Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Annexin A6Annexin A1Annexin A2Annexin A5AnnexinsAnnexin A4Annexin A7Annexin A3Molecular Sequence DataAmino Acid SequenceModels, MolecularS100 ProteinsPhosphatidylserinesApoptosis
ANXA5AntibodyCompany in the Annexin A5 fieldProteinRecombinantELISA KitANXA4ApoptosisAnti-annexinProteinsImmunogenSymbolSerumPlasma membranePharmaceuticals ABPhosphatidylserineLipocortinCellsAntigensANXVAffinity chromatographyBiotechnologyPhospholipaseTissuesGeneDiseasesOvarianMedical OfficerDecreaseSwedenSignificanceTissue
ANXA52
  • AnxA5 2D-network mediates E-cadherin mobility in the plasmalemma that triggers human trophoblasts aggregation and thereby cell fusion. (cusabio.com)
  • Annexin A5(ANXA5), is a member of the structurally related family of?annexin?proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. (bioactiva.com)
Antibody10
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Annexin A11 (ANXA11) in Tissue homogenates and other biological fluids. (jsce-ip.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Annexin A7 (ANXA7) in tissue homogenates, cell lysates and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Annexin A7 (ANXA7) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • Monovariate logistic regression evaluation demonstrated a optimistic dose-effect relationship for anti-annexin V IgM with VOC, with elevated VOC danger seen with elevated antibody titers. (ncbcs.org)
  • Induction of apoptosis by cross-linking antibodies certain to human B-lymphoma cells: expression of Annexin V binding websites on the antibody cap. (ncbcs.org)
  • Here we report a novel method utilizing the unique photoluminescence properties of plant leaf-derived graphene quantum dots (GQDs) modified with annexin V antibody (Ab A5 ) to form (Ab A5 )-modified GQDs (Ab A5 -GQDs) enabling us to label apoptotic cells in live zebrafish (Danio rerio). (nycu.edu.tw)
  • A hottest embodiment makes use of a novel human monoclonal antibody that binds to a conserved space of the gp41 transmembrane subunit of the virus. (kits-elisa.com)
  • The antibody is produced by regular cell traces developed using human B lymphocyte cells collected from a affected individual possessing extreme titers of anti-HIV antibodies. (kits-elisa.com)
  • Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 60187-1-Ig (Cytokeratin 19 antibody) at dilution of 1:51200 (under 10x lens. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 60187-1-Ig (Cytokeratin 19 antibody) at dilution of 1:51200 (under 40x lens. (ptglab.com)
Company in the Annexin A5 field2
Protein14
  • Annexin A4 is a protein that in humans is encoded by the ANXA4 gene. (wikipedia.org)
  • Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. (wikipedia.org)
  • Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. (wikipedia.org)
  • Recombinant Human ANXA3 Protein 1-323 aa (full-length) with a 6xHis tag was expressed in E.coli. (creativebiomart.net)
  • Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. (bioactiva.com)
  • Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. (bioactiva.com)
  • We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. (maastrichtuniversity.nl)
  • Since the very moment we saw the first indication that Annexin A5 might be a very potent and useful medicine, we have been advancing this protein through preclinical and clinical development. (annexinpharma.com)
  • The protein Annexin A5 has been used for many years in laboratories. (annexinpharma.com)
  • The biological drug candidate ANXV - a human recombinant protein, Annexin A5 - is primarily intended for the acute treatment of a number of diseases that include vascular damage and inflammation. (annexinpharma.com)
  • The company's biological drug candidate ANXV - a human recombinant protein, Annexin A5 - is primarily intended for treatment of patients with injuries and inflammation of the blood vessels, but also for cancer. (mercadofinanciero.com)
  • Annexin V is a Ca(2+)-dependent, phospholipid-binding protein, which is proposed to regulate inflammation by inhibiting cytosolic phospholipase A(2). (ox.ac.uk)
  • Blom A. M . , Berggård K., Webb J. H., Villoutreix B., Lindahl G. and Dahlbäck B. (2000) Human C4b-binding protein has overlapping but not identical binding sites for C4b and streptococcal M-proteins. (lu.se)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
Recombinant3
  • Description: ANXA7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 490 amino acids (1-466 a.a.) and having a molecular mass of 52.9kDa. (2sars.com)
  • Dompé developed the application of rhNGF (recombinant human Nerve Growth Factor) approved by the FDA and EMA. (ois.net)
  • Annexin Pharmaceuticals is a public clinical stage biotech company advancing a first in class biologic with a broad therapeutic potential, ANXV (a recombinant human Annexin A5). (ois.net)
ELISA Kit4
  • Description: A sandwich ELISA kit for detection of Annexin A11 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
  • Description: A sandwich ELISA kit for detection of Annexin A7 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • Description: Quantitativesandwich ELISA kit for measuring Mouse Annexin A7 (ANXA7) in samples from serum, plasma, tissue homogenates. (2sars.com)
  • Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. (lipidx.org)
ANXA43
  • Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Antigen standard for annexin A4 (ANXA4) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • ANXA4 can also interact with other annexin proteins or cytoskeletal proteins, potentially contributing to its diverse cellular functions. (creativebiomart.net)
Apoptosis4
  • Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. (duke.edu)
  • Annexin A5 was proposed to use in detection of apoptosis. (cusabio.com)
  • However, a significantly higher percentage of PS-positive PLTs was found with lactadherin than annexin V. CONCLUSION: PS exposure on the surface of stored PLTs has been previously underestimated due to the wide use of annexin V. Lactadherin provides a truer reflection of the degree of PS exposure and offers a new calcium-independent approach to studying PLT activation and/or apoptosis. (ox.ac.uk)
  • Flow cytometric analysis of annexin V binding/PI exclusion and DNA fragmentation disclosed that all these alkaloids could induce apoptosis in OCM-1 cells. (unideb.hu)
Anti-annexin14
  • Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and Anti-Annexin V Antibodies. (ncbcs.org)
  • A attainable co-appearance of anticardiolipin (aCL), anti-β2-glycoprotein I (anti-β2-GPI), anti-prothrombin (aPT) and anti-annexin V (aANXV) antibodies of IgG, IgM and IgA class have been studied in 58 sufferers with SLE alone and 32 sufferers APS within the view of rational laboratory diagnostics. (ncbcs.org)
  • Anti- annexin V IgG and IgM antibodies in sickle cell illness sufferers with vaso-occlusive disaster. (ncbcs.org)
  • In view of their prothrombotic nature, we hypothesized that SCA-associated VOC could also be because of the presence of anti-annexin V antibodies. (ncbcs.org)
  • Anti-annexin V antibodies have been measured with ELISA in 177 VOC and 81 steady-state SCA sufferers. (ncbcs.org)
  • Anti-annexin V IgM and IgG concentrations have been considerably larger in VOC sufferers than in steady-state sufferers and have been related to elevated VOC danger. (ncbcs.org)
  • After categorizing anti-annexin V antibodies, the adjusted odds ratio elevated because the percentile worth elevated. (ncbcs.org)
  • Multivariate logistic regression analyses confirmed the affiliation of anti-annexin V IgM, extra so than IgG, as an unbiased VOC danger issue. (ncbcs.org)
  • Anti-annexin V IgG antibodies correlated positively with VOC kind and negatively with HbF and age of VOC onset, whereas anti-annexin V IgM correlated positively with VOC kind, length, frequency, web site, ache severity, hospitalization, and medicine, and negatively with age of VOC onset and HbS ranges. (ncbcs.org)
  • Excessive ranges of anti-annexin V IgM antibodies represent a danger issue for VOC in SCA sufferers. (ncbcs.org)
  • Scientific significance of serum anti- annexin V antibodies in Egyptian sufferers with scleroderma. (ncbcs.org)
  • We investigated the prevalence of anti-annexin V IgG and IgM antibodies in sera of scleroderma sufferers and their relation to the presence of different antibodies and improvement of illness morbidity. (ncbcs.org)
  • Sera of 40 scleroderma sufferers and 15 wholesome controls have been examined for IgG and IgM anti-annexin V antibodies by ELISA and anticentromere antibodies by oblique immunofluorescence. (ncbcs.org)
  • In conclusion, measurement of serum anti-annexin V IgG antibodies in scleroderma sufferers could also be necessary for early prognosis of vascular and pulmonary issues. (ncbcs.org)
Proteins4
  • Annexins are a multigene family of Ca++-regulated phospholipid-binding proteins. (rndsystems.com)
  • The name annexin derives from the fact that initial studies suggested that acidic membrane phospholipids and Ca++ annexed, or recruited, special cytosolic proteins into a membrane-interacting ternary complex. (rndsystems.com)
  • Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. (wikipedia.org)
  • The incorporation of cytosolic phospholipase A(2) into the membrane fraction of thrombin-activated platelets parallels that of annexin V, which suggests an interaction between the two proteins. (ox.ac.uk)
Immunogen2
Symbol1
Serum4
  • Description: A competitive ELISA for quantitative measurement of Canine Annexin A11(ANXA11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (jsce-ip.com)
  • Serum level of annexin A5 is related to annexin A5 expression in cancer tissues. (cusabio.com)
  • Serum annexin A5 level was not altered in pre-eclampsia. (cusabio.com)
  • Description: A competitive ELISA for quantitative measurement of Human Adrenomedullin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (lipidx.org)
Plasma membrane2
  • Annexins possess a series of unique 70 amino acid annexin-repeat modules that form a curved disk and allow for the creation of an intercessory complex between plasma membrane and cytofilaments. (rndsystems.com)
  • 6. Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. (mutalig.eu)
Pharmaceuticals AB1
  • Annexin Pharmaceuticals AB (publ) was established in 2014 in Stockholm, Sweden. (annexinpharma.com)
Phosphatidylserine3
  • Reutelingsperger, Chris P. M. / Phosphatidylserine targeting for diagnosis and treatment of human diseases . (maastrichtuniversity.nl)
  • Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V. (ox.ac.uk)
  • BACKGROUND: Annexin V binding to platelets (PLTs) is considered the gold standard for monitoring phosphatidylserine (PS) exposure. (ox.ac.uk)
Lipocortin1
  • Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. (wikipedia.org)
Cells5
  • By using human lungs and cells, this new system provides a novel way to culture cells in vitro to investigate matrix contributions to lung pathology in a disease-specific manner. (atsjournals.org)
  • Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface. (maastrichtuniversity.nl)
  • The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. (uchicago.edu)
  • Also, we propose two new targets of therapy (WG2-T1), which are TCL1 and Annexin A4, respectively involved in lymphoma development and drug resistance to paclitaxel in lung cancer cells. (mutalig.eu)
  • The GQDs have further been used to image human breast adenocarcinoma cell line (MCF-7 cells), human cervical cancer cell line (HeLa cells), and normal human mammary epithelial cell line (MCF-10A). (nycu.edu.tw)
Antigens1
  • BACKGROUND: We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular antigens and characterized their identity. (duke.edu)
ANXV2
  • Annexin Pharmaceuticals announces that all patients in the first dose group with the lowest dose have now completed treatment in the company's clinical phase 2 study in patients with retinal vein occlusion (RVO) with the investigational drug candidate ANXV. (mercadofinanciero.com)
  • In August 2023 , Annexin reported promising efficacy signals in two out of four patients treated with ANXV in the ongoing Phase 2 study. (mercadofinanciero.com)
Affinity chromatography1
  • Finally, we show that cytosolic phospholipase A(2) can be specifically purified from platelet membranes by affinity chromatography on GST-annexin V and that immunoprecipitation using antibodies against cytosolic phospholipase A(2) copurify annexin V and cytosolic phospholipase A(2) from activated platelets. (ox.ac.uk)
Biotechnology1
Phospholipase8
  • Investigation of the relocation of cytosolic phospholipase A2 and annexin V in activated platelets. (ox.ac.uk)
  • Here, we have studied the association of cytosolic phospholipase A(2) and annexin V with platelet membranes after thrombin stimulation. (ox.ac.uk)
  • In a time-dependent manner, an exact correlation was found between the membrane association of cytosolic phospholipase A(2) and annexin V. Calcium from the intracellular stores was sufficient for the relocation of intracellular annexin V and cytosolic phospholipase A(2) to platelet membranes. (ox.ac.uk)
  • Activation in the presence of arginyl-glycyl-aspartyl-serine (RGDS), which inhibits binding of fibrinogen to its adhesive ligand, does not alter the amount of cytosolic phospholipase A(2) or annexin V that binds to membranes. (ox.ac.uk)
  • When activation-induced actin polymerisation was prevented by cytochalasin E, the recovery of both annexin V and cytosolic phospholipase A(2) remained unchanged. (ox.ac.uk)
  • However, complete depolymerisation of the cytoskeleton with DNase I almost abolished the association of cytosolic phospholipase A(2) with the membranes, and it completely abolished the relocation of annexin V to platelet membranes. (ox.ac.uk)
  • These findings suggest that following platelet activation with thrombin, both cytosolic phospholipase A(2) and annexin V, relocate to platelet membranes where they interact. (ox.ac.uk)
  • An intact cytoskeleton seems to be a prerequisite for the interaction of cytosolic phospholipase A(2) and annexin V with platelet membranes. (ox.ac.uk)
Tissues3
  • This methodology is expected to allow investigation of important ECM-based hypotheses in human tissues and permits future scientific exploration in an organ- and disease-specific manner. (atsjournals.org)
  • In patients with colon cancer, annexin A5 expression in cancer tissues is related to lymph node metastasis and tumor grade. (cusabio.com)
  • PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
Gene3
  • This gene encodes a member of the annexin family. (creativebiomart.net)
  • In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. (gsea-msigdb.org)
  • The used of a comprehensive dataset of gene profiles from all the major human leukocyte subsets enabled a novel and powerful means for identification of genes associated with single leukocyte subsets, or different immune paradigms. (gsea-msigdb.org)
Diseases1
Ovarian2
  • Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
  • The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
Medical Officer1
  • We remain committed to our plan to have all patients included in the study during the first quarter of next year and to be able to report 4-month follow-up data thereafter", says Dr. Anna Frostegård, Chief Scientific and Medical Officer at Annexin Pharmaceuticals. (mercadofinanciero.com)
Decrease1
  • increase in VEGF and Apelin, and decrease in Annexin A5 supports roles of hemo-dynamic alterations in fetoplacental circulation and structural alterations in uteroplacental bed occurring in preeclampsia. (cusabio.com)
Sweden1
  • The development programme of Annexin Pharmaceuticals is based on an earlier discovery by Dr. Anna Frostegård and Professor Johan Frostegård at Karolinska Institutet in Stockholm, Sweden. (annexinpharma.com)
Significance1
  • Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. (cancerindex.org)
Tissue3
  • Sera were tested by Western blots for immunoreactive bands against human donor macular tissue homogenates. (duke.edu)
  • Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. (cancerindex.org)
  • Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)