• Epstein-Barr virus (EBV) infection of B lymphocytes is near universal in humans and stimulates high levels of EBV-specific helper and cytotoxic T cells, which persist indefinitely. (nih.gov)
  • In immunology, reactive lymphocytes, variant lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8+) lymphocytes that become large as a result of antigen stimulation. (wikipedia.org)
  • Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. (wikipedia.org)
  • Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. (bvsalud.org)
  • Cytotoxic- T-lymphocyte (CTL) escape mutations in human immunodeficiency viruses encode amino acid substitutions in positions that disrupt CTL targeting, thereby increasing virus survival and conferring a relative fitness benefit. (bvsalud.org)
  • Following consumption of 1.2 litres of cows' milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fcγ-receptors). (karger.com)
  • In man it was found that Fcγ-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. (karger.com)
  • It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. (karger.com)
  • The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of 'fluid-phase' Fcγ-receptors found in normal human serum. (karger.com)
  • Human T-lymphocytes activated by phytohemagglutin acquire insulin receptors in culture. (diabetesjournals.org)
  • High levels of interleukin-2 receptors (IL-2R) can be found mainly on the surface of activated T lymphocytes (both CD4+ and CD8+, mainly Th1 lymphocytes) [ 1 - 3 ] after endogenous stimulation. (springer.com)
  • A CD4 count is mostly used to check the health of your immune system if you are infected with HIV (human immunodeficiency virus). (medlineplus.gov)
  • It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
  • CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
  • In 1994, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) recognized that, although strategies were available to reduce the frequency of opportunistic infections in patients who have human immunodeficiency virus (HIV) infection, information regarding prevention of both exposure and disease often was published in journals not regularly reviewed by health-care providers. (cdc.gov)
  • Although guidelines have been established for prophylaxis against Pneumocystis carinii pneumonia (PCP) for adults with human immunodeficiency virus (HIV) infection, they have not been available for children (1). (cdc.gov)
  • In vitro treatment of peripheral blood lymphocytes with TSO induced significant number of micronuclei in all samples. (scialert.net)
  • There are various ways of detecting the antigenotoxic potential of these substances from short-term genotoxicity assays in vitro to bioassays in humans. (scialert.net)
  • In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)
  • There was a significant decrease in PWM-induced B-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. (karger.com)
  • These data suggest that the inhibition of spontaneous lymphocyte proliferation by glucocorticoids in vitro is related to glucocorticoid receptor function. (karger.com)
  • At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. (the-scientist.com)
  • Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
  • The results showed the existence of an in vitro adaptive response in lymphocyte cell exposed to low dose of gamma radiations. (ijmcmed.org)
  • Đelić N, Potparević B, Živković L, Marković B, Dačić S. In vitro analysis of clastogenic effects of adrenaline on human lymphocytes. (ac.rs)
  • In contrast, tonsillar lymphocytes demonstrate a similar initial phase of swelling but fail to restore their isotonic volume. (jci.org)
  • The data confirm that the response of peripheral blood and tonsillar lymphocytes to a hypotonic environment can be accounted for by differences in the proportions of T and B cells, and the differential behaviour of B and T lymphocytes is based on differences in membrane permeability to K+ upon swelling. (jci.org)
  • To assess whether HBoV is present in tonsillar lymphocytes and therefore possibly explain the high rate of PCR positives obtained by Longtin et al. (cdc.gov)
  • However, the molecular drivers of these processes and the cells generating chemotactic signals that affect B cells in human LNs are not well understood. (nih.gov)
  • In human LNs we find CXCL13 is prominently expressed at the follicular edge, often associated with fibroblastic reticular cells located in these areas, whereas follicular dendritic cells show minimal contribution to CXCL13 expression. (nih.gov)
  • Human B cells rapidly downregulate CXCR5 on encountering CXCL13, but recover CXCR5 expression in the CXCL13-low environment. (nih.gov)
  • We have identified two populations of human lymphocytes differing in responsiveness to the plant mitogen concanavalin A (Con-A). When peripheral blood lymphocytes are passed through a nylon column a population of lymphocytes highly responsive to Con-A adheres to the fibers while a second population of cells relatively unresponsive to Con-A emerges from the column. (jci.org)
  • The untreated peripheral blood lymphocytes are termed "unfiltered" cells while the lymphocytes which pass through the column are termed "filtered" cells. (jci.org)
  • Persistent infections and dependence on rapidly dividing cells are common features of the related parvoviruses, for example, human erythrovirus B19 ( 7 ). (cdc.gov)
  • Abstract: 'A stereologic method was used to obtain these quantities [diameter, volume, and membrane area of the cells and their nuclei] from transmission electron microscopy (TEM) of random sections through human white blood cells (neutrophils, lymphocytes, monocytes, and eosinophils). (harvard.edu)
  • treatment of resting human B cells with phorbol ester, calcium ionophore and forskolin results in modest increases in cell surface levels of CD25. (gla.ac.uk)
  • Similarly, this latter treatment abrogates any increase in CD25 levels observed in response to anti-Iimmunoglobulin and anti-CD40 antibodies, the only other stimuli capable of inducing CD25 expression in primary human B cells. (gla.ac.uk)
  • Additionally, we have demonstrated that IL-4-induced cAMP production is dose dependent and leads to the activation of the cAMP-dependent protein kinase, PKA, in primary human B cells. (gla.ac.uk)
  • Atypical lymphocyte population often express features of activated CD8+ T cells, such as CD29, CD38, HLA-DR, CD45RO and CD95. (wikipedia.org)
  • Some pathogen-related causes include: Epstein-Barr virus Cytomegalovirus Toxoplasma gondii Treponema pallidum (syphilis) Streptococcus agalactiae (group B streptococci) Hepatitis C Hantavirus The presence of Downey cells were observed in many COVID-19 cases, together with the atypical plasmacytoid lymphocytes (which could be one of the less usual atypical lymphocyte types). (wikipedia.org)
  • To study the nonthermal effects of radiofrequency fields on human immune cells ( peripheral blood mononuclear cells ) exposed to a Global System for Mobile Communication ( GSM ) signal generated by a commercial cellular phone and by a sinusoidal non- modulated signal ( continuous wave ). (emf-portal.org)
  • They're also called CD4 T lymphocytes or "helper T cells. (medlineplus.gov)
  • A rogue hybrid lymphocyte, bearing characteristics of both B and T cells, may play a role in driving autoimmunity in the disease, although the mechanism is far from clear. (the-scientist.com)
  • Some, called human leukocyte antigens (HLA), tag your cells so your body can ID itself. (webmd.com)
  • Lymphocytes called T cells and B cells work together to build your acquired immunity. (webmd.com)
  • We now validated whether [ 18 F]FB-IL2 can be used to quantify activated human peripheral blood mononuclear cells (hPBMC) in rats by pharmacokinetic modelling. (springer.com)
  • In our previous studies, we demonstrated the ability of [ 18 F]FB-IL2 to selectively detect activated human peripheral blood mononuclear cells (hPBMC) in rodent models of inflammation by noninvasive PET imaging [ 22 ]. (springer.com)
  • Chromosomal studies were performed in phytohaemagglutinin-stimulated cultures of lymphocytes and in bone marrow cells without culture from 115 patients with megaloblastic anaemia resulting from nutritional deficiency of folate and vitamin B 12 Essentially similar chromosomal abnormalities were observed in the two cell lines. (karger.com)
  • The two main types of lymphocytes are T cells and B cells , which function in the adaptive immune system . (newworldencyclopedia.org)
  • Other lymphocyte-like cells are commonly known as natural killer cells, or NK cells, and are part of the innate immune system . (newworldencyclopedia.org)
  • The NK cells are sometimes labeled "large granular lymphocytes," while the T cells and B cells are labeled as "small lymphocytes. (newworldencyclopedia.org)
  • While offering protection against millions of possible invaders, including viruses , bacteria , are cancer cells, lymphocytes allow normal body cells and helpful, symbiotic bacteria to flourish at the same time. (newworldencyclopedia.org)
  • A stained lymphocyte surrounded by red blood cells viewed using a light microscope. (newworldencyclopedia.org)
  • The two main categories of lymphocytes are the B lymphocytes ( B cells ) and T lymphocytes ( T cell ), both of which are involved in the adaptive immune system (Alberts 1989). (newworldencyclopedia.org)
  • In addition, lymphocyte-like cells called natural killer (NK) cells are involved in the immune system, albeit part of the innate immune system . (newworldencyclopedia.org)
  • The human body has the ability to form millions of different types of B cells each day, and each type has a unique receptor protein (referred to as the B cell receptor, or BCR) on its membrane that will bind to one particular antigen. (newworldencyclopedia.org)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (centralx.com)
  • DAbR1 was subcloned together with green fluorescent protein into an SFG-retroviral vector and used to transduce CD3/CD28-activated primary human T cells and second-generation 1928z (CAR) T cells. (snmjournals.org)
  • 50%), compact MC infiltrates are accompanied by perifocal clusters of lymphocytes containing a mixture of B and T cells. (bmj.com)
  • In this study, we investigated the adaptive response using 5cGy conditioning dose of gamma rays followed by 2 Gy challenging dose in peripheral human lymphocyte cells. (ijmcmed.org)
  • Consequently, the number of micronuclei (MN) in binuclear lymphocyte cells was counted as an endpoint. (ijmcmed.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • This all makes GNLY 1000 times less effective in pore formation in human cells than in microbe cells. (wikipedia.org)
  • In the United States, opportunistic infections continue to produce morbidity and mortality among the estimated 650,000-900,000 persons who are infected with HIV, especially among the estimated 200,000-250,000 persons who are severely immunosuppressed (i.e., persons who have a CD4+ T-lymphocyte count of less than 200 cells/uL) (6-10). (cdc.gov)
  • The results showed that the mean frequency of micronuclei in binuclear lymphocytes which have received both conditioning and challenge doses are significantly reduced in comparison to those only exposed to 2 Gy (20.46±2.13, 30.2±3.29) (P (ijmcmed.org)
  • The methodology for determination of micronuclei (MN) in lymphocytes (CBMN) is well established, and accumulating data demonstrated a correlation to enhanced risk of cancer development. (cdc.gov)
  • Identification of differences between the two major lymphocyte subpopulations. (jci.org)
  • Autoradiographic studies of chromosomes after pulse-labelling with 3 H-thymidine during the terminal 6 h of phytohaemagglutinin-stimulated lymphocyte cultures revealed a differential pattern of distribution of the radionucleotide in the chromosomes of megaloblastic lymphocytes as compared to those from normal lymphocytes. (karger.com)
  • but many of these morphological chromosomal changes (i.e. despiralization and breaks) persisted in the lymphocytes of a significant proportion of patients for variable periods up to 6-12 months after haematological remission resulting from therapy with the deficient vitamins. (karger.com)
  • In this study, we examined the possible protective effect of Tempol against DNA damage induced by cisplatin in human lymphocytes using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) assays. (tempol.info)
  • These attributes are scored on 132 CpG islands across the entire human Chromosome 21, whose methylation status was previously established for normal human lymphocytes. (mpg.de)
  • We predicted, and subsequently experimentally examined 12 CpG islands from human Chromosome 21 with unknown methylation patterns and found more than 90% of our predictions to be correct. (mpg.de)
  • In addition, we applied our prediction method to analyzing Human Epigenome Project methylation data on human Chromosome 6 and again observed high prediction accuracy. (mpg.de)
  • Tempol protects against radiation-induced chromosome aberrations in human peripheral blood lymphocytes. (tempol.info)
  • It is part of the saponin-like protein family, and its gene is found on the 2nd chromosome in humans. (wikipedia.org)
  • GNLY gene is located on human chromosome 2 and has 5 exons, which code for a 15 kDa protein. (wikipedia.org)
  • We used immunofluorescence microscopy, flow cytometry and functional assays to study molecular mechanisms of B-cell migration within human LNs, and found subtle but important differences to previous murine models. (nih.gov)
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
  • To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function, dose-response curves were obtained for Con A-and PHA-induced T-cell mitogenesis, PWM-generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls. (karger.com)
  • This phenomenon was transient and apparently confined to the lymphocyte Fcγ-receptor +ve subpopulation. (karger.com)
  • These studies demonstrate the activated human T-lymphocyte is an insulinsensitive tissue that is capable of limiting its physiologic response to insulin by receptor- and postreceptor-mediated mechanisms. (diabetesjournals.org)
  • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (nature.com)
  • Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. (ox.ac.uk)
  • We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Antigen 96 (LY96) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Lymphocyte Antigen 96 (LY96) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
  • Description: Quantitativesandwich ELISA kit for measuring Mouse Lymphocyte antigen 96 (LY96) in samples from serum, plasma, tissue homogenates. (hudsen.org)
  • The effect of antilymphocyte antibody on lymphocyte transformation. (eurekamag.com)
  • DOTA antibody reporter 1 (DAbR1) comprises a single-chain fragment of the antilanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid ( S )-2-(4-acrylamidobenzyl)-DOTA (AABD). (snmjournals.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
  • We read with great interest the recent report by Longtin and colleagues ( 1 ) describing human bocavirus (HBoV) infection among Canadian children with acute respiratory tract illnesses (ARI). (cdc.gov)
  • In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Antigen 96 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
  • Following exposure to hypotonic media, human peripheral blood lymphocytes swell initially but restore their isotonic volume within minutes. (jci.org)
  • A method is proposed to allow quantitative estimates to be made of mutation frequency.The induction of SCE and cytogenetic aberrations in human lymphocytes and point-mutation in Salmonella has been investigated following exposure to a range of selected direct-acting chemical mutagens. (soton.ac.uk)
  • The adaptive response (AR) induced by radiation in human lymphocytes has been reported in a range of 1-20cGy pre-exposure. (ijmcmed.org)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for methyl parathion. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • Nevertheless, the effects in human health as result of chronic exposure to low levels are not yet completely understood. (cdc.gov)
  • A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. (wikidata.org)
  • Specifically, hESC-MSC treatment prevented disease-associated interstitial inflammation, protein cast deposition and infiltration of CD3 + lymphocytes in the kidneys. (nature.com)
  • Before observing SCE's in chemically treated lymphocytes the spontaneous SCE frequency in human lymphocytes was investigated for natural variation eg due to donor age or sex differences. (soton.ac.uk)
  • Reactive lymphocytes have been found to accumulate in areas of inflammation like the liver and pharynx of individuals with infectious mononucleosis and skin window preparations. (wikipedia.org)
  • Later in 1923 the features of the reactive lymphocytes were characterized in greater detail by Hal Downey and C.A. McKinlay, who also discovered the association with EBV and CMV. (wikipedia.org)
  • Downey type II cell is the most common type of reactive lymphocyte. (wikipedia.org)
  • now it is more suggested that reactive lymphocytes are activated T-lymphocytes produced in response to infected B-lymphocytes. (wikipedia.org)
  • Reactive lymphocytes are usually associated with viral illnesses, but they can also be present as a result of drug reactions (such as phenytoin), immunizations, radiation, and hormonal causes (such as stress and Addison's disease), as well as some autoimmune disorders (such as rheumatoid arthritis). (wikipedia.org)
  • Some observations even suggest that the presence of particular reactive lymphocytes in some of the infected patients could be an indicator of a better prognosis of the disease. (wikipedia.org)
  • Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? (bmj.com)
  • To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
  • Focal accumulations of lymphocytes in the bone marrow of SM are reactive in nature and could be termed lymphocytosis. (bmj.com)
  • This range of highly validated ELISA kits from Hycult can be used to measure granulocyte and lymphocyte proteins in a wide variety of samples. (bioscience.co.uk)
  • We have studied the ionic basis for this second or regulatory volume decrease (RVD) phase using lymphocytes from peripheral blood, tonsil, and thymus. (jci.org)
  • The increase in K+ permeability in response to hypotonic challenge was characteristic for T lymphocytes obtained from peripheral blood, tonsil, or thymus. (jci.org)
  • This study was taken up to evaluate the antigenotoxic potential of ginger in human peripheral blood lymphocytes. (scialert.net)
  • The peripheral B lymphocytes showed more than 90% positive, while the peripheral T lymphocytes showed approximately 60% positive at 48 h after activation by PMA/ionomycin, respectively. (korea.ac.kr)
  • ABSTRACT Crude antigenic preparations from Setaria equina were used in ELISA and Western blotting to examine cross- reaction with human sera from areas endemic for bancroftian filariasis. (who.int)
  • ELISA et transfert Western afin d'étudier la réaction croisée avec des sérums humains en provenance de zones endémiques pour la filariose de Bancroft. (who.int)
  • The human CD44 cell-surface glycoprotein participates in a wide variety of cell-cell interactions including lymphocyte homing and tumor metastasis. (ox.ac.uk)
  • Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (msdmanuals.com)
  • In recent times, spices are being discovered to have antimutagenic and anticarcinogenic potentials and there has been substantial evidence of data, supporting that dietary factors have a profound effect on prevention and etiology of human cancer (Weisburger, 2000). (scialert.net)
  • The use of cisplatin in treatments of human malignancies is limited by its side effects that include DNA damage and the subsequent risk of developing secondary cancer. (tempol.info)
  • They further categorized the atypical lymphocytes of different etiologies under three subtypes: Type I as highly differentiated "leukocytoid lymphocyte", round-to-lobulated nucleus, mature clumped chromatin with or without nucleoli and with varying degree of basophilia in the cytoplasm. (wikipedia.org)
  • Micronucleus frequencies in lymphocytes and reticulocytes in a pesticide -exposed population in Portugal. (cdc.gov)
  • In response to short DNA fragments, lymphocytes release mitochondrial DNA that helps trigger an immune response. (the-scientist.com)
  • There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
  • Therefore, we tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia. (jneurosci.org)
  • This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
  • B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
  • Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ + and TCRαβ + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). (nature.com)
  • Based on our findings, we present a model of B-cell migration within human LNs, which has both similarities and interesting differences to that proposed for mice. (nih.gov)
  • 2002) reported that Zerumbone, which was isolated from Zingiber aromaticum and Zingiber zerumbet had an antiproliferative effect on various human colonic adenocarcinoma cell lines. (scialert.net)
  • abstract = "The alkaline single-cell gel electrophoresis (or comet) assay was applied to evaluate the eventual DNA damage induced by the triphenolic metabolite of benzene, 1,2,4-benzenetriol (BT), in isolated human lymphocytes. (uab.cat)
  • Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • 1997 revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunode- ficiency virus [HIV]. (cdc.gov)
  • Single amino acid substitutions were introduced to the CAP1 peptide (YLSGANLNL), an immunogenic HLA-A2 + -binding peptide derived from human carcinoembryonic antigen (CEA). (aacrjournals.org)
  • The atypical lymphocytes have been best studied from blood of patients with infectious mononucleosis. (wikipedia.org)
  • 1998. Profiles of Great Lakes critical pollutants: A sentinel analysis of human blood and urine. (cdc.gov)