Human astrocytoma and glioblastoma. Medical search. Frequent questions

Astrocytomas, including the most malignant form, glioblastoma multiforme, are the most frequent and deadly primary tumors of the human nervous system. (nih.gov)
To study the possible role of TP53 in astrocytoma development, 24 randomly chosen human astrocytic tumors were examined for genomic TP53 sequence aberrations using primer-directed DNA amplification in conjunction with direct sequencing. (nih.gov)
These data suggest that TP53 mutations may play a role in astrocytoma development and are predominantly associated with higher grade tumors. (nih.gov)
The majority of diffuse astrocytomas arise in the cerebrum, but no region of the central nervous system (CNS) is spared as these tumors may occur in the basal ganglia, brainstem, cerebellum, and spinal cord. (medscape.com)
Molecular data have indicated a direct progression from diffuse astrocytoma to anaplastic astrocytoma to glioblastoma in patients whose tumors bear mutations in the IDH1/2 genes and TP53 genes, a finding that marks the pathogenic pathway of 5% of all glioblastomas. (medscape.com)
Studies are underway to use and develop the dog as a model of this devastating disease of humans in the hope that characterizing and successfully treating these tumors in dogs may lead to improved therapies for humans afflicted with this disease. (wikipedia.org)
brachycephalic (short-nosed) breeds such as the boxer, pug, Boston terrier and bulldog have a marked (25 times the normal occurrence) predilection for developing primary brain tumors to include glioblastomas. (wikipedia.org)
Intracranial tumors (such as glioblastoma) more commonly rely on radiation therapy as surgical access to the tumor may be prohibitively dangerous. (wikipedia.org)
Malignant gliomas are the most aggressive human brain tumors without any curative treatment. (aacrjournals.org)
Like all brain tumors, astrocytomas are very serious and are usually described by the medical community based upon their grade. (microscopyu.com)
In children, the majority of astrocytomas that occur are classified as low-grade, but in adults most of the tumors are of the high-grade variety. (microscopyu.com)
Astrocytes are non-excitable cells in the CNS that can cause life-threatening astrocytoma tumors when they transform to cancerous cells. (mdpi.com)
In the present study, MDR1 P-gp was immunodetected by Western blot analysis in 60 human brain tumors, including meningiomas, schwannomas, low-grade gliomas (astrocytomas, pilocytic astrocytomas) and high-grade gliomas (anaplastic astrocytomas, glioblastomas and anaplastic oligodendrogliomas). (nih.gov)
Glioblastomas (GBM), also called grade IV astrocytomas, are very aggressive primary tumors of the central nervous system. (biomedcentral.com)
According to the 2007 World Health Organization(WHO) classification of tumors of the central nervous system, the WHO defines diffusely astrocytic tumors with cytological atypia as grade II (diffuse astrocytoma), those also showing anaplasia and mitotic activity as grade III (AA), and tumors additionally showing microvascular proliferation and/or necrosis as WHO grade IV. (upmc.edu)
We think that defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity that makes treatment of human brain tumors so challenging. (stanford.edu)
To explore the possibility that VEGF may act as a driving force in the progression of AA to GBM, the VEGF isoforms VEGF 121 and VEGF 165 were overexpressed in genetically modified, mutant H-Rastransformed human astrocytes that on intracranial implantation form AA-like tumors. (northwestern.edu)
The parental mutant H-Ras-modified astrocytes expressed four times more endogenous VEGF than normal human astrocytes, but on intracranial implantation formed hypovascular, hypoxic, small AA-like tumors. (northwestern.edu)
An elevated expression of CCN2 has also been detected by Northern blotting in human invasive mammary ductal carcinomas, dermatofibromas, pyogenic granuloma, endothelial cells of angiolipomas and angioleiomyomas, and in pancreatic tumors. (neuromics.com)
In astrocytomas, CCN2 expression was particularly elevated in high grade tumors, with a marked effect of CCN2 on cell proliferation. (neuromics.com)
This phase I clinical trial measures the amount and effect of lidocaine injected into patients with glioblastoma while they are undergoing surgical removal of their brain tumors. (braintumor.org)
Glioblastoma multiforme (GBM) is the most common and most aggressive of the primary brain tumors. (medscape.com)
The current World Health Organization (WHO) classification of primary brain tumors lists GBM as a grade IV astrocytoma . (medscape.com)
Among primary brain tumors, malignant astrocytomas are the most common in all age groups. (medscape.com)
According to Timothy Fan (ACPP/CGD), a professor of veterinary clinical medicine, dogs may be better than rodents in many cancer drug-testing models because the latter need to be implanted with human cancer cells to mimic specific types of tumors. (illinois.edu)
Dogs are also more similar in size to humans and are, therefore, better models to test how well the drugs work on larger tumors. (illinois.edu)
When they tested the drug in mice models of human estrogen-receptor-positive breast cancers and their metastases in the bone, brain, liver, and lungs, the drug killed 95-100% of the cancer cells and shrank large tumors to undetectable levels. (illinois.edu)
Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)
As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. (bvsalud.org)
Li-Fraumeni syndrome, Cowden syndrome and neurofibromatosis 1 syndrome represent three genetic conditions with associated high risks of developing tumors such as glioblastoma, schwannoma and astrocytoma. (hilarispublisher.com)
There is a correlation between countries with high Human Development Index (HDI) and the incidence and mortality of brain tumors. (hilarispublisher.com)
We have used immunohistochemistry (IHC) and isotope-based liquid chromatography mass spectrometry (LC-MS) to investigate the presence and distribution of 5 hmC in human brain and brain tumors. (scilifelab.se)
In tumors, positive staining of cells ranged from 1.1% in glioblastomas (GBMs) (WHO Grade IV) to 8.9% in Grade I gliomas (pilocytic astrocytomas). (scilifelab.se)
The present study provides new insights into TERT p mutational spectrum occurring in central nervous system tumors, with the identification of new recurrent somatic gain-of-function mutations, occurring in 0.8% of glioblastoma IDH -wildtype. (biomedcentral.com)
The abnormal reactivation of human Telomerase Reverse Transcriptase (TERT) is a common hallmark of human solid tumors. (biomedcentral.com)
Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
Astrocytomas Astrocytomas are central nervous system tumors that develop from astrocytes. (msdmanuals.com)
Both primary and secondary glioblastomas have distinct genetic characteristics, which can change as the tumors evolve. (msdmanuals.com)
Researchers from the University of Florida have published a study evaluating a high-fat, low-carbohydrate diet in the treatment of glioblastoma brain tumors. (medscape.com)
Preliminary data have shown that the modified diet appears to make glioblastoma tumors more sensitive to treatment with radiation and chemotherapy. (medscape.com)

Five of the 11 grade III astrocytomas (glioblastoma multiforme), but only one of seven grade II astrocytomas (anaplastic astrocytoma) and none of either the grade I astrocytomas or oligodendrogliomas demonstrated distinct point mutations involving the TP53 gene. (nih.gov)
They show an average value of MIB-1 in the three groups of grade II astrocytoma, AA and glioblastoma multiforme (GBM) of approximately 3,12, and 16 respectively. (upmc.edu)
Whereas VEGF is up-regulated in only a portion of anaplastic astrocytoma (AA), it is overexpressed in most glioblastoma multiforme (GBM), and the level of expression is correlated with grade of glioma. (northwestern.edu)
Polymorphism at codon 31 of CDKN1A (p21) as a predictive factor for bevacizumab therapy in glioblastoma multiforme. (cdc.gov)
Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib. (medscape.com)
Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy. (medscape.com)
Spinal drop metastases in recurrent glioblastoma multiforme. (medscape.com)
Currently in the human trials, PAC-1 has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain. (illinois.edu)
Formerly known as glioblastoma multiforme, the term "multiforme" reflects a robust heterogeneous variety of cell types coexisting within the tumor. (biomedcentral.com)

Infiltrative, or diffuse, astrocytomas represent a group of astrocytic gliomas that are prone to exhibit diffuse invasion of the brain parenchyma. (medscape.com)
A strong upregulation of LC3B, p62, LAMP2 and CTSB was detected in perinecrotic areas in glioblastomas suggesting micro-environmental changes as a driver of autophagy induction in gliomas. (oncotarget.com)
BACKGROUND: Glioblastoma (GBM) is a fatal CNS malignancy, representing 50 % of all gliomas with approximately 12-18 months survival time after initial diagnosis. (gwu.edu)
In addition, human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) have also been associated with low-grade gliomas, but few studies have examined HHV-6 and EBV in glioblastomas. (gwu.edu)
[ 1 ] Astrocytoma is one of 3 distinct types of gliomas in the brain, although mixed cell types occur as well. (medscape.com)
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
In gliomas, TERT p mutations ( TERT p mut ) mainly occur in oligodendroglioma and glioblastoma. (biomedcentral.com)
We screened, for TERT p hotspot mutations, 301 adult patients with gliomas and identified heterozygous mutations in 239 cases: 94% of oligodendroglioma, 85% of glioblastoma, and 37.5% of diffuse/anaplastic astrocytoma. (biomedcentral.com)
p.I827N) were detected in 42 (24%) gemistocytic astrocytomas and the olig2 labelling index three patients with gliomas. (who.int)
ERCC1 were absent in other low-grade in lowgrade diffuSe glioMaS schwannomas also carried the MSH4 diffuse gliomas and in primary (de novo) germline mutation and, in addition, a glioblastomas (Ohta et al. (who.int)

Anaplastic astrocytomas represent the intermediate stage in the spectrum of progressive astrocytomas that range from diffuse astrocytoma (grade II) to glioblastoma (grade IV). (medscape.com)
Under the modified WHO classification, GBM differs from anaplastic astrocytomas (AA) by the presence of necrosis under the microscope. (medscape.com)
Pilocytic, other low-grade, or anaplastic astrocytomas tend to develop in younger patients. (msdmanuals.com)
Anaplastic astrocytomas, in particular, can later evolve into glioblastomas (called secondary glioblastomas). (msdmanuals.com)

In the present study, we investigated the therapeutic potential of TRAIL in primary human glioma cells. (aacrjournals.org)
We established a stable culture model for isolated primary human glioma cells. (aacrjournals.org)
Astrocytomas are the most common variety of glioma (tumor that arises from glial cells) and may be benign or malignant. (microscopyu.com)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. (bvsalud.org)

[ 10 ] TERT mutations are found consistently in both oligodendrogliomas as well as glioblastomas occurring in patients with no previous history of astrocytomas (primary glioblastoma). (medscape.com)
[ 10 ] Interestingly, while IDH1/2 mutations and TERT mutations occur together in oligodendrogliomas, they are mutually exclusive in glioblastomas, further supporting the distinction between primary and secondary glioblastomas. (medscape.com)
Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. (thermofisher.com)
Therefore, the entire oligodendroglial differentiation, diffuse astrocytomas, oligoastrocytomas, coding sequence of the LATS1 gene in IDH1 Mutation, and 1P/19q loSS and oligodendrogliomas. (who.int)
Like astrocytomas, oligodendrogliomas can evolve into more aggressive forms, such as anaplastic oligodendrogliomas (WHO grade III), which are managed accordingly. (msdmanuals.com)

For instance, grade I tumours, like pilocytic astrocytomas (according to the 4th edition of WHO classification), are curable glial tumours, while grade IV astrocytic tumours, glioblastomas, are rapidly progressive and lethal [ 2 ]. (hindawi.com)

Despite this aggressive treatment, median survival of glioblastoma patients is only about 15 months, and recurrence remains almost inevitable ( 1 , 2 ). (frontiersin.org)
Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence. (cdc.gov)
F]FET PET/MRI scans with DCE MRI from patients with suspected recurrence of anaplastic astrocytoma and glioblastoma were included retrospectively. (regionh.dk)
Glioblastoma (GBM) has a high incidence rate, invasive growth, and easy recurrence, and the current therapeutic effect is less than satisfying. (researchsquare.com)

She returned to UCSF to conduct translational research, and apply her combined expertise in stem cells and signaling on the study of brain neoplasms and human stem and progenitor cells. (stanford.edu)

Based on histologic and molecular findings at the time of the original diagnosis, a prognostic grade can be assigned to a diffuse astrocytoma. (medscape.com)
II) is a rare variant of diffuse astrocytoma, characterized by the presence of neoplastic gemistocytes and a consistent tendency to progress to secondary glioblastoma (WHO grade IV) and have a poor prognosis. (who.int)

This region contains a candidate tumor suppressor gene, TP53, which has recently been implicated in the etiology of a broad array of human cancers. (nih.gov)
Astrocytomas are the most common neuroectodermal tumor of dogs. (wikipedia.org)
We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
Perturbed homeostasis of the neurotransmitter glutamate is associated with astrocytoma tumor onset and progression, but the factors that govern this phenomenon are less known. (mdpi.com)
Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. (biomedcentral.com)
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
In agreement with CCN2 playing a role in brain tumor angiogenesis, immunocytochemistry studies indicated that both glioblastoma tumor cells and proliferating endothelial cells stained positive for CCN2. (neuromics.com)
The present invention relates to the Multiple Tumor Suppressor (MTS) genes in mice, their expression products, and their homology to the human MTS genes. (justia.com)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and a median overall survival of less than two years. (biomedcentral.com)
Glioblastoma (GBM) is the most aggressive type of primary brain tumor. (biomedcentral.com)
These results indicate that D-2HG may influence the tumor vascular microenvironment by reducing the intratumoral vasculature density and by inhibiting the transport of metabolites and extravasation of circulating cells into the astrocytoma microenvironment. (bvsalud.org)
levels were related to tumor differentiation, ranging from lowest values of 0.078% 5 hmC/dG in GBMs (WHO Grade IV) to 0.24% 5 hmC/dG in WHO Grade II diffuse astrocytomas. (scilifelab.se)
However, natural disease studies of human infection and experimental disease studies suggest that a potential outcome of some polyomavirus (PyV) infections is tumor formation ( 4 - 6 ). (cdc.gov)

PAC-1 is currently in phase I clinical trials in humans and has been granted orphan drug status by the U.S. Food and Drug Administration for the treatment of glioblastoma, a deadly brain cancer. (illinois.edu)

This phase I trial is studying the safety and effectiveness of nivolumab in combination with ipilimumab and surgery when used in the treatment of recurrent glioblastoma. (braintumor.org)

Fan and his colleagues are also looking at PAC-1 in combination with radiation and in combination with temozolomide, a brain cancer drug used in humans and dogs. (illinois.edu)
PURPOSE: To report the long-term outcomes in adult patients with grade 2 IDH-mutant astrocytoma treated with temozolomide (TMZ)-based chemoradiation. (bvsalud.org)

Patients with gemistocytic astrocytoma with oligodendroglial differentiation, IDH1 samples from a Li-Fraumeni family with and secondary glioblastoma with RRAS mutation, and 1p/19q loss, suggesting a TP53 germline mutation and multiple deletion tended to have shorter survival that FUBP1 immunohistochemistry is nervous system tumours revealed times than those without deletion. (who.int)

Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma. (cdc.gov)
The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. (justia.com)
Secondary glioblastomas typically have mutations in the IDH1 or IDH2 genes. (msdmanuals.com)

The human MTS genes are involved in human cancers. (justia.com)
The invention is further related to the use of the MTS genes in the therapy, diagnosis and prognosis of human cancer. (justia.com)
Exome sequencing was carried out in gemistocytic astrocytomas, and homozygous deletion of genes was identified at 19q13, i.e. (who.int)

What predicts survival in glioblastoma? (gu.se)
Our results show that autophagy is enhanced in astrocytomas as compared to normal CNS tissue, but largely independent from the WHO grade and patient survival. (oncotarget.com)
Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model. (uib.no)
Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients. (uib.no)

The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. (justia.com)
Additionally, certain cancers in dogs are genetically similar to those in humans and respond to the same medications. (illinois.edu)
The American Cancer Society estimates that infectious pathogens are associated with up to 20% of all human cancers worldwide. (cdc.gov)

This review discusses the similarities and differences between the morphology of astrocytes and astrocytoma cells, and the role that dysregulation in glutamate and calcium signaling plays in the aberrant morphology of astrocytoma cells. (mdpi.com)
The aim of the present study was, therefore, to investigate the cytostatic and cytotoxic impact of the new iron chelator deferasirox (DFX) on human GBM cells in well-defined clinical situations represented by radiation therapy and mild-hypoxia. (biomedcentral.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. (biomedcentral.com)
Glioblastomas contain chromosomally heterogeneous cells. (msdmanuals.com)
Rarely, astrocytomas contain astrocytoma and oligodendroglioma cells. (msdmanuals.com)
They used human-derived glioblastoma cells in a mouse model. (medscape.com)

DQFHUV DVVRFLDWHG ZLWK FKURQLF LQIHFWLRQV IARC epidemiologists have estimated that in developing countries up to 20% of all human neoplasms develop in association with chronic infectious conditions. (who.int)
the genetics of human neoplasms. (who.int)

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma. (uib.no)
Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation. (uib.no)
Expression in glioblastomas highly variable. (thermofisher.com)

F]FET) PET in patients with anaplastic astrocytoma and glioblastoma following standard therapy. (regionh.dk)
This phase I/II trial studies the side effects and best dose of Visudyne (liposomal verteporfin) to see how well it treats patients with high-grade EGFR-mutated glioblastoma that has come back (recurrent). (braintumor.org)
Information gained from this study may help researchers come up with new treatments to help patients with glioblastomas in the future. (braintumor.org)
METHODS: One hundred and three patients with histologically proven grade 2 astrocytoma received radiation therapy (RT), 50.4-54 Gy in 1.8 Gy fractions, and adjuvant TMZ up to 12 cycles. (bvsalud.org)
In some instances people consider euthanasia to be a fundamental human right, which allows patients to determine when their own life should be taken away from them. (edubirdie.com)

Recent molecular genetic analyses of astrocytomas have demonstrated frequent chromosome 17 deletions involving the telomeric region of the short arm (17p12-pter). (nih.gov)
A case of glioblastoma harboring non-amplified epidermal growth factor receptor variant III: Critical molecular detection using RNA-based panel analysis. (cdc.gov)
The association of the molecular variant A-20C of the angiotensinogen gene with the prognosis of human hypertension as determined by the G-6A molecular variant is disclosed. (justia.com)
80%), little has been known about the molecular profile of gemistocytic astrocytomas. (who.int)

Genetic pathways to primary and secondary glioblastomas. (who.int)
17%) gemistocytic astrocytomas and in mutation with a sensitivity of 100% and 3 of 24 (13%) secondary glioblastomas. (who.int)
Two family in 8 of 24 (33%) secondary glioblastomas. (who.int)

Weighty lower RUNX3 protein level was observed in GMB specimens compared to grade II-III astrocytomas. (hindawi.com)
METHODS: This study analyzed 112 brain tissue specimens, including 45 glioblastoma, 12 astrocytoma grade III, 2 astrocytoma grade II, 4 astrocytoma grade I, and 49 controls. (gwu.edu)

The present invention relates generally to the field of human genetics. (justia.com)

Transscleral optical spectroscopy of uveal melanoma in enucleated human eyes. (uib.no)

Although histology in neurooncology represents gold standard in diagnostics, the recently described identification of molecularly different glioblastoma oncotypes and its correlation with clinical characteristics is important step in patient stratification into clinically distinct subgroups that could eventually benefit from personalized therapeutic strategy [ 3 - 5 ]. (hindawi.com)

The current WHO classification of human astrocytomas has limitation in predicting prognosis and diagnosis. (upmc.edu)

[ 1 ] whereas the higher grades of the biologic spectrum are assigned as "anaplastic astrocytoma" (grade III) and "glioblastoma" (grade IV). (medscape.com)

A reproducible brain tumour model established from human glioblastoma biopsies. (uib.no)

Epidemiologic data support a peak incidence in the fifth decade, a point between the peak incidence of diffuse astrocytomas (fourth decade) and glioblastomas (seventh decade). (medscape.com)

Three primary members of the ADAR family have been identified in humans: ADAR1, ADAR2 and ADAR3 (Figure 1 b) [ 1 ]. (biomedcentral.com)
Glioblastomas can also develop de novo (called primary glioblastomas), usually in middle-aged or older people. (msdmanuals.com)

Recombinant full length protein within Human PD-L1. (abcam.com)
Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
Recombinant protein encompassing a sequence within the N-terminus region of human OLIG2. (thermofisher.com)

6FLHQWLILF VWUDWHJ\ The Agency pursues three main objectives: the identification of the causes of human cancer, the elucidation of the mechanisms of carcinogenesis and the development of scientific strategies for cancer prevention. (who.int)
Multicentre case-control studies clearly demonstrated a cervical cancer risk associated with infection with a variety of human papillomaviruses (HPV) other than types 16 and 18. (who.int)
Aberrant ADAR activity has been associated with a wide range of human diseases, including cancer, neurological disorders, metabolic diseases, viral infections and autoimmune disorders. (biomedcentral.com)
Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. (justia.com)

In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
There is positive evidence of human fetal risk during pregnancy. (drugs.com)

Johannessen AL, Torp SH (2006) The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas Pathol Oncol Res Epub 200612:143-7. (upmc.edu)
ErSO has been licensed by the pharmaceutical company Bayer AG and is currently being tested for human clinical trials. (illinois.edu)
In 2013, a $4 million investment, informed by the trials in dogs, helped PAC-1 on the road to human clinical trials. (illinois.edu)
It takes a lot of time, effort, and money to do human clinical trials. (illinois.edu)

Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation. (edu.pl)

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. (uib.no)

Glioblastomas are considered a subset of astrocytomas-a particularly damaging, invasive, and undifferentiated type. (wikipedia.org)

The mechanism of this effect involved both a diminishment of the tumor's energy supply and an alteration of the glioblastoma cellular signaling pathways. (medscape.com)

In the normal adult human brain, LC-MS also showed highest values in cortical areas (1.17% 5 hmC/dG [deoxyguanosine]), in the cerebral WM we measured around 0.70% 5 hmC/dG. (scilifelab.se)

Anatomy7

Organisms3

Diseases16

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes6

Information Science3

Tumors40

Multiforme9

Gliomas10

Anaplastic astrocytomas4

Glioma6

Oligodendrogliomas5

Pilocytic1

Recurrence4

Brain Neoplasms1

Diffuse astrocytoma2

Tumor15

Treatment of Glioblastoma1

Recurrent glioblastoma1

Temozolomide2

Tumours1

Mutations3

Genes3

Survival4

Cancers3

Cells7

Neoplasms2

Expression3

Patients5

Molecular4

Secondary3

Specimens2

Genetics1

Melanoma1

Distinct1

Prognosis1

Grade IV1

Biopsies1

Incidence1

Primary2

Protein3

Cancer4

Evidence2

Clinical4

Radiation1

Angiogenesis1

Invasive1

Pathways1

Adult1