• Calcium-binding protein 1 which is a neuron -specific member of the calmodulin (CaM) superfamily which modulates Ca2+-dependent activity of inositol trisphosphate receptors (InsP3RS). (wikipedia.org)
  • This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. (wikipedia.org)
  • This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. (nih.gov)
  • NCS1 regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. (prospecbio.com)
  • According to the most current studies, the most important CBP (Calcium Binding Protein) in the human body is Calmodulin. (lcngrain.com)
  • The Battle for the EF-Hand: Magnesium-Calcium Interference in Calmodulin. (lu.se)
  • Full length human recombinant protein of human ANXA1 produced in HEK293T cell. (thermofisher.com)
  • We have now shown the dissociation constant for this site to be approximately 160 microM in a recombinant protein fragment consisting of residues 1-85 in human fIX. (lu.se)
  • Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation. (cdc.gov)
  • Intracellular psoriasin has been found to interact with various signalling proteins, including the nuclear factor (NF)-kB regulator Jab1, while secreted psoriasin functions as an antimicrobial peptide and has the ability to induce chemotaxis of neutrophils and T cells (6). (medicaljournals.se)
  • Cyclosporine binds to cyclophilin, an intracellular protein, which, in turn, prevents formation of interleukin 2 and the subsequent recruitment of activated T cells. (medscape.com)
  • Both extracellular and intracellular calcium concentrations are tightly regulated by bidirectional calcium transport across the plasma membrane of cells and intracellular organelles, such as the endoplasmic reticulum, the sarcoplasmic reticulum of muscle cells, and the mitochondria. (msdmanuals.com)
  • Calcium is also involved in the action of other intracellular messengers, such as cAMP (cyclic adenosine monophosphate) and inositol 1,4,5-triphosphate, and thus mediates the cellular response to numerous hormones, including epinephrine , glucagon , vasopressin (antidiuretic hormone), secretin , and cholecystokinin. (msdmanuals.com)
  • Despite its important intracellular roles, about 99% of body calcium is in bone, mainly as hydroxyapatite crystals. (msdmanuals.com)
  • Both S100β and PTCH1 cells were present in human vessels while S100β cells were enriched in arteriosclerotic lesions. (dcu.ie)
  • Recombinant SHh promoted myogenic differentiation of human induced pluripotent stem cell-derived S100β neuroectoderm progenitors in vitro. (dcu.ie)
  • S100 calcium-binding protein A5 ( S100A5 ) is a protein that in humans is encoded by the S100A5 gene . (wn.com)
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (wn.com)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wn.com)
  • This protein has a Ca 2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. (wn.com)
  • We can also express that CaBP1 may regulate Ca2+ dependent activity of InSP3Rs by promoting structural contacts between suppressor and core domains but has no effect on INsP3 binding to the receptor. (wikipedia.org)
  • This interaction occurs in calcium dependent manner after the Synaptic NMDA receptor stimulation and thus this prevents nuclear import of NSMF. (wikipedia.org)
  • This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. (wikipedia.org)
  • We later identified PIAS (protein inhibitor of activated STAT)xalpha as a DJ-1-binding protein, and found that DJ-1 restored androgen receptor (AR) transcription activity that was repressed by PIASxalpha. (nih.gov)
  • Now, Boston area scientists have found that this occurs because mutations in the LDL receptor prevent the protein from folding into its normal shape. (mit.edu)
  • Based on these data and other biochemical information, researchers speculate that the mutations in the LDL receptor affect the receptor's ability to bind calcium and therefore its ability to fold into its proper shape. (mit.edu)
  • We have shown previously that extracellular psoriasin binds to the receptor for advanced glycation end products (RAGE), promoting endothelial cell proliferation (8). (medicaljournals.se)
  • It blocks the effects of TNF-alpha by inhibiting receptor binding. (medscape.com)
  • CaBP1 And CaM both bind to IQ-domain in the cytoplasmic C-terminal domain. (wikipedia.org)
  • KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. (fishersci.com)
  • Allograft inflammatory factor-1 (AIF-1 or Iba1) is a 17kDa cytoplasmic, cytokine-induced, calcium-binding protein first discovered in rat cardiac allografts with chronic rejection. (ihcworld.com)
  • Enables kinase binding activity and protein serine/threonine kinase activator activity. (nih.gov)
  • This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. (thermofisher.com)
  • The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. (medicaljournals.se)
  • Pregnancy is characterized by physiologic changes in mineral metabolism, to allow calcium accretion in the fetal skeleton [ 1-3] . (who.int)
  • Here, we analyzed rat and human spinal cord, combining in situ hybridization and immunohistochemistry, complementing newly collated data on mouse spinal cord for direct comparisons. (scilifelab.se)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. (medlineplus.gov)
  • mechanics (QM), in particular the Schr ¨odinger equation, allow us different proteins, e.g. alcohol dehydrogenase, blue copper proteins, to calculate any measurable property of a defined set of atoms. (lu.se)
  • A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown [ ( PUBMED:2288911 ) ( PUBMED:6334307 ) ( PUBMED:3534958 ) ( PUBMED:6607417 ) ( PUBMED:3282918 ) ] to be present in a large number of membrane-bound and extracellular, mostly animal, proteins. (embl.de)
  • About 1% of bone calcium is freely exchangeable with the extracellular fluid and, therefore, is available for buffering changes in calcium balance. (msdmanuals.com)
  • The related protein neuronal calcium sensor-1did not get affected on the [Ca2+] responses to agonist stimulation. (wikipedia.org)
  • Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. (scilifelab.se)
  • Neuronal calcium-binding protein 1 and -2 (NECAB1/2) localize to multiple excitatory neuron populations in the mouse spinal cord. (scilifelab.se)
  • Thus, our study suggests that the phenotypic segregation of NECAB1 and -2 to respective excitatory and inhibitory spinal systems can underpin functional modalities in determining the fidelity of synaptic neurotransmission and neuronal responsiveness, and might bear translational relevance to humans. (scilifelab.se)
  • Neuronal Calcium Sensor 1 213 a.a. (prospecbio.com)
  • NCS1 is part of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed primarily in neurons. (prospecbio.com)
  • A basic difference between HD pathology in human and tgHD51 rats is in the rate of NDP progression that originates primarily from slow neuronal degeneration consequently resulting in lesser extent of concomitant reactive gliosis in the brain of tgHD51 rats. (hindawi.com)
  • MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. (nih.gov)
  • The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. (wikipedia.org)
  • AIF-1 is a marker of human microglia and is expressed by macrophages in injured skeletal muscle and regulates reduced proliferation and differentiation of satellite cells. (ihcworld.com)
  • Mutations of the IQ-Domain that weakens this two protein binding, stops the functional effect of CaM but not CaBP1. (wikipedia.org)
  • The discovery of inactivating mutations in the BRCA1-associated protein 1 gene in sporadic and hereditary mesothelioma has opened up a variety of novel molecular, clinical, and diagnostic investigations. (nih.gov)
  • SwissProt sequences and OMIM curated human diseases associated with missense mutations within the EGF_CA domain. (embl.de)
  • SMOC1 gene mutations often result in a nonfunctional SMOC-1 protein. (medlineplus.gov)
  • Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. (medlineplus.gov)
  • Each of two mutations, V46E and Q50E, made to investigate whether the extra negative charge would increase the affinity of the calcium binding site manifested a negligible increase in affinity. (lu.se)
  • They can act as transport proteins, regulator proteins, or activator proteins. (rush.edu)
  • The proteins S100A8 and S100A9 form a heterodimer called calprotectin . (wn.com)
  • Infliximab is a tumor necrosis factor (TNF) antagonist that is a chimeric human-murine monoclonal antibody. (medscape.com)
  • Calcium-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Deregulated Expression of ANXA1 in Human. (pathologika.com)
  • Now, researchers in Whitehead Institute Member Richard Young's lab find that many transcription factors can also bind RNA, which fine tunes their regulation of gene expression, suggesting new therapeutic opportunities. (mit.edu)
  • Secreted modular calcium binding protein 1 (SMOC1) is an osteonectin/SPARC associated matricellular protein, whose expression is regulated by miR-223. (ncbcs.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Yasuo Fukuuchi, MD (2001) Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain. (ihcworld.com)
  • This dataset is a manually curated database of genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in mammals that reflect current knowledge of the genetics of human aging and longevity. (johnsnowlabs.com)
  • This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. (assaysolution.com)
  • Theoretical splicing for expression of viral protein (VP) 1 is shown. (cdc.gov)
  • All proteins are strings of amino acids that must fold into a unique shape to perform their function. (mit.edu)
  • SRI Human Recombinant fused with a 23 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 221 amino acids (1-198 a.a.) and having a molecular mass of 24.1kDa. (prospecbio.com)
  • Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a) and having a molecular mass of 24.3kDa. (prospecbio.com)
  • Myopathy and Rhabdomyolysis: Risks increase when higher doses are used concomitantly with cyclosporine and strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, human immunodeficiency virus (HIV) or hepatitis C virus (HCV) protease inhibitors). (nih.gov)
  • The toxic effects of lead result from its interference with the physiologic actions of calcium, zinc, and iron, through the inhibition of certain enzymes, and through binding to ion channels and regulatory proteins. (cdc.gov)
  • This negative surface provides binding sites for enzymes and cofactors of the coagulation system, resulting in the formation of a clot (secondary hemostasis). (medscape.com)
  • The alignment of the PLA2 regions of representatives of 5 protoparvovirus species show the calcium-binding region and catalytic residues in Tusavirus. (cdc.gov)
  • B) Phylogenetic trees generated with nonstructural protein (NS) 1 and VP1 of Tusavirus and of the 5 International Committee on Taxonomy of Viruses-designated species in the Protoparvovirus genus. (cdc.gov)
  • Urine appears to be the major route of excretion, with a urine:fecal ratio of approximately 3:1 in humans. (cdc.gov)
  • Calcium balance is maintained through renal calcium excretion averaging 200 mg/day, which also depends on circulating PTH and calcitonin levels. (msdmanuals.com)
  • There is insufficient information on the excretion of hyoscine butylbromide and its metabolites in human milk. (janusinfo.se)
  • In contrast, the human lens protein gammaS-crystallin, which contains defunct calcim-binding sites binding sites, does not bind any divalent cations and aggregates readily in the presence of zinc. (uci.edu)
  • Lead absorption is augmented when iron, zinc, and/or calcium deficiency is also present. (medscape.com)
  • Df1 /+ mice have a multi-gene deletion analogous to the chromosomal microdeletion that causes human 22q11.2DS, and like human 22q11.2DS patients exhibit high rates of hearing loss arising primarily from susceptibility to middle ear inflammation. (biorxiv.org)
  • UCd is a biomarker for lifetime cadmium exposure among people with lower, nonoccupational exposures because, in the absence of episodes of high-level exposure, cadmium-binding sites, primarily in the kidney and liver, are not saturated, and UCd increases in proportion to the amount of cadmium stored in the body ( Dillon and Ho 1991 ). (nih.gov)
  • This dataset comes from the GenAge (Genetic Aging) section of the Human Ageing Genomic Resources (HAGR) which is a repository containing information about the genetics of human aging. (johnsnowlabs.com)
  • Immunohistochemical analysis of paraffin-embedded human neuroendocrine carcinoma of the lung using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated) performed on the Leica ® BOND ™ Rx. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human ovarian clear cell carcinoma using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated) (left) or Iba1/AIF-1 (E4O4W) XP ® Rabbit mAb #17198 (right) performed on the Leica ® BOND ™ Rx. (cellsignal.com)
  • These two antibodies detect independent, unique epitopes on human Iba1/AIF-1 protein. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human non-Hodgkin's lymphoma using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated) performed on the Leica ® BOND ™ Rx. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded normal human brain using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated). (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated) (left) compared to concentration-matched Mouse (G3A1) mAb IgG1 Isotype Control #5415 (right). (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human mucoepidermoid carcinoma of the larynx using Iba1/AIF-1 (E5N4J) Mouse mAb (IHC Formulated). (cellsignal.com)
  • This in turn impedes the receptor's ability to bind bad cholesterol and remove it from the bloodstream, causing the hypercholesterolemia. (mit.edu)
  • Knowing that a protein folding defect is at the root of familial hypercholesterolemia may allow scientists to design better therapies. (mit.edu)
  • Hypertension (HTN) and smoking are established risk factors for cardiovascular disease ( U.S. Department of Health and Human Services 2000 ), the leading cause of death worldwide ( World Health Organization 2009 ). (nih.gov)
  • Protein folding defects have also been implicated in other human diseases, including cystic fibrosis, a-1-antitrypsin deficiency, retinitis pigmentosa, and Marfan's syndrome. (mit.edu)
  • Here, we report that a novel inhibitor of S100A4 can specifically block its increase in cell migration in rat (IC50, 46 µM) and human (56 µM) triple negative breast cancer (TNBC) cells without affecting Western-blotted levels of S100A4. (bvsalud.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • Abnormalities of proximal tubular function included reduced reabsorption of beta-2-microglobulin, retinol binding protein, calcium and phosphate. (cdc.gov)
  • The remaining 60% includes ionized calcium plus calcium complexed with phosphate and citrate. (msdmanuals.com)
  • Calcium absorption is higher in physiologic states in which there is an increased demand for calcium, such as pregnancy and lactation, suggesting that strontium absorption may also be higher as well. (cdc.gov)
  • Calcium-binding may be crucial for numerous protein-protein interactions. (embl.de)
  • Absorption of strontium from the gastrointestinal tract shares a common mechanism with absorption of calcium. (cdc.gov)
  • Available data suggest no differences in oral absorption of strontium between males and females, nor do available human data suggest a difference in absorption between children and adults (ATSDR 2001e). (cdc.gov)
  • Characterizing the binding affinity of compounds to HSA is ess. (researchgate.net)
  • The Gla module (here with Glu instead of Gla) thus increases the affinity of the EGF module calcium ion binding site. (lu.se)
  • Combining nuclear magnetic resonance (NMR) spectroscopy and other biochemical methods, researchers also found that the normal copy of this fragment was unable to fold properly in the absence of calcium, and adding calcium restored its folding ability. (mit.edu)
  • For human coagulation factor IX it has been shown [ ( PUBMED:7606779 ) ] that the calcium-ligands form a pentagonal bipyramid. (embl.de)
  • The first EGF-like module of human coagulation factor IX contains a single functionally important calcium ion binding site. (lu.se)
  • Calcium (Ca) is required for the proper functioning of muscle contraction, nerve conduction, hormone release, and blood coagulation. (msdmanuals.com)
  • AIF-1 is expressed in various human immunerelated tissues and may play a role in macrophage activation and function. (ihcworld.com)
  • For metal- powerful methods to obtain and compare reaction and activation loproteins, a third method to obtain local information about the energies for suggested enzyme mechanisms and they can also provide atomic details about the protein dynamics. (lu.se)
  • Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
  • Calcium-binding protein 1 is a calcium-binding protein discovered in 1999. (wikipedia.org)
  • To further characterize the function of DJ-1, we cloned cDNA encoding a novel DJ-1-binding protein, DJBP, by a yeast two-hybrid system. (nih.gov)
  • The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). (medlineplus.gov)
  • Transcription factors bind DNA and protein. (mit.edu)
  • Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. (thermofisher.com)
  • Cytosolic ionized calcium is maintained within the micromolar range ( 1/1000 of the serum concentration). (msdmanuals.com)
  • Calcium binding to the first EGF-like module of human factor IX in a recombinant fragment containing residues 1-85. (lu.se)
  • EGF-like module}}, language = {{eng}}, number = {{2}}, pages = {{100--104}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{Calcium binding to the first EGF-like module of human factor IX in a recombinant fragment containing residues 1-85. (lu.se)
  • At higher exposure levels, especially under conditions of inadequate calcium, phosphorus, and vitamin D, stable strontium will interfere with normal bone development, causing `strontium rickets' of variable severity. (cdc.gov)
  • In the blood, absorbed lead is bound to erythrocytes and then is distributed initially to multiple soft tissues and eventually into bone. (cdc.gov)
  • Lately, in 1993, gene IT15 (interesting transcript 15), which codes unstable protein huntingtin (htt) comprising variable number of CAG repeats, was identified [ 5 ]. (hindawi.com)
  • Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. (assaysolution.com)