Human cell adult human stem cells. Medical search. Frequent questions

Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
The new technique targets the cytoskeleton - or inner "scaffolding" - of the hPSC to direct their differentiation into pancreatic cells. (medicalnewstoday.com)
However, recent identification of spontaneous cell fusion and limited neuronal differentiation has tempered initial optimism. (ox.ac.uk)
Our results now suggest that 4-MU treatment of MSC not only affects the formation of SG via increased levels of O-linked glycosylation of cellular proteins but also that MSC cultivated under osteogenic stimulation develop SG, which in turn support MSC differentiation into osteogenic precursor cells. (europa.eu)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
If this differentiation of adult stem cells can be controlled in the laboratory, these cells may become the basis of therapies for many serious common diseases. (news-medical.net)
Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
Drs. John B. Gurdon, Irving L. Weissman, and Shinya Yamanaka have been pioneers in studying stem cells and the reprogramming of highly differentiated adult cells into pluripotent cells capable of directing differentiation from a single cell to an adult animal. (brandeis.edu)
More specifically, in patients with encephalitis who have CSF leukocytosis, detection of HHV-6 DNA via PCR (provided the method is sensitive enough) will always occur, complicating differentiation of true disease from ciHHV6 DNA detected in white blood cells of the CSF. (medscape.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)
We generate patient-derived induced pluripotent stem cells (iPSCs) revealing impaired neural differentiation along with dysregulation of genes essential for neurodevelopment. (bvsalud.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
The model also predicts that reprogramming the network from a differentiated state, in particular the endoderm state, into a stem cell state, is best achieved by over-expressing Nanog, rather than by suppression of differentiation genes such as Gata-6. (lu.se)

We may never be able to choose between iPS and ES cell research because we don't know which type of cell will be best for eventual therapies. (sciencedaily.com)
Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies. (hopkinsmedicine.org)
HACK: In their search for regenerative cell therapies that might some day cure Parkinson's, Alzheimer's, and other diseases, scientists have studied adult stem cells found in the hair follicles of mice. (loe.org)
Neural stem cells (NSCs) have generated considerable interest because of their potential as a source of defined cells for drug screening or cell-based therapies for neurodegenerative diseases. (ox.ac.uk)
While most panelists felt that clinical use of pancreatic stem cells as a cure for diabetes was 15-20 years away, they also believed that application of stem cell therapies would likely include spinal cord injuries, Parkinson's disease and dementia. (news-medical.net)
The findings suggest that cell-based therapies might be an effective way to treat human corneal blindness and vision impairment due to the scarring that occurs after infection, trauma and other common eye problems, said senior investigator James L. Funderburgh, Ph.D., associate professor, Department of Ophthalmology. (news-medical.net)
He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. (cshlpress.com)
Experts in the field of regenerative medicine believe one of the first areas of success when using stem cell-derived therapies will be the treatment of macular degeneration, which causes progressive loss of sight, and other retinal diseases. (cnn.com)
His demonstration that the expression of four master regulatory genes was sufficient to cause the reprogramming of adult cells has opened up many possibilities for human stem cell therapies. (brandeis.edu)
NHEJ, unlike HDR, is active in both dividing and nondividing cells, not just dividing cells, which means that it could enable gene therapies that would focus on nondividing adult cells, such as cells of the eye, brain, pancreas, or heart. (genengnews.com)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)

Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
Of all mesenchymal cells, human adipose-derived stem/stromal cells (hADSCs) are more safely and easily accessible, produce more growth factors compared to other mesenchymal stem cells, have the ability to differentiate to various cell lines, secrete high levels of angiogenic factor and their feasibility, safety and efficacy have been confirmed. (ac.ir)
The researchers started out with human pluripotent stem cells, which can differentiate into various cell types. (israel21c.org)
The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
By culturing these multipotent cells with proteins and minerals, Dr. Xu has already gotten the hair follicle stem cells to differentiate into skin, nerve, muscle, bone, cartilage, and fat tissue. (loe.org)
Pluripotent stem cells are an attractive option for researchers from a therapeutic standpoint because they can self-renew in lab cultures and can differentiate into a variety of cell types. (medicalnewstoday.com)
Sites of loosely packed extracellular matrix (ECM) also offer stem and progenitor cell optimal space to proliferate and differentiate. (europa.eu)
Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
They can differentiate into all types of specialized cells in the body. (healthline.com)
The breakthrough has created a way to "de-differentiate" the stem cells. (healthline.com)
MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
Certain kinds of adult stem cells seem to have the ability to differentiate into a number of different cell types, given the right conditions. (news-medical.net)
As stem cells within a developing human embryo differentiate within the cell, their capacity to diversify generally becomes more limited and their ability to generate many differentiated cell types also becomes more restricted. (erlc.com)
By learning how stem cells differentiate and become specialized, scientists hope to gain a better understanding of how cells in general work and what can go wrong. (erlc.com)
Adult stem cells are sometimes referred to as somatic stem cells to differentiate them from human germ cells, sperm cells and egg cells. (erlc.com)
Stem cells are unique due to their ability to limitlessly self-renew and differentiate into each cell type in the adult body. (biolegend.com)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)
The have been applied to both the plant and ani- stem cells possess pluripotential charac- mal kingdoms without even stirring a ripple teristics, and can differentiate into various of concern in international conscience [ 2 ]. (who.int)

In the laboratory of Prof. Jacob Hanna at the Weizmann Institute of Science , researchers created complete models of human embryos from stem cells cultured in a lab grew them up to day 14. (israel21c.org)
Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
Chinese scientists have successfully created chimeric embryos containing a combination of human and pig cells. (bioedge.org)
The issue of research involving stem cells derived from human embryos is increasingly the subject of a national debate and dinner table discussions," said President George W. Bush in a 2001 speech announcing his policy on embryonic stem cell research. (erlc.com)
Where do the embryos for embryonic stem cells come from? (erlc.com)
Currently, all human embryonic stem cell lines in use today were created from embryos generated by IVF. (erlc.com)
Even some people who do not believe that human embryos are deserving of full moral status worry about what the effects of normalizing such practices may have on society. (erlc.com)
Stem cells exist both in embryos and adult cells. (articlecity.com)
Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
In 2000, the National Institutes of Health issued guidelines for the use of embryonic stem cells in research, specifying that scientists receiving federal funds could use only extra embryos that would otherwise be discarded. (cnn.com)
Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)
Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)

The researchers analyzed more than 2,000 scientific papers and found adult stem cells are not replacing human embryonic stems cells in the laboratory. (sciencedaily.com)
The researchers examined stem cell research papers published between 1998 and 2010. (sciencedaily.com)
Of all the cells, mesenchymal stem cells have been and still are of interest to the researchers for use in pre-clinical and clinical studies due to being easily accessible, pluripotency, secretion of numerous growth factors, low risk of immunological rejection, and not having ethical issues for clinical use. (ac.ir)
Therefore, in the last decade, it has received more attention from researchers, compared to other cell sources. (ac.ir)
The researchers reprogrammed the pluripotent stem cells to an earlier (naïve) stage corresponding to day 7 of a natural human embryo, around the time it implants itself in the womb. (israel21c.org)
Prof. Jacob Hanna (center) and his team of researchers working on the development of the stem-cell embryo models. (israel21c.org)
Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)
One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," says Cheng. (hopkinsmedicine.org)
Still, some mistakes or protein damage are inevitable, so the researchers set out to understand how stem cells ensure these proteins are properly discarded. (scitechdaily.com)
When the researchers genetically disabled the aggrephagy pathway, the stem cells started to accumulate aggregated protein, which impaired their fitness, longevity and regenerative activity. (scitechdaily.com)
Researchers have previously used hPSCs to create insulin-producing beta cells. (medicalnewstoday.com)
Targeting this structure allows the researchers to create fewer irrelevant cells and better functioning beta cells that helped control blood sugar. (medicalnewstoday.com)
18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
6 Jun, 2007 07:00 pm Researchers have reprogrammed skin cells into embryonic stem cells. (scitizen.com)
Gould and the researchers reported new neurons in adult marmoset monkeys are added to three neocortical association areas important in cognitive function: the prefrontal, inferior temporal and posterior parietal cortex. (wikipedia.org)
Stem cells collected from human corneas restore transparency and don't trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine. (news-medical.net)
A few years ago, Dr. Funderburgh and other University of Pittsburgh researchers identified stem cells in a layer of the cornea called the stroma, and they recently showed that even after many rounds of expansion in the lab, these cells continued to produce the biochemical components, or matrix, of the cornea. (news-medical.net)
In the next steps, the researchers intend to use the stem cells to treat lab animals that have corneal scars to see if they, too, can be repaired with stem cells. (news-medical.net)
The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
Researchers from the University Medical Centers in Leiden, Utrecht and Rotterdam, jointly affiliated with the "Institute for human organ and Disease Model Technologies (hDMT)," intend to develop new organ and disease models using human stem cells. (umcutrecht.nl)
This funding will be used to establish a national state-of-the-art infrastructure, hDMT INFRA StemCells, that will provide support in setting up and conducting studies on stem cells to all researchers across the Netherlands and beyond. (umcutrecht.nl)
According to hDMT INFRA StemCell researchers, some shortcomings can be overcome by combining these stem cell types. (umcutrecht.nl)
Since the initial discovery of the self-renewing properties of stem cells in the early 1960s - pioneered by a small team of researchers at the Ontario Cancer Institute [3] - the understanding of the power and diversity of stem cells has increased rapidly. (articlecity.com)
In January 2014, researchers announced they had developed a new method of making stem cells: by placing skin cells in an acidic environment. (cnn.com)
iPSCs "can be turned into disease-relevant cells such as nerve cells, allowing researchers to study disease biology in the very types of cells that become affected. (jax.org)
Researchers at Lund University have discovered that a specific group of genetic elements in our DNA influence the development of the human brain, their study was published in Science Advances. (lu.se)
Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. (lu.se)
In Lund, researchers are investigating these repetitive regions of our DNA to understand the role transposable elements play in human brain development and evolution. (lu.se)
To better understand how these repetitive genetic sequences influence brain development, researchers analyzed both fetal and adult brain tissue samples. (lu.se)
Researchers are conducting the first-in-human trial of a universal influenza vaccine candidate, the National Institutes of Health (NIH) announced April 3. (medscape.com)
By focusing on the HA stem, the researchers believe the new vaccine candidate could provide wider and longer-lasting immunity. (medscape.com)
To create the vaccine candidate, researchers used the stem of an H1N1 influenza virus. (medscape.com)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
By triggering certain genes, researchers may be able to cause the stem cells to specialize and become the cells that need to be replaced. (msdmanuals.com)
But researchers think that these stem cells have the most potential for producing different kinds of cells and for surviving after transplantation. (msdmanuals.com)

Discovering a cell type with the highest efficiency and the least side-effects is one of the priorities of scientists active in this field. (ac.ir)
Scientists have managed to create synthetic human embryo models without using egg, sperm or womb, in a feat that could impact research on fertility, tissue growth and drug testing, as well as improve science's understanding of the first weeks of embryonic development. (israel21c.org)
Scientists have isolated adult stem cells in human hair follicles. (loe.org)
Scientists at UC San Diego have discovered that stem cells' unique method of discarding misfolded proteins could hold the key to preserving long-term health and avoiding illness. (scitechdaily.com)
According to a study recently published in the journal Cell Stem Cell , scientists at the University of California San Diego School of Medicine discovered that blood stem cells employ a surprising technique to eliminate their misfolded proteins. (scitechdaily.com)
UC San Diego scientists found misfolded proteins were aggregated and caged into a single area (green) within stem cells before being disposed of. (scitechdaily.com)
Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
Scientists are hoping that the cells can be made from someone's own skin to treat a disease. (healthline.com)
One panelist even added, "If the political hurdle would be removed, I believe there is a lot of pent-up momentum from both scientists and drug companies [for stem cell research]. (news-medical.net)
These findings have led scientists to ask whether adult stem cells could be used for transplants. (news-medical.net)
Since adult stem cells avoid the ethical debate surrounding embryonic stem cells , most scientists on the panel feel more comfortable pursuing this line of research. (news-medical.net)
Scientists at Columbia University have created part of a human jaw joint by growing human adult stem cells on a tissue scaffold. (bioedge.org)
Scientists view stem cells as a possible gateway to curing many medical conditions, from Parkinson's disease to diabetes. (cnn.com)
In February 2012, early research published by scientists at Cedars-Sinai Medical Center and Johns Hopkins University showed that a patient's own stem cells can be used to regenerate heart tissue and help undo damage caused by a heart attack. (cnn.com)
Use of human iPSCs in dementia research has revolutionized the way scientists study disease biology, Ward says. (jax.org)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)
Scientists are developing ways of enabling (inducing) other cells (such as a blood or skin cell) to act as stem cells. (msdmanuals.com)

Pluripotent stem cells are those capable of differentiating into any type of tissue, hence the attractiveness of embryonic stem cells, or hESCs, also called ES cells, which are also pluripotent. (sciencedaily.com)
The project now has a consistent source of human dermis tissue from which stem cells can be isolated. (ca.gov)
Comparing animal skin and human skin showed notable differences, including morphology, response to enzymatic digestion, and the rate at which cells attach to tissue culture plastic. (ca.gov)
8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
Ethical and practical considerations limit the availability of human fetal-derived neural tissue and highlight the need to consider alternative sources of human NSCs. (ox.ac.uk)
Stem cells are essential for regeneration and repair of worn-out or injured tissue. (europa.eu)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
Human skin completely renews itself every month thanks to the presence of stem cells in the deepest layer, which generate all the upper layers of this tissue. (cea.fr)
The discoveries of a French research team from the CEA, INSERM and the University of Paris, produced in collaboration with I-Stem, the AFM-Téléthon laboratory, and the University of Évry, opens perspectives for regenerative cutaneous medicine, in particular for the bio-engineering of skin grafts for tissue reconstruction. (cea.fr)
In the future, keratinocytes produced from pluripotent stem cells could be an alternative to adult stem cells in certain reconstructed tissue bio-engineering applications. (cea.fr)
Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
Adult stem cells, from bone marrow, umbilical cord blood, nasal tissue, and even fat, have a flexibility that can be harnessed in treatment regimens transcending their tissue of origin. (cbc-network.org)
These were seeded into a tissue scaffold which had been formed into the precise shape of the human jaw bone by using digital images. (bioedge.org)
The Pitt corneal stem cells were able to remodel scar-like tissue back to normal. (news-medical.net)
Mice that lack the ability to produce lumican develop opaque areas of their corneas comparable to the scar tissue that human eyes form in response to trauma and inflammation, Dr. Funderburgh said. (news-medical.net)
Several kinds of experiments indicated that the human cells were alive and making lumican, and that the tissue had rebuilt properly," Dr. Funderburgh noted. (news-medical.net)
With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
This volume is therefore an indispensable reference for molecular, cell, and developmental biologists, as well as anyone wishing to explore the possibilities of stem cells in regenerative medicine and tissue engineering. (cshlpress.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)

Moreover, tranylcypromine treatment affects neurons and astrocytes, which impairs cell density and arrangement. (frontiersin.org)
The new neurons appeared to originate in the subventricular zone, where stem cells giving rise to other cell types are located. (wikipedia.org)
Several 1962 papers revealed the research at MIT by Joseph Altman claiming that adult rats, cats, and guinea pigs all formed new neurons. (wikipedia.org)
Kaplan is reported as remembering Rakic telling him that "Those [cells] may look like neurons in New Mexico, but they don't in New Haven. (wikipedia.org)
She demonstrated that adult marmosets created new neurons in their brains, especially in the olfactory cortex and the hippocampus. (wikipedia.org)
Gould's laboratory at Princeton studies the production of new neurons in the early postnatal and adult mammalian brain. (wikipedia.org)
Gould and her team are also endeavoring to discover how hormones modulate the production of new neurons and how experience affects new cell production and if so, through what underlying mechanisms. (wikipedia.org)
With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
In this image of the adult mouse brain, cell nuclei are blue and genome-edited neurons are green. (genengnews.com)
Based on clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) technology, here we devise a homology-independent targeted integration (HITI) strategy, which allows for robust DNA knock-in in both dividing and non-dividing cells in vitro and, more importantly, in vivo (for example, in neurons of postnatal mammals)," wrote the authors of the Nature article. (genengnews.com)
First, HITI components were brought to neurons derived from human embryonic stem cells. (genengnews.com)
Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. (lu.se)
Using single cell RNA sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons with high similarity to those in developing and adult human midbrain. (lu.se)
Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)

Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes. (wjgnet.com)
A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)

Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)

MSCs can be differentiated along different cell lineages of mesodermal origin including osteoblasts, chondrocytes, skeletal myocytes or visceral stromal cells 9 . (nature.com)
Human Adipose-Derived Stem/Stromal Cells from Children or Adults? (ac.ir)
Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
The cornea and its stromal stem cells themselves appear to be "immune privileged," meaning they don't trigger a significant immune response even when transplanted across species, as in the Pitt experiments. (news-medical.net)
We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. (jcancer.org)
Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into athymic nude mice. (jcancer.org)
The C-Kit inhibitor, imatinib mesylate, was administrated to confirm the effect of stromal cells on the tumorigenesis. (jcancer.org)
The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
In contrast, the data was significantly lower with DU145 and stromal cells from TZ than DU145 alone. (jcancer.org)
The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
These effects of the stromal cells in the PZ on DU145 cells could be blocked using imatinib mesylate. (jcancer.org)
in contrast, the stromal cells in the TZ inhibit it through down-regulating the expression of C-Kit. (jcancer.org)

The deciphering of genes that regulate stemness remains an enigma that is only partially resolved, in particular for human skin. (cea.fr)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)
Expression of top 10 differentially expressed genes (DEGs) of Cluster1 in Figure 1B and classic spermatogonial stem cell (SSC) and SPG markers in adult human germ cells. (elifesciences.org)
A proof-of-concept study has shown that a new genome-editing approach not only works in nondividing cells, it also allows for the efficient and targeted insertion of genes when it is used in animal models. (genengnews.com)
We now have a technology that allows us to modify the DNA of nondividing cells, to fix broken genes in the brain, heart, and liver," noted Dr. Izpisua Belmonte. (genengnews.com)
Thanks to human induced pluripotent stem cell (iPSC) and gene-editing technologies, it's possible to derive every kind of brain cell type, insert dementia -related genes and study them in culture. (jax.org)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
One way to induce these cells is to inject them with material that affects their genes, a process called reprogramming. (msdmanuals.com)

Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
In vitro assays have also been performed to assess whether the lentiviral vector could potentially transform cells. (ca.gov)
These results show that human brain organoids can be applied as an in vitro model for CNS drug screening to evaluate structural, cellular, and molecular changes in the normal brains or brains of patients with neuropsychiatric disorders after drug treatments. (frontiersin.org)
Compared with conventional mice model, this model can recapitulate the human brain development in vitro ( 20 ). (frontiersin.org)
The cerebral organoids, which can mimic the endogenous development of human brain, have been applied to different studies as in vitro models for a wide range of brain diseases ( 16 , 21 , 22 ). (frontiersin.org)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)

In addition to NSF, this research was funded by grants from the National Institutes of Health, and the Stanford Institute for Stem Cell Biology and Regenerative Medicine. (sciencedaily.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. (cshlpress.com)
Dr. Irving L. Weissman is professor of pathology and developmental biology at the Stanford University School of Medicine , where he is director of the Institute of Stem Cell Biology and Regenerative Medicine. (brandeis.edu)
At the core of the network reside Oct4, Sox2 and Nanog, into embryonic stem cells [1,2,3,4,5], have made major inroads which form a self-organized core of the TFs maintaining into stem cell biology. (lu.se)

These multipotent stem cells contain certain proteins - called markers - that have previously been found only in embryonic stem cells. (loe.org)
Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)

Autologous transplantation of hADSCs is only the best choice in ages that these cells have the optimum efficacy. (ac.ir)
For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
These stem cells are most often used for transplantation. (msdmanuals.com)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)

This expansion phase involves a risk: it may be accompanied by a quantitative loss or degradation of stem cells, leading to a loss of regenerative potential. (cea.fr)
If stem cells can be used to produce new and differentiated cells that are damaged because of disease (such as Parkinson's disease) or injury (e.g., spinal cord damage), it would transform regenerative medicine. (erlc.com)
Given their plasticity and regenerative abilities, stem cells provide opportunities for treating human diseases such as diabetes. (cshlpress.com)
Such an approach is highly relevant to regenerative medicine since it allows for a rapid search over the host of possibilities for reprogramming to a stem cell state. (lu.se)

Pancreatic islets are groups of cells located in the pancreas. (medicalnewstoday.com)
The panel was responding to recently published research where pancreatic insulin-producing islet cells were discovered in mice. (news-medical.net)
Methylcellulose colony assay and single-cell micro-manipulation reveal progenitor-like cells in adult human pancreatic ducts. (harvard.edu)

UC San Diego researcher Robert Signer, Ph.D., describes how stem cells contribute to aging and age-related diseases. (scitechdaily.com)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
2. University of Évry, University of Paris-Saclay, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), 91100 Corbeil Essonne, France. (cea.fr)
3. Centre for the Study of Stem Cells (CECS), Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I Stem), 91100 Corbeil Essonne, France. (cea.fr)
More knowledge on how disease affects specific tissues in the human body is essential, so that instead of treating symptoms, the actual causes of diseases can be addressed much more specifically. (umcutrecht.nl)
However, the process of making iPSCs from patients with these diseases, and the subsequent genetic engineering of the cell lines, is "difficult, expensive and time consuming," says Ward. (jax.org)

Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
Gould and her colleagues found that the ovarian steroid estrogen enhances cell proliferation in the dentate gyrus of the adult rat. (wikipedia.org)
They discovered that cell proliferation peaks during proestrus, a time when estrogen levels are highest. (wikipedia.org)
Also and conversely, steroid hormones of the adrenal glands were found to inhibit cell proliferation in the dentate gyrus but do so indirectly via an NMDA receptor-dependent mechanism. (wikipedia.org)
Gould's research has shown that exposure of aversive stimuli results in a decrease in cell proliferation in the dentate gyrus of adult rats, tree shrews and marmoset monkeys. (wikipedia.org)
The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
Patient lymphoblasts show impaired cell survival, proliferation, and hypersensitivity to oxidative stress. (bvsalud.org)

Cord blood stem cells are harvested from the umbilical cord after childbirth. (healthline.com)
Cord blood stem cells have successfully treated sickle cell anemia. (cbc-network.org)
President Bush vetoed the overhyped embryo research bill, and also greeted Ryan Schneider, treated for cerebral palsy with cord blood stem cells and now symptom-free according to his mother, and Stephen Sprague and Nathan Salley, leukemia-free. (cbc-network.org)

By 2010, some 161 of 574 or 28 percent of papers reported on studies of both cell technologies, and 62.1 percent of those papers paired adult and embryonic cell lines. (sciencedaily.com)

Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
Second, stem cells may prove to be an indispensable source of transplantable cells and tissues for repair and regeneration. (erlc.com)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)

A preclinical study is also ongoing in mice to assess the safety of combining the gene-modified T cells and stem cells in mice. (ca.gov)
The insulin-producing cells created 'rapidly cured' type 1 diabetes in mice, and the benefits lasted for 9 months. (medicalnewstoday.com)
Millman and team transplanted "islet-sized aggregates" of beta cells differentiated from hPSC into mice with type 1 diabetes. (medicalnewstoday.com)
The new stem cell protocol "can rapidly cure preexisting diabetes in mice," they emphasize later on. (medicalnewstoday.com)
We were able to make more beta cells, and those cells functioned better in the mice, some of which remained cured for more than a year. (medicalnewstoday.com)
These mice had very severe diabetes with blood sugar readings of more than 500 milligrams per deciliter of blood (mg/dL)- levels that could be fatal for a person - and when we gave the mice the insulin-secreting cells, within 2 weeks their blood glucose levels had returned to normal and stayed that way for many months. (medicalnewstoday.com)
RUNX1-deficient mice fail to generate hematopoietic stem cells. (biolegend.com)
D ) Immunostaining for ZBTB16 (red), FOXC2 (green), and DAPI (blue) in testicular paraffin sections from wild-type adult C57 mice. (elifesciences.org)
F ) Immunostainings for MKI67 (red), FOXC2 (green), and DAPI (blue) in adult mice testis and the proportion of MKI67 + cells in FOXC2 + population (n=10). (elifesciences.org)
Validation and characterization of the magnetic-activated cell sorting (MACS)-sorted THY1 + undifferentiated spermatogonia (uSPG) from wild-type adult C57 mice. (elifesciences.org)
B ) Immunostainings for LIN28A (red), DAPI (blue), and newly found markers (green) in testicular paraffin sections from adult mice. (elifesciences.org)
In 1988 he first identified and isolated the blood-forming stem cells from mice and went on to define the stages of development between the stem cells and differentiated cells of the immune system. (brandeis.edu)
Then they were brought to the brains of adult mice. (genengnews.com)
Protocol for xenotransplantation of human skin and streptozotocin diabetes induction in immunodeficient mice to study impaired wound healing. (harvard.edu)

Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. (ox.ac.uk)

27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)

Cookson, a cell biologist who studies the underlying pathways that lead to Parkinson's disease and related disorders, explains that a typical iPSC project would involve reverting a cell line from a patient with a given mutation back to the wild-type (or "normal") sequence, to compare the two. (jax.org)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

This Development Candidate Feasibility Award is a first step toward the overall goal of developing a cell-based cartilage repair therapy using stem cells derived from the skin. (ca.gov)
The therapy would consist of using a skin biopsy to harvest dermis-isolated, adult stem cells (DIAS cells), which will undergo processing to yield neocartilage. (ca.gov)
A strategy in the treatment of cancer by harnessing the immune system, called adoptive cell therapy, is to use an individual's own immune cells (T cells) and genetically modify them to target them to kill the cancer. (ca.gov)
This work has been extended to other types of cells of interest for cutaneous cell therapy. (cea.fr)
this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)
This is expected to provide much better insight into the response of the human body to therapy in the future. (umcutrecht.nl)
In May 2011, stem cell therapy in sports medicine was spotlighted after New York Yankees pitcher Bartolo Colon was revealed to have had fat and bone marrow stem cells injected into his injured elbow and shoulder while in the Dominican Republic. (cnn.com)
He was the first to appreciate the therapeutic potential of stem cell therapy and has pioneered its development. (brandeis.edu)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

Previous research has pointed to human pluripotent stem cells (hPSCs) as a potential therapeutic avenue for type 1 diabetes. (medicalnewstoday.com)
The ability to generate almost limitless numbers of neural precursors from a readily accessible autologous adult human source provides a platform for further studies and potentially has important therapeutic implications. (ox.ac.uk)
We investigated the feasibility of intracerebral implantation of the allogeneic human neural stem cell line CTX0E03 in the subacute-chronic recovery phase of stroke and potential measures of therapeutic response in a multicentre study. (nih.gov)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)

The patient's own white blood cells and stem cells from their blood are modified in the laboratory using genetic techniques to express a specific receptor against cancer cells. (ca.gov)
Gene modification of cells involves the transfer of foreign genetic material (DNA) into a cell, in this case the immune system cells and stem cells. (ca.gov)
10 Oct, 2007 12:18 pm The field of functional genomics explores the various functions of genetic sequences within the human genome. (scitizen.com)
Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
However, animal models lack human genetic features and some brain region identities, such as outer subventricular zone, making it hard to figure out how these drugs affect central nervous system ( 7 , 8 ). (frontiersin.org)
Moreover, 3D human brain organoids show great potential to investigating psychiatric disease origin and pathology, as well as drug screening and genetic modifications ( 19 ). (frontiersin.org)
These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)
Induced pluripotent stem cells, which harness the power of genetic reprogramming - basically, the altering of a cell's DNA - to change the course of cellular development. (articlecity.com)
In 1962 he made the stunning observation that it was possible to take a differentiated adult cell from a frog and to re-set its genetic program so that the reprogrammed nucleus could be implanted in an enucleated egg and direct the development of tadpoles. (brandeis.edu)
HITI looks particularly promising because it opens a largely unused pathway to the targeted genetic revision of live adult organisms. (genengnews.com)
By isolating and reprogramming brain cells with dementia-causing genetic mutations, a team at JAX offers a powerful new research tool. (jax.org)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
Johan Jakobsson, a professor at Lund University and research group leader at Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

A closeup of a microscope slide taken in 2000 at the Reproductive Genetics Institute's Chicago laboratory shows transplanted stem cells taken from the umbilical cord blood of a baby named Adam Nash. (cnn.com)
Molly received a stem cell transplant from stem cells from Adam's umbilical cord. (cnn.com)
Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)
Stem cells can be obtained from the blood in the umbilical cord or placenta after a baby is born. (msdmanuals.com)

These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
Skarnes and the Cellular Engineering laboratory at The Jackson Laboratory for Genomic Medicine in Farmington, Conn., recently established improved techniques for introducing single -nucleotide variants in human iPSCs via CRISPR/Cas9. (jax.org)
Unlike embryonic stem cells, iPSCs are derived from adult human cells. (jax.org)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)

Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)

H ) t-SNE plot of germ cells in adult human testis (GSE112013), colored by germ cell type. (elifesciences.org)
Feature plot showing the expression patterns of FOXC2 and MKI67 in human germ cells. (elifesciences.org)
I ) The developmental trajectory of the human germ cells, colored by germ cell type, FOXC2 expression cells (red), or MKI67 expression cells (red). (elifesciences.org)
C ) Feature plots showing the expression pattern of classic SSCs and SPG markers in adult human germ cells. (elifesciences.org)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)
Reproductive cloning versus germ cell (egg, ovum). (who.int)

In the bone marrow MSC share the niche with haematopoietic stem cells (HSC). (europa.eu)

Her laboratory explores issues related to the regulation of cell production and survival in three brain regions the hippocampus, the olfactory bulb and the neocortex in rodents and primates (marmosets and macaques). (wikipedia.org)
A stem cell line is a family of constantly dividing cells, the product of a single group of stem cells, which can be grown indefinitely in the laboratory. (erlc.com)
Above, a human stem cell colony, which is no more than 1 millimeter wide and comprises thousands of individual stem cells, grows on mouse embryonic fibroblast in a research laboratory in September 2001. (cnn.com)
Above, dozens of packages containing frozen embryonic stem cells remain in liquid nitrogen in a laboratory at the University of Sao Paulo's human genome research center in Sao Paulo, Brazil, in March 2008. (cnn.com)
His laboratory has also identified human stem cells including human leukemia stem cells that have helped to form the concept of cancer stem cells. (brandeis.edu)

As a result, induced pluripotent stem cells do not offer an easy solution to the difficult ethical questions surrounding embryonic stem cell research," he says. (sciencedaily.com)
Our stem cell-derived human embryo model offers an ethical and accessible way of peering into this box. (israel21c.org)
Ethical Stem Cell Breakthrough! (scitizen.com)
Adult stem cells don't present any ethical problems. (healthline.com)
The panelists acknowledged the current ethical concerns surrounding stem cell research, but most felt that the impediments to research put in place by the current administration were unfortunate, and that science preceded ethics on most issues. (news-medical.net)
Adult human stem cells should have less controversy compared to embryonic human stem cells in terms of ethical issues. (news-medical.net)
This type of stem cell is very versatile and has a wide range of uses, though procuring them entails medical and ethical challenges. (articlecity.com)
The use of the technique of nuclear transfer for reproduction of human beings is surrounded by strong ethical concerns and controversies and is considered a threat to human dignity. (who.int)
This technique is surrounded by strong ethical concerns and is considered a threat to human dignity. (who.int)

A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

These cells have been described as embryonic stem cells (ESCs) and. (scitizen.com)
Embryonic stem cells (ESCs) are stem cells that have been taken from the inner cell mass of a blastocyst, an embryo of about 150 cells that has not yet implanted into a woman's uterus. (erlc.com)

Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)

Previous work showed that stem cells, including HSCs, synthesize proteins much slower than other cell types, prioritizing quality over quantity. (scitechdaily.com)
This helps them make fewer mistakes in the process, as misfolded proteins can become toxic to cells if allowed to build up. (scitechdaily.com)
In most cells, damaged or misfolded proteins get individually tagged for disposal. (scitechdaily.com)
This left the team puzzled: if getting rid of damaged proteins is so important to stem cells, why is the proteasome less active? (scitechdaily.com)
A main advantage of the proteasome method is that it breaks proteins down immediately, producing amino acids that the cell can reuse to build new proteins. (scitechdaily.com)
But stem cells are less interested in building new proteins. (scitechdaily.com)
Thus the authors suggest that by storing a collection of damaged proteins in one place, stem cells may be creating their own cache of resources that can be used at a later time when they are actually needed, such as after an injury or when it is time to regenerate. (scitechdaily.com)
The authors suggest that stem cells' inability to efficiently destroy misfolded proteins during aging is likely a key contributing factor to their declining function and the resulting age-related disorders. (scitechdaily.com)
Previously, we would identify various proteins and factors and sprinkle them on the cells to see what would happen. (medicalnewstoday.com)
By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)

25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)

He notes the science behind adult stem cells that can be "reprogrammed," called human induced pluripotent stem cells (hiPSCs), is still in its infancy, having become widely available in 2007. (sciencedaily.com)

The ability to grow millions of the cells in the lab could make it possible to create an off-the-shelf product, which would be especially useful in countries that have limited medical and surgical resources but a great burden of eye disease due to infections and trauma. (news-medical.net)
Advocates of ESC research, however, argue that it is unethical to impede potential advances that could heal disease and relieve the suffering of fully developed human beings. (erlc.com)
This makes it possible to develop new and better organ and disease models that can accurately mimic the pathology and physiology of the human body," said Christine Mummery. (umcutrecht.nl)
We are delighted to be part of this groundbreaking NIH-funded effort to establish a community resource of human disease models of neurodegenerative disease," Skarnes says. (jax.org)
He adds that by engineering disease-causing mutations in a set of genetically diverse iPS cells, "the project is designed to ensure reproducibility of data across laboratories and to explore the effect of natural variation in dementia. (jax.org)
Human herpesvirus 6 (HHV-6) is a herpesvirus that causes roseola infantum (or exanthema subitum [sixth disease]) in infants and children. (medscape.com)
Notably, no human disease models are available to explore the pathological impact of OXR1 deficiency. (bvsalud.org)
However, patient-derived cells may be more prone to develop disease-associated pathology after grafting. (lu.se)

It's critical to mix in the right kinds of cells at the beginning, which can only be derived from naïve stem cells that have no developmental restrictions. (israel21c.org)
RESULTS: We report a novel loss-of-function mutation in the TLDc domain of the human OXR1 gene, resulting in early-onset epilepsy, developmental delay, cognitive disabilities, and cerebellar atrophy. (bvsalud.org)

Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)

The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)
In this study, we demonstrate the monoclonal neural and mesodermal potential of adult human bone marrow mesenchymal cells. (ox.ac.uk)
Human neural stem cell implantation may offer improved recovery from stroke. (nih.gov)
Administration of human neural stem cells by intracerebral implantation is feasible in a multicentre study. (nih.gov)

Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. (lu.se)
We model the function of OXR1 in early human brain development using patient-derived brain organoids revealing that OXR1 contributes to the spatial-temporal regulation of histone arginine methylation in specific brain regions. (bvsalud.org)

Identification of the FOXC2 + spermatogonial stem cells (SSCs) in adult mouse and human testis. (elifesciences.org)
They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. (cshlpress.com)

Our emerging clinical data demonstrates that these gene-modified T cells are very active in killing tumor cells initially, but they lose their ability to function within a few weeks. (ca.gov)
Under the auspices of UPMC Eye Center's recently established Center for Vision Restoration, they plan also to develop the necessary protocols to enable clinical testing of the cells. (news-medical.net)
In November 2010, William Caldwell, CEO of Advanced Cell Technology, said the FDA had granted approval for his company to start a clinical trial using cells grown from human embryonic stem cells. (cnn.com)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)

Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
Stem cells have two unique characteristics: (1) an almost unlimited capacity for self-renewal (they can theoretically divide without limit to replenish other cells for as long as the person is alive) and (2) they retain the potential to produce differentiated and specialized cell types. (erlc.com)
Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
Background: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. (lu.se)

Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)
Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights. (cshlpress.com)
Stomach-derived human insulin-secreting organoids restore glucose homeostasis. (harvard.edu)
We therefore designed bioengineered ventral midbrain organoids supported by recombinant spider-silk microfibers functionalized with full-length human laminin. (lu.se)
We show that silk organoids reproduce key molecular aspects of dopamine neurogenesis and reduce inter-organoid variability in terms of cell type composition and dopamine neuron formation. (lu.se)

Lead researcher Dr Gordana Vunjak-Novakovic told the BBC: 'The availability of personalised bone grafts engineered from the patient's own stem cells would revolutionise the way we currently treat these defects. (bioedge.org)

A particular stem cell type in the adult human-being is the 'Mesenchymal stem cell' (MSC). (europa.eu)

Anatomy60

Organisms13

Diseases8

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes62

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Named Groups1

Health Care2

Differentiation19

Therapies16

Differentiate22

Embryos16

Researchers38

Scientists21

Tissue33

Neurons24

Induced pluripotent stem cell-deriv2

Hematopoietic stem and progenitor cells2

Stromal12

Genes10

Vitro7

Biology4

Multipotent stem2

Transplantation6

Regenerative4

Pancreatic3

Diseases6

Proliferation7

Blood stem cells3

Embryonic cell lines1

Regeneration3

Mice14

Bone marrow derived1

Tissues in the huma1

Parkinson's2

Therapy10

Therapeutic6

Somatic cell3

Genetic14

Umbilical4

IPSCs5

MSCs1

Germ6

Haematopoietic stem1

Laboratory5

Ethical9

20161

ESCs2

Sickle cell a1

Proteins10

Research using stem1

Called human induced1

Disease8

Developmental2

Cartilage1

Neural4

Brain organoids2

Testis2

Clinical4

Self-renewal4

Organoids5

Patient's1

Type in the adult1