Human aging brain. Medical search. Frequent questions

Dr. Gary Small, Parlow-Solomon Professor on Aging, a professor of psychiatry and biobehavioral sciences at the Semel Institute and director of the UCLA Longevity Center, was interviewed Feb. 12 on Las Vegas' KLAS-Channel 8 about his book "The Alzheimer's Prevention Program" and what individuals can do to keep their cognitive skills sharp as they age. (ucla.edu)
Aging is the biggest risk factor for neurodegenerative diseases, such as Alzheimer's disease. (lu.se)
Just the right amount is needed for proper cell function, yet too much is associated with brain diseases like Alzheimer's and Parkinson's. (sciencedaily.com)
Iron accumulates in our bodies as we age," Bartzokis said, "and in the brain contributes to the development of abnormal deposits of proteins associated with several prevalent neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies. (sciencedaily.com)
Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. (eaapublishing.org)
Leaky Blood-Brain Barrier a Harbinger of Alzheimer's? (alzforum.org)
BACKGROUND: Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. (lisanwanglab.org)
Application of this method to brains samples from select regions in two diseases-Alzheimer's disease (AD, superior frontal gyrus), frontotemporal lobar degeneration (FTLD, in rostral aspect of frontal cortex ∼BA10)-showed that while control cohorts exhibited no significant difference between physiological and chronological ages, FTLD and AD exhibited prematurely aged expression profiles. (lisanwanglab.org)
Currently, a definitive diagnosis of Alzheimer's disease is only possible postmortem, when the distribution and type of pathology in the brain can be directly verified via histology. (iit.edu)
The purpose of this work was to investigate the use of magnetic resonance imaging (MRI) as diagnostic tool for Alzheimer's and other types of pathology that are common in the elderly human brain. (iit.edu)
Interestingly, such decrease has been correlated with the development of age-related neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) [ 11 ]. (aging-us.com)

Disclaimer: The statements on this page represent the views of the UCLA Semel Institute for Neuroscience and Human Behavior and do not necessarily represent the views of the University of California, or UCLA or its Chancellor. (ucla.edu)
This association was identified by a team of scientists including Lara Puhlmann and Pascal Vrtička from the Max Planck Institute for Cognitive Brain Sciences in Leipzig together with Elissa Epel from the University of California and Tania Singer from the Social Neuroscience Lab in Berlin as part of Singer's ReSource Project. (mpg.de)
The brain communicates via electrical impulses," explained study team member Dr. Robert M. G. Reinhart , a cognitive neuroscientist and assistant professor of psychological and brain sciences and biomedical engineering, and director of the Cognitive & Clinical Neuroscience Laboratory at Boston University. (medicalnewstoday.com)
Dr. Anderson is the Principal Investigator of the Cognition and Neuroscience of Aging Lab. (mcgill.ca)
Dr. George Bartzokis, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, and colleagues compared iron levels in women who had undergone a hysterectomy before menopause -- and thus, did not menstruate and lose iron -- with levels in postmenopausal women who had not had a premenopausal hysterectomy. (sciencedaily.com)
Her previous research has spanned multiple subfields of the brain including cognitive neuroscience, olfaction science, and mental health and wellbeing where she has worked on the relationship between attention and memory, scene reconstruction in memory and imagination using fMRI, and the translation of olfaction induced insights using EEG and measures of emotional, physical and mental wellbeing into product design. (sapienlabs.org)

Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles. (lisanwanglab.org)
CONCLUSIONS: This study establishes a quantitative scale for measuring premature aging in neurodegenerative disease cohorts, and it identifies specific physiological mechanisms common to aging and some forms of neurodegeneration. (lisanwanglab.org)
Recent Findings: Flavonoids have been found to decrease neuroinflammation, reduce oxidative stress, and mediate neuroplasticity in animal models of neurodegeneration and aging. (usda.gov)
Summary: Flavonoid supplementation, as well as dietary modification to include whole foods high in flavonoids, may provide therapeutic potential for aging individuals experiencing cognitive deficits resulting from neurodegeneration. (usda.gov)
Methods: This 18-month clinical trial longitudinally measured brain structure volumes by magnetic-resonance-imaging using hippocampal-occupancy (HOC) and lateral-ventricle-volume (LVV) expansion scores as neurodegeneration markers. (nuthealth.org)
Either the upregulation of neurotransmitter receptor genes or suppression of the downregulation could improve synaptic dysfunction associated with age-related neurodegeneration. (neurosciencenews.com)

Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
Researchers from Boston University have found that applying noninvasive electrical stimulation to certain parts of the brain may help improve long-term and working memory in people over the age of 65 for up to a month. (medicalnewstoday.com)
Researchers estimate that about 40% of people ages 65 and older experience memory loss. (medicalnewstoday.com)
The researchers found that the participants who received high-frequency electric stimulation to the dorsolateral prefrontal cortex of the brain improved their ability to recall words from the start of the list, showing improved long-term memory. (medicalnewstoday.com)
Researchers also found that participants who received low-frequency electric stimulation to the inferior parietal lobule of the brain had an easier time remembering words toward the end of the list, showing working memory improvement. (medicalnewstoday.com)
Recently, researchers have successfully used machine-learning methods to derive a biomarker that is commonly referred to as predicted brain age (PBA) or brain age based on brain imaging data. (nature.com)
The researchers used an MRI technique that can measure the amount of ferritin iron in the brain (ferritin is a protein that stores iron). (sciencedaily.com)
This study, conducted by researchers in the United Kingdom, tackles the "use it or lose it" conjecture - the widely held belief that a person can maintain or enhance his or her cognitive function, and offset age-related declines in mental performance, by engaging in intellectual "exercise. (latimes.com)
The researchers set out to follow these Scots for roughly the next 15 years, testing two dimensions of their cognitive health - mental speed and verbal memory performance - four times as they aged. (latimes.com)
In the end, the study allowed the researchers to compare the cognitive trajectories of 98 subjects essentially from grade school to the age of 82. (latimes.com)
While the study's recruits differed in their levels of ingoing intelligence, educational attainment and lifelong intellectual engagement, the researchers could measure and account for these factors to show how they influenced cognitive aging in recruits. (latimes.com)
Researchers have long suspected that a breached blood-brain barrier increases the risk for neuronal damage and cognitive decline, but where that breach first occurs has been a mystery. (alzforum.org)
Now, in the January 21 Neuron, researchers led by Berislav Zlokovic at the University of Southern California, Los Angeles, report that in older adults the blood-brain barrier first becomes compromised in subdivisions of the hippocampus. (alzforum.org)
Researchers found that a single gene, called Arc, played a crucial role in maintaining and restoring brain plasticity. (earth.com)
SCN brain cells are electrically active during the day and electrically silent during the night in younger animals and younger people, the researchers said, but that difference is reduced with aging. (uclahealth.org)
The researchers studied how people of different ages performed when put through a battery of cognitive tests , which included guessing the number of asterisks on a screen (fewer or more than 50) and identifying strings of letters as either words or non-words. (3quarksdaily.com)
Individuals aged 60 and older also had a slower response time for these tasks, but the researchers found that instead of just taking longer to follow the same thought process as young people, the older people took longer to make sure they responded accurately. (3quarksdaily.com)
Researchers discovered a mechanism linking insulin-like growth factors (IGF) to brain plasticity. (neurosciencenews.com)
Researchers discovered that through temporary increases in brain malleability and simultaneous desensitization to fear memories, they could control fear responses in mice. (neurosciencenews.com)
Building on their earlier work that indicated that people who meditate have less age-related atrophy in the brain's white matter, a new study by UCLA researchers has discovered that meditation appeared to help preserve the brain's gray matter, the tissue that contains neurons. (fisu.org)
People in both groups showed a loss of gray matter as they aged, as we would expect, but the researchers found among those who meditated, the volume of gray matter did not decline as much as it did among those who didn't. (fisu.org)
Dr. Florian Kurth, a co-author of the study and postdoctoral fellow at the UCLA Brain Mapping Center , said the researchers were surprised by the magnitude of the difference. (fisu.org)
Researchers at the University of Bonn and Hebrew University have discovered that low, regular doses of tetrahydrocannabinol (THC), one of the main active ingredients or cannabinoids found in marijuana, may help to keep our brains from 'slowing down' as we get older. (forbes.com)
To test the chemical's effect on brains of different ages, researchers put mice that were two months, one year, and 18 months old on a daily regimen of THC over the course of a month. (forbes.com)
Overall, the results seem to support researchers' belief that the benefits for older mice are a result of stimulating the brain's endocannabinoid system, a biochemical pathway in both mice and human that grows less active over time. (forbes.com)

It is known that certain lifestyle habits are associated with accelerated atrophy in specific brain regions. (nature.com)
One of only a few Neuroscientists in East Africa, Dr. Vianney has dedicated her career to investigating neurodegenerative diseases and brain atrophy and factors that contribute to neuronal maintenance and regeneration. (sapienlabs.org)
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS). (nuthealth.org)
Background: The effect of diet on age-related brain atrophy is largely unproven. (nuthealth.org)
Objective: To explore the effect of a Mediterranean diet higher in polyphenols and lower in red/processed meat (Green-MED diet) on age-related brain atrophy. (nuthealth.org)
Conclusions: A Green-MED, high-polyphenol diet, rich in Mankai, green tea and walnuts and low in red/processed meat is potentially neuroprotective for age-related brain atrophy. (nuthealth.org)
Post mortem studies have shown that even healthy aging is accompanied by notable cortical atrophy and loss of brain weight from the sixth life decade onwards ( Skullerud, 1985 ). (frontiersin.org)
New brain research findings have suggested that long-term meditation may lead to less age-related gray matter atrophy in the human brain. (fisu.org)
I have also said, as Gururaj before me, that meditation awakens dormant brain cells, so this could indeed be a mixture of atrophy but also of newly awakened brain cells. (fisu.org)

Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study. (eaapublishing.org)
Compared to people with less "cognitive reserve," such people appear to navigate daily challenges for longer despite having the physical hallmarks of advanced dementia in their brains. (latimes.com)
Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. (humanconnectome.org)

Aging has a profound effect on circadian timing," said Block, a professor of psychiatry and biobehavioral sciences and of physiological science. (uclahealth.org)
These results indicate that the outputs of the central circadian clock start to decline in middle age and suggest that the same may be true in humans," said study co-author Christopher Colwell, a UCLA professor of psychiatry and biobehavioral sciences who has conducted research with Block for many years. (uclahealth.org)

The hippocampus area of the brain stores long-term memories. (medicalnewstoday.com)
Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. (nature.com)
We conclude that recruitment of young neurons to the primate hippocampus decreases rapidly during the first years of life, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans. (nature.com)
Here, we show that testosterone supplementation significantly alleviates exploratory behavioral deficits and oxidative damage in the substantia nigra and hippocampus of aging male rats. (aging-us.com)

OBJECTIVE: To characterize the brain-wide expression of Aβ42 throughout the life span of outbred Wistar rats, and to relate these findings to brains of human subjects without neurological disease. (lu.se)
Overall, Ifit2 plays a crucial role in mounting host immunity against neurotropic murine coronavirus in the acute phase while preventing mice from developing viral-induced severe chronic neuroinflammatory demyelination, the characteristic feature of human neurological disease multiple sclerosis (MS). (bvsalud.org)

To what degree is late life cognitive decline driven by age-related neuropathologies? (crossref.org)
The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved. (nature.com)
We review recent research exploring the protective effects of flavonoids on age-related cognitive decline and neurodegenerative disorders in humans and animals. (usda.gov)
As we age, we begin to see a decline in cognitive function and brain plasticity. (earth.com)
A new study of the brain's master circadian clock - known as the suprachiasmatic nucleus, or SCN - reveals that a key pattern of rhythmic neural activity begins to decline by middle age. (uclahealth.org)
Healthy ageing coincides with a progressive decline of brain gray matter (GM) ultimately affecting the entire brain. (frontiersin.org)
Comparing GM decline between 21 young subjects (mean age 23) and 18 elderly (mean age 66) revealed that volumetric measurements differed significantly between methods. (frontiersin.org)
Listening to or practicing music had positive implications on cognitive decline in older adults by stimulating the production of gray matter in key brain areas, a new study reveals. (neurosciencenews.com)

He has published over 200 scientific articles, books, and chapters, the majority applying evolutionary ideas to human behavior and thought processes. (ecampus.com)
But sedentary behavior doesn't reward your fatigued brain and body - it makes you more fatigued. (youngupstarts.com)

However, human cognition is not a timeless singularity. (mcgill.ca)
habitat: Bolivian Amazon), were studied for their effects on brain health and cognition. (usda.gov)
Our brain-to-body ratio is six times that of other mammals, and the neurons in our cerebral cortex (the brain's outer layer, responsible for cognition) are more densely packed than those of any other creature on Earth. (discovermagazine.com)
We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n? (cdc.gov)

We also find that the number of proliferating progenitors and young neurons in the dentate gyrus declines sharply during the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age. (nature.com)
Figure 3: The number of young neurons declines in the human DG from infancy into childhood. (nature.com)
It correlated with damage to pericytes, specialized cells that seal blood vessels in the brain and protect neurons from toxins in the plasma, and occurred in the absence of changes to cerebrospinal fluid levels of Aβ or tau. (alzforum.org)
Sleep deprivation doesn't just alter brain activity, it also changes the connection between neurons. (neurosciencenews.com)
Neurons in the brain die with repeated exposure to stress, resulting in a loss of brain mass and ability. (youngupstarts.com)
RESULTS: In healthy Wistar rats, we find intracellular Aβ42 (iAβ42) in neurons throughout the brain at all ages, but levels vary greatly between brain regions. (lu.se)
Although, there is still an incomplete understanding of how the teamwork between astrocytes, neurons, and other cells in the brain is carried out and what consequences occur when astrocytes stop working properly. (lu.se)

To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. (frontiersin.org)

Exploring these factors promises to reveal the rich spectrum of human ability across the lifespan and challenges what we think of as "normal" performance and aging. (mcgill.ca)
No, your brain is more like one of those muscles that will reward you for having worked it across the full length of your lifespan. (latimes.com)
Telomeres and the natural lifespan limit in humans. (sens.org)
Cognitive changes occur across the human lifespan, with consequences for economic conditions. (hagley.org)
RICHMOND, Calif.--( BUSINESS WIRE )--BioAge Labs, Inc. ("BioAge"), a privately held clinical-stage biotechnology company developing therapeutics that target the molecular causes of aging to extend healthy human lifespan, today announced that the company will provide updates on the company's progress in novel target identification and drug development in the brain aging area at upcoming conferences in the US and UK. (businesswire.com)
BioAge is a clinical-stage biotechnology company developing a pipeline of treatments to extend healthy lifespan by targeting the molecular causes of aging. (businesswire.com)
It is the most intensive period of brain development throughout the lifespan and therefore is the most critical stage of human development. (who.int)

Interestingly, the rates of these "epigenetic clocks" change in various human diseases, suggesting that changes in the epigenetic patterns contribute to age-related disease processes by altering an individual's "biological age. (lu.se)

Telomere length is therefore regarded as a marker for the biological age of a person - in contrast to their chronological age. (mpg.de)
The exciting premise is that telomere lengthening may represent a reversal of biological aging processes. (mpg.de)
The result: 'Across systems, our biological aging appears to change more quickly than we thought. (mpg.de)
Biological samples and brain magnetic resonance images were collected. (eaapublishing.org)
The research marks the first time this has been achieved in middle-aged animals and the first time scientists have watched the central biological clock of aging animals in action. (uclahealth.org)
Instead, by developing models in the dish with high biological relevance and predictive value for the human brain, we can accelerate our knowledge about what occurs during diseases affecting humans. (lu.se)
This study leveraged data from the Multi-Ethnic Study of Atherosclerosis (MESA) on experiences of threat and deprivation in participants' early lives (i.e., before the age of 18) to examine whether exposure to specific dimensions of early life adversity are associated with epigenetic profiles at older ages that are indicative of accelerated biological aging. (cdc.gov)

However, the underlying central mechanisms of obesity, and vice versa, how eating behaviour and other obesity-related factors affect brain structure and function, are far from understood. (mpg.de)
An increased understanding of the molecular mechanisms behind brain aging and how it contributes to the disease process is the key to the development of new therapies. (lu.se)
Aging is a progressive process influenced by genetic and environmental factors that have recently been linked to epigenetic mechanisms. (lu.se)
The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders. (mcgill.ca)
The UCLA research team examined the SCN in mice and found that while critical neural activity rhythms were already disrupted in middle age, the molecular mechanisms that generate these rhythms were not significantly altered. (uclahealth.org)
The BioAge platform has implicated multiple mechanisms in brain aging, including chronic activation of the NLRP3 inflammasome and declining apelin pathway activity. (businesswire.com)
Our mission of understanding the mechanisms of brain aging enables us to pursue the development of therapies with far-reaching potential and impact. (businesswire.com)
By targeting the mechanisms of aging with a large and mechanistically diverse portfolio of drugs, BioAge is unlocking opportunities to treat or even prevent age-related disease in entirely new ways. (businesswire.com)

The average adult brain is about the size of a medium cauliflower. (ageuk.org.uk)
The average adult brain contains around 100 billion brain cells. (ageuk.org.uk)
It's exciting because it suggests that by just manipulating one gene in adult brains, we can boost brain plasticity," said Dr. Jason Shepherd, the lead researcher and Assistant Professor of Neurobiology and Anatomy at the University of Utah Health. (earth.com)
Unlike the latter, which is oriented towards adult education developed for the needs of schools and industries, this type of learning is concerned with the development of human potential, recognizing each individual's capacity for it. (wikipedia.org)
The findings shed new light on adult neurogenesis and brain plasticity. (neurosciencenews.com)

Mitochondrial dysfunction is a common feature of normal aging and is closely associated with the development of age-related neurodegenerative disease [ 1 - 3 ]. (aging-us.com)
Thus, ensuring normal mitochondrial function is critical for delaying aging and reducing the risk of age-related neurodegenerative disease [ 4 , 7 , 8 ]. (aging-us.com)

Total daily physical activity, brain pathologies, and parkinsonism in older adults. (crossref.org)
About 40% of adults ages 65 and older experience memory loss. (medicalnewstoday.com)
First author Axel Montagne and colleagues imaged 12 different regions of the brain in cognitively normal young and old adults, and in older adults with mild cognitive impairment. (alzforum.org)
However, while the learning process can be applied to learners of all ages, there is a focus on adults who are returning to organized learning. (wikipedia.org)
Exposure to methylmercury is more dangerous for developing fetuses and children under four years of age than for adults because it may interfere with normal brain development, causing additional developmental problems and nervous system disorders. (cdc.gov)
From 2000 to 2005, INTERPHONE interviewed 14,000 adults about their cell phone use, other exposures to RF radiation, and other factors conceivably related to brain cancer. (cdc.gov)
Principal investigator Elisabeth Cardis said, "Overall, my opinion is that the results show a real effect… It is too early to make strong recommendations to adults and children concerning the use of phones… But there are ways to limit exposure to the brain from mobile telephones, through the use of [text messaging], speakers or other hands-free devices. (cdc.gov)

For two people of the same chronological age, the person with shorter telomeres has an increased risk of developing age-related diseases such as Alzheimer's or cancer, and even a shorter life expectancy. (mpg.de)
It is also known that some neurological and age-related diseases are associated with faster cortical thinning in certain brain regions. (mpg.de)
These higher levels may be part of the explanation for why men develop these age-related neurodegenerative diseases at a younger age. (sciencedaily.com)
And of interest to both men and women, he said, is that it's possible that brain iron can be influenced by peripheral iron levels -- that is, iron levels throughout the body -- and may thus be a modifiable risk factor for age-related degenerative diseases. (sciencedaily.com)
Higher brain iron levels in men may be part of the explanation for why men develop these age-related neurodegenerative diseases at a younger age, compared to women. (sciencedaily.com)
To describe the study design and baseline characteristics of the Brain Aging National Cohort (BANC)-Peking Union Medical College (PUMC), a study aiming to identify risk and protective factors that contribute to brain aging and age-related neurological diseases. (eaapublishing.org)
The BANC-PUMC study has the potential to unravel the causes and consequences of age-related neurological diseases via a clinicopathological correlation study. (eaapublishing.org)
Topics to be addressed include the diseases on which biotech and pharma should focus to improve healthy longevity, including neurodegenerative diseases driven by brain aging. (businesswire.com)
BioAge is deeply rooted in human biology and data, enabling us to uncover diverse strategies for promoting healthy aging and preventing age-related diseases," said Leong. (businesswire.com)
In this interview, we learn more about her efforts to facilitate future research that explores the role of astrocytes in disease and could lead to the development of new efficient treatments for many diseases affecting the brain. (lu.se)
My Ph.D. studies have focused on developing ways to generate human astrocytes from pluripotent stem cells and fibroblasts for modeling diseases affecting the human brain. (lu.se)
We focused on one of the main cell types found in our brains, the astrocyte, which over the last decade has emerged as an important contributor to a wide range of neurological diseases. (lu.se)

A non-significant elevated mortality rate for "other" mental disorders showed a SMR of 1.09 and suicide rates showed significant and non-significant excesses in mortality when stratified by year and age. (cdc.gov)
BioAge is developing a novel class of CNS-penetrant NLRP3 inhibitors for neurodegenerative and neurosensory disorders associated with aging, and its apelin receptor agonist BGE-105 for multiple indications. (businesswire.com)
It is very difficult to develop therapeutics for central nervous system disorders owing to several challenges in studying the human brain due to its exceptionally high complexity that is not present in other animal species, and inaccessibility to tissue samples from patients and healthy individuals. (lu.se)
In my thesis, we more specifically focused on a group of disorders called leukodystrophies - a group of rare, genetic disorders that affect the white matter of the brain - in which some have clear indications that malfunctioning astrocytes are the primary cause. (lu.se)
Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)

Brain plasticity, or brain flexibility, refers to our brain's remarkable way of adapting and changing in reaction to internal or environmental factors. (earth.com)
Brain plasticity is crucial to early development and is part of our cognitive ability to learn and transition between different concepts we are introduced to as we age. (earth.com)
Through aging, we lose brain plasticity, and our brain's ability to repair itself or adapt to new environmental factors is hindered. (earth.com)
Reversing the effects that aging has on brain plasticity and cognitive functions could lead to life-saving treatments for stroke victims and victims of severe brain injuries. (earth.com)
A study from the University of Utah Health discovered a gene in mice that actually reversed aging effects on brain plasticity and restored the brain to youthful flexibility, allowing the mice to adapt to external factors and recover quickly from changes in input. (earth.com)
The research team examined how Arc was involved in a window period of brain plasticity in mice. (earth.com)
This groundbreaking study uncovers how IGF1 and IGF2 promote brain health and functionality, including learning and memory, through the activation of IGF1-Receptor during synaptic plasticity. (neurosciencenews.com)
Boosting Brain Plasticity: A New Pathway for PTSD Therapy? (neurosciencenews.com)
The study also found the TrkB receptor in PV+ interneurons plays a crucial role in these effects, which may offer new possibilities for the development of psychiatric treatments targeting brain plasticity. (neurosciencenews.com)
Study reveals structural changes of connectivity in the thalamus to other brain areas in those with congenital blindness, providing evidence of brain plasticity. (neurosciencenews.com)

If the telomeres changed in length, this was associated with structural changes in the brain. (mpg.de)
The human brain undergoes continuous structural changes due to development and aging. (frontiersin.org)

Overview and findings from the rush Memory and Aging Project. (eaapublishing.org)
PRINCIPAL FINDINGS: We have developed a computational method for assessing an individual's "physiological brain age" by comparing global mRNA expression datasets across a range of normal human brain samples. (lisanwanglab.org)
These findings suggest that testosterone supplementation may be a viable approach to ameliorating brain mitochondrial dysfunction and thus prevent or treat cognitive-behavioral deficits and neurodegenerative conditions associated with aging. (aging-us.com)
After five years of debate, the INTERPHONE epidemiologists recently published their findings on brain cancer , but their paper raise more questions than it answers. (cdc.gov)

Figure 2: Human DG proliferation declines sharply during infancy and a layer of proliferating progenitors does not form in the SGZ. (nature.com)
While SIRT6 expression declines significantly with age acetylated H3K9 protein expression is increased throughout the brain. (frontiersin.org)

For example, measurements of DNA methylation patterns can accurately determine an individual's age. (lu.se)

From the abstract: 'Can the long arm of childhood on aging-related health be measured in real time? (cdc.gov)

We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. (frontiersin.org)
This was achieved by inhibiting the Acan gene, thereby decreasing the presence of the protein Aggrecan, which solidifies and reduces malleability in the brain. (neurosciencenews.com)
One such protein is called brain-derived neurotrophic factor (BDNF), which is produced only during exercise and works like fertilizer to help new brain cells grow. (youngupstarts.com)
Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP) to increase Aβ production or the Aβ42/40 ratio. (lu.se)

1994 Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. (cdc.gov)
Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection in Infants and Children Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Human immunodeficiency virus (HIV) is a retrovirus. (msdmanuals.com)

In adolescents, brain areas associated with emotional, social, and cognitive functions appear to remain more plastic, or malleable, than other brain areas, thus rendering young people more sensitive to socioeconomic environments throughout adolescence. (neurosciencenews.com)
In 2022, 2.3 million children and adolescents aged ≤17 years had ever received a diagnosis of a concussion or brain injury. (cdc.gov)

At our very foundation, says cognitive neuroscientist Adam Gazzaley, "humans are information-seeking creatures. (discovermagazine.com)

However, it remains unclear if telomere elongation actually reflects any improvement in a person's overall health and aging trajectory. (mpg.de)
The above results suggest that even short-term changes in telomere length over just three months might reflect general fluctuations in the body's health- and aging status. (mpg.de)
Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging. (sens.org)

This suggests that "epigenetic clocks" exist in human cells and that such processes are directly linked to human aging. (lu.se)
In this study, two different species of acai, naturally grown in two distinct regions of the Amazon, Brazilian and Bolivian, were studied for their effects on brain health and mental processes. (usda.gov)
The SCN, located in the hypothalamus, is the central circadian clock in humans and other mammals and controls not only the timing of the sleep-wake cycle but also many other rhythmic and non-rhythmic processes in the body. (uclahealth.org)

These results provide an important validation of source-localized fNIRS in the context of concurrent multimodal imaging for future studies of the relationship between physiological effects in the human brain. (humanconnectome.org)

There is a growing interest in detecting AD pathology in the brain in the very early stages of the disorder. (humanconnectome.org)

METHODS: Aβ42 immunolabeling of 12 Wistar rat brains (3-18 months of age) and brain sections from six human subjects. (lu.se)

Previous research with mice by the Universities of Bonn and Mainz also suggested that the brain's main cannabis receptor and neural pathways are closely related to brain health in later life, and seem to play a role in preventing brain degeneration when active. (forbes.com)

The team plans to explore the potential impact of THC on older human brains with a clinical trial later this year, being one of few to focus on more aged subjects so far. (forbes.com)

Across two parallel lines of research, I ask how experiences and changes in context modify age differences in cognitive control, and what this means for how we define typical cognitive performance. (mcgill.ca)
The results of this study, he said, suggest that menstruation-associated blood loss may explain gender differences in brain iron. (sciencedaily.com)
The unified segmentation/normalization of SPM5/SPM8 revealed the largest age-related differences and DARTEL the smallest, with FSL being more similar to the DARTEL approach. (frontiersin.org)
After transforming each individual brain image into the same stereotactic space (thus correcting for global differences in position, size, and shape across individuals) these voxel-based tissue probabilities can be statistically compared between different populations to determine local alterations of brain structure. (frontiersin.org)
Prior to coffee consumption, among the coffee group, there was "a tendency" toward lower functional connectivity (FC) patterns in the components of most brain networks, but significant between-group differences were found only in the somatosensory and limbic networks, including the right precuneus and right insula. (medscape.com)

My research program uses behavioral and neuroimaging techniques in concert with multivariate analyses to explore how context and experience alter evoked brain and behavioral responses. (mcgill.ca)
The Feindel Brain and Mind Seminar Series will advance the vision of Dr. William Feindel (1918-2014), Former Director of the Neuro (1972-1984), to constantly bridge the clinical and research realms. (mcgill.ca)
The research is reported in the current online edition of the journal Neurobiology of Aging . (sciencedaily.com)
Hysterectomy is the most common non-obstetrical surgery among women in the United States, with one in three having had a hysterectomy by age 60, said Bartzokis, who is also a member of the UCLA Laboratory of Neuro Imaging and the UCLA Brain Research Institute. (sciencedaily.com)
I am excited to be a bridge between the Center for Research of Brain and Mind (CEREBRAM) at NM-AIST and Sapien Labs, as we collaborate to promote wellbeing in Tanzania and across the globe. (sapienlabs.org)
Jennifer came to Sapien Labs out of a curiosity for the workings of the human mind and a desire to blend academic research with real world impact. (sapienlabs.org)
The BANC-PUMC is a longitudinal study established in 2017 in the city of Beijing, enrolling participants who agreed to donate their bodies and brains for medical research. (eaapublishing.org)
Some research in humans shows similar results. (healthline.com)
Despite promising results from animal research, human studies are lacking. (healthline.com)
However, human-based research is lacking. (healthline.com)
Limited human studies, however, demonstrate the need for further clinical research investigating flavonoids. (usda.gov)
If you look at nonhuman primates, it's like they have another set of hands down there," notes Dean Falk, a professor of anthropology at Florida State University and senior scholar at Santa Fe's School for Advanced Research, who specializes in brain evolution. (discovermagazine.com)
The Friends Foundation facilitates groundbreaking brain research. (nin.nl)
The new research added young kids into the mix, from elementary-school age through college age. (3quarksdaily.com)
Notwithstanding, there is a paucity of research on the effects of testosterone supplementation on age-related mitochondrial dysfunction in the brain. (aging-us.com)
Research at King's College in the UK shows the brains of elderly people who practice a healthy lifestyle are the same as people decades younger. (youngupstarts.com)
Brain Research, 163 (2),195-205. (bvsalud.org)
Research on the various cell types in the brain, such as astrocytes, has been hindered by difficulties in obtaining the actual cells to study. (lu.se)
There is extremely limited access to brain tissue for research purposes, both from healthy individuals as well as from patients with brain disease. (lu.se)

A recent study analyzed brain imaging data and chronological age (CA) information from twins and suggested that the brain aging process was heritable 14 . (nature.com)

Services USDoHaH, Department of Health and Human Services. (crossref.org)
This may have health benefits, especially in men, and may help counteract the negative effects of aging on the brain by reducing the iron available to catalyze, or speed up, damaging free-radical reactions. (sciencedaily.com)
I'm interested in how scientific insights can be translated into tangible applications that have real-life benefit, and the opportunity to shape the future of brain health and mental health care, ultimately enabling people to receive care and support that is more tailored to their needs. (sapienlabs.org)
Vitamin B3 has several health benefits, including performance, beauty and brain health. (dsm.com)
Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services. (cdc.gov)
References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. (cdc.gov)
The company uses its discovery platform, which combines quantitative analysis of proprietary longitudinal human samples with detailed health records to map out the key molecular pathways that impact healthy human aging. (businesswire.com)
MRLs are health guidance values established by ATSDR and are intended for use by health assessors as screening tools when determining whether further evaluation of potential human exposure at hazardous waste sites is warranted. (cdc.gov)
Coffee holds "particular interest for human health, in view of its short-term effects on attention, sleep, and memory and its long-term impact on the appearance of different disease and on healthy span of aging," the authors write. (medscape.com)
Based on parent or guardian responses to the questions, "Has (child) ever been checked for a concussion or brain injury by a doctor, nurse, athletic trainer, or other health professional? (cdc.gov)
and "Did a doctor, nurse, athletic trainer, or other health professional ever say that (child) had a concussion or brain injury? (cdc.gov)
MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. (cdc.gov)

Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain anatomical characteristics. (nature.com)

To determine the role of telomer length on brain structure scientists measured their length with the DNA of leukocytes from the blood using a polymerase chain reaction. (mpg.de)
Scientists used the tACS system to deliver oscillating electrical currents through electrodes placed on the scalps of 150 people between the ages of 65 and 88. (medicalnewstoday.com)
In recent years, scientists have identified about two dozen genetic changes that might have helped make our brains not only bigger but incomparably capable. (discovermagazine.com)
The scientists studied young mice, which were just a few months old, and middle-aged mice, which were more than a year old. (uclahealth.org)
As industrialization sped up work, and enhanced the wealth of society, social scientists and business leaders struggled to better understand the aging process, and to address its implications in the workplace. (hagley.org)
The scientists looked directly at the association between age and gray matter. (fisu.org)

Indices of aging can vary together significantly in just three months,' says Puhlmann. (mpg.de)
As has been similarly observed with humans, younger animals excelled at the tests when 'sober' but tended to struggle significantly under the influence of THC. (forbes.com)
0.22), significantly influenced healthy aging more than age and sex. (cdc.gov)

The study indicates that training the brain to block out negative thoughts could improve symptoms of anxiety, depression, and PTSD. (medicaldaily.com)
A new study now shows that if telomeres change in their length, that change is also reflected in our brain structure. (mpg.de)
This study identifies previously unknown roles for sirtuins in regulating cellular homeostasis and healthy aging. (frontiersin.org)
The mission and approach of Sapien Labs in performing a large-scale study on brain and mental wellbeing across continents will continue to reveal much about the brain interactions to its surroundings. (sapienlabs.org)
Non-significant elevated mortality rates were noted for ages 35-54 in each of the five-year increments for the entire study period 1953-2003. (cdc.gov)
Drinking coffee on a regular basis appears to enhance concentration and improve motor control and alertness by inducing functional and connectivity changes in the brain, a new imaging study suggests. (medscape.com)
The study "was not intended to measure the beneficial vs deleterious effect of caffeine in the brain, where there are several conflicting results," said Sousa. (medscape.com)
Early-Life Adversity Associations With Later Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis. (cdc.gov)

We find experiences of deprivation, but not threat, are associated with later-life GrimAge epigenetic aging signatures that were developed to predict mortality risk. (cdc.gov)

Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated. (frontiersin.org)
In addition, increases in the levels of brain- originating antioxidants (molecules involved in counteracting stress and inflammation), as well as molecules responsible for their production, were found in the brains of the acai-fed rats. (usda.gov)
These effects were consistent with improved mitochondrial function, reflected by testosterone-induced increases in mitochondrial membrane potential (MMP), antioxidant enzyme (GSH-PX, catalase, and Mn-SOD) expression/activity, and mitochondrial respiratory complex activities in both brain regions. (aging-us.com)

The investigation was carried out on healthy volunteers of 18-25, 40-50 and 65-75 years of age. (beckleyfoundation.org)
Among the 885 participants, 43.3% were men, and the mean age of the cohort was 71.3 ± 8.2 years. (eaapublishing.org)
Sometime between 6,550 and 6,800 years ago, two human bodies and that of a young sheep or goat were laid to rest among some of their earthly possessions in a cave on the Southern Iberian Peninsula, where they remained in the shadows along with their mysteries. (syfy.com)
But by the time Homo sapiens emerged at least 300,000 years ago, brain volume had tripled. (discovermagazine.com)
Co-author Andras Bilkei-Gorzo told the Guardian , "If we can rejuvenate the brain so that everybody gets five to 10 more years without needing extra care then that is more than we could have imagined. (forbes.com)
Mycovirus-like DNA virus sequences from cattle serum and woman, 47 years of age, who had immigrated to Spain from human brain samples from multiple sclerosis patients. (cdc.gov)
The groups did not differ in age (range, 19 - 57 years) or number of years of formal education. (medscape.com)
Early childhood spans the prenatal period to eight years of age. (who.int)
Emphasizing the conclusion's first sentence, Swedish researcher Maria Feychting said: "The use of mobile phones for over ten years shows no increased risk of brain tumors. (cdc.gov)
Diagnosis of a concussion or brain injury increased with age, from 1.0% among those aged 0-5 years to 2.3% among those aged 6-11 years, and 5.9% among those aged 12-17 years. (cdc.gov)

Figure 1: Early fetal development of the human DG. (nature.com)
Exposure to excessive levels of elemental (metallic), inorganic or organic mercury can permanently damage the brain and kidneys of people of all ages and interfere with fetal development. (cdc.gov)

Bartzokis suggests it may be possible to reduce age-related brain iron accumulations by reducing the levels of iron throughout the body. (sciencedaily.com)
Although evidence suggests that the two phenomena are interrelated, it is unclear whether testosterone supplementation ameliorates mitochondrial dysfunction in the aging male brain. (aging-us.com)

While associations between individual human brain regions and environmental or genetic factors have been investigated, how brain age is associated with those factors remains unclear. (nature.com)
Our results suggest that both environmental and genetic factors are associated with structural brain aging. (nature.com)
Besides lifestyle habits, genetic factors are also thought to be involved in brain aging. (nature.com)
Therefore, we also investigated if genetic factors are associated with brain aging in addition to smoking and alcohol consumption. (nature.com)
Therefore, it is important to explore if there is genetic and environmental factor interaction in association with brain aging. (nature.com)
Further studies aimed at exploring genetic diversity and natural history of gemycircularviruses in human hosts are needed. (cdc.gov)

Men have more iron in their bodies and brains than women. (sciencedaily.com)

This is good news, because it points where in the cell to look for the age-related 'lesion' and thus helps inform what type of measures may be available to reduce these age-related deficits. (uclahealth.org)
Altered mitochondrial recycling, resulting from abnormal biogenesis/mitophagy cycles, coupled to decreased antioxidant capacity and hence unmitigated reactive oxygen species (ROS) production, all result in impaired ATP synthesis and trigger energy deficits largely responsible for the progressive cellular dysfunction characteristic of aging [ 3 , 4 ]. (aging-us.com)

Yan W , Zhang T , Kang Y , Zhang G , Ji X , Feng X , Shi G , . Testosterone ameliorates age-related brain mitochondrial dysfunction. (aging-us.com)
Brain mitochondrial dysfunction and reduced testosterone levels are common features of aging in men. (aging-us.com)

The changes we observed in the electrical rhythm between the young and middle-aged animals, which are quite dramatic, occur even though we do not see significant changes in the underlying molecular rhythm," Block said. (uclahealth.org)

Lung transplant is surgery to replace one or both diseased lungs with healthy lungs from a human donor. (medlineplus.gov)
Factors associated with healthy aging in Latin American populations. (cdc.gov)

Working with colleagues at USC, and other institutions in the LA area, Zlokovic used dynamic contrast-enhanced MRI to measure the permeability of the blood-brain barrier. (alzforum.org)
Almost three decades ago, we postulated the same hypothesis, based on histologic analysis of aged brains, demonstrating a blood brain barrier (BBB) breakdown and leakage of serum proteins in aged (but not young) human brain ( Pappolla and Andorn, 1987 ). (alzforum.org)
The reason for a leaky blood-brain barrier (BBB) with aging may well rest with how dysregulated the HPG axis becomes after menopause and during andropause. (alzforum.org)
Furthermore, infected Ifit2-deficient mice showed impaired activation of T cells in the cervical lymph node and relatively intact blood-brain barrier integrity. (bvsalud.org)

And end of the day, you are not only going to look younger at work, your brain is going to work better at work. (bigthink.com)
That's bad news for the middle-age-ish among us who must compete with the endless line of fresh-faced, energetic younger workers jostling for position. (youngupstarts.com)

To date, it is still unclear how smoking and alcohol consumption is associated with brain structural aging, especially when the morphology of all the brain regions is considered. (nature.com)
They looked at several areas in the brain three white-matter regions and and five gray-matter regions. (sciencedaily.com)
Chemical analyses were performed in critical brain regions associated with memory and mental processing of 19-month-old acai-fed rats, in which the mental-processing benefits of acai had been established. (usda.gov)
To address this issue, we evaluated behavioral responses, assessed neuronal function and integrity, and conducted a comprehensive analysis of mitochondria-related parameters in selected brain regions of aged (24 months old) male rats supplemented with testosterone propionate (TP). (aging-us.com)
Instead, what we actually observed was a widespread effect of meditation that encompassed regions throughout the entire brain. (fisu.org)
This deterioration of critical brain regions hinders memory processing, strategic planning, and the ability to manage anxiety, which are all crucial skills for the executive. (youngupstarts.com)

Results indicated significant reductions in the levels of brain molecules known to cause cellular stress and inflammation in acai-fed rats. (usda.gov)

Here's how, with your support, Age UK is supporting older people through the cost of living crisis. (ageuk.org.uk)
What we have shown here and elsewhere is that we can apply safe and noninvasive applications of low-intensity alternating current in a specialized way that is keyed to the intrinsic brain rhythms implicated in memory processing, and as a result, control and enhance these brain rhythms and their corresponding memory systems, especially for people with poorer cognitive function," he noted to Medical News Today . (medicalnewstoday.com)
But while late-life slides in mental performance afflict both the intellectually fit and the disengaged, people who stayed cognitively active will probably start their age-related mental descent from a higher perch. (latimes.com)
They found that the BBB became more permeable as people aged, and even leakier in those with MCI. (alzforum.org)
Summary GSE may help reduce blood pressure, particularly in young to middle-aged people and those who have excess weight. (healthline.com)
Was botched brain surgery or human sacrifice the end for these Neolithic people? (syfy.com)
Magazines are now useless and impossible to understand, for digital natives'-that is, for people who have been interacting with digital technologies from a very early age. (scientificamerican.com)
Brain aging can lead to devastating neurological conditions, which affect millions of people every year," said Kristen Fortney, PhD, CEO and co-founder of BioAge. (businesswire.com)
The not so good news is that starting when people are in their mid-to-late-20s, the brain begins to wither - its volume and weight begin to decrease - and yes, this seem so early in life. (fisu.org)
The brains of people who are chronically fatigued show signs of shrinking, which means stressed executives have about the same brain capacity as people decades older. (youngupstarts.com)
Lung transplants may be recommended for people under age 65 who have severe lung disease. (medlineplus.gov)

Therefore, an acai-enriched diet might modulate a number of cellular pathways, counteracting stress, reducing inflammation, and stimulating clearance of toxic molecules which might lead to improvement in cognitive function of the aging brain. (usda.gov)

Anatomy56

Organisms14

Diseases35

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Psychiatry and Psychology17

Phenomena and Processes41

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science9

Named Groups1

Health Care7

Alzheimer's11

Neuroscience6

Neurodegeneration6

Researchers26

Atrophy9

Dementia3

Professor of psychiatry and biobehavioral sciences2

Hippocampus4

Neurological disease2

Decline8

Behavior2

Cognition4

Neurons7

Characterize1

Lifespan7

Altering an individual's1

Biological7

Mechanisms8

Adult5

Neurodegenerative disease2

Adults7

Diseases12

Disorders5

Plasticity10

Structural changes2

Findings4

Declines2

Individual's1

Abstract1

Protein4

Immunodeficiency virus4

Adolescents2

Cognitive neuroscientist1

Telomere3

Processes3

Physiological1

Pathology in the brain1

Methods1

Brain's1

Clinical trial1

Differences5

Research19

Chronological age1

Health12

Characteristics1

Scientists6

Significantly3

Study8

Epigenetic1

Increases3

Years10

Fetal development2

Suggests2

Genetic6

Bodies1

Deficits2

Dysfunction2

Molecular1

Healthy2

Blood-Brain B4

Younger2

Regions6

Rats1

People11

Cellular1