com)
  • genomic
  • Some of the most interesting data on Inc proteins has come from Chlamydiales genomic comparisons, where 20 open reading frames were identified for the genus Chlamydia . (asmscience.org)
  • high
  • A cervical sample was obtained for hybrid capture assays for HPV-A (low-oncogenic-risk types), HPV-B (intermediate- and high-oncogenic-risk types), C. trachomatis , and N. gonorrhoeae . (hindawi.com)
  • Via high resolution confocal analysis the infection with C. trachomatis was discovered to trigger profound changes in the epithelial mucosa, causing loss of cell adhesion and polarity. (hu-berlin.de)
  • among
  • The positive rates for HPV-A, C. trachomatis , and N. gonorrhoeae were also significantly higher among the CSW than among the control subjects. (hindawi.com)
  • Davis's suggested solution was, among other things, to start using humans as their own models, taking advantage of the large numbers of humans who are routinely screened and overcoming the lack of experimental control by taking a "systems" approach, including large-scale data collection from healthy and ill people and large-scale informatics as part of the analysis. (iayork.com)