• Human umbilical vein ECs (lane 4) and immortalized cell lines with high telomere length, provided by the Roche Diagnostics Corp. (lane 5), were used as controls. (jci.org)
  • Until now, evidence has pointed to immediate consumption of marrow following the procurement and removal of soft tissues. (phys.org)
  • As assessed by imaging (gamma camera), PCR, and in situ hybridization analysis, the authors' results demonstrate the presence of human MSC in bone marrow, spleen, and mesenchymal tissues of recipient mice. (nih.gov)
  • Fifty human statues (above) were stationed along Orchard Road yesterday to represent 50 patients waiting for a matching donor at any one time in Singapore. (asiaone.com)
  • The chief executive of the Bone Marrow Donor Programme (BMDP) is out to bust myths about marrow donation and get more minorities on the donor registry. (asiaone.com)
  • Ms Prior spoke to The Sunday Times last Friday, the eve of the inaugral World Marrow Donor Day, when the BMDP deployed 50 'human statues' along Orchard Road to represent the 50 patients waiting for a matching donor at any one time in Singapore. (asiaone.com)
  • Our data reveal valuable information on the kinetics of radiation-induced MN-RET of human bone marrow cultured in the 3D bioreactor, a synthetic bioculture system, and suggest that this model may serve as a promising tool for studying MN-RET formation in human bone marrow, thereby providing opportunities to study bone marrow genotoxicity testing, mitigating agent effects, and other conditions that are not ordinarily feasible to experimental manipulation in vivo. (pubmedcentralcanada.ca)
  • To study the molecular mechanisms involved in human leukemias and to improve treatment options, it is critically important to establish in vivo xenograft models that faithfully recapitulate the disease. (bloodjournal.org)
  • In the present study, the authors investigated, by using imaging, polymerase chain reaction (PCR), and in situ hybridization, the biodistribution of human bone marrow-derived MSC after intravenous infusion into unconditioned adult nude mice. (nih.gov)
  • Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice. (ca.gov)
  • For several years, researchers have been trying to reproduce natural bone marrow in the laboratory in order to better understand the mechanisms of blood formation and to develop new therapies - such as for the treatment of leukemia. (eurekalert.org)
  • Tel Aviv University researchers, in collaboration with scholars from Spain, have uncovered evidence of the storage and delayed consumption of animal bone marrow at Qesem Cave near Tel Aviv, the site of many major discoveries from the late Lower Paleolithic period some 400,000 years ago. (phys.org)
  • The researchers contend that the deer metapodials were kept at the cave covered in skin to facilitate the preservation of marrow for consumption in time of need. (phys.org)
  • The researchers evaluated the preservation of bone marrow using an experimental series on deer, controlling exposure time and environmental parameters, combined with chemical analyses. (phys.org)
  • Analysis of MN-RET frequency in humans is useful for evaluating cytogenetic damage resulting from chemotherapy, radiotherapy, medicine, diet, and lifestyle choices [ 6 - 13 ]. (pubmedcentralcanada.ca)
  • Here, we investigated the roles of S1P and S1P receptors (S1PRs) in migration of human BMSCs. (hindawi.com)
  • In the present study, we characterized the different effects of S1P receptors on S1P-mediated migration of human BMSCs and investigated the downstream signaling pathway in this process. (hindawi.com)
  • The combination of archaeological and experimental results allowed them to isolate the specific marks linked to dry skin removal and determine a low rate of marrow fat degradation of up to nine weeks of exposure. (phys.org)
  • The human leukemia xenograft mouse models that we have established here will serve as an excellent resource for future studies aimed at exploring novel therapeutic approaches. (bloodjournal.org)
  • C ) Clonally isolated hBMSCs cultured for 120 PDs were labeled with PE- or FITC-conjugated Abs against human CD29, CD44, CD73, CD105, CD90, or CD117, or Ig isotype controls. (jci.org)
  • However, the effects of S1P signaling on human BMSCs and the mechanisms that regulate their chemotactic behavior are incompletely understood. (hindawi.com)
  • This is the earliest evidence of such behavior and offers insight into the socioeconomics of the humans who lived at Qesem," says Dr. Ruth Blasco. (phys.org)
  • This kind of behavior allowed humans to evolve and enter into a far more sophisticated kind of socioeconomic existence. (phys.org)
  • However, there are no reliable data showing the fate of human MSC infused into conditioned or unconditioned adult recipients. (nih.gov)
  • Continued investigation of the human bone marrow compartment is essential to the understanding of the bone marrow's response to radiation injury and of the genotoxic effect, which may confer carcinogenic potential. (pubmedcentralcanada.ca)
  • hBMSCs were harvested from surgical waste bone specimens from 3 healthy adults with IRB approval. (umich.edu)
  • For gene expression comparison, total RNA was extracted from hBMSCs using RNeasy Kit (Qiagen) and gene expression was examined with human Mesenchymal Stem Cell PCR Array (SABiosciences). (umich.edu)
  • In order to determine a possible relationship between the two granule subsets, immunoelectron-microscopic techniques were used to determine the presence and precise intragranular distribution of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and arylsulfatase B of eosinophil granules, as well as the Charcot-Leyden crystal (CLC) protein, in eosinophil progenitors of the bone marrow. (lu.se)
  • On the other hand, oral administration of 50, 100 and 150 mg kg(-1) b.w. of SEM showed a statistically significant effect in MN frequencies on Wistar rats' bone marrow PCEs, with no dose-response pattern. (biomedsearch.com)
  • Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on growth inhibition in human pulmo. (biomedsearch.com)
  • We show for the first time in our study that 420,000 to 200,000 years ago, prehistoric humans at Qesem Cave were sophisticated enough, intelligent enough and talented enough to know that it was possible to preserve particular bones of animals under specific conditions, and, when necessary, remove the skin, crack the bone and eat the bone marrow," Professor Avi Gopher explains. (phys.org)
  • We found that the deer leg bones, specifically the metapodials, exhibited unique chopping marks on the shafts, which are not characteristic of the marks left from stripping fresh skin to fracture the bone and extract the marrow. (phys.org)
  • We found that S1P exerted a powerful migratory action on human BMSCs. (hindawi.com)
  • Professor Karim Nayernia, and his team from the Universities of G?ttingen and the Medical School of Hanover, took stem cell samples from the bone marrow of male volunteers. (ivf.net)
  • Bone marrow constitutes a significant source of nutrition and as such was long featured in the prehistoric diet," says Professor Ran Barkai. (phys.org)
  • Thyroid hormones influence both bone formation and bone resorption. (nih.gov)
  • Human BM-MSCs (hBM-MSCs) were transduced with lentiviral vectors encoding miR-499a-3p or miR-499a-5p and analyzed by immunostaining and western blotting methods 14 days post-transduction. (springer.com)
  • We discovered that preserving the bone along with the skin, for a period that could last for many weeks, enabled early humans to break the bone when necessary and eat the still nutritious bone marrow," adds Dr. Blasco. (phys.org)
  • The bones were used as 'cans' that preserved the bone marrow for a long period until it was time to take off the dry skin, shatter the bone and eat the marrow," Professor Barkai emphasizes. (phys.org)
  • In our paper, we present evidence of storage and delayed consumption of bone marrow at Qesem Cave. (phys.org)