• Residue Gln384 is located in the large lipid transfer module of apoB that has been suggested to be important for lipidation of apolipoprotein B through interaction with microsomal triglyceride transfer protein. (bvsalud.org)
  • Apolipoprotein B (apoB)-lipoproteins initiate and promote atherosclerotic cardiovascular disease. (bvsalud.org)
  • MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
  • Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
  • Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
  • The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
  • 6 There are also rare forms of FH that result from mutations in genes for apolipoprotein B-100 (ApoB), proprotein convertase subtilisin/kexin type 9 (PCSK9), 8 and the low-density lipoprotein receptor adaptor protein 1 (LDLRAP1), which causes a rare form of autosomal recessive FH. (acc.org)
  • Hepatic LDL-receptor mRNA concentrations were significantly decreased in animals fed on TP, while apolipoprotein B mRNA concentrations were significantly increased. (cambridge.org)
  • With regards to 20-30% involving patients usually do not found just about any mutation from the known genes (LDLR, APOB and also PCSK9). (bms-754807inhibitor.com)
  • Cellular lipid droplets were evident and apoB secretion was decreased by 76% in these cells. (johnshopkins.edu)
  • Our results indicate that FABP5 mRNA knockdown results in the accumulation of cellular triglycerides, decreased cholesterol levels, and reduced secretion of apoB100 protein and lipoprotein-like particles. (johnshopkins.edu)
  • Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. (affbiotech.com)
  • Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p. (wikipedia.org)
  • We found that tPA, partially through the lysine-binding site on its Kringle 2 domain, binds to the N terminus of apoB, blocking the interaction between apoB and microsomal triglyceride transfer protein (MTP) in hepatocytes, thereby reducing very-low-density lipoprotein (VLDL) assembly and plasma apoB-lipoprotein cholesterol levels. (bvsalud.org)
  • To elucidate the role of FABP5 in lipid metabolism, the production of the FABP5 protein in a human RPE cell line was inhibited using RNA interference technology. (johnshopkins.edu)
  • The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. (thermofisher.com)
  • and 3) describing the functions of cholesteryl ester transfer protein (CETP) in regulating the LDL:HDL ratio in humans, including therapeutic strategies targeting CETP. (biomedcentral.com)
  • out there in PMC 2015 January 01.FeigPageIn addition, mRNA concentrations of quite a few well-known proteins implicated in atherothrombosis, including vascular cell adhesion protein-1 (VCAM-1), monocyte chemotactic protein 1 (MCP-1) and tissue factor, are decreased in foam cells throughout regression. (squalene-epoxidase.com)
  • They are capable of converting low-quality feed into high-quality protein and essential minerals with high bioavailability, which can be easily incorporated into human diets. (biomedcentral.com)
  • These proteins can be targeted using a variety of approaches, such as protein inhibition or interference, inhibition of translation at the mRNA level. (cdc.gov)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
  • LDL receptor analysis can be used to identify the specific LDL receptor defect, and LDL receptor or apoB-100 studies can help distinguish heterozygous FH from the similar syndrome of familial defective apoB-100. (medscape.com)
  • Notably, human genetic variants in the MIR541, ZNF101, and CASZ1 loci are significantly associated with plasma lipids and lipoprotein levels. (bvsalud.org)
  • Plasma tissue plasminogen activator (tPA) activity is negatively associated with atherogenic apoB-lipoprotein cholesterol levels in humans, but the mechanisms are unknown. (bvsalud.org)
  • Humans with PAI-1 deficiency have smaller VLDL particles and lower plasma levels of apoB-lipoprotein cholesterol. (bvsalud.org)
  • Humans have a peripheral lipoprotein profile where low-density lipoproteins (LDL) represent the dominant lipoprotein fraction and high-density lipoproteins (HDL) represent a minor lipoprotein fraction. (biomedcentral.com)
  • The LDL:HDL ratio in humans is set mainly by CETP activity, which exchanges cholesteryl esters for triglycerides across lipoprotein fractions to raise LDL and lower HDL as CETP activity increases. (biomedcentral.com)
  • Unlike humans, wild-type mice do not express catalytically active CETP and have HDL as their major lipoprotein fraction. (biomedcentral.com)
  • Our study group created the strategy of transplanting a segment of plaque-containing aorta from a (WD-fed) hyperlipidemic apoE- mouse (i.e. an exceptionally pro-atherogenic milieu consisting of high plasma apoB levels and low HDL-cholesterol levels), into a wild-type recipient (i.e. quickly normalizing the lipoprotein atmosphere, which can be sustainable indefinitely). (squalene-epoxidase.com)
  • ApoB antibody detects endogenous levels of total ApoB. (affbiotech.com)
  • Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human APOBEC2. (prosci-inc.com)
  • Editing of this gene product has been found to occur in mice and rats as well as humans. (wikipedia.org)
  • We identified miR-541-3p that both decreases apoB and increases apoA1 expression by inducing mRNA degradation of two different transcription factors, Znf101 and Casz1. (bvsalud.org)
  • Mice, rats and humans have conserved sequences flanking the editing site consisting of 10 nucleotides before the editing site and four after the site. (wikipedia.org)
  • Genetic restoration of CETP expression in mice to generate a more human-like lipid profile may increase the relevance of murine models for VCID studies. (biomedcentral.com)
  • In spite of the abundance of research on the roles of TE on the genome biology in humans, model organisms (e.g., mice and Drosophila ), and plants (especially crop species), few studies on TE have been conducted in livestock and poultry. (biomedcentral.com)
  • Combined infection of apoA-I-/- mice with a mixture of adenoviruses expressing both apoE4 (2x10(9) pfu) and human LCAT (lecithin:cholesterol acyltransferase) (5x10(8) pfu) cleared the triacylglycerol-rich lipoproteins, increased HDL and converted the discoidal HDL into spherical HDL. (omicsdi.org)
  • Similarly, co-infection of apoE-/- mice with apoE4 and human LCAT corrected the hypercholesterolaemia and generated spherical particles, suggesting that LCAT is essential for the maturation of apoE-containing HDL. (omicsdi.org)
  • interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
  • Livestock and poultry play a significant role in human nutrition by converting agricultural by-products into high-quality proteins. (biomedcentral.com)
  • The mRNA translates genetic code into proteins. (encoredocs.com)
  • Also binds to APOB mRNA transcripts around the RNA editing site. (epigentek.com)
  • It binds the 3′ AG splice acceptor dinucleotide of the pre-mRNA target intron, and forms a heterodimer with U2AF2 , which binds the adjacent polypyrimidine tract. (massgenomics.org)
  • Purified recombinant fragment of human ApoB expressed in E. Coli. (affbiotech.com)
  • Recombinant antibodies against peptides of MDA-modified apoB one hundred happen to be shown to considerably decrease atherosclerosis.36 As previously reported, scFv and Fab against in vitro oxidized LDL inhibited foam cell formation and also the progression of atherosclerotic lesions by blocking the binding of oxLDL to macrophages and their subsequent internalization.37 Furthermore, passive immunization with anti-tumor necrosis factor and anti-platelet glycoprotein IIb/Table 1. (emlinhibitor.com)
  • Metazoan miRNAs guide the miRISC to partially complementary sites in the 3' UTRs of target mRNAs to promote their translational repression or deadenylation and degradation. (biomedcentral.com)
  • Plasminogen activator inhibitor 1 (PAI-1) sequesters tPA away from apoB and increases VLDL assembly. (bvsalud.org)
  • These results suggest a mechanism that fine-tunes VLDL assembly by intracellular interactions among tPA, PAI-1, and apoB in hepatocytes. (bvsalud.org)
  • Chemically modified antimiR oligonucleotides sequester the mature miRNA in competition with cellular target mRNAs leading to functional inhibition of the miRNA and derepression of the direct targets. (biomedcentral.com)
  • Moreover, there is now ample evidence that perturbations in the levels of individual or entire families of miRNAs are strongly associated with the pathogenesis of a wide range of human diseases. (biomedcentral.com)
  • It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. (affbiotech.com)
  • BMS-754807 effectively inhibits the growth of a broad range of human tumor types in vitro. (bms-754807inhibitor.com)
  • Possible mechanisms for the different effects of this and other missense mutations affecting the large lipid transfer module on the two forms of apoB, are discussed. (bvsalud.org)
  • Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) stop the liver from producing functional LDL or Lp(a) mRNA molecules. (encoredocs.com)
  • Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • Find APOBEC3A Antibodies for a variety of species such as anti-Human APOBEC3A, anti-Mouse APOBEC3A, anti-Rat APOBEC3A. (antibodies-online.com)
  • It involves located that the liver cathepsine transcription 2( SH2 Smart-Growth) of PLC-gamma and of regulatory presenting complexes( mammalian as Negotiating decay and compartment Reversible fibronectin) organize their mRNA toward telomeric differentiation transporters of the FGFR. (erik-mill.de)
  • Znf101 enhances apoB expression while Casz1 represses apoA1 expression. (bvsalud.org)
  • In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
  • Inside top layer cell lymphoma (MCL) as well as follicular lymphoma individuals, high mRNA phrase associated with CD24 linked using poor general emergency, while CD47 phrase didn't. (bms-754807inhibitor.com)
  • In search of a molecular regulator that could simultaneously and reciprocally control both LDL and HDL levels, we screened a microRNA (miR) library using human hepatoma Huh-7 cells. (bvsalud.org)
  • Cytosine exists in all living species, ranging from bacteria to plants to humans. (hmdb.ca)
  • RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. (mcw.edu)
  • Our data demonstrated that exposure of human monocytic cells to oxLDL-IC leads to increased cell survival compared to oxLDL alone. (musc.edu)
  • There were no apparent differences in the amount of U2AF1 mRNA between wild-type and mutated samples. (massgenomics.org)
  • It causes been that the download insurgency complex peptide 2( SH2 tRNA) of PLC-gamma and of cyanobacterial shedding features( such as elongating site and necrosis pleiotropic circulation) develop their presence toward post-translational p38 Humans of the FGFR. (erik-mill.de)
  • HIPK2 can early diminish RUNX1 and EP300( production) found to the RUNX1: human impact( Aikawa et al. (erik-mill.de)
  • Nearly 60,000 polymorphic TE have been found in humans. (biomedcentral.com)
  • Livestock and poultry play a crucial role in human survival and development. (biomedcentral.com)
  • In combination with Cited2 activates WT1 the Steroidogenic factor 1 There is some evidence for RNA editing of human WT1 mRNA. (wikipedia.org)
  • Since 2000, there are only 72 studies on TE in livestock and poultry genomes, compared to nearly 1700 studies in humans (PubMed database). (biomedcentral.com)