Human bone tissue. Medical search. Frequent questions

Overall, our results suggest that MM induces a plethora of peripheral nervous system alterations that may contribute to the failure of current analgesics and suggest neuroprotective drugs as appropriate strategies to treat early onset MIBP.SIGNIFICANCE STATEMENT Multiple myeloma (MM) is a painful bone marrow cancer that significantly impairs the quality of life of the patients . (bvsalud.org)
Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
In addition to WAT and BAT, adipocytes also exist in the bone marrow, and such marrow adipose tissue (MAT) has been estimated to account for over 10% of total adipose tissue mass in lean, healthy humans ( 3 ). (frontiersin.org)
However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)

Simulation of radiation dose distribution in human organs and tissues is possible by tissue equivalent materials. (hindawi.com)
ICRU report 44 [ 1 ] describes various types of tissue substitutes for human organs and tissues. (hindawi.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)

Seeding of bone implants with mesenchymal stem cells (MSCs) may promote osseointegration and bone regeneration. (nih.gov)
Guided bone regeneration (GBR) and guided tissue regeneration (GTR) are dental surgical procedures that use barrier membranes to direct the growth of new bone and gingival tissue at sites with insufficient volumes or dimensions of bone or gingiva for proper function, esthetics or prosthetic restoration. (wikipedia.org)
guided tissue regeneration typically refers to regeneration of periodontal attachment. (wikipedia.org)
Guided bone regeneration is similar to guided tissue regeneration, but is focused on development of hard tissues in addition to the soft tissues of the periodontal attachment. (wikipedia.org)
At present, guided bone regeneration is predominantly applied in the oral cavity to support new hard tissue growth on an alveolar ridge to allow stable placement of dental implants. (wikipedia.org)
When bone grafting is used in conjunction with sound surgical technique, guided bone regeneration is a reliable and validated procedure. (wikipedia.org)
Use of barrier membranes to direct bone regeneration was first described in the context of orthopaedic research 1959. (wikipedia.org)
The theoretical principles basic to guided tissue regeneration were developed by Melcher in 1976, who outlined the necessity of excluding unwanted cell lines from healing sites to allow growth of desired tissues. (wikipedia.org)
Based on positive clinical results of regeneration in periodontology research in the 1980s, research began to focus on the potential for re-building alveolar bone defects using guided bone regeneration. (wikipedia.org)
The theory of Guided tissue regeneration has been challenged in dentistry. (wikipedia.org)
Recent studies have shown greater attachment gain for guided tissue regeneration (GTR) over open flap debridement. (wikipedia.org)
Guided tissue regeneration surgery can be applied here, aiming to regenerate the periodontal tissues. (wikipedia.org)
The first application of barrier membranes in the mouth occurred in 1982 in the context of regeneration of periodontal tissues via GTR, as an alternative to resective surgical procedures to reduce pocket depths. (wikipedia.org)
A dental bone graft is a procedure that replaces missing bone in your jaw with bone grafting material to encourage regeneration. (colgate.com)
Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
Biodegradability can be imparted into polymers through molecular design with a controlled rate in concert with tissue regeneration [ 18 - 21 ]. (hindawi.com)
Typical bone regeneration -- wherein bone is taken from a patient's hip and grafted onto damaged bone elsewhere in the body -- is limited and can cause great pain just a few years after operation. (ted.com)
The adipose tissue is an important reservoir of adult stem cells which have capacity of differentiating in osteoblasts with potential implication in reaching bone regeneration. (bvsalud.org)
bone regeneration. (bvsalud.org)
Despite of the great potential of repair by bone tissue, in some situations, according to the proportion of defects, the regeneration cannot be complete because the defect can be invaded by the surrounding conjunctive tissue which has a proliferation and cellular migration speed faster than those of bone tissue. (bvsalud.org)
Tissue bioengineering is a new branch of Science aiming to investigate and integrate techniques of tissue regeneration thorugh new biomaterials including natural markers (growth factors) and tissue and cellular components (mesenchymal stem cells). (bvsalud.org)

The destructive gum condition, chronic periodontitis, in the susceptible individual results in the breakdown of both the connective tissues which attach the tooth, and the bone supporting the root. (wikipedia.org)
Conventional treatment arrests the disease but does not regain bone support or connective tissue that was lost in the disease process. (wikipedia.org)
A barrier membrane is utilized in the GBR technique to cover the bone defect and create a secluded space, which prevents the connective tissue from growing into the space and facilitates the growth priority of bone tissue. (wikipedia.org)
My research focuses primarily on tissue engineering of load bearing connective tissues, including ligament and tendon, cartilage, and bone. (rochester.edu)
Collagen is a protein that is essential to the health and function of connective tissues in your body. (webmd.com)
Connective tissues weave your different body parts - skin, bones, and organs - together and give your body shape. (webmd.com)
Bone broth is made by simmering animal bones and connective tissue for an extended period of time. (webmd.com)
If you've ever prepared a whole chicken, you know there's quite a bit of connective tissue in the meat. (webmd.com)
The muscle will taper at its opposite end into a more slender connective tissue, the muscle tendon, to the connection with the bone, the point of insertion. (faqs.org)

Barrier membrane criteria should be as follows: Biocompatible Excludes unwanted cell types Allows tissue integration Creates and maintains space Is easy to trim and place Several surgical techniques via GBR have been proposed regarding the tri-dimensional bone reconstruction of the severely resorbed maxilla, using different types of bone substitutes that have regenerative, osseoinductive or osseoconductive properties which is then packed into the bony defect and covered by resorbable membranes. (wikipedia.org)

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)
Mesenchymal stem cells have the ability to differentiate in osteoblasts with potential implications for the engineering of human bone tissue 11 . (bvsalud.org)
The stem cells coming from the adipose tissue can be an important source of progenitor mesenchymal stem cells which can be employed in tissue engineering for bone repairing 8 . (bvsalud.org)

In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. (ntnu.no)
This resemblance to native bone indicates a model system with potential for studying osteocyte-like cell differentiation, cross-talk between bone cells, and the mineralization process in a bonelike structure in vitro without artificial scaffolds. (ntnu.no)
The printers create three-dimensional structures, known as tissue scaffolds. (bbc.co.uk)
In this study, the printing capability of two different additive manufacturing (3D printing) techniques, namely PolyJet and micro-stereolithography (µSLA), are investigated regarding the fabrication of bone scaffolds. (mdpi.com)
Printed bone scaffolds with complex structures produced using additive manufacturing technology can mimic the mechanical properties of natural human bone, providing lightweight structures with modifiable porosity levels. (mdpi.com)
Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)

Autografts use bone tissue obtained from the patient's own body. (colgate.com)
The practitioner typically takes this tissue from the patient's chin, shin, or hip. (colgate.com)
The University of Manchester team say the inkjets will be able to "print out" tailor-made human cells to fit a patient's exact dimensions. (bbc.co.uk)
Instead, it is used as a framework for the patient's existing bone to grow around to fill the area. (icoi.org)
Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)

There are approximately 28 different types of collagen in the human body, but four are considered the most common. (webmd.com)
Research indicates that taking collagen peptide supplements can increase bone mineral density in women who have gone through menopause . (webmd.com)
The process extracts collagen from the bones and skin and places it into the broth. (webmd.com)
Researchers at the National Institutes of Health have discovered that a previously unexplained fatal form of Osteogenesis Imperfecta - a disorder that weakens bones and which may cause frequent fractures - results from a genetic defect in a protein involved in the production of collagen. (nih.gov)
The well-known forms of Osteogenesis Imperfecta (OI) result from a defect in the genes for type I collagen, which serves as a kind of molecular scaffolding that holds together bone, tendons, skin and other tissues. (nih.gov)
The collagen defects result from dominant mutations, requiring only one copy of a mutant gene to cause bone disease. (nih.gov)
In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)

In cases where augmentation materials used are autografts (tissue transfer from same person) or allografts (tissue from genetically dissimilar members of same species) the bone density is quite low and resorption of the grafted site in these cases can reach up to 30% of original volume. (wikipedia.org)
Allografts come from a human donor, usually cadaver bone that has undergone treatments to make it neutral to immune reactions and free of host diseases. (colgate.com)
In dentistry, allografts such as bone grafts are used to build up the bone where an implant or prosthesis will be placed. (icoi.org)

Patients who have experienced bone loss might require a bone graft to help support existing teeth or an upcoming restoration. (colgate.com)
Patients without sufficient bone mass for an implant may require a bone graft to complete nthe dental implant procedure. (icoi.org)

The ALPL gene provides instructions for making an enzyme called tissue-nonspecific alkaline phosphatase (TNSALP). (medlineplus.gov)

Six clinical forms have been identified: perinatal, prenatal benign (with spontaneous improvement of skeletal defects despite prenatal signs of disease), infantile, juvenile, adult form, and odontohypophosphatasia (no clinical changes in long bones, only biochemical and dental manifestations). (medscape.com)
Events such as aging, missing teeth, genetic or development defects, untreated periodontal disease, and trauma to the jaw can lead to bone loss. (colgate.com)
The aim of the present investigation was to evaluate the healing of bone defects (fresh extraction sockets) after implant installation with flap elevation, and primary closure compared with implant installation without flap elevation. (allenpress.com)
This study use histologic and histomorphometric analyses to evaluate tissue healing around dental implants with marginal bone defects with and without flap elevation 1 week, 4 weeks, and 12 weeks after implantation in the dogs. (allenpress.com)
To evaluate the immunoexpression of BMP-2 protein on the bone repairing of critical size defects (CSD) surgically created in rat calvaria and treated by autogenous macerated adipose tissue. (bvsalud.org)
Within the limits of this present study, it can be concluded that the adipose tissue grafting did not favor bone neoformation in critical size defects and BMP-2 signaling was not observed. (bvsalud.org)
The repair of extensive bone defects, caused by either traumas or pathologies, constituted a great problem for both Medicine and Dentistry. (bvsalud.org)
13 verified that stromal cells (CD 34+) derived from the adipose tissue has the potential of osteogenic differentiation both in vitro and in vivo, being considered as a promising cellular therapy for the healing of bone defects. (bvsalud.org)

This study aims to conduct a direct head-to-head comparison of the biological characteristics of the two types of MSCs under human platelet lysate-supplemented culture conditions for their ability to be used in regenerative medicine applications. (biomedcentral.com)
Our approach is to develop in vivo and in vitro models of musculoskeletal injury and clinically-translatable outcome measures to assess the efficacy of regenerative and tissue engineering solutions. (rochester.edu)

An allograft is a type of graft which utilizes tissue from genetically dissimilar members of the same species. (icoi.org)

We have undertaken a longitudinal investigation into the mobilization of lead from the human maternal skeleton to determine whether lead is mobilized from the maternal skeleton during pregnancy and lactation, and if so, when and how much is released. (edu.au)
Lead in bone: implications for toxicology during pregnancy and lactation. (aaem.pl)

More than 90% of the Pb in the adult human body and 70% in a child's body is stored in the bones. (aaem.pl)
My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
bioceramics and bioglasses, raising great interest in the research with adipose tissue as a reservoir of adult stem cells, generating good results. (bvsalud.org)

Imbalances between the strength of the skeletal muscle, the laxity or otherwise in the tendon, and the connection to the bone surface are common causes of muscle injury in athletes. (faqs.org)

BestBets: Should the type of fish bone ingested guide need for soft tissue neck Xray? (bestbets.org)
The fish bone is not visible on soft tissue plain radiograph of the neck. (bestbets.org)
The researchers looked at the shape of thumb bones and soft tissue, which is occasionally preserved. (newscientist.com)
The scientists took into account soft tissue as well as bone anatomy. (localnews8.com)
The technique of immediate implant placement after extraction has been conceived for preserving residual bone support and soft tissue morphology. (allenpress.com)
Under the experimental conditions of this study, no biological differences were observed between the 2 groups with and without flap elevation in terms of crestal bone repair, inflammation, marginal bone loss, and soft tissue downgrowth. (allenpress.com)
Periodontitis is a serious, chronic, non-communicable gum infection that damages the soft tissue and bone that supports the teeth. (medicalnewstoday.com)
It could be bones, soft tissue, internal. (pets.ca)
They are categorized into 3 groups: soft tissue, bone, and diabetic foot infections. (medscape.com)
Many events can be responsible for these soft tissue infections. (medscape.com)
A description of soft tissue infections includes simple, moderate, and severe infections, which includes but is not limited to the immunocompromised patient, infections associated with PVD, emergency soft tissue infections, and infections associated with trauma. (medscape.com)
It is predisposed to this because of the close proximity to the skin and lack of a thick, soft tissue, protective layer throughout most parts of the foot. (medscape.com)
Individuals with diabetes tend to develop ulcerations in the feet, which often lead to infection of the soft tissue and bones. (medscape.com)
Soft Tissue and Bone Tumours is now available in print format. (who.int)
Soft Tissue and Bone Tumours is the third volume in the 5th edition of the World Health Organization (WHO) series on the classification of human tumours. (who.int)
The clinical utility of next-generation sequencing for bone and soft tissue sarcoma. (cdc.gov)
This volume will be of particular interest to pathologists, oncologists, surgeons, and epidemiologists who manage or research soft tissue and bone tumours. (who.int)
Sections are included on all recognized neoplasms of the soft tissue and bone, as well as on genetic tumour syndromes affecting these sites. (who.int)

For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
My first postdoctoral position was held jointly between Imperial College and the Royal London Hospital School of Medicine and Dentistry (with Professor Francis Hughes) looking at the roles of the nitric oxide and prostaglandin pathways in bone biology, specifically the osteoblast. (nottingham.ac.uk)
From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and model bone biology, pathology and repair. (nottingham.ac.uk)

TNSALP is essential for the process of mineralization, in which minerals such as calcium and phosphorus are deposited in developing bones and teeth. (medlineplus.gov)
Mineralization is critical for the formation of bones that are strong and rigid and teeth that can withstand chewing and grinding. (medlineplus.gov)
Mutations in the ALPL gene lead to the production of an abnormal version of TNSALP that cannot participate effectively in the mineralization of developing bones and teeth. (medlineplus.gov)
Researchers believe that a buildup of one of these compounds, inorganic pyrophosphate, underlies the defective mineralization of bones and teeth in people with hypophosphatasia. (medlineplus.gov)
Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization. (medlineplus.gov)
It dephosphorylates several substrates, including inorganic pyrophosphate (PPi), which inhibits bone mineralization produced by osteoblasts and chondrocytes. (medscape.com)

In addition, natural extracellular matrix may allow for the study of tissue-specific biochemical, biophysical, and mechanical properties. (ntnu.no)
Researchers have optimized specialized ink made from extracellular matrix proteins, combined the ink with human stem cells, and used the ink-plus-cells to 3D-print the chambered structure. (techbriefs.com)
A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
The NIH team was led by Joan Marini, M.D., Ph.D., Chief of NIH's Bone and Extracellular Matrix Branch and was assisted by colleagues at other institutions. (nih.gov)

Using human fat-derived stem cells from young (aged 24-36 years), middle-aged (aged 48-55 years), and elderly (aged 60-81) participants, the team used ECIS to collect complex measurements during the growth and differentiation stages the hASC exhibited as they converted to bone cells. (futurity.org)
Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
The evaluation of the osteoblastic differentiation can be verified through immunohistochemical markers such as bone morphogenetic protein- 2 (BMP-2). (bvsalud.org)
This evaluation of osteoblastic differentiation is commonly evaluated through different protein markers, among them bone morphogenetic protein-2 (BMP-2). (bvsalud.org)

A year and a half after the initial human infection, the matous and necrotizing suppurative components. (cdc.gov)
Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
The jawbone may fail to heal after surgical trauma, which can lead to complications such as swelling, pain, infection, and exposed bone. (icoi.org)
This ulceration could be probed to bone, and a deep space infection was present. (medscape.com)
Rates of bone infection are extortionately high and an increasing number of patients are showing signs of antibiotic resistance, which increases the chance of amputation and the risk of infection to other patients. (who.int)
A dedicated osteomyelitis (bone infection) treatment centre, built by Médecins Sans Frontières-France in 2020, will be located adjacent to the Limb Reconstruction Centre and complement it. (who.int)
Human Immunodeficiency Virus (HIV) Infection and AIDS The human immunodeficiency virus (HIV) is a type of virus called a retrovirus. (msdmanuals.com)

Multiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain . (bvsalud.org)
We have established cell culture conditions that favored the natural 3D orientation of the bone cells and stimulated the cascade of signaling needed for primary human osteoblasts to differentiate into osteocytes with the characteristically phenotypical dendritic network between cells. (ntnu.no)
We report on the use of a DNA staining dye to locate and record nucleated osteocytes and other bone-related cells within sections of archived formalin-fixed and paraffin-embedded human tibia from which informative DNA profiles were obtained. (edu.au)
Diamond™ Nucleic Acid Dye was applied to the sections and cells within the matrix of the bone fluoresced so that their location and number of cells could be photographed. (edu.au)
Staining cells to determine the prevalence of bone cell nuclei allows a triage of samples prior to any subsequent DNA profiling. (edu.au)
Scientists can now watch how human fat cells transform into bone tissue cells. (futurity.org)
however, there is still a lot to learn about how stem cells grow and convert to needed tissues," says Elizabeth Loboa, dean of the University of Missouri's College of Engineering. (futurity.org)
therefore, our team decided to analyze and study a new approach to monitoring stem cells as they transform into tissues we may need to treat disease. (futurity.org)
The team's target was stem cells derived from human fat, or human adipose (hASC) cells and the process these stem cells use to convert to bone cells when stimulated to do so. (futurity.org)
This is the first study to use ECIS to predict and monitor the potential of adipose cells transforming into bone cells," Loboa says. (futurity.org)
In the past, researchers have tried to 3D-print cardiomyocytes, or heart muscle cells, that were derived from pluripotent human stem cells. (techbriefs.com)
The researchers achieved the goal of high cell density within less than a month to allow the cells to beat together, just like a human heart. (techbriefs.com)
Now, Akira Kudo at Tokyo Tech, together with scientists across Japan, have shown that medaka fish reared on the International Space Station for 56 days experienced increased osteoclast activity - bone cells involved in the re-absorption of bone tissue - likely leading to a subsequent reduction of bone density. (titech.ac.jp)
Kudo and his team generated 312 modified fish whose osteoclasts and osteoblasts (cells responsible for bone formation) would emit two different fluorescent signals when activated. (titech.ac.jp)
Human cells are suspended in a nutrient-rich liquid before being printed out in several thin layers. (bbc.co.uk)
Prof Brian Derby, head of the Ink-jet Printing of Human Cells Project research team, said the technology has tremendous potential. (bbc.co.uk)
They are made up of several thin layers of human cells, each 10 microns thick - 1,000 cell layers would measure 1cm thick. (bbc.co.uk)
I was also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), part of the Centre for Biomolecular Sciences, which is now the Biodiscovery Institute. (nottingham.ac.uk)
Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)

Allogeneic grafts, or allogenic bone grafts, are becoming more popular in the field of implant dentistry. (icoi.org)

Adipose tissue is typically classified into two broad subtypes, white adipose tissue (WAT) and brown adipose tissue (BAT). (frontiersin.org)
Instead, it is donor bone, typically harvested during other surgeries, such as hip surgeries. (icoi.org)
Typically, they follow a traumatic event or tissue loss with contamination by foreign materials and/or colonization by bacteria. (medscape.com)

A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

Prolia (denosumab) is a monoclonal antibody used to treat bone loss ( osteoporosis ) in women who are at high risk for bone fracture after menopause . (rxlist.com)
A decreasing bone mineral density level can lead to an increased risk of bone fracture or worse bone breaks. (webmd.com)
In other forms, individuals may lead a relatively normal life, but have bones that fracture easily. (nih.gov)
In still other cases, affected individuals may have only a slightly increased risk for bone fracture. (nih.gov)

Astronauts who spend a number of weeks in space have been shown to suffer from reduced bone mineral density, leading to skeletal problems. (titech.ac.jp)
Information has been obtained on the initial skeletal distribution of bone surface seeking radionuclides in man from measurements on subjects injected with yttrium-88 and neptunium-239. (europa.eu)
The skeletal muscles are those tissues that are attached to the bones of the body beneath the skin. (faqs.org)
Human musculo-skeletal system. (faqs.org)
All skeletal muscles are positioned relative to the bone in a similar fashion no matter where in the body they may be positioned, irrespective of the muscle function. (faqs.org)
The prime place of attachment between a skeletal muscle and the adjacent bone is the point of origin for the muscle. (faqs.org)
In this perspective the archaeological context of the crypt of Ca' Granda in Milan offers an extraordinary substrate on which to verify the presence in the human remains of drug therapies mentioned in the archives of the hospital (or unexpected ones), but never extracted from skeletal remains, as well as the opportunity to test to what extent modern toxicological techniques can help in the reconstruction of the past. (nature.com)

Finally, rosiglitazone upregulated uncoupling protein 1 in brown adipose tissue (BAT), but this protein was undetectable in tibiae, suggesting that MAT is unlikely to share thermogenic properties of BAT. (frontiersin.org)
For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. (cshlpress.com)

[ 1 ] Patients presenting with abnormal bone features should undergo alkaline phosphatase and vitamin B6 testing to rule out this diagnosis. (medscape.com)
Investigation of the same topic in a human population by setting up a controlled, randomized, prospective trial including a sufficient amount of patients investigated according to the split-mouth method would be beneficial. (allenpress.com)
This tilted placement allows patients to undergo prosthetic surgery without first requiring a bone graft as it utilizes already available bone. (icoi.org)
Some patients have insufficient bone due to disease or other health concerns and therefore do not have the proper foundation for an implant. (icoi.org)
Meanwhile, Medical News Today recently reported progress on the development of a saliva test for identifying cancer that is soon to be tested in human patients. (medicalnewstoday.com)
After learning of Dr. Morello and Dr. Lee's findings, Dr. Marini and her coworkers examined tissue samples from three patients in Dr. Marini's NIH laboratory. (nih.gov)
In this paper, we present the results of toxicological analyses of preserved brain tissue and bone samples from the remains of the seventeenth century patients of the Ospedale Maggiore , the main hospital in Milan and one of the most innovative hospitals in Europe from the Renaissance period. (nature.com)
The work of Neufeld et al from the late 1960s demonstrated that mucopolysaccharide accumulation in fibroblasts from patients with Hurler and Hunter syndromes could be corrected by co-culturing them with fibroblasts or tissue extracts from patients with a different MPS. (medscape.com)

However, implant material surfaces, such as titanium or bovine bone mineral, fail to support rapid and efficient attachment of MSCs, especially under serum-free conditions that may be desirable when human applications or tightly controlled experiments are envisioned. (nih.gov)
The lower bone mineral content and the weaker mechanical properties of bones from Pb-treated rats are associated with the pathologic state dependent of the exposure of lead. (aaem.pl)
Palaniappan PL. RM, Krishnakumar N, Vadivelu M, Vijayasundaram V. The study of the changes in the biochemical and mineral contents of bones of Catla. (aaem.pl)
Studies have shown that astronauts experience a significant drop in bone mineral density when they have been on space missions, but the exact molecular mechanisms responsible for this are unclear. (titech.ac.jp)
Kudo and his team found that bone mineral density in the pharyngeal bone (the jaw bone at the back of the throat) and the teeth of the fish reduced significantly, with decreased calcification by day 56 compared with the control group. (titech.ac.jp)
They performed X-ray analysis of the bones of the fish at day 56 to ascertain mineral density changes. (titech.ac.jp)
Alloplasts are created from hydroxyapatite, a naturally occurring mineral in bone. (colgate.com)
Instead, the bone graft material alloplast is usually made from hydroxyapatite, which is a natural mineral that is the primary component of bone. (icoi.org)
Bone mineral density tests measure bone strength and are used to help diagnose people with osteoporosis . (webmd.com)

Jewell will discuss new degradable polymer depots that could improve the selectivity of therapies for autoimmune diseases such as multiple sclerosis and diabetes by locally reprogramming the function of lymph nodes - tissues that coordinate immune function. (jhu.edu)
When this happens, lymph draining from body tissues has looks at a swollen limb to see if it's lymphedema, they people in tropical areas across 72 countries and nowhere to go and gets stuck in the tissue. (medlineplus.gov)

This enzyme plays an important role in the growth and development of bones and teeth. (medlineplus.gov)

If you need a tooth extraction and are considering a dental implant, your dental professional might recommend bone grafting. (colgate.com)
Combining tooth extraction with bone grafting encourages faster healing. (colgate.com)
2 , 3 When a tooth is extracted, some bone loss is inevitable. (allenpress.com)
This can prove challenging for periodontists who intend to place an implant in the area where the tooth was extracted, and bone grafting may become necessary. (icoi.org)

Brun-Heath I, Taillandier A, Serre JL, Mornet E. Characterization of 11 novel mutations in the tissue non-specific alkaline phosphatase gene responsible for hypophosphatasia and genotype-phenotype correlations. (medlineplus.gov)
Mornet E. Hypophosphatasia: the mutations in the tissue-nonspecific alkaline phosphatase gene. (medlineplus.gov)
Initially recognized by Rathbun in 1948, HPP is a rare inborn error of metabolism caused by mutations in the ALPL gene located on chromosome 1 (1p36.1) and consists of 12 exons distributed over 50 kb, encoding tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). (medscape.com)
Three of these isoforms are tissue specific and are known as germ cell, placental, and intestinal alkaline phosphatase. (medscape.com)

Proteins are vital to making and repairing tissues like bone, muscles, and skin. (medicinenet.com)
Cardiac muscles are controlled through the function of the autonomic nervous system, the aspect of human function regulated by the hypothalamus region of the brain. (faqs.org)

The main qualitative findings showed that after 1 week of implantation almost no bone repair was observed, and there was no significant difference between the 2 groups in terms of bone-healing performance, inflammatory infiltrates (slight to moderate grade), and bone resorption (moderate to marked grade) limited to the coronal portion of the implanted sites. (allenpress.com)
Alendronate sodium is a nitrogen-containing bisphosphonate medication that is most commonly used in the treatment of osteoporosis because it inhibits the resorption of osteoclast-mediated bone. (icoi.org)

The precise molecular mechanisms responsible for loss of bone density are not yet fully understood. (titech.ac.jp)
The team found subsequent reduction in bone density in the space fish compared with a control group of fish kept on Earth. (titech.ac.jp)
Fortunately, bone augmentation procedures like bone grafting can help restore the density and volume of your jawbone. (colgate.com)
In cases where a patient does not have sufficient bone density for an implant, a graft may be necessary. (icoi.org)

While treatment with these types of medications can be effective for preventing bone loss due to osteoporosis, the dental industry has seen negative side effects. (icoi.org)

In an informative talk, Molly Stevens introduces a new stem cell application that harnesses bone's innate ability to regenerate and produces vast quantities of bone tissue painlessly. (ted.com)
Stem Cell Research Tools in Human Metabolic Disorders: An Overview. (cdc.gov)

What Is a Dental Bone Graft? (colgate.com)
As the natural bone grows, it absorbs the graft material, resulting in a fully integrated region of new bone. (colgate.com)
Why Do You Need a Dental Bone Graft? (colgate.com)
What Are the Steps of a Dental Bone Graft Procedure? (colgate.com)
Before your dental bone graft procedure, you will meet with a periodontist or oral surgeon to discuss the treatment plan and determine the bone grafting material to be used. (colgate.com)
Then, he or she will attach the bone graft material to the exposed bone. (colgate.com)
This surgical procedure divides the jawbone into an inner and outer section to insert bone graft material, create new bone, and widen the jaw to support dental implants. (colgate.com)
An allogenic bone graft is done using human bone, but unlike other types of bone grafts, the bone is not harvested from the patient receiving the graft. (icoi.org)
A bone graft can decrease the risk of implant rejection or failure, and can position the implant so that it is both functional and aesthetically pleasing. (icoi.org)
This is considered a synthetic bone graft, however, it is used more frequently than other types of bone grafts due to the material's superior hardness, osteoconduction, and compatibility with natural bone. (icoi.org)

Katerina Harvati at the University of Tübingen in Germany and her colleagues looked at thumb efficiency across different fossil human species. (newscientist.com)
It was at this time an early species of humans first left Africa, and our dexterity could have been the driving force behind a more complex human culture that emerged then. (localnews8.com)
This involved comparing the grip of recent and early modern humans, living chimpanzees and six different hominin species. (localnews8.com)
Those six species include one of the earliest - Australopithecus afarensis (Lucy) - and more recent archaic humans such as Neanderthals who existed before and, in some cases, alongside early Homo sapiens in the centuries and millennia before we emerged as the lone hominin survivor. (localnews8.com)
The researchers' results suggested that the powerful thumb that characterizes the human hand evolved only in some fossil hominin species around 2 million years ago. (localnews8.com)
Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)

Complete STR profiles were generated from ten bone extracts where low-level inhibition was recorded with an incomplete STR profile obtained from one sample with higher inhibition. (edu.au)

Learn more about dental bone grafts and how they can increase the viability of your dental implant. (colgate.com)
In fact, it is estimated that half of implant placement procedures require bone grafts. (colgate.com)
The patient benefits of All-on-4® include no need for bone grafts, immediate function and aesthetics of the prosthesis, fewer surgeries, reduced healing time, and less expense. (icoi.org)
Because of this, allogenic bone cannot grow new bone by itself, like other types of bone grafts. (icoi.org)
Alloplastic grafts are not made of bone like other types of grafts. (icoi.org)

It is also active in many other tissues, particularly in the liver and kidneys. (medlineplus.gov)

Mechanistically, we investigated MM induced gene expression changes in the dorsal root ganglia ( DRG ) innervating the MM-bearing bone of male mice and found alterations in pathways associated with cell cycle , immune response and neuronal signaling. (bvsalud.org)

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)

Here we demonstrate that a branched poly[Lys(Ser(i)-DL-Ala(m))] polymer functionalized with cyclic arginyl-glycyl-aspartate, when immobilized by simple adsorption to tissue culture plastic, surgical titanium alloy (Ti6Al4V), or Bio-Oss(®) bovine bone substitute, significantly accelerates serum-free adhesion and enhances seeding efficiency of human adipose tissue-derived MSCs. (nih.gov)
Human platelet lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. (biomedcentral.com)

At this time Homo erectus emerged - the earliest humans to have body proportions similar to Homo sapiens and the first to disperse from Africa - as well as evidence of systematic butchering of hunted animals and use of aquatic resources. (localnews8.com)
The findings provide valuable details of bone structure physiology and the abnormalities caused by the stress to the body at reduced gravity. (titech.ac.jp)
Time spent in so-called 'microgravity' environments - where the force of gravity is considerably less than on Earth - can cause significant problems for the human body. (titech.ac.jp)
Their findings hold implications for longer space missions and the impact of microgravity on the human body. (titech.ac.jp)
I took inspiration from starfish, sea urchins, and hydras, which are animals that have a different body axis symmetry than most animals on earth, including humans. (avpgalaxy.net)
You also might need IV sedation if they source the tissue from your own body or if you experience dental anxiety. (colgate.com)
If you source the bone from your body, the surgeon will also stitch that area together. (colgate.com)
Biodegradable polymers degrade through hydrolysis process and are gradually absorbed by the human body thus allowing the supported tissue to gradually recover its functionality [ 8 , 17 ]. (hindawi.com)
To improve methods of assessing intakes and body content of bone seeking radionuclides an improved model of plutonium biokinetics has been developed for assessing systemic uptake of plutonium from excretion measurements. (europa.eu)
Medical products of human origin are derived wholly or in part from the human body and intended for clinical application. (who.int)
The lymphatic on the study of parasites--small organisms system is part of the body's immune system and includes that survive by living off the human body. (medlineplus.gov)

Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)

My research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions. (rochester.edu)

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. (nature.com)

Using conventional methods, you are only able to grow tissues which are a few millimetres thick, which is fine for growing artificial skin, but if you wanted to grow cartilage, for instance, it would be impossible. (bbc.co.uk)

The radiation dose from radon and its progeny is measured in terms of the energy that they impart to tissue (in units called gray or rem for public exposure, or working levels for occupational exposure). (cdc.gov)
In the presented study, the effects of lead exposure on bones were studied for rats treated orally with Pb acetate in drinking water for 14 days. (aaem.pl)
The hypothesis was tested that lead exposure negatively affects bone structure. (aaem.pl)
Studies of medaka fish raised on the International Space Station shed light on how bone responds to sustained exposure to microgravity. (titech.ac.jp)
XRF was used to measure the mercury content of head and bone tissue in 298 dentists with long-term exposure to mercury-containing amalgams. (cdc.gov)

Anatomy52

Organisms10

Diseases23

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes39

Disciplines and Occupations5

Technology, Industry, Agriculture21

Information Science2

Marrow11

Organs and tissues7

Regeneration23

Connective9

Substitutes1

Mesenchymal4

Scaffolds7

Patient's5

Collagen7

Allografts3

Require a bone graft2

Called tissue-nonspecific1

Defects8

Regenerative2

Genetically dissimilar members1

Pregnancy and lactation2

Adult3

Tendon1

Soft18

Osteoblast3

Mineralization6

Extracellular4

Differentiation5

Infection7

Cells19

Dentistry1

Typically3

Donor1

Fracture4

Skeletal7

Protein3

Patients8

Mineral9

Lymph2

Enzyme1

Tooth4

Alkaline phosphatase4

Muscles2

Resorption2

Density4

Osteoporosis1

Stem2

Graft10

Species6

Extracts1

Grafts5

Liver1

Gene1

Biological1

MSCs2

Body11

Mechanical properties1

Clinical1

Epithelium1

Cartilage1

Exposure5